简介:【目的】通过测定H型高血压患者血浆中血栓调节蛋白(thrombomodulin,TM)、超敏C反应蛋白(highsensitivityCreactiveprotein,hs-CRP)的水平变化,初步探讨H型高血压患者血管内皮受损后诱发炎症反应的状态。【方法】将80例H型高血压患者根据血同型半胱氨酸(homocysteinemia,Hcy)水平分为两组,H型高血压A组(Hcy15~30μmol/L)40例,男21例,女19例;H型高血压B组(Hcy≥30μmol/L)40例,男20例,女20例。再选取40例非H型高血压组,其中男22例,女18例;另选健康对照者20例,其中男9例,女11例作为对照。采取入选者的清晨空腹状态下肘静脉血,应用酶联免疫吸附法测定血浆TM、hs-CRP水平。【结果】(1)H型高血压患者血浆TM、hs-CRP水平均高于非H型高血压人群(P〈0.05),并高于健康对照组(P〈0.05);(2)H型高血压B组血浆TM高于H型高血压A组(P〈0.05);hs-CRP水平无显著差异(P〉0.05)。【结论】(1)H型高血压患者血浆TM、hs-CRP水平明显增高,表明不仅存在血管内皮受损,并启动血管炎症反应。(2)H型高血压患者随着血Hcy水平的升高,血浆TM、hs-CRP水平增高,提示高同型半胱氨酸血症加重血管内皮受损,增加血管炎症反应,促进动脉粥样硬化的进展。
简介:摘要目的探讨氨氯地平联合叶酸治疗对H型高血压患者临床治疗作用的研究.方法收集H型高血压患者100例分为试验组和对照组各50例,试验组患者接受氨氯地平联合叶酸治疗,对照组仅接受氨氯地平降压治疗,所有患者规律治疗6个月,在治疗前后测量患者血压、检测同型半胱氨酸、甘油三酯和胆固醇,并进行比较,观察两组患者治疗期间的不良反应发生率.结果两组患者经过治疗后血压均显著下降P<0.01,试验组患者的同型半胱氨酸经治疗后显著降低P<0.01,同时治疗后的同型半胱氨酸也显著低于对照组P<0.01,而对照组的同型半胱氨酸治疗前后无显著变化P>0.05.试验组患者治疗后的甘油三酯和胆固醇均显著低于对照组P<0.01,两组患者不良反应发生率无统计学差异P>0.05.结论氨氯地平联合叶酸治疗H型高血压不仅可以有效地降低患者血压,同时可以显著降低患者体内的同型半胱氨酸,改善患者体内脂类代谢,因此适宜临床用于治疗H型高血压.关键词H型高血压;氨氯地平;叶酸ThetherapeuticeffectsofamlodipinecombinedwithfolateacidonpatientsH-typehypertensionXuShipingZhouYuguiAbstractobjectiveToexploreThetherapeuticeffectsofamlodipinecombinedwithfolateacidonpatientsH-typehypertension.Methods100patientswithH-typehypertensionweredividedintotrialgrouptreatedbyamlodipinecombinedwithfolateacidandcontrolgrouptreatedbyamlodipine.Bloodpressure,homocysteine,triglycerideandcholesterolweredetectedbeforetreatmentandsixmonthlatter.Sideeffectsoftwogroupswererecorded.ResultsBloodpressureoftwogroupsweresignificantlydecreasedaftertreatment.Homocysteineoftrialgroupweredecreasedaftertreatment;controlgroupnodifference.Homocysteineoftrialgroupwerelessthancontrolgroupaftertreatment.Triglycerideandcholesteroloftrialgroupwerelessthancontrolgroupaftertreatmt.Sideeffectsoftwogroupswerenodifference.ConclusionsAmlodipinecombinedwithfolateacidcandecreasethebloodpressureandreducethehomocysteineeffectively.SoamlodipinecombinedwithfolateacidcanbeusedtotreatH-typehypertension.KeywordsH-typehypertension;Amlodipine;Folateacid中图分类号R353文献标识码A文章编号1008-6315(2015)12-0130-02
简介:Forsyngasproduction,thecombustionoffossilfuelsproduceslargeamountsofCO2asagreenhousegasannuallywhichintensifiesglobalwarming.Inthisstudy,chemicalloopingcombustion(CLC)hasbeenutilizedfortheeliminationofCO2emissiontoatmosphereduringsimultaneoussyngasproductionwithdifferentH2/COratioinsteamreformingofmethane(SR)anddryreformingofmethane(DR)inaCLC-SR-DRconfiguration.InCLC-SR-DRwith184reformertubes(similartoanindustrialscalesteamreformerinZagrosPetrochemicalCompany,Assaluyeh,Iran),DRreactionoccursoverRh-basedcatalystsin31tubes.Also,SRreactionishappenedoverNi-basedcatalystsin153tubes.CLCviaemploymentofMn-basedoxygencarrierssuppliesheatforDRandSRreactionsandproducesCO2andH2Oasrawmaterialssimultaneously.AsteadystateheterogeneouscatalyticreactionmodelisappliedtoanalyzetheperformanceandapplicabilityoftheproposedCLC-SR-DRconfiguration.Simulationresultsshowthatcombustionefficiencyreached1attheoutletoffuelreactor(FR).Therefore,pureCO2andH2OcanberecycledtoDRandSRsides,respectively.Also,CH4conversionreached0.2803and0.7275attheoutletofSRandDRsides,respectively.Simulationresultsindicatethat,3223kmolh-1syngaswithaH2/COratioequalto9.826wasproducedinSRsideofCLC-SR-DR.Afterthat,1844kmolh-1syngaswithaH2/COratioequalto0.986wasachievedinDRsideofCLC-SR-DR.ResultsillustratethatbyincreasingthenumberofDRtubesto50tubesandconsidering184fixedtotaltubesinCLC-SR-DR,CH4conversionsinSRandDRsidesdecreased2.69%and3.31%,respectively.However,thissubjectcausedtotalsyngasproductioninSRandDRsides(inallof184tubes)enhanceto5427kmolh-1.Finally,thermalandmolarbehaviorsoftheproposedconfigurationdemonstratethatCLC-SR-DRisapplicableforsimultaneoussyngasproductionwithhighandlowH2/COratiosinanenvironmentalfriendlyprocess.
简介:目的探讨Wnt/β-连环蛋白(β-catenin)信号通路对非小细胞肺癌NCI-H23细胞干性的调控作用。方法以非小细胞肺癌NCI-H23细胞为对象,以糖原合成酶激酶-3β(GSK-3β)抑制剂(CHIR-99021)和β-cateninsiRNA为干预剂,分别采用噻唑蓝比色法、体外干细胞成球培养、划痕实验及免疫印迹法检测其增殖能力、体外成球能力和迁移能力方面的改变。结果CHIR-99021作用24h后NCI-H23细胞的增殖能力、干细胞成球率均明显提升,与对照组的差异均有统计学意义(P〈0.05),划痕愈合时间缩短。CHIR-999021干预后的NCI-H23细胞、NCI-H23干细胞中,GSK-3β磷酸化显著降低,增殖细胞核抗原、CD133、乙醛脱氢酶1A1、Nanog、基质金属蛋白酶-2表达增加。β-cateninsiRNA沉默β-catenin后NCI-H23中CD133、乙醛脱氢酶1A1和Nanog表达减少,干细胞成球率也较对照组降低(P〈0.05)。结论Wnt/β-catenin通路参与了非小细胞肺癌NCI-H23细胞干性调节,这对于非小细胞肺癌的防治有一定价值。
简介:摘要目的探讨老年H型高血压病患者血浆同型半胱氨酸(Hcy)水平与血管性痴呆的关系.方法选择福州地区军队离退休老干部中226名Hcy水平正常的高血压病患者和340名Hcy升高的高血压病患者,采用简易精神状况检查表(MMSE)进行认知功能检查,并收集相关资料.结果伴有Hcy水平升高的H型高血压患者MMSE总分、注意力和计算力得分均低于普通高血压病患者,差异有统计学意义.结论血浆同型半胱氨酸水平升高可能是导致血管性痴呆的一种危险因素.关键词高血压病;同型半胱氨酸;血管性痴呆StudytherelationshipbetweentheelderlypatientswithHhypertensionandvasculardementiaChenshan-shanHuangMin?Wangli-e(Fuzhougeneralhospitalofnanjingmilitaryregion,fuzhou350025,fujian,China)AbstractObjectiveToexploretherelationshipbetweentheelderlyHtypehypertensionpatientplasmahomocysteine(Hcy)levelandvasculardementia.MethodsChoose226hypertensionpatientswithnormalHcylevelsand340hypertensionpatientswithelevatedHcylevelsinfuzhouareaarmyretiredcadres,andusethesimplementalhealthchecktable(MMSE)oncognitivefunction,andcollecttherelevantinformation.ResultsTheMMSEscore,attentionandcalculationforcescoredofHtypehypertensivepatientsarelowerthanordinaryhighbloodpressurepatients,thedifferencewasstatisticallysignificant.ConclusionElevatedplasmaKehyomwoorcdyssteinelevelsmaybeariskfactorforvasculardementia.Hypertension;Homocysteine;Vasculardementia中图分类号R544文献标识码B文章编号1008-6315(2015)12-0014-02
简介:摘要目的探讨24h动态心电图监测对中老年心血管疾病患者的临床效果。方法选取我院2005年6月—2013年6月收治的500例中老年心血管疾病患者,分成中年组和老年组,采用美林12导联动态心电图记录仪进行24h连续监测,记录患者不同时段的缺血时间、心肌缺血的变化、心率变异和心律失常状况。结果心电图监测显示患者发生心肌缺血的时间范围大部分在凌晨0点到上午8点。老年组心律失常的发生率显著高于中年组。结论随着人们年龄的增长,心发生率也逐渐增加,24h动态心电监测技术在临床中的应用,提高了心肌缺血和心律失常等心血管疾病的检出率,可及时有效地对患者的病情做出诊断,尽早干预,有效控制或防止心血管疾病的发生,具有较高的临床推广价值。
简介:对制造的单mesa终端4H-SiCPIN二极管,采用数值仿真和测试结果比对的方法,分析了各向异性迁移率效应对4H-SiCPIN二极管正向直流特性的影响。详细阐述了器件的正向直流仿真物理模型和参数选取,其中,迁移率的各向异性关系是在各向同性迁移率模型的基础上引入的,载流子寿命采用空间赋值的方法代入模型进行计算。对比结果显示,采用各向同性迁移率模型的仿真结果与实验值偏差较大,对迁移率模型进行各向异性修正后,仿真结果与实验结果符合得较好。研究表明,实际制造的4H-SiCPIN二极管在直流开态下,存在迁移率的各向异性效应。
简介:AIM:ToinvestigatetheroleoftheoverexpressionofB7-H3inapoptosisincolorectalcancercelllinesandtheunderlyingmolecularmechanisms.METHODS:SW620cellsthathighlyoverexpressedB7-H3(SW620-B7-H3-EGFP)andHCT8cellsstablytransfectedwithB7-H3shRNA(HCT8-shB7-H3)werepreviouslyconstructedinourlaboratory.CellstransfectedwithpIRES2-EGFPwereusedasnegativecontrols(SW620-NCandHCT8-NC).Real-timePCRandwesternblottinganalysiswereusedtodetectthemRNAandproteinexpressionsoftheapoptosisregulatorproteinsBcl-2,Bcl-xlandBax.Acellproliferationassaywasusedtoevaluatethesurvivalrateanddrugsensitivityofthecells.Theeffectofdrugresistancewasdetectedbyacellcycleassay.Activecaspase-3westernblottingwasusedtoreflecttheanti-apoptoticabilityofcells.WesternblottingwasalsoperformedtodeterminetheexpressionofproteinsassociatedwiththeJak2-STAT3signalingpathwayandtheapoptosisregulatorproteinsafterthetreatmentwithAG490,aJak2specificinhibitor,inB7-H3overexpressingcells.ThedatawereanalyzedbyGraphPadPrism6usinganon-pairedt-test.RESULTS:WhetherbyoverexpressioninSW620cellsordownregulationinHCT8,B7-H3significantlyaffectedtheexpressionofanti-andpro-apoptoticproteins,atboththetranscriptionalandtranslationallevels,comparedwiththenegativecontrol(P<0.05).AcellproliferationassayrevealedthatB7-H3overexpressionincreasedthedrugresistanceofcellsandresultedinahighersurvivalrate(P<0.05).Inaddition,theresultsofcellcycleandactivecaspase-3westernblottingprovedthatB7-H3overexpressioninhibitedapoptosisincolorectalcancercelllines(P<0.05).B7-H3overexpressionimprovedJak2andSTAT3phosphorylationand,inturn,increasedtheexpressionofthedownstreamanti-apoptoticproteinsB-cellCLL/lymphoma2(Bcl-2)andBcl-xl,basedonwesternblotting(P<0.05).AftertreatingB7-H3overexpressingcellswiththeJak2-specificinhibitorAG490,thephosphorylationofJak2andSTAT3,andtheexp
简介:Layeredcathodematerialsofhigh-temperaturelithiumbatteries,LiNi1/3Mn1/3Co1/3O2aresynthesizedbyasol-gelmethodwithvariationinfinalsinteringtemperatureforboreholeapplications.Thestructure,morphologyandhigh-temperaturedischargeperformanceoftheseresultingproductsareinvestigatedbyX-RayDiffraction(XRD),scanningelectronmicroscopy(SEM),laserparticlesizeanalysis,galvanostaticandpulsedischarge.Theresultsofstructuralanalysisindicatethatthesamplesinteredat800℃hasthecharacteristicsofgoodcrystallinity,narrowsizedistributionandlargespecificsurfaceareaatthesametime.Thedischargeexperimentsalsoindicatethatthissamplehasthebestelectrochemicalproperties,withthemaximumdischargecapacitiesof314.57and434.14mAh·g-1at200and300℃respectivelyandtheminimumcellinternalresistancesatbothtemperatures.