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简介:摘要回顾性分析2019年2月华中科技大学同济医学院附属武汉儿童医院诊治的1例支气管Dieulafoy病患儿的临床资料。患儿,男,9月龄,因"间断呕血6 h"入院,胸部CT提示双肺磨玻璃样影,电子支气管镜检查发现右下叶支气管开口处一向管腔内隆起的新生物,术中新生物基底段可见新鲜血液渗出,患儿因反复咯血行支气管动脉造影术及经导管支气管动脉栓塞术,术中诊断支气管动脉血管畸形,查阅相关文献资料后最终诊断支气管Dieulafoy病。本病较为罕见,以支气管黏膜下发育畸形的动脉破裂出血为特征,其病因及发病机制尚不明确,在儿童病例中可能与先天血管发育畸形相关,对于儿童不明原因的咯血行支气管检查时应谨慎,镜下如见到小而光滑隆起的结节状病灶,需要考虑支气管Dieulafoy病可能,不能过多触碰,更不能盲目活检,行支气管动脉造影及支气管动脉栓塞术可避免致命性大出血。
简介:AbstractType 1 diabetes (T1D) is an autoimmune disease that resulted from the severe destruction of the insulin-producing β cells in the pancreases of individuals with a genetic predisposition. Genome-wide studies have identified HLA and other risk genes associated with T1D susceptibility in humans. However, evidence obtained from the incomplete concordance of diabetes incidence among monozygotic twins suggests that environmental factors also play critical roles in T1D pathogenesis. Epigenetics is a rapidly growing field that serves as a bridge to link T1D risk genes and environmental exposures, thereby modulating the expression of critical genes relevant to T1D development beyond the changes of DNA sequences. Indeed, there is compelling evidence that epigenetic changes induced by environmental insults are implicated in T1D pathogenesis. Herein, we sought to summarize the recent progress in terms of epigenetic mechanisms in T1D initiation and progression, and discuss their potential as biomarkers and therapeutic targets in the T1D setting.
简介:摘要胰岛素样生长因子2 mRNA结合蛋白1(IGF2BP1)是机体发育过程中mRNA代谢和转运的关键调控因子。近年来研究发现,IGF2BP1在肝癌、肺癌、结肠癌、卵巢癌、乳腺癌等多种肿瘤中异常表达。IGF2BP1不仅与肿瘤细胞的增殖、迁移和侵袭有关,而且还与患者不良预后密切相关。进一步研究IGF2BP1在恶性肿瘤中的作用机制有望为肿瘤靶向治疗提供新的方法。
简介:摘要:目的:探讨对1例隐翅虫皮炎患者治疗及护理干预的效果。方法:选取本院收治的1例隐翅虫皮炎患者,选取时间为2020年09月~2021年09月,采取不同的护理干预手段,分别实施常规护理和优质护理,对比观察患者的护理效果。结果:患者实施优质护理后,满意度评分为(95.65±3.26),实施常规护理后,患者护理满意度评分为(86.59±2.33),两种护理手段满意度评分比较,差异有统计学意义(P<0.05)。结论:对
简介:摘要:《萧萧》是沈从文代表性的小说, 以童养媳为题材讲述着萧萧的生命情态和人性美丽。小说在乡土古老习俗、规矩和自然中,描写萧萧与生活和光同尘的生命生命美感,并在乡土生活与“女学生”世界的明显对照中,表达了作者文化立场和对生命、人性的理解。