简介:Thismini-reviewpresentstheauthors'visiononthecurrentstatusandfuturetrendsinthedevelopmentofneuroprotectiveagentsworkingviaactivationofnuclearfactorerythroid2-relatedfactor2(Nrf2),andinparticular,viadisruptionofNrf2-Keaplinteraction.Therearetwoopposite'chemical'mechanismsunderlyingsuchactivation:thefirstoneisanon-specificcovalentmodificationofKeap1thiols,resultinginsideeffectsofvariedseverity,andthesecondoneistheshiftoftheNrf2-Kelch-likeECHassociatedprotein-1(Keap1)bindingequilibriuminthepresenceofacompetitiveandchemicallybenigndisplacementagent.Atthispoint,nodisplacementactivatorsexhibitsufficientbiologicalactivityincomparisonwithcommonNrf2activatorsworkingviaKeaplthiolmodification.Hence,thehopeintherapeuticsisnowlinkedtotheFDAapproveddimethylfumarate,whosederivative,monomethylfumarate,aswedemonstratedrecently,ismuchlesstoxicbutequallybiologicallypotentandanidealcandidateforclinicaltrialsrightnow.AnewlyemergingplayerisanuclearinhibitorofNrf2,BTBdomainandCNChomolog1(Bach1).ThecommerciallydevelopedBachlinhibitorsarecurrentlyunderinvestigationinourlaboratoryshowingpromisingresults.Inourviewpoint,theperfectfuturedrugwillpresentthecombinationofadisplacementactivatorandBachlinhibitortoinsuresafetyandefficiencyofNrf2activation.
简介:摘要中药美容制剂在日常生活中应用久远,在古时早有研究,为后人积累了丰富的资料。我们根据中医辩证施治的基本原则,在药物筛选上选择了活血化瘀、清热祛风、行气消散等品种的中药,如白芷、白附子、川穹、细辛等。在研制霜剂的过程中,由于中药成分复杂,我们选择了水包油型软膏基质,这样可以提高中药成分的释放度及对皮肤的穿透力,从而提高疗效。本次科研做了进一步的研究。
简介:Tungstendisulfide(WS2)isatypeofanisotropic-layeredcompoundandhasbroadbandsaturableabsorptionfeaturesassaturableabsorbers(SAs).WithWS2-basedSAs,darksolitonsinerbium-dopedfiber(EDF)lasersarefirstobtained.Forthegenerateddarksolitons,thecenterwavelengthismeasuredtobe1530nm,andtherepetitionrateisabout116.5MHz.Aseriesofopticalspectraisexhibited.Theelectricalsignal-to-noiseratioisbetterthan94dB.ResultsinthispaperdemonstratethatWS2-basedSAsarethepromisingSAsforgeneratingdarksolitonsinEDFlasers.