简介：Benignprostatichyperplasia(BPH)isanage-relateddiseaseofunknownetiology,characterizedbyprostaticenlargementcoincidentwithdistinctalterationsintissuehistology.Inthepresentstudy,weinvestigatedwhethertriptolidecanpreventtestosterone-inducedprostatichyperplasiainrats.Castrationwasperformedviathescrotalrouteafterurethaneaesthesia.BPHwasinducedinexperimentalgroupsbydailysubcutaneousinjectionsoftestosteronepropionate(TP)fortwoweeks.Triptolidewasadministereddailybyoralgavageatadoseof100and50μg×kg~(-1)for2weeks,alongwiththeTPinjections.Onday14,theanimalswerehumanelykilledbycervicaldislocationafteraesthesia.Prostateswereexcised,weighed,andusedforhistologicalstudies.Testosteroneanddihydrotestosterone(DHT)levelsinserumandprostateweremeasured.Theresultsshowedthattriptolidesignificantlyreducedtheprostateweight,andthetestosteroneandDHTlevelsinboththeserumandprostate.HistopathologicalexaminationalsoshowedthattriptolidetreatmentsuppressedTP-inducedprostatichyperplasia.Inconclusion,triptolideeffectivelyinhibitsthedevelopmentofBPHinducedbytestosteroneinaratmodel.