简介：Generally,ROSareregardedashostdefensemoleculesthatarereleasedbyneutrophilstodestroyexogenouspathogenssuchasbacteriaandtoactassecondarymessengersinsignaltransduction.However,increasedproductionofROSisalsoinvolvedininducingpathophysiologicalchangessuchasapoptosis,cellcycledisruption,andnecrosis.Forthisreason,inductionofROS-mediateddamageincancercellsbypharmacologicalagentsthateitherpromoteROSgenerationordisablethecellularantioxidantsystemisconsideredapotentialtherapeuticstrategyforpreferentiallykillingcancercells[1].

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简介：InstitutionofModernPhysics(IMP)hasdesigned,fabricatedandinstalledthefirstSRFcavityelectropolishingsystemofChina.It’ssizedfor1.3GHzSRFcavities,andalsocanworksformultiplecellcavitieswithfurtherupgradeofstructure.

简介：Fromtheperspectiveofcarbondisclosuregoal,thepaperdefinedthedetailtypesofcontentsaboutcarboninformationdisclosure,thenconstructedthecarboninformationdisclosureindex,byusingtheindicesto2011annualreportofA-sharelistedcompaniesinShanghaiandShenzhenSecurityExchange,wefoundthatChineseenterprises’carbondisclosurescattered,industrystructurequitedifferentcharacteristics,quantityinformationandqualityinformationasymmetry.

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简介：AIM:Toanalyzethemismatchrepair(MMR)statusandtheARID1Aexpressionaswellastheirclinicopathologicalsignificanceingastricadenocarcinomas.METHODS:WeexaminedtheexpressionsofMMRproteinsandARID1Abyimmunohistochemistryinconsecutive489primarygastricadenocarcinomas.Theresultswerefurthercorrelatedwithclinicopathologicalvariables.RESULTS:ThelossofanyMMRproteinexpression,indicativeofMMRdeficiency,wasobservedin38cases(7.8%)andwassignificantlyassociatedwithanolderage(68.6±9.2vs60.4±11.7,P<0.001),afemalesex(55.3%vs31.3%,P=0.004),anantrallocation(44.7%vs25.7%,P=0.021),andadifferentiatedhistology(57.9%vs39.7%,P=0.023).AbnormalARID1Aexpression,includingreducedorlossofARID1Aexpression,wasobservedin109cases(22.3%)andwassignificantlycorrelatedwithlymphaticinvasion(80.7%vs69.5%,P=0.022)andlymphnodemetastasis(83.5%vs73.7%,P=0.042).ThetumorswithabnormalARID1AexpressionmorefrequentlyindicatedMMRdeficiency(47.4%vs20.2%,P<0.001).AmultivariateanalysisidentifiedabnormalARID1Aexpressionasanindependentpoorprognosticfactor(HR=1.36,95%CI:1.01-1.84;P=0.040).CONCLUSION:OurobservationssuggestthattheAIRD1Ainactivationisassociatedwithlymphaticinvasion,lymphnodemetastasis,poorprognosis,andMMRdeficiencyingastricadenocarcinomas.

简介：Riceleaffolder,Cnaphalocrocismedinalis,isoneofthemajorfoliagefeedersfoundinthericegrowingregionsinIndia.Whenthecropwasatmaturity,numerousadultsofriceleaffolderwerefoundinthericefieldsthoughthelarvalpopulationgraduallydecreased,andnoeggswerefoundonriceleaves.ThepopulationcharacteristicsofC.medinaliswereassessedbasedonthephysiologicalagestatusofadultsatdifferentcropgrowthstages.Basedoneggdevelopmentwithinovarioles,ovarioleappearance,numberandcolouroffatbodies,andcharacteristicsofbursacopulatrix,physiologicalagestatusoftheadultswasdescribed,whichservedasabasisforthedeterminationofagecomposition.C.medinalisadultswerefoundduringthefirstweekofAugustonriceplants,ofwhich44%wereinAge0withimmatureovaries,indicatingimmigrants.However,28%adultseachwereatAges1–2withdevelopingovaries,indicatinglocalbreedingpopulation.Thecarryoverandoff-seasonsurvivalofC.medinaliswerealsostudiedtodeterminethecontributionofthealternativehostsinthepopulationgrowththathelpedindevisingefficientmanagementstrategies.RicewasthemostpreferredhostfollowedbyTriticumaestivum,EchinochloacrusgulliandBrachiariaplantaginea.VariousroutesofthecarryoverofC.medinalisfromseasontoseasonwerediscussed.

简介：AIM:Toinvestigatetheefficacyandsafetyofkryptonlaserperipheraliridoplasty(LPIP)forChinesepatientswithprimaryangleclosure(PAC)orprimaryangle-closureglaucoma(PACG)statuspostlaseriridotomyinreversingthepositiveresultsofthedarkroomprovocativetest(DRPT).METHODS:Thisstudywasprospective,noncomparative,interventionalcaseseries.Thirty-threepatients(thirty-eighteyes)withPACorPACGstatuspostpatentlaseriridotomyandmaintainednormalintraocularpressure(IOP)butwithpositiveDRPTresultswereenrolled.AllthesubjectsweretreatedwithkryptonLPIP.DRPTwasrepeatedafterkryptonLPIP.ResultsofDRPTwererecorded.Thevisualacuity,IOPandgonioscopywereanalyzedbeforeandafterkryptonLPIP.Aminimumtimelimitforfollow-upwas6mo.RESULTS:Thirty-threepatients(thirty-eighteyes)werefollowedfor17.7±8.37mo(range7-41mo)afterLPIP.PositiveresultsofDRPTdecreasedfrom38eyesto9eyes(23.7%)afterLPIP.Peripheralanteriorsynechiaeofanglein34of38eyes(89.5%)remainedunchangedatdynamicgonioscopythroughoutthefollow-upperiodafterLPIP.CONCLUSION:LPIPdecreasedpositiveratesoftheDRPTsignificantly.ThemechanismmaybethatLPIPminimizedcontactbetweentheperipheralirisandtrabecularmeshwork,whichisakeyfactorfordevelopingperipheralanteriorsynechiae.