简介：AIM:Tocharacterizetemporalpatternofresolutionandrecurrenceofnaivechoroidalneovascularization(CNV)secondarytowetage-relatedmaculardegeneration(AMD)treatedwithintravitrealbevacizumabonasneededregimen,andtoanalyzebaselineriskfactorsforCNVresolutionorrecurrence.METHODS:Ninety-oneeyesof80patientswithnewlydiagnosedwetAMDwereretrospectivelystudied.Alleyesweretreatedwitharoundofthreemonthlyintravitrealbevacizumabinjections,followedbyoneadditional’bonus’injectionafterresolutionofCNVactivity.Duringfollow-up,eyesweremonitoredwithfluoresceinangiography,opticalcoherencetomography,andbest-correctedvisualacuity(BCVA).IncaseofrecurrencesofCNVactivity,eyeswereretreatedwithotherroundsofbevacizumabinjectionsfollowingthesametreatmentprotocol.RESULTS:Overamedianfollow-upof532d,themedianresolutiontimeofCNVactivityinthefirst,second,andthirdtreatmentroundwas98d,126d,and111d,respectively.Themedianrecurrencetimeforthethreeroundswas154d,126d,and151d,respectively.Nosignificantdifferenceinresolutiontime(P=0.09)orinrecurrencetime(P=0.11)wasdetectedamongtreatmentrounds.Age(P=0.0082)andlensstatus(P=0.035)werefoundtobeassociatedwithCNVresolution;forevery1-yearincreaseinagetherewas4%greaterchanceofCNVresolution;Phakiceyesdemonstrateda33%betterchancetoexperienceCNVresolutionthanpseudophakiceyes.ForCNVrecurrence,lensstatus(P=0.0009)andgender(P=0.0446)werefoundtobepredictive;pseudophakiceyeshada3.69-foldgreaterrisktoexperiencerecurrenceofCNVactivitycomparedtophakiceyes;maleshada2.19-foldgreaterrisktoexperiencerecurrenceofCNVactivitythanfemales.NosignificantBCVAchangesamongthreetreatmentroundswerenoted(P=0.56).CONCLUSION:ResolutiontimeandrecurrencetimeofCNVactivitywerenotsignificantlydifferentamongtreatmentrounds,suggestingabsenceoftachyphylaxistobevacizumab.Acautiousdecisionshouldbemadeupondisco

简介：AIM:ToevaluatetheefficacyofSeprafilmtransplantationfollowingadhesiolysisforpreventingpostoperativereadhesionandimprovingsurgicaloutcomes.METHODS:Primaryblepharoplastywascarriedoutonbotheyelidsof18albinorabbits.After2weeks,anewskinincisionwasmade,andadhesiolysiswasperformedonbotheyelids.Therabbitswerecategorizedintotwogroups,onewithadhesiolysisaloneinthelefteyelid(controlgroup),andtheotherwithadhesiolysiswithaSeprafilmgraftintherighteyelid(Seprafilmgroup).Thedegreesofinflammationandfibrosiswereexaminedwithhematoxylin-eosin(HE)andMasson’strichromestains.Expressionofα-smoothmuscleactin(α-SMA)wasalsoimmunohistochemicallyexamined.RESULTS:Eyelidexaminationimmediatelyaftertheoperationrevealedmildswellingandhemorrhageinbothgroups,butthesesymptomsresolvedafter1week-2weeks,andeyelidshapehadrecoveredcompletelyinbothgroups.MicroscopicassessmentsdemonstratedthattheSeprafilmgroupshowedlessinflammationandfibrosisthanthecontrolgroup.TheSeprafilmgroupalsoexhibitedfewerα-SMA-positivecellsthanthecontrolgroup.CONCLUSION:Basedonthesefindings,weconcludethatSeprafilmgraftwithadhesiolysisisaneffectivemethodforpreventingpostoperativereadhesionsaftereyelidsurgery.

简介：AIM:ExcessivedissolveofcornealtissueinducedbyMMPswhichwereactivatedbycytokinsandchemokineswillleadtocornealulcer.ThemolecularmechanismofLipoxinA4(LXA4)oncornealcollagendegradationinthreedimensionswasinvestigated.·METHODS:Rabbitcornealfibroblastswereharvestedandsuspendedinserum-freeMEM.TypeIcollagen,DMEM,collagenreconstitutionbufferandcornealfibroblastsuspensionweremixedonice.Theresultantmixturesolidifiedinanincubator,afterwhichtestreagentsandplasminogenwasoverlaidandthecultureswerereturnedtotheincubator.Thesupernatantsfromcollagengelincubationswerecollectedandtheamountofhydroxyprolineinthehydrolysatewasmeasured.ImmunoblotanalysisofMMP-1,-3andTMMP-1,-2wasperformed.MMP-2,-9wasdetectedbythemethodofGelatinzymography.Cytotoxicityassaywasmeasured.RESULTS:LXA4inhibitedcornealcollagendegradationinadoseandtimemanner.LXA4inhibitedtheIL-1βinducedincreasesinthepro-MMP-1,-2,-3,-9andactiveMMP-1,-2,-3,-9inaconcentrationdependentmanner.LXA4alsoinhibitedtheIL-1βinducedincreasesinTIMP-1,-2.CONCLUSION:Asapotentanti-inflammationreagent,LXA4caninhibitcornealcollagendegradationinducedbyIL-1βincornealfibroblaststhusinhibitingcornealdissolvingpathologyprocess.

简介：·AIM:Toinvestigatethetherapeuticeffectsofnanophtha-locyaninephotosensitizersonanexperimentalratchoroidalneovescularization(CNV)model,aswellastoevaluatethecytotoxicityofwhichonhumanretinalpigmentepithelia(HRPE)andhumanretinalendothelialcells(HRECs).·METHODS:Twotypesofphotosensitizers,G1-ZnPc(COOH)8andG1-ZnPc(COOH)8/mrespectively,wereadministratedforphotodynamictherapy(PDT)afterasuccessfulestablishmentofCNVmodelonBrown-Norway(BN)ratsviafundusphotocoagulation.Thetherapeuticeffectsofthetwodrugswereassessedthroughopticalcoherencetomography(OCT),fluoresceinfundusangiography(FFA)andtransmissionelectronmicroscopy(TEM).Forcytotoxicitytests,cellcountingkit-8(CCK-8)assaysandchangesofmitochondrialtransmembranepotential(△Ψm)wereconductedonHRPEandHRECsafterinitialuptakeofthetwodrugs.·RESULTS:Bothphotosensitizersdemonstratedanimprove-mentofvascularleakageandclosureofCNV1weekafterPDTasconfirmedbyfundusimage,OCT,FFAandTEM.TwoweeksafterPDT,G1-ZnPc(COOH)8/mshowedabetterCNVclosureeffectversusG1-ZnPc(COOH)8(P<0.05).Asignificantdifference(P<0.01)wasfoundinuptakeofthetwodrugsinHRPEandHRECs,withnodifferencebetweenthedrugs(P>0.05).BothphotosensitizersshowedcytotoxicityonHRPE,butG1-ZnPc(COOH)8/minducedalowercellviability.·CONCLUSION:G1-ZnPc(COOH)8/mmediatedPDTisbetterthanG1-ZnPc(COOH)8inCNVclosureandalsohavetheadvantageoffastmetabolismleadingtolesssideeffect.·

简介：<正>DearSir,IamDr.Jing-WenGong,fromtheDepartmentofOphthalmology,ZhejiangProvincialPeople’sHospital,Hangzhou,China.Iwritetopresentapeculiarcasereportofjerkysee-sawnystagmusininternuclear

简介：由于众所周知的原因，“近三十年的诗歌”在2008年成为了一个被热议的命题。尽管从社会政治的背景出发看待文学多有局限和盲区，诗歌本身自有运变的轨迹与规律，一个政治化的时间段落并不见得是考察诗歌的最佳标尺，但考虑到大环境所提供的条件，以及这个时期文学与现实政治特殊的紧密关系，做这样的考察也非完全没有意义。

简介：AIM:Tostudytheimpactofscleralflapposition,underwhichtheposteriorchamberintraocularlenses(PC-IOL)weresulcus-fixedbytrans-scleralsuture,oncorneaastigmatism.METHODS:Twenty-sixaphakicorcataracteyeswerecomprisedinthisprospectivenoncomparativecaseseriesstudy.Eleveneyeshadtraumaticcataractremovedwithoutsufficientcapsularsupport,3hadblunttraumawithsubluxatedtraumaticcataract,8hadundergonevitreoretinalsurgeryand4hadcongenitalcataractremoved.Theaverageagewas54years(range21-74years),with17menand7women.ThefoldablePC-IOLwasfixedinsulcusbytrans-scleralsuture.TheincisionforIOLimplantationwasmade1mmposteriortolimbusalongthesteepestmeridianofcornea,whilescleralflapstoburytheknotsoftrans-scleralsutureweremadealongtheflattestmeridian.Allthesurgerieswereperformedbyasingledoctor(MaL),andthefollowupwasatleast13months(range13-28months).Thepreoperative,3monthsand1yearpostoperativecornealcurvaturealongthesteepestandflattestcorneameridianandoverallcorneaastigmatismwerecompared.RESULTS:Thecurvaturealongthesteepestmeridianchangedfrom44.25±2.22Dpreoperativelyto44.08±2.16Dat3monthspostoperatively,and43.65±5.23Dat1yearpostoperatively(P>0.05);thecurvaturealongtheflattestmeridianchangedfrom41.24±2.21Dpreoperativelyto43.15±3.94Dat3monthspostoperatively,and42.85±5.17Dat1yearpostoperatively(P<0.05);andthesurgeryinducedastigmatism(SIA)oncorneawascalculatedbyvectoranalysis,whichwas2.42±2.13Dat3monthspostoperatively,and2.18±3.42Dat1yearpostoperatively,thedifferencewasstatisticallysignificant(P<0.05).CONCLUSION:Thescleralflapmadealongtheflattestmeridian,underwhichtheposteriorchamberintraocularlenses(PCIOL)weresulcus-fixedbytrans-scleralsuture,cansteepenthecorneainvaryingdegrees,thusreducingpreexistingcornealastigmatism.

简介：我做了一个捉月亮的网，今晚就要外出捕猎。我要飞着把它抛向天空，我已经捉到我的猎物，

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简介：我们是建平县第三小学学前大班付秋然的爷爷奶奶。每期的画报发到小孙子手里．我们都会陪他一起读。孩子最开始会把注意力放到生动的图画上面,可是时间一长．他就被我们所读的内容吸引了。

简介：学习目标：小班学会把相同宽窄的对象配对。中班学会比较宽与窄。大班学会从宽到窄排列顺序。

简介：从汉语言文学的语法来解释：“的”是通用的，可以作为的、地、的替代语，日常都可以通用。

简介：再次站在母校的大门口。仿佛又看到了那个初次来到新学校，激动地大声呼喊“高中，我来了!”的小女生；看到了那个在早晨的教学楼前背书时用手背挡在眼前，似乎要握住全世界的阳光的女孩；看到了那个偶尔坐在楼梯间发呆的姑娘……呵呵，曾经的自己怀揣着一份少年的狂傲，一份青春的执著，走入了高三。

简介：海德格尔著作中的神深奥晦涩。透过对他的思想整体方向的把握,我们发现,在海德格尔这里,最后的神是救渡人出离＂存在离弃状态＂之困境的神,但他不是基督教的上帝,上帝反倒是走向无神的虚无主义的起源。海德格尔敏锐地看到,近代以来人作为主体并未因脱离上帝而变得自由,反而精神贫困,无能于思考,无能于真理,人无根地生存。与此相对,海德格尔的神召唤人出离困境从而踏上返乡之途。这种神有自己的＂面目＂和出场方式,但他不是不缺乏任何存在的最高的存在者,甚至也不是存在自身。神不是神化的人,但人却从神获取尺度,成为＂半神＂,在＂家乡＂中人共神同在。这种神是人确立自己的本质的必经之途和最短而最陡峭的路径。这种非神学的神打开了思考神性和人性的另一条路。

简介：

简介：那天上午,老余电话来,说“老爷子不在了”。我一时恍惚,觉得特别的意外。因为,就在前一天的中午,他还乐呵呵地给我打手机,让我帮他找多年前写金庸的一篇文章,他说他的观点还能立得住,他要一个电子版。竟然就是这么快,前后相隔,不到二十四小时,仁健先生就走了,阴阳两界,让人痛感无常。

简介：<正>1.所谓“O（的）V（的）N”指这种偏正短语:a.语言运用角度b.语言运用的角度c.语言的运用角度d.语言的运用的角度我们用“O”代表动词语“V”（“运用”）前的V”的受事成分（“语言”）,“N”代表“V”后那个名词语（“角度”）,括号里的“的”表示有时出现,有时不出现。本文想要探讨的是如何分析“O（的）V（的）N”的内部层次关系。层次关系不同,该短语所属的类型自然也就不同。例拿a来说,下面的切分表示这是一个带有多层定语的偏正短语:a1语言运用角度而下面的切分则表示这是一个由偏正短语充当定语的偏正短语:a2语言运用角度

简介：班上有64个同学，身高都有一些微小差异。让他们排成8行8例的方阵。如果从每一行8个同学中挑出一个最高的，那么在挑出的8个同学中一定有一个最矮的同学A。让这些同学回到各自原来的位置站好后，

简介：谢林的上帝概念是与他的自由概念分不开的,谢林将人的自由奠基于上帝的自由之中,　　谢林的自由概念的独特性不仅在于它的

简介：谢林的自由概念是一个哲学与神学的综合性的概念,自由的体系至少存在于上帝的理智之中,而人的自由又基于上帝之中