简介：Tofindouttheoptimalconcentration,infusionrateanddosageofsalineforresuscitation.Methods:Forty-fivedogswereusedtoestablishhypovolemicshockmodels.Thedogswereresuscitatedwithsalineofdifferentconcentrationsanddifferentdosagesunderdifferentinfusionrates,andtheresuscitationresultswerecompared.Results:Thebestconcentrationwas7.5%,thebestrateofinfusion20ml/min(avolumeequivalentto15%oftheshedblood)andthebestdosage5.71ml/kg.Themethodwaseffectiveforresuscitation,themeanarterialpressure(MAP)couldbeelevatedto89%ofthebaseline,andthisMAPcouldbekeptformorethanonehour.Conclusions:Using7.5%sodiumchloridesolutionequivalentto15%oftheshedbloodataninfusionrateof20ml/mincanachieveabestresuscitationresult.

简介：Diffuseaxonalinjury(DAI)isaxonalandsmallvesselinjuryproducedbyasuddenaccelerationoftheheadbyanexternalforce,andisamajorcauseofdeathandseveredisability(Paterakisetal.,2000).Prognosisispoorerinpatientswithapparenthemorrhagethaninthosewithout(Paterakisetal.,2000).Therefore,itisimportanttoidentifythepresenceandprecisepositionofhemorrhagicfociforamoreaccuratediagnosis.CTandmagneticresonanceimaging(MRI)havelongbeenappliedinthediagnosis

简介：Objective:Tostudytheeffectofmethylprednisolone(MP)onreperfusioninjuryinsevereuncontrolledhemorrhagicshockandexplorethepossiblemechanisminvolved.Methods:Twelvedogswererandomlydividedintotwogroups,controlgroup(GroupI,n=6)andMPgroup(GroupII,n=6).Theanimalswerebledcontinuouslyfromafemoralarterycathetertoproduceuncontrolledhemorrhagicshockmodels.ResuscitationwithlactatedRinger's(LR)solutionwasinitiatedwhenmeanarterialpressure(MAP)decreasedto20mmHg,andMAPwasmaintainedat30-40mmHg.MP(4mg/kg)wasinjectedintravenouslyinGroupIIwhenresuscitationbegan.WhileinGroupI,normalsaline(NS)wasinjectedinstead.Thelevelsofsuperoxidedismutase(SOD)andmalondialdehyde(MDA)weremeasuredbeforeexsanguination(T1),whenMAPdecreasedto20mmHg(T2),60min(T3)and120min(T4)afterresuscitation.Heartrate,MAPandcardiacoutput(CO)levelswererecordedconcomitantly.Results:InfusionvolumeandhemorrhagevolumeshedfromthesuperiormesentericarteryinGroupIwerehigherthanthoseinGroupII(P<0.01andP<0.05).Afterreperfusion,bloodSODlevelsdecreasedprogressivelyandMDAlevelsincreasedrapidlyinGroupI.InGroupII,bloodSODlevelsatT3andT4decreasedascomparedwiththatatT1butastepwiseincreasewaspresent.AtT4,bloodSODlevelwassignificantlyhigherinGroupIIthaninGroupI(P<0.01).AtT3andT4,MDAlevelsweremarkedlylowerinGroupIIthaninGroupI.Duringreperfusion,MAPwasmoresteadyinGroupIIthaninGroupIandsurvivalrateafter120min(atT4)washigherinGroupIIthaninGroupI(P<0.05).Conclusions:MPhasaprotectiveeffectonsevereuncontrolledhemorrhagicshockandsubsequentreperfusioninjury.Themechanismmainlyinvolvestheanti-lipidperoxidationactivityofMP.

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简介：导致放射的胃炎是胃肠的流血的一个很少发生的原因。从放射治疗产生是严肃的复杂并发症的。起始的损害是胃的mucosa的表示特性地尖锐的发炎。我们介绍了一个46岁的男病人，出血性的胃炎为hepatocellular癌的变形retroperitoneal淋巴节点由外部放射疗法导致了。内视镜的考试在胃和十二指肠的灯泡的整个muscosa与毛细管扩张显示出弥漫的edematoushyperemicmucosa。有活跃流着的多重出血性的补丁在窦上被发现。反秘书治疗为hemostasis被开始，但是melena仍然发生了离开并且在上。最后，他被氢化尼松治疗成功地对待。我们强烈因此争论赞成perdnisolone治疗有效地与导致放射的出血性的胃炎对待病人。

简介：ＩＤｅｐａｒｔｍｅｎｔｏｆＣｌｉｎｉｃａｌＰｈａｒｍａｃｏｌｏｇｙ，ＦｉｒｓｔＡｆｉｌｉａｔｅｄＨｏｓｐｉｔａｌ，ＣｈｏｎｇｑｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＭｅｄｉｃａｌＳｃｉｅｎｃｅｓ，Ｃｈｏｎｇｑｉｎｇ４０００１６，Ｃｈｉｎａ（ＺｈｏｕＹＤ，Ｗ...

简介：ＡＲｅｓｅａｒｃｈＩｎｓｔｉｔｕｔｅｏｆＳｕｒｇｅｒｙ，ＤａｐｉｎｇＨｏｓｐｉｔａｌ，ＴｈｉｒｄＭｉｌｉｔａｒｙＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，Ｃｈｏｎｇｑｉｎｇ４０００４２，Ｃｈｉｎａ（ＬｉｕＬＭ，ＣｈｅｎＨＳ，ＨｕＤＹ，ＬｕＲＱ，ＣｈｅｎＹ...

简介：Inordertoanalyzethenucleoprotein(NP)geneofCrimean-Congohemorrhagicfevervirus(CCHFV),viralRNAwasamplifiedbyRT-PCRbyusingtheproof-readingDNApolymerasetoproducethecompleteNPgene.ThePCRproductwassequenced,analyzedforphylogenesisandclonedintotheexpressionvectorpE132aandtherecombinantplasmidexpressedinE.coilBL-21withhighyield.Theprimarilypurifiedfusedprotein.wasusedtocoatELISAplatesforthedetectantibodies.ItwasfoundthesimilaritiesbetweenNPgeneofBA88166andotherXHFVsinnucleotidelevelandaminoacidcontentswereverysignificant,andtheNPgeneofBA88166encodedanucleoproteinwith482aminoacidandadeducedmolecularweight(MW)of54kDa.Westernblotassayshowedthatthefusionproteinexpressedinbacteriapossessedgoodantigenicity.TheresultswithELISAforthedetectionofthehumanandanimalseracollectedinendemicareaswerefoundtobeingoodaccordancetotheclinicaldiagnosis.ItconcludedthattherelationsofNPgenesofXHFVBA88166andotherXHFVsappearedtobeevolutionallyclose.Themethodologiesestablishedinthisstudywereaccurate,specific,rapidandreproduciblefortheclinicalexaminationsandepidemiologicalsurvey.

简介：客观：在试验性的出血性的吃惊老鼠在心肌层和hepatocyte线粒体的功能上调查海水沉浸的效果。方法:24只男Wistar老鼠被划分成三个组(8在各个组织的n=)：控制组，HSL组(土地上的出血性的吃惊组)和HSS组(在海水的出血性的吃惊组)。血液动力学的参数，H~+-ATPase(adenosinetriphosphatase)的活动，succinatedehydrogenase(同步数字系列)和Ca~(2+)-Mg~(2+)-ATPase，在心肌层和hepatocytemitochondria的钙内容被测量，越过内部mitochondrialmembrane的质子translocation的变化被分析。结果：hernodynamic索引和H~+-ATPase的活动，同步数字系列，在HSS组的Ca~(2+)-Mg~(2+)-ATPase是比在控制组和HSLgroup的那些显著地低的(P<0.05)。在HSS组，在心肌层andhepatocyte的织物和线粒体的钙层次与控制组和HSL组相比显著地被提高(P<0.05)。在在三个组之中的质子translocation的Therewas不重要的差别。结论：Thisinvestigation证明那海水沉浸能加重出血性的吃惊老鼠的条件。

简介：Objective:Toinvestigatethetherapeuticeffectofcisaprideongastricinjuryfollowinghemorrhagicshockresuscitation.Methods:108Wistarratsweighing(200g±30g)wererandomlydividedintoashamshock(SS)group(n=36),ahemorrhagicshockresuscitation(HS)group(n=36)andahemorrhagicshockcisapridetreated(HSC)group(n=36).Samplingat1,2and4hoursafterresuscitationwasdoneand6samplesforeachobservationitemweretaken.Thegastricbloodflowvolumewasmeasuredbyisotopelabelbiologicalmicroglobulin.GastricpHi,gastricemptying,MDAandNa+-K+-ATPaseofgastricmucosaweremeasured.Results:IntheHSCgroup,therelativeresidualrateofgastricpigmentdecreasedsignificantly,thegastricbloodflowvolumeelevated;gastricpHiincreasedsignificantlyat2hours;thelevelofmucosalMDAdecreasedat4hours,theactivityofNa+-K+-ATPaseincreasedandthelacticacidlevelintheportalveindecreasedsignificantlycomparedtotheHSgroup.Conclusions:Afterhemorrhagicshockresuscitation,cisapridecontainedthefollowingfunctions,1)promotinggastricemptying,2)increasingthebloodflowofgastricbloodflowvolumeandgastricpHi,3)depressingthelacticacidconcentrationoftheportalveinandimprovingMDAvolumeandNa+-K+-ATPaseactivityofgastricmucosa.Itsuggeststhataftercomplementingeffectivecirculatingbloodvolumeforhemorrhagicshockresuscitation,earlyuseofcisaprideforgastricmotilityishelpfulforanimprovementoflastingischemiaandhypoxiainstomach.

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简介：Thispaperintroducesthecurativeeffectson142cases(278eyes)ofAfricanepi-demichemorrhagicconjunctivitistreatedbyacupuncture,and128(90.1%)cases(250eyes)ofallpatientshavebeenimproved.Threegroupswereclinicallyobservedinthepresentreport.Therewere55cases(104eyes)inthefirstgroupforbodyacupuncture,ofwhich46(83.6%)caseswereeffec-tivelytreated;Inthesecondgroupforauricularacupuncture,34(91.6%)cases(68eyes)outof37cases(74eyes)wereimproved;Therewere50cases(100eyes)inthethirdgroupforboyauricular-acupuncture,amongwhich48(96.0%)cases(96eyes)wereimproved.Thecurativeeffectsofthethirdgroupwerebetterthanthoseoftheothertwogroups.

简介：摘要

简介：Themajortherapyforischemicstrokeisthrombolytictreatment,butsevereconsequencesoccurwhenthismethodisusedtotreathemorrhagicstroke.Currently,computedtomographyandmagneticresonanceimagingareusedtodifferentiatebetweentwotypesofstroke,butthesetwomethodsarein-effectiveforpre-hospitalcare.

简介：TheZ10andZ37strainsofhemorrhagicfeverwithrenalsyndrome(HFRS)virusandtheMongoliangerbil(Merionsunguiculatus)kidneycellswereusedtopreparetheinactivatedbivalentvaccine.AphaseⅡclinicaltrialuseofthisvaccinewasmadein750Chinesevolunteers.Theresultsshowedthatthesidereactionratewas2.5%andthesero-conversionrateofneutralizingantibodiesagainstHantaanandSeoulvirusesintheinoculatedvolunteerswere87.6%and96.3%respectively.

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简介：Inordertoelucidatethemolecularandimmunologicalmechanismsaswellasthepathogenesisofhemorrhagicfeverwithrenalsyndrome(HFRS),theCD8^+cytotoxicTlymphecytes(CTL)clonewasestablisheddirectlyfromperipheralbloodmononuclearcells(PBMC)ofpatientswithHFRS.TheactivitiesofCTLweredetectedasusualwithEBV-transformedlymphoblastoidcellline(BLCL)astargetcells.TheresultsshowedthattheCTLclonecouldrecognizedandkilledthetargetcellswithspecificityofnucleocapsidproteinofHantaanvirus(HTNVNP)withthecytotoxicitypercentagesof50.2%,25.4%and39.0%respectively.TheseresultsdemonstratedthattheantigenicepitopesofHTNVNPmainlylocatedontheC-temainaloftheviralnucleocapsidprotein.

简介：AbstractDespite overwhelming evidence from large randomized clinical trials supporting a clear benefit of low-density lipoprotein cholesterol (LDL-C) lowering therapy on the primary and secondary prevention of atherosclerotic cardiovascular disease, data from epidemiological and clinical observations demonstrated an increased incidence of hemorrhagic stroke in patients with low LDL-C exposure (<70 mg/dL), especially among East Asians. Meanwhile, emerging studies have reported a paradoxical phenomenon in which hypercholesterolemia is associated with better short-term outcomes in acute coronary syndrome patients, the "lipid paradox." The underlying mechanism for these two closely connected clinical observations is not clear. This review aimed to summarize the evolution and clinical implications of these two low LDL-C related concepts, and proposed a "double-hit" hypothesis that may help explain these phenomena. It is worth noting that in the era of increasing use of high-intensity LDL-C lowering and dual antiplatelet strategies in atherosclerotic cardiovascular disease in patients receiving percutaneous coronary intervention, balancing the risk of thrombosis with bleeding complication should be a priority in clinical practice. Our hypothesis may raise clinicians’ awareness to identify potential high risk patients with low LDL-C (<70 mg/dL), especially among East Asians.