简介：Thispaperproposesanewcellintuitionsimulationmethodwhichisacombinationofintuitivesimulationcalculationmethodandtheoperationofbinaryimage,andapplieditintheinnovationofthegraphicdesignprocess.Firstofall,westudyhowtoexpressavarietyofgraphics,andestablishthedefinitionofcellintuitivemodel,workoutthecellintuitiveoperationprocessandmanynewcellularoperatorssuchasavarietyofmatrixblockscrossoveroperator,avarietyofmatrixblocksmutationoperator,matrixblocksreplaceoperator,matrixblockscompressionoperator,matrixblocksextensionoperator.Bychoosingtwoormorecellsandselectingtheartificialselectionorfitnessselection,wecansetupandvisualizethedesignandpickthebestdesignresults.Finally,validationismadeonthisalgorithmbyanexample,andainnovationgraphicisalsorepresented.

简介：Thispaperdevelopesatemperaturecontrolsysteminordertocarryoutarealtimeandcontinuousobservationonlivingcellsunderthemicroscope.Inthissystem,transparentindiumtinoxid(ITO)conductivefilmwasusedasaheater,temperaturewasmeasuredbythetemperaturedependenceofresistancebehavioroftheITOfilm,C8051F340single-clupwasusedasthecontrolhardwarecore,andthemodifiedPIDalgorithmandpulsewidthmodulation(PWM)wereadoptedasthekeycontrolsoftwareprograms.Thetemperaturesystemhadasimplestructurewithoutaddedtemperaturesensor,anuniformtemperaturedistributionwithin±1℃ontheITOfilmsurfaceandtemperaturecontrolprecisionof±0.2℃couldbeobtained.ThesystemcouldmaintainagoodgrowthstateforBHK-21livingcellunderthemicroscopefor48h.

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简介：Inthiswork,sandwichbeamsarestudiedtorevealtheunderlyingsizeeffectsoftheperiodiccorecellsforthefirsttimewithintheframeworkoffreevibrationanalysisofsuchanadvancedlightweightstructure.Theenergyequivalencemethodisformulatedasatheoreticalapproachthattakesintoaccountthecellsizeeffect.Itiscomparedwiththeasymptotichomogenizationmethodanddirectfiniteelementmethodsystematicallytoshowtheirconsistenceandapplicability.Theaccuracyoffreevibrationresponsespredictedbythedetailedfiniteelementmodelisusedasthestandardofcomparison.Itisshownthatthecellsizeisanimportantparametercharacterizingthecellularcorerigiditiesthatinfluencevibrationresponses.Thehomogenizationmodelagreesexactlywiththeasymptoticsolutionoftheanalyticalexpressionofthebeammodelonlywheneverthecellsizetendstobeinfinitelysmall.

简介：Duringtheonsetofadiseaseacellmayexperiencealterationsinboththecompositionandorganizationofitscellularandmolecularstructures.Thesealterationsmayeventuallyleadtochangesinitsgeometricalandmechanicalpropertiessuchascellsizeandshape,deformabilityandadhesion.Assuch,knowinghowdiseasedcellsrespondtomechanicalforcescanrevealwaysbywhichtheydifferfromhealthyones.Here,wewillpresentbiomechanisticinsightsintoredbloodcellrelateddiseasesthatmanifest...

简介：Inarecentstudy,researcherstookadultfemaleFischerratsandperformedaspinalcordtransectionontheminanattempttostudythegrowthoftransplantedearly-stageneurons.Whensuchearly-stageneuronsweretransplantedintoratssufferingfromparalysis,remarkableaxonalgrowthwasobserved.Theresultwasmanynewrelaycircuitsthatformed,whichsignificantlyimprovedfunction,

简介：Mammaliancelltotipotencyisasubjectthathasfascinatedscientistsforgenerations.AlonglastingquestionwhethersomeofthesomaticcellsretainstotipotencywasansweredbythecloningofDollyattheendofthe20thcentury.Thedawnofthe218thasbroughtforwardgreatexpectationsinharnessingthepoweroftotipotentcyinmedicine.Throughstemcellbiology,itispossibletogenerateanypartsofthehumanbodybystemcellengineering.Considerableresourceswillbedevotedtoharnesstheuntappedpotentialsofstemcellsintheforeseeablefuturewhichmaytransformmedicineasweknowtoday.Atthemolecularlevel,totipotencyhasbeenlinkedtoasingulartranscriptionfactoranditsexpressionappearstodefinewhetheracellshouldbetotipotent.NamedOct4,itcanactivateorrepresstheexpressionofvariousgenes.Curiously,verylittleisknownaboutOct4beyonditsabilitytoregulategeneexpression.ThemechanismbywhichOct4specifiestotipotencyremainsentirelyunresolved.Inthisreview,wesummarizerethestructureandfunctionofOct4andaddresstoOct4functioninmaintainingtotipotencyorpluripotencyofembryonicstemcels.

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简介：Esophagealcancerisoneofthemostfataldiseasesworldwidemainlybecauseofitsrapidprogressionandpoorprognosis.AlthoughtheincidenceofesophagealadenocarcinomahasmarkedlyriseninNorthAmericaandEuropeinthepastseveraldecades,esophagealsquamouscellcarcinomaisstillthepredominantsubtypeofesophagealcancer,especiallyinChina.Itaccountsformorethan90%ofallesophagealsquamouscellcarcinomacasesinChina.Geographicaldifferentiationisoneofthemostdistinctivecharacteristicsofesophagealcancer.Theprogression,riskfactors,andprognosisofthesetwosubtypesofesophagealcancerdiffer.Thisstudyreviewstheepidemiology,etiology,andpreventionofesophagealsquamouscellcarcinomainChina,therebyprovidingsystematicreferencesforpolicy-makerswhowilldecideonissuesofesophagealcancerpreventionandcontrol.

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简介：AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses spread unscrupulously virtually every corner on the planet in a very quick speed leading to an unprecedented world pandemic of COVID-19 claiming a great many of people’s life. Paramount importance has been given to the studies on the virus itself including genomic variation and viron structure, as well as cell entry pathway and tissue residence. Other than that, to learn the main characteristic of host immunity responding to SARS-CoV-2 infection is an eminent task for restraining virus and controlling disease progress. Beside antibody production in response to SARS-CoV-2 infection, host cellular immunity plays an indispensable role in impeding virus replication and expansion at various stages of COVID-19 disease. In this review, we summarized the recent knowledge regarding the aberrant regulation and dysfunction of multiple immune cells during SARS-CoV-2 infection. This includes the dysregulation of immune cell number, Th polarity, cytokine storm they implicated with, as well as cell function exhaustion after chronic virus stimulation. Notwithstanding that many obstacles remain to be overcome, studies on immunotherapy for COVID-19 treatment based on the known features of host immunity in response to SARS-CoV-2 infection offer us tangible benefits and hope for making this SARS-CoV-2 pandemic under control.

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简介：ForwardMaskingTemporalaudiotoryresolutionistheabilityoftheauditorysystemtoresolveauditorysignalsinthetimedomain.Forwardmaskingisameansofstudyingtemporalresolutionwhereonetone,theprobe,ismaskedbyaprecedingtone,themasker.Forwardmaskingis

简介：AutoreactiveB房间是在全身的豺狼座erythematosus(SLE)的致病被含有的关键有免疫力的房间之一。除了有害自身抗体(auto-Abs)的生产，B房间作为介绍抗原的房间告知autoreactiveT房间并且分泌大量支持inflammatorycytokines有autocrine和paracrine效果。调制B房间的代理人可能因此具有潜在的治疗学的价值。当前的策略包括指向B房间表面抗原，cytokines支持B房间生长和功能，和B房间和T房间相互作用。在这篇文章，我们在动物和人的研究在SLE考察B细胞的角色，并且我们检验为这个条件的处理作为有希望的策略支持B房间调整的以前的报告。另外，我们在场评估了在人的SLE反对CD20，CD22和B淋巴细胞激发器(BLyS)的代理人的治疗学的功效和安全的临床的试用上的更改。当这些研究的许多的结果仍然保持不确定时，belimumab，对BLyS的人的monoclonal抗体，显示出诺言并且最近被US食物药品管理局为病人作为显示的治疗同意了与对中等SLE温和。无疑，在B房间免疫学的进展将继续带我们到SLE致病的更好的理解和指向B房间的新奇特定的治疗的发展。

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简介：Objective:Squamousesophagealcarcinomaishighlyprevalentindevelopingcountries,especiallyinChina.TuBeiMu(TBM),atraditionalfolkmedicine,hasbeenusedtotreatesophagealsquamouscellcarcinoma(ESCC)foralongterm.tubeimosideI(TBMS1)isthemaincomponentofTBM,exhibitinggreatanticancerpotential.Inthisstudy,weinvestigatedthemechanismofTBMS1cytotoxiceffectonEC109cells.Methods:Comparativenuclearproteomicapproachwasappliedinthecurrentstudyandweidentifiedseveralalteredproteinspots.Furtherbiochemicalstudieswerecarriedouttodetectthemitochondrialmembranepotential,cellcycleandcorrespondingproteins’expressionandlocation.Results:SubcellularproteomicstudyinthenucleusfromEC109cellsrevealedthatalteredproteinswereassociatedwithmitochondrialfunctionandcellproliferation.FurtherbiochemicalstudiesshowedthatTBMS1-inducedmoleculareventswererelatedtomitochondria-inducedintrinsicapoptosisandP21-cyclinB1/cdc2complex-relatedG2/Mcellcyclearrest.Conclusions:ConsideringtheconventionalapplicationofTBMinesophagealcancer,TBMS1thereforemayhaveagreatpotentialasachemotherapeuticdrugcandidateforESCC.

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简介：摘要胆管癌起病隐匿且缺乏早期诊断标志物，大多数患者在确诊时已处于疾病晚期。目前手术治疗是胆管癌患者的首选方案，但手术也会面临着风险大、难点多等问题。近年研究发现，长链非编码RNA（lncRNA）和环状RNA（circRNA）具有调节胆管癌细胞增殖、转移、侵袭、上皮间质转化及耐药性等功能。文章综述lncRNA和circRNA在胆管癌发生、发展机制中的潜在调控作用，以期为胆管癌的早期诊断、靶向治疗及患者预后评估提供临床借鉴。