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简介：AbstractPancreatic ductal adenocarcinoma (PDAC) is an extremely malignant disease, which has an extremely low survival rate of <9% in the United States. As a new hallmark of cancer, metabolism reprogramming exerts crucial impacts on PDAC development and progression. Notably, arginine metabolism is altered in PDAC cells and participates in vital signaling pathways. In addition, arginine and its metabolites including polyamine, creatine, agmatine, and nitric oxide regulate the proliferation, growth, autophagy, apoptosis, and metastasis of cancer cells. Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy. However, drug resistance develops during arginine depletion treatment, along with the re-expression of ASS1, metabolic dysfunction, and the appearance of anti-drug antibody. Additionally, arginase 1 exerts crucial roles in myeloid-derived suppressor cells, indicating its potential targeting by cancer immunotherapy. In this review, we introduce arginine metabolism and its impacts on PDAC cells. Also, we discuss the role of arginine metabolism in arginine deprivation therapy and immunotherapy for cancer.

简介：胰腺的假包囊(PP)是被纤维组织衬里并且可以包含坏死的碎片或血的胰腺的分泌物的集合。包括经皮、内视镜或外科的途径的干预基于假包囊的尺寸，地点，症状和复杂并发症。与先进成像系统和照相机的可获得性，更好止血的设备和优秀laparoscopic技术，很假的包囊能被腹腔镜检查发现并且设法。我们与对laparoscopic胰囊肿胃吻合术顺从的胰腺的假包囊描述一个30岁的男病人的一个盒子。一个切口通过前面的胃的墙被做用一个超声的联盟者在与假包囊的靠近的接触暴露以后的胃的墙激活的解剖刀。然后，另一个切口被做让胰囊肿胃吻合术获得完全、没有障碍的排水。病人在手术以后恢复了很好并且在6瞬间后续期间是没有症状的，建议laparoscopic胰囊肿胃吻合术是打开为PP的最低限度地侵略的管理的胰囊肿胃吻合术的一种安全、有效的选择。

简介：AbstractThe tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules. This low tumor perfusion microenvironment with physical dense fibrotic stroma shields PDAC from traditional antitumor therapies like chemotherapy and various strategies that have been proven successful in other types of cancer. Immunotherapy has the potential to treat minimal and residual diseases and prevent recurrence with minimal toxicity, and studies in patients with metastatic and nonresectable disease have shown some efficacy. In this review, we highlighted the main components of the pancreatic tumor microenvironment, and meanwhile, summarized the advances of some promising immunotherapies for PDAC, including checkpoint inhibitors, chimeric antigen receptors T cells, and cancer vaccines. Based on our previous researches, we specifically discussed how granulocyte-macrophage colony stimulating factor based pancreatic cancer vaccine prime the pancreatic tumor microenvironment, and introduced some novel immunoadjuvants, like the stimulator of interferon genes.

简介：Anewflowtheoryisestablishedthroughtheobjectivityrequirementonthefluiddynamics.Itwasknownthatinhomogeneousfluidmotiongaverisetoviscousforcewhiletheselectionofobserversondifferentspace-timepointswouldchangesuchaninhomogeneouscharacter.Therefore,whentheviscousforcewasconsideredasanobjectiveexistenceforeigntotheselectionofobservers,theforminvariancesofviscousforceandmomentumequationunderlocalrotationtransformationrequiredanewdynamicfield,namelythevortexfieldtobeintroduced.ThenthedynamicalequationsofallflowfieldswereobtainedthroughconstructingtheLagrangiandensityoffluidsystemandusingthevariationalapproachofenergy.

简介：WithoutsimplifyingtheN-SequationsofGermano’s,westudytheflowinahelicalcircularpipeemployingperturbationmethod.Athirdperturbationsolutionisfullypresented.Thefirst-second-andthird-ordereffectsofcurvatureкandtorsionтonthesecondaryflowandaxialvelocityarediscussedindetail.Thefirst-ordereffectofcurvatureistoformtwocounter-rotatingcellsofthesecondaryflowandtopushthemaximurnaxialvelocitytotheouterbend.Thetwocellsarepushedtotheouterbendbythepuresecond-ordereffectofcurvature.Thecombinedhigher-order(second-,third-)effectsofcurvatureandtorsion,arefoundtobeanenlargementofthelowervortexofthesecondaryflowatexpenseoftheupperoneandaclockwiseshiftofthecentersofthesecondaryvorticesandthelocationofmaximumaxialvelocity.Whentheaxialpressuregradientissmallenoughorthetorsionissufficientlylargerthanthecurvature,thelocationofthemaximalaxialvelocityisneartheinnerbend.Theequationofthevolumefluxisobtainedfromintegratingtheperturbationsolutionsofaxialvelocity.Fromtheequationthevalidityrangeoftheperturbationsolutionsinthispapercanbeobtainedandtheconclusionthatthethreetermsoftorsionhavenoeffectonthevolumefluxcaneasilybedrawn.Whentheaxialpressuregradientislessthan22.67,thevolumefluxinahelicalpipeislargerthanthatinastraightpipe.

简介：为米饭核心收集的十一评估参数被估计基于ongenotypic价值和分子的标记信息。与混合线性模型相结合的蒙特卡罗模拟被用来从环境消除干扰以便拉更可靠的结果。范围(CR)的巧合率是最佳的参数。吝啬的Simpson索引(M_D)，基因差异(M_I)的吝啬的Shannon编织索引和吝啬的多型性信息内容(M_(照片))是重要的评估参数。变异系数(VR)的可变的率能为评估核心收集的变化度充当一个重要引用参数。多态的loci(p)的百分比能为核心收集的尺寸被用作一个决心参数。吝啬的差别百分比(MD)是为核心收集的可靠性判断的一个决心参数。为在研究选择的核心收集的有效评估参数能在不同plantgermplasm人口为采样百分比被用作标准。

简介：Theflowcharacteristicsinaspouted-fluidbeddifferfromthoseinspoutedorfluidizedbedsbecauseoftheinjectionofthespoutinggasandtheintroductionofafluidizinggas.Theflowbehaviorofgas-solidphaseswaspredictedusingtheEulerian-Euleriantwo-fluidmodel(TFM)approachwithkinetictheoryforgranularflowtoobtaintheflowpatternsinspouted-fluidbeds.Thegasfluxandgasincidentanglehaveasignificantinfluenceontheporosityandparticleconcentrationingas-solidspouted-fluidbeds.Thefluidizinggasfluxaffectstheflowbehaviorofparticlesinthefountain.Inthespouted-fluidbed,thesolidsvolumefractionislowinthespoutandhighintheannulus.However,thesolidsvolumefractionisreducednearthewall.

简介：Thispaperdescribesanovelsharpinterfaceapproachformodelingthecavitationphenomenainincompressibleviscousflows.Aone-fieldformulationisadoptedforthevapor-liquidtwo-phaseflowandtheinterfaceistrackedusingavolumeoffluid(VOF)method.PhasechangeattheinterfaceismodeledusingasimplificationoftheRayleigh-Plessetequation.Interfacejumpconditionsinvelocityandpressurefieldaretreatedusingalevelsetbasedghostfluidmethod.Thelevelsetfunctionisconstructedfromthevolumefractionfunction.Amarchingcubesmethodisusedtocomputetheinterfaceareaattheinterfacegridcells.Aparallelfastmarchingmethodisemployedtopropagateinterfaceinformationintothefield.Adescriptionoftheequationsandnumericalmethodsispresented.Resultsforacavitatinghydrofoilarecomparedwithexperimentaldata.

简介：Thepaperstudiestheproblemoffluidflowandfluidshearstressincanaliculiwhentheosteonissubjecttoexternalmechanicalloadingandbloodpressureoscillation.Thesingleosteonismodeledasasaturatedporoelasticcylinder.Solidskeletonisregardedasaporoelastictransverselyisotropicmaterial.Togetnear-realisticresults,boththeinterstitialfluidandthesolidmatrixareregardedascompressible.BloodpressureoscillationintheHaveriancanalisconsidered.Usingtheporoelasticitytheory,ananalyticalsolutionoftheporefluidpressureisobtained.Assumingthefluidincanaliculiisincompressible,analyticalsolutionsoffluidflowvelocityandfluidshearstresswiththeNavier-Stokesequationsofincompressiblefluidareobtained.Theeffectofvariousparametersonthefluidflowvelocityandfluidshearstressisstudied.更多还原

简介：AbstractPancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf of the Chinese Pancreatic Surgery Association, which consisted of surgical oncologists, gastroenterologists, medical oncologists, endocrinologists, radiologists, pathologists, and nuclear medicine specialists. By reviewing the important issues regarding the diagnosis and treatment of pNENs, the committee concluded evidence-based statements and recommendations in this article, in order to further improve the management of pNENs patients in China.

简介：AbstractIntroduction:Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that disproportionately affects geriatric patients. Combination therapy with surgery and chemotherapy is associated with longer survival than medical treatment or supportive care. Preoperative selection of patients for surgical treatment, based on patient-specific factors such as sarcopenia, may help risk-stratify patients and improve outcomes. This paper aims to review the current literature on the impact of sarcopenia and sarcopenic obesity on patients undergoing treatment for PDAC.Outcomes:The impact of sarcopenia and sarcopenia obesity on perioperative and long-term outcomes after treatment for PDAC is variable. Sarcopenia has been associated with high-grade complications, longer length of hospital, and intensive care unit stays, more frequent discharge to skilled nursing facilities and decreased utilization of adjuvant therapy in patients treated with curative intent surgery. Sarcopenic obesity has been associated with more complications, high-grade complications, and hematologic toxicities. Patients with sarcopenic obesity may have even lower overall survival than sarcopenic patients.Discussion:The effect of a pre-treatment diagnosis of sarcopenia or sarcopenic obesity on outcomes for patients undergoing treatment for PDAC remains unknown, in part due to the heterogeneity of studies and definitions. Prehabilitation programs including resistance exercise and nutritional supplementation have shown benefit in sarcopenic patients.Conclusion:PDAC remains a deadly disease and patient-specific factors such as sarcopenia and sarcopenic obesity identified at the time of cancer diagnosis offer potential as risk stratification measures and points of intervention. Currently, a paucity of standardized measurement tools, definitions, and prehabilitation regimens limits the clinical implementation of such knowledge.

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简介：AbstractA pancreatic cystic neoplasm (PCN) is a rare pancreatic disease. Malignant PCNs are usually identified incidentally while evaluating other lesions. However, PCNs are being identified more frequently owing to the increased use of abdominal imaging. Malignant PCNs have complicated and diverse biological behaviors, including various malignant risk factors, diverse molecular features, natural history, and complex pathological classifications. Although many diagnostic methods, such as cross-sectional imaging and endoscopic evaluation, have been developed, malignant PCNs are still difficult to differentiate from benign tumors. On searching for related articles in the recent decade, we found that some molecular biomarkers such as carcinoembryonic antigen could be useful for discriminating between malignant tumors and benign tumors. However, cytopathologic evaluation is the most useful method for differentiating between benign and malignant lesions. Although cytopathologic evaluation has a specificity of 100% for identifying malignancies, its accuracy is often hampered by the low cellularity of PCN cells in the cystic fluid. Herein, we review the progress in the use of cellular and molecular markers for the accurate identification of PCNs.

简介：wellposedness问题为一各向异性不可压缩粘滞在3的液体，在向量B附近旋转(t，x):=(b1(t，x)，b2(t，x)，b3(t，x))，被学习。在同类的案例中的全球wellposedness(B=e3)与在空间B0的足够地快的旋转，？被证明。在不同类的案例中(B=B(t，xh))，在B0的答案的全球存在和唯一，？被获得，如果起始的数据是足够的与水平粘性相比小。而且，我们在一样的函数空格获得解决方案的一致本地存在和唯一。我们也在B2,1获得整齐的繁殖吗？在另外的假设下面，那B仅仅取决于一个水平空间变量。

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简介：所有液体动态方程在他们的当模特儿的规模下面是有效的，意味着免费路径例如粒子并且意味着Boltzmann方程的碰撞时间规模和NavierStokes(NS)方程的水动力学规模。当前的计算液体动力学(CFD)集中于部分微分方程(PDE)的数字答案，并且它的目的是得到这些管理方程的精确答案。在如此的一个CFD惯例下面，它是难的开发盖住流动物理从的一个统一计划对水动力学运动因为没有能用Boltzmann做光滑的转变到当模特儿的NS的如此的管理方程，连续地可伸缩。液体动力学的学习需要超出传统的数字部分微分方程。出现设计应用程序，例如为近空间的飞行和流动和热转移在的空气车辆设计微设备，确实要求煤气的动力学的概念的进一步的扩大到物理现实，而非传统的可区分的管理方程的更大的域。在当前的阶段，非平衡流动物理很好还没由于适当工具的缺乏被探索了或清楚地理解。不幸地在当前的数字PDE途径下面，它是难的由于有效PDE的缺席开发如此的一个有意义的工具。以便多尺度的构造和类似于构造管理方程的Boltzmann或NS的当模特儿的过程的multiphysics模拟方法，一个数字算法的发展应该基于物理建模的第一个原则。在这份报纸，而不是跟随传统的数字PDE路径，我们介绍为CFD算法开发的作为一个原则的直接建模。因为所有计算与有限房间分辨率在一个discretized空格被进行，要当模特儿的流动物理不得不在网孔尺寸和时间步骤规模被做。这里，CFD是差不多分离数字进化方程的直接构造，在网孔尺寸和时间步骤将玩的地方，在建模的动态角色处理。与在网孔之间的比率的变化，尺寸和本地粒子意味着免费路径，从到水动力学波浪繁殖的运动粒子运输和碰撞的计划愿望俘获流动物理。基于直接建模，流动运动的连续动力学�

简介：Thispaperconsiderstheunsteadyunidirectionalflowofamicropolarfluid,producedbythesuddenapplicationofanarbitrarytimedependentpressuregradient,betweentwoparallelplates.Theno-slipandtheno-spinboundaryconditionsareused.ExactsolutionsforthevelocityandmicrorotationdistributionsareobtainedbasedontheuseofthecomplexinversionformulaofLaplacetransform.Thesolutionoftheproblemisalsoconsiderediftheupperboundaryoftheflowisafreesurface.Theparticula...

简介：小浪变换(WT)方法被采用了把一个原来的地球物理的信号分解成关于象毛孔液体，岩性学，和毛孔结构那样的水库特征包含不同信息的一系列部件。我们基于WT精力系列分析，反映水库液体性质的信号部件被提取开发了一个新方法。我们成功地用这个方法在华中从一块油地处理了真实木头数据。水库液体鉴定的结果同意井测试的结果。

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