简介：TheenergymodelwasfoundedtocalculatethecriticalpowerofkeyholeformationbyusingthelimitprincipleinCW(continuouswave)Nd:YAGlaserdeeppenetrationweldingprocess.Themodelwasvalidatedbyexperiments.Theresultsshowthattherearetwoerrorsbetweenthecalculatedcriticalpowerofkeyholeformationandthatofexperiments:oneisthatthecalculatedresultsislessthanthoseofexperiments,whichiscausedbynotconsideringtheenergylossby!heatconductioninthemodelofkeyholeformation.Theotheristhatthereis0/9mmerrorbetweentheaxisofthecalculatedcurveofcriticalpowerwithlocationoflaserfocusandthatofexperimentalcurve,whichisinducedbytheexcursionoflaserfocusinlaserdeeppenetrationwelding.Atlast,thetwoerrorswererevisedaccordingtotheanalysesoftheerrors.

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简介：ThispaperdealswiththeCauchyproblemforadoublysingularparabolicequationwithaweightedsource■whereN≥1,1max{0,3-p-p/N}satisfying21,andα>N(3-p-m)-p.Wegivethesecondarycriticalexponentonthedecayasymptoticbehaviorofaninitialvalueatinfinityfortheexistenceandnon-existenceofglobalsolutionsoftheCauchyproblem.Moreover,thelifespanofsolutionsisalsostudied.更多还原

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简介：Gastrointestinaltoxicities(GIT),includingoralmucositis,nauseaandvomiting,anddiarrhea,arecommonsideeffectsofchemotherapyandtargetedagentsinpatientswithadvancedcolorectalcancerandpancreaticcancer.Beingoftenunderreported,itisstilldifficulttopreciselyestablishtheirburdenintermsofbothpatient’squalityoflifeandcancercarecosts.Moreover,withtheuseofmoreintensiveupfrontcombinationregimens,thefrequencyofthesetoxicitiesisrapidlygrowingwithapotentialnegativeeffectalsoonpatient’soutcome,asaresultofdosereductions,delaysorevendiscontinuationofactivetreatments.Thus,identifyingpatientsathigherriskofdevelopingGITaswellasanoptimalmanagementareparamountinordertoimprovepatient’scomplianceandoutcome.Afterthedescriptionofthemaintreatment-inducedGIT,wediscussthecurrentknowledgeonthepathophysiologyofthesesideeffectsandcommentthescalescommonlyusedtoassessandgradethem.WethenprovideacriticalupdateonGITincidencebasedontheresultsofkeyrandomizedtrialsconductedinpatientswithmetastaticcolorectalcancerandadvancedpancreaticcancer.

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简介：AcousticBarkhausenEmission(ABE)andElectromagneticBarkhausenEmission(EBE)havebeenmeasured.Explanationsofthere-sponseofnickeltoanappliedmagneticfieldareconsideredusingenergydensitydiagramsandcriticalfieldsdeducedusingKersten’smodifiedtheory.ThesetheoreticalmodelsarecorrelatedwithABEandEBEmeasurements,providingfurtherconfirmationoftheoriginsofABEbeingnon-180°domainwallmotion.Thispaperalsoshowsthatthemotionofdomainwalls,onincreasingthemagnetisingfieldsfromsaturationtosatu-ration,followsthesequenceof71°-180°-109°.Valuesofcriticalfieldscorrepondingto71°,180°and109°wallmotionsinnickelarede-terminedusingthesetechniques.

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简介：AbstractBackground:The burden of human immunodeficiency virus (HIV) infection in people who use drugs (PWUD) is significant. We aimed to screen HIV infection among PWUD and describe their retention in HIV care. Besides, we also screen for hepatitis C virus (HCV) infection among HIV-seropositive PWUD and describe their linkage to care.Methods:We conducted a prospective study in 529 PWUD who visited the "Cañada Real Galiana" (Madrid, Spain). The study period was from June 1, 2017, to May 31, 2018. HIV diagnosis was performed with a rapid antibody screening test at the point-of-care (POC) and HCV diagnosis with immunoassay and PCR tests on dried blood spot (DBS) in a central laboratory. Positive PWUD were referred to the hospital. We used the Chi-square or Fisher’s exact tests, as appropriate, to compare rates between groups.Results:Thirty-five (6.6%) participants were positive HIV antibodies, but 34 reported previous HIV diagnoses, and 27 (76%) had prior antiretroviral therapy. Among patients with a positive HIV antibody test, we also found a higher prevalence of homeless (P < 0.001) and injection drug use (PWID) (P < 0.001), and more decades of drug use (P= 0.002). All participants received HIV test results at the POC. Of the 35 HIV positives, 28 (80%) were retained in HIV medical care at the end of the HIV screening study (2018), and only 22 (62.9%) at the end of 2020. Moreover, 12/35 (34.3%) were positive for the HCV RNA test. Of the latter, 10/12 (83.3%) were contacted to deliver the HCV results test (delivery time of 19 days), 5/12 (41.7%) had an appointment and were attended at the hospital and started HCV therapy, and only 4/12 (33.3%) cleared HCV.Conclusions:We found almost no new HIV-infected PWUD, but their cascade of HIV care was low and remains a challenge in this population at risk. The high frequency of active hepatitis C in HIV-infected PWUD reflects the need for HCV screening and reinforcing the link to care.

简介：AbstractBackground:Feeding intolerance (FI) among intensive care unit (ICU) patients undergoing early continuous enteral nutrition (EN) is related to poor outcomes. This study aimed to explore the prevalence and risk factors of FI in ICU patients.Methods:We retrospectively enrolled 1057 patients who received early continuous EN via a nasogastric tube between January 2014 and August 2019. The prevalence of FI during the first 7 days of ICU stay was calculated, and the risk factors were investigated using multivariate logistic regression analysis.Results:The prevalence of FI during the first 7 days of ICU stay was 10.95%. FI occurred in 159 of 1057 (15.04%) patients on ICU day 2, 114 of 977 (11.67%) patients on ICU day 3, and 86 of 715 (12.03%) patients on ICU day 7. Mechanical ventilation (MV) (odds ratio [OR]: 1.928, 95% confidence interval [CI]: 1.064–3.493, P = 0.03) was an independent risk factor for FI defined by a gastric residual volume (GRV) of 200 mL and/or vomiting, and acute renal failure (OR: 3.445, 95% CI: 1.115–10.707, P = 0.032) was an independent risk factor of FI defined by a GRV of 500 mL and/or vomiting. Continuous renal replacement therapy (CRRT) was an independent predictor regardless of the FI defined by a GRV of 200 mL (OR: 2.064, 95% CI: 1.233–3.456, P = 0.006) or 500 mL (OR: 6.199, 95% CI: 2.108–18.228, P = 0.001) in the ICU patients.Conclusions:FI occurs frequently in early ICU days, especially in patients receiving MV and CRRT. However, further investigation of a consensus definition of FI and risk factors is still warranted in future studies.

简介：2006年8月7日～8日，中国石油和化工行业信息化发展大会在北京召开，标志着中国石油和化工行业信息化“十一五”规划工作全面启动。作为行业排头兵．中石油在其主营业务信息化方面取得的成就受到了业界的广泛关注。

简介：摘要目的对比女性胸部CT检查中应用X-CARE技术的有效性。方法随机选择我院2015年10月~2017年10月收治的胸部CT女性患者108例作为研究对象，分成观察组与对照组，对照组仅通过胸部CT进行检查，不作任何处理；观察组在胸部CT检查中应用X-CARE技术，对比两组患者的扫描结果。结果数据显示，观察组、对照组的ED分别为（1.01±0.11）mSv、（1.59±0.32）mSv，相对于对照组来说，观察组ED明显较低（P＜0.05）；观察组、对照组前部、后部的主观评分、图像噪声、SNP等图像质量对比差异不明显，无统计学意义（P＞0.05）。结论X-CARE技术用于女性胸部CT检查中可获得较为理想的图像效果，不影响影像学图像，还能降低辐射，值得全面推广应用。

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简介：AccordingtoNHFPCwebsite,tostrengthenmoralconstructionofmedicalandhealthcareindustry,promotepracticesinaccordancewiththelawandadvocatehonestmedicalpractices,NationalHealthandFamilyPlanningCommission(NHFPC)andStateAdministrationofTraditionalChineseMedicinejointlyreleasedinDecember26,2013'NineProhibitionsto

简介：BackgroundTwo-dimensionalspeckletrackingimaging(2D-STI)andreal-timethree-dimensionalechocardiography(RT-3DE)havemoreadvantagesinevaluatingleftventricular(LV)systolicdyssynchronythantraditionalechocardiographictechniques.ThestudyaimedtoevaluateLVdyssynchronyparametersbyboth2D-STIandRT-3DE,andthecorrelationbetweenthesetwotechniques.MethodsAtotalof43chronicheartfailure(CHF)patientsand27healthyvolunteerswereenrolled.Therewere23dyssynchronyparametersselectedtoevaluateleftventricularsystolicsynchronization,involving15from2D-STIand8fromRT-3DE.ResultsFewofthedyssynchronyparametersshowednegativecorrelationswithLVejectionfraction(LVEF)intheCHFgroup.Thedifferencebetweentimetopeak-systolicradialstrainoftheanteroseptalandposteriorsegmentsatthelevelofpapillarymuscles[AS-P(RS)]from2D-STIshowedpositivecorrelationswithpartsoftheparametersfromRT-3DE(P<0.05).ConclusionsLVsystolicdysfunctiondoesnotcorrelatewithdyssynchrony.Moreover,thereisaweakassociationbetween2D-STIandRT-3DEinassessmentofleftventriculardyssynchrony.

简介：TheexistenceandmultiplicityofpositivesolutionsarestudiedforaclassofquasilinearellipticequationsinvolvingSobolevcriticalexponentswithmixedDirichlet-Neumannboundaryconditionsbythevariationalmethodsandsomeanalyticaltechniques.

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