简介：目的研究距角膜缘不同距离切口对非超声乳化小切口白内障人工晶体植入术后角膜散光及角膜内皮细胞变化的影响。方法对150例（150只眼）白内障患者按切口距角膜缘距离分为A、B和C三组。在角膜上方部位行直线形切口的非超声乳化小切口白内障人工晶体植入术。分别于术前及术后1周、1个月、3个月用角膜地形图仪测量平均角膜散光度,用角膜内皮显微镜测量角膜内皮细胞计数。比较三组的平均角膜散光度和角膜内皮细胞平均密度及细胞平均丢失率。结果A、B、C组的平均角膜散光度在术后一周时分别是（2.29±0.84）、（1.90±0.77）、（1.79±0.85）D,其中A组与B组差异有统计学意义（P=0.008）,B组与C组差异无统计学意义（P=0.0573）,术后1月、术后3月各组差异无统计学意义（P〉0.05）。三组的角膜内皮细胞密度及角膜内皮细胞丢失率在术后差异无统计学意义（P〉0.05）。结论切口所处的位置距角膜屈光中心的距离越远,术后早期平均角膜散光度越小。白内障手术切口与术后角膜内皮细胞丢失无直接关系。非超声乳化小切口白内障人工晶体植入术的最佳切口位置是角膜缘后2.0mm。

简介：AIM:Toinvestigatethelevelsofserumsolubleintercellularadhesionmolecules-1(sICAM-1)andneutrophilicexpressionofCD18inpatientswithvariousstagesofdiabeticretinopathyandtodeterminetheirdifferentexpressionpatterninthedevelopmentofdiabeticretinopathy(DR).·METHODS:LevelsofserumsICAM-1andCD18onthesurfaceofneutrophileweremeasuredin41DRpatients,theywereclassifiedinthreesubgroupsaccordingtothestageofretinopathyasdeterminedbyfund’sophthalmoscopy;10controlsubjectswerealsostudied.sICAM-1weremeasuredbyenzyme-linkedimmunosorbentassayandCD18byflowcytometry.·RESULTS:TheneutrophilicCD18expressionandserumsICAM-1levelwereallsignificantlyelevatedinalldiabeticsubgroupscomparedtocontrolsubjects(P<0.01).ThedifferencesofCD18andsICAM-1amongthediabeticsubgroupsweresignificantinCD18butnotinsICAM-1.TheprogressionofretinopathywasassociatedwithanincreasebothinCD18andinsICAM-1levelsbysimplecorrelationanalysis(β=0.74,P<0.001;β=0.38,P<0.01,respectively).ButstepwisemultipleregressionanalysisrevealedthatonlyCD18wasindependentdeterminantofretinopathy(β=1.04,P<0.01).·CONCLUSION:OurresultsconfirmthecontributionofendothelialandneutrophilicactivationinthedevelopmentofDRasindicatedbyincreasedlevelsofCD18andsICAM-1.However,adirectimplicationofCD18andICAM-1intheprogressionofDRcanbesupportedonlyintheCD18butnotICAM-1.CD18andICAM-1mayplaydifferentroleinthedevelopmentofdiabeticretinopathy.