简介：TranslationalCancerResearch(TranslCancerRes;TCR;PrintISSN:2218-676X;OnlineISSN2219-6803;www.thetcr.org)launchedinAugust2013aspecialissueonApplicationsofNanotechnologyinRadiationResearchinvitingProf.RaoV.L.PapinenifromUniversityofKansas

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简介：NeuralRegenerationResearch(NRR)isafirst-classinternationalacademicjournalpublishedinEnglish.ItissupervisedbytheMinistryofHealth,P.R.China.NRR(CN11-5422/R,ISSN1675-5374)isamonthlyjournal,distributedallovertheworld.

简介：目的：观察针刺治疗女性更年期综合征的疗效。方法：依据中医治疗本病以肾为主的法则，取关元、中极、子宫、三阴交为主，治疗女性更年期综合征30例。结果：针刺治疗本病总有效率为90．0％。针刺后患者的血：青内分泌激素较针刺有明显的改变(P<0．05)。结论：初步认为针刺对机体的神经内分泌系统可起到综合的调节作用：可以使紊乱的植物神经内分泌功能重新恢复到稳态，从而消除或减轻女性更年期的各种临床症状。

简介：BackgroundNoncompactionofventricularmyocardium(NVM)isararetypeofprimarycardiomyopathy.Thediseaseiscausedbythedisorderinthedensificationofthemyocardiumintheearlystageoftheembryoprocess.Themorphologicalcharacteristicsareprojectingtrabeculationintheventricleandthedeeptrabecularspaceinterlinkedwithventricularchamber.Inrecentyears,manystudieshavefoundthattheleftventriculargrowthassociatedgeneticmutationiscloselyrelatedtotheoccurrenceofNVM.Themostclinicalmanifestationssuchasheartfailure,thromboembolismandarrhythmiaarespecific.EchocardiographyisthemostcommonlyusedtechniqueforthediagnosisofNVM.Cardiaccomputedtomography(CT)scan,cardiacmagneticresonanceimagingandleftventricularangiographyareotherimportanttechniquesforitsdiagnosis.TheNVMpatientshavealongcourseofdisease,poorprognosisandahighrateofmisdiagnosis.Thisarticlereviewstheresearchprogressintheaspectsofepidemiologicalcharacteristics,geneticcharacteristics,clinicalmanifestations,pathophysiology,diagnosis,treatmentandsoon,inordertoprovidethebasisforthediagnosisandtreatmentofNVM.

简介：Integrityofthemembranouslabyrinthbarriersystemisofcriticalimportance,whichpromotesinnerearhomeostasisandmaintainsitsfeatures.Themembranouslabyrinthbarriersystemisdividedintoseveralsubsetsofbarrierswhich,althoughindependentfromeachother,areinterrelated.Thesamesubstancemaydemonstratedifferentpermeabilitycharacteristicsthroughdifferentbarriersandunderdifferentconditions,whiledifferentsubstancescanhavedifferentpermeabilityfeatureseveninthesamebarrierunderthesamecondition.Allpartsofthemembranouslabyrinthbarrierstructure,includingtheirmorphology,enzymesandchannelproteins,andtheirspermeabilitycharacteristicsundervariousphysiologicalandpathologicalconditionsarereviewedinthispaper.Infections,noiseexposure,ototoxicitymayallincreasepermeabilityofthebarriersandleadtodisturbancesininnerearhomeostasis.

简介：AbstractTransmission network analysis is a crucial evaluation tool aiming to explore the characteristics of the human immunodeficiency virus epidemic, develop evidence-based prevention strategies, and contribute to various areas of human immunodeficiency virus/acquired immunodeficiency syndrome prevention and control. Over recent decades, transmission networks have made tremendous strides in terms of modes, methods, applications, and various other aspects. Transmission network methods, including social, sexual, and molecular transmission networks, have played a pivotal role. Each transmission network research method has its advantages, as well as its limitations. In this study, we established a systematic review of these aforementioned transmission networks with respect to their definitions, applications, limitations, recent progress, and synthetic applications.

简介：AbstractThe incidence and prevalence of asthma have increased remarkably in recent years. There are lots of factors contributing to the occurrence and development of asthma. With the improvement of sequencing technology, it has been found that the microbiome plays an important role in the formation of asthma in early life. The roles of the microbial environment and human microbiome in the occurrence and development of asthma have attracted more and more attention. The environmental microbiome influences the occurrence of asthma by shaping the human microbiome. The specific mechanism may be related to the immune regulation of Toll-like receptors and T cells (special Tregs). Intestinal microbiome is formed and changed by regulating diet and lifestyle in early life, which may affect the development and maturation of the pulmonary immune system through the intestinal-pulmonary axis. It is well-recognized that both environmental microbiomes and human microbiomes can influence the onset of asthma. This review aims to summarize the recent advances in the research of microbiome, its relationship with asthma, and the possible mechanism of the microbiome in the occurrence and development of asthma. The research of the microbial environment and human microbiome may provide a new target for the prevention of asthma in children who have high-risk factors to allergy. However, further study of "when and how" to regulate microbiome is still needed.

简介：Aim:TopresentapersonalaccountoftheinvolvementoftheWorldHealthOrganization(WHO)inthecollaborativedevelopmentinAsiaofthoseareasofandmlogyconcernedwithmalecontraceptionandreproductivehealth.Methods:TheandrologytrainingthroughworkshopsandinstitutionsupportundertakenbytheWHOHumanReproductionProgramme(HRP)andhowtheycontributedtothestrengtheningofaudrologyresearchinAsiaaresummadsed.Results:Theauthor'sexperienceandtheAsianscientificcontributionstotheglobalresearchinthefollowingareasarereviewed:thesafetyofvasectomyandthedevelopmentofnewmethodsofvasocclusion;gossypolanditsfailuretobecomeasafe,reversiblemaleantifeltilitydrug;Tripterygiumandwhetheritspuleextractswillpassypolthroughtheappropriatetoxicologyandphasedclinicalstudiestobecomeacceptablecontraceptivedrugs;hormonalmethodsofcontraceptionformen.Conclusion:TheWHOpolicyofresearchcapacitybuildingthroughtrainingandinstitutionstrengthening,togetherwiththecollaborationofAsianandrologists,hascreatedstrongNationalinstitutionsnowabletodirecttheirownprogrammesofresearchinclinicalandscientificandrology.(AsianJAndrol1999Jun;1:7-12)

简介：AbstractSkin diseases were characterized by various types and high incidence, which seriously affect people’s health. At present, skin pathogenesis research and the therapeutic drug development for skin diseases are limited by the lack of reasonable research models that recapitulate the development of skin diseases. Organoids are three-dimensionally cultured cell populations derived from skin stem cells, which exhibits the ability of multicell assembly and the similar histological characteristics with the living tissues and organs. This article reviews the establishment of normal skin organoids and skin tumor organoids, and summarizes the application of skin organoids in the evaluation of drug sensitivity, pathological mechanism research, and individualized treatment. In addition, the advantages and limitations of organoids in skin disease research are also discussed, which provides a basis for revealing the pathogenesis of skin diseases and developing preventive and therapeutic drugs for skin diseases.

简介：AbstractGlioblastoma (GBM) is the most common primary malignancy of the central nervous system in adults. The prognosis for late-stage glioblastoma (World Health Organization grade IV astrocytic glioma) is very poor. Novel treatment options are sought after and evaluated by clinicians and researchers, and remarkable advances have been made in surgical techniques, radiotherapy, and chemotherapy. However, the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few months. There has been notable progress in the field of immunotherapy, particularly with the use of tumor vaccines, for treating glioblastoma; especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell vaccines. However, the results of the current clinical trials for vaccination are not satisfactory. This article reviews the progress in the development of vaccines for glioblastoma.

简介：<正>IntroductionDeafnessisoneofthemostcommonotologicdiseasesandamajordiseasethatgreatlyimpactstheChinesepopulation.FromtheSecondNationalSampleSurveyofDisabledPersons,itisestimatedthatthereare27,800,000hearingdisabledpersonsinChina,about2.14%of

简介：NeuralRegenerationResearch(NRR,CN11-5422/R,ISSN1673-5374)isaninternationaljournalpublishingpeer-reviewedoriginalEnglisharticleschargedbytheMinistryofHealth,

简介：AbstractNephrotic syndrome is a relatively common clinical disease. Associated dyslipidemia is a risk factor for the occurrence and development of cardiovascular and renal diseases that might gradually develop into atherosclerosis, glomerulosclerosis or tubulointerstitial injury. It also confers an elevated risk of complications such as thromboembolism. If not properly controlled over the long term, dyslipidemia will become a key factor in a poor prognosis. Furthermore, dyslipidemia correlates with an increase in hepatic compensatory synthetic lipoprotein levels and a decrease in lipoprotein clearance, which can be sourced to the downregulation of hepatic and lipoprotein lipase activities in endothelial cells, muscle, and adipose tissue, and clinically characterized as hypertriglyceridemia or hypercholesterolemia. However, further investigations into the mechanism(s) of dyslipidemia are needed, with the resultant detailed perspectives and analyses substantially aiding the further development of treatment guidelines. Currently, statins represent the most popular type of pharmaceutical intervention because they lower hepatic cholesterol production and promote the absorption of low-density lipoprotein-cholesterol from the bloodstream, followed by second-line and other potential therapies to regulate the expression of specific receptors.

简介：AbstractPsoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis. Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis, therapeutic monitoring, prediction of the efficacy of psoriasis management, and further discovery of new metabolism-based therapeutic targets.

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简介：AbstractPericyte, a kind of pluripotent cell, may regulate the irrigation flow and permeability of microcirculation. Pericytes are similar to the smooth muscle cells, which express several kinds of contractile proteins and have contractility. The dysfunction of pericytes is related to many microvascular diseases, including hypoxia, hypertension, diabetic retinopathy, fibrosis, inflammation, Alzheimer's disease, multiple sclerosis, and tumor formation. For a long time, their existence and function have been neglected. The distribution, structure, biomarker, related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review.

简介：Objective:Toevaluatethetherapeuticeffectofacupunctureinthetreatmentofdepressivepsychosis.Methods:Atotalof62casesofdepressivepsychosispatientswererandomlydividedintotreatmentgroup(n=32)andcontrolgroup(n=30).AcupointsusedintreatmentgroupwerebilateralHegu(LI4),bilateralTaichong(LR3),Baihui(GV20)andYintang(EX-HN3).PatientsofcontrolgroupwereaskedtotakeFluoxertinehydrochloride20mg/d.ThetherapeuticeffectwasassessedusingHamilton'sdepression(HAMD)scales.Results:After8weeks'treatment,intreatmentandcontrolgroups,4and3caseswerecured,8and6experiencedmarkedimprovement,14and14hadimprovement,6and7hadnoeffect,withtheeffectiveratesbeing81.25%and76.66%separately,andnosignificantdifferencewasfoundbetweentwogroupsinHAMDscales(P＞0.05).Conclusion:Acupuncturetherapyisaneffectivemethodfortreatmentofdepressivepsychosis.

简介：BackgroundMyocardialfibrosisisoneprocessofthevariousheartdiseases,whichleadstocommonpathologicalchangeswhenitdevelopstoacertainstage.Itisthemaincauseofventricularremodelingwhicheventuallyleadstodifferentdegreesofcardiacdysfunction,malignantarrhythmiasandsuddencardiacdeath.Manystudieshaveshownthatvariouscytokinesplayaveryimportantroleinthedevelopmentofmyocardialfibrosis.Thispaperreviewsthelatestresearchesontheroleofcytokinesinmyocardialfibrosis.

简介：在美国，尽管许多慢性病的治愈率已有所提高，但公众对慢性病有效治疗的需求仍很急迫，传统中医（TCM）用草药治疗各种疾病已有两千多年的历史，有些中药在临床上已表现抗肿瘤和增强免疫活性的功能，因此，我们更需要努力工作，以便成功地发现新型治疗药物。1990年－1997年，包括中医药及天然草药（TCM－NH）的替代药物在美国的使用率从30％增至40％，目前每年约600万病人寻求替代医疗，1997年替代医疗的消费总额已经达到210亿美元，其中120亿美元白白浪费，寻找替代医疗服务的花费已经超过了美国常用和药和住院的费用。然而不幸的是，替代药物与生物医学研究领域研究和应用研究及发展获得传统医学知识，所以他们常常不知道临床前试验和临床试验的重要性，这对替代医学是一个冲击，病人和医师在缺权威的有关添加剂及其相互作用方面的指导的情况下，使用替代药物尤其是草药方剂，已经引起了需要特别关注的法律和道德问题。来自国家研究所，国防部以及其它国际上私人及商业组织对生物医学研究及规范化的资助，必将加强TCM－NH的知识基础，对疾病过程有更深的认识，从而取得能与常规治疗组相结合的有效研究资料，为未来的商业运作的成功打下知识基础。