简介:AbstractAs human life expectancy continues to increase and the birth rate continues to decline, the phenomenon of aging is becoming more prominent worldwide. Therefore, addressing the problems associated with global aging has become a current research focus. The main manifestations of human aging are structural degeneration and functional decline of aging tissues and organs, quality of life decline, decreased ability to resist diseases, and high incidence rates of a variety of senile degenerative diseases. Thus far, no ideal treatments have been found. Stem cell (SC) therapies have broad application prospects in the field of regenerative medicine due to the inherent biological characteristics of SCs, such as their plasticity, self-renewal, and multidirectional differentiation potential. Thus, SCs could delay or even reverse aging. This manuscript reviews the causes of human aging, the biological characteristics of SCs, and research progress on age reversal.
简介:AbstractReverse genetics via targeted modification of gene sequences to obtain a phenotype and the inference of a gene's function or regulatory mechanism is widely used as a potent tool in viral biology and application. However, while reverse genetics has contributed significantly to our understanding of molecular biology and the pathogenesis of viruses, its accessibility (operation) and openness (data) have raised many concerns regarding biosafety and biosecurity. In this review, we retrospectively examine the development of reverse genetics and its applications in virology, then emphasize global biosafety and biosecurity concerns regarding reverse genetics, and summarize global regulations, governance, and laws on reverse genetics. This review seeks to enhance our understanding and rational application of reverse genetics technology for the benefit of humankind.
简介:有弹性的移植被采用multicomponent处理地震数据的向量广泛地付了注意。光线基于的有弹性的Kirchhoff移植有象高灵活性和高效率的如此的性质。然而,它没能解决multipath引起的许多问题。在另一方面,有弹性的反向时间的移植(请读使用手册)基于双向波浪方程被知道能够处理这些问题,但是当在3D情况和速度模型大楼中适用时,它是极其昂贵的。基于有弹性的Kirchhoff-Helmholtz积分,我们计算decoupled由介绍有弹性的格林的向后继续的wavefields为P-waves,和S波浪工作,它被elastodynamicGaussian横梁的求和表示。PP和改正极性的PS图象被计算关联在之间获得向下并且decoupled向后继续的向量wavefields,在极性修正被分析在极化之间的关系执行的地方,变换PS的方向飘动并且接口上的事件角度。到大程度,我们的方法把基于光线的移植的高效率与波浪方程的高精确性相结合基于的反向时间的移植。到从差错模型和Marmousi2的合成数据集建模的multicomponent的这个方法的申请表明新方法的有效性,灵活性和精确性。
简介:Anoptimumdesignapproachtoreverse-flowcyclonesbasedontheconceptofoptimizingcyclonedimensionsisintroducedinthispaper.Thisapproachinvolvesoptimizingcyclonedimensionsbycategories,calculatingcycloneperformancebycorrelatingsimilitudenumbersandoptimizingthecombinationoffourcycloneparameters,D1KA1dr^-andvi,whichhasbeenproventobeapplicablenotonlyforsingle-stagecyclone,butalsoformultistagecycloneseparators.ApplicationsofthedesignedcyclonesinFCCunitsandacrylonitrilereactorsarealsopresented.
简介:Inrecentyears,intravascularultrasound(IVUS)follow-upisalwaysusedintheevaluationofthedevelopmentofatherosclerosis,anditcanalsobeusedastheendpointofdrugtherapyinclinicalobservation.Since1994,thefirststatinlipid-lowering4Sexperimentresultswasreported,thefollowingstatinforlipid-loweringtestsrepresentedbyREVERSALPROVE-IT,TNT,IDEAL,ASTEROIDandJUPITERstronglyconfirmedthatfurtherreducetheefficacyoflow-densitylipoproteincholesterol(LDL-C)(toenhancethelipid-loweringtreatment)accesstoincreaseeffectofthecardiovascularprotectionandalsoreversetheplaques'progress.Butscholars'opinionsonthemeritsanddemeritsofenhancestatincholesterol-loweringtherapyhasbeenindebate.Wereviewtherecentworkonstatinsandreversalofarterialplaquesforanumberofclinicalstudies.
简介:thereconstructionoftransitionsurfaceisoneoftimeconsumingactivitiesduringsurfacemodelinginreverseengineering.Yetcurrentlyavailablesoftwareapplicationssufferfromshortcominginprocessingtheconnectionamongfreeformsurfaces.Inthispaper,anewmethodisputforwardcombiningSurfacerwithUnigraphicstoresolvethisproblem:CurvesandsurfacesarefirstconstructedinSurfacer,then,thefinisheddataisimportedintoUnigraphicsbasedonIGESformat.Atlast,thetransitionsurfacecanbereconstructedinUnigraphics.Theapplicationofthismethodintransitionsurfacereconstructionisillustratedbymeansoftwocasestudies,showingtheconnectionbetweenfreeformsurfaces;filletingandroundingamongmultiplesurfaces;transitionsurfacebetweentwosetsofsurfaces.
简介:聚类的地震指在时空与对方一起仔细发生的地震事件。因为他们的重叠波形记录使拣第一到达困难,聚类地震的hypocenters不能被traveltime地点方法精确地决定。这里,我们使用一个反向时间的成像(RTI)方法印射聚类地震。拿直接使用波形的优点,RTI方法是有能力的印射单个小地震或浓密地散布的一些在2-D下面聚类地震地震数组。在3-D情况中,RTI方法成功地被使用从一套稀疏地分布式的表面车站用数据定位长偏移量的马甲地震。为一样的获得几何学,然而,在印射的RTI相遇挑战浓密地散布了聚类地震。当改进印射聚类地震与照明角度的更宽的范围要求一个更稠密的接收装置网络,是明显的时,与合成数据验证RTI方法的实际分辨率是必要的。在我们在三个峡区域的学习区域,我们3-D情况的测试建议在线性排列亚数组下面的一些事件有合理分辨率。
简介:Reverseengineeringdealingwithimagesistraditionallybasedonimageprocessingandcontourrecognition.Anewmethodispresentedbasedonthecombinationofsectionalslicingwithimagemosaic.Sectionalcontoursofthetargetobjectaregeneratedbycolorfulliquidorlaserscanning,theseimagesfromdifferentviewsarefusedintoasetofcompletecross-sectionalimages,therebythewholepracticalmodelisreconstructedin3Dspace.
简介:LetAbearealsquarematrixandVTAV=GbeanupperHessenbergmatrixwithpositivesubdiagonalentries,whereVisanorthogonalmatrix.ThentheimplicitQ-theoremstatesthatoncethefirstcolumnofVisgiventhenVandGareuniquelydetermined.Inthispaper,threeresultsareestablished.First,itholdsareverseorderimplicitQ-theorem:oncethelastcolumnofVisgiven,thenVandGareuniquelydeterminedtoo.Second,itisprovedthatforaKrylovsubspacetwoformulationsoftheArnoldiprocessareequivalentandinonetoonecorrespondence.Finally,bytheequivalencerelationandthereverseorderimplicitQ-theorem,itisprovedthatfortheKrylovsubspace,ifthelastvectorofvectorsequencegeneratedbytheArnoldiprocessisgiven,thenthevectorsequenceandresultingHessenbergmatrixareuniquelydetermined.
简介:集成电路(IC)camouflaging技术对反向的工程(RE)作为一项反措施被使用了。然而,它的有效性被布尔可满足性威胁(坐)基于伪装de攻击,它能在仅仅分钟以内恢复camouflaged电路。作为到坐基于伪装de攻击的防卫,崭新的camouflaging策略(叫的CamoPerturb)最近被建议了,它使不安由改变一门功能的一minterm然后与分开的camouflaged块恢复使不安的电路,对坐基于攻击完成好抵抗。在这份报纸,我们由说明门代替导致的minterm不安的机制分析CamoPerturb的安全危险,然后建议攻击恢复改变的门功能,并且恢复camouflaged电路。攻击算法被促进感受性和含意原则在自动测试模式产生(ATPG)便于技术。试验性的结果证明我们的方法能与很小的时间消费恢复camouflaged电路。