简介：ApoptosisplaysanessentialroleinTcellbiology.ThymocytesexpressingnonfunctionalorautoreactiveTCRsareeliminatedbyapoptosisduringdevelopment.ApoptosisalsoleadstothedeletionofexpandedeffectorTcellsduringimmuneresponses.Thedysregulationofapoptosisintheimmunesystemresultsinautoimmunity,tumorogenesisandimmunodeficiency.Twomajorpathwaysleadtoapoptosis:theintrinsiccelldeathpathwaycontrolledbyBcl-2familymembersandtheextrinsiccelldeathpathwaycontrolledbydeathreceptorsignaling.Thesetwopathwaysworktogethertoregu

简介：让M是增加由的操作符在在开的单位磁盘上分析的函数的一个Hilbert空格。为为增加操作员Mz的不变的subspaceF，我们导出一些光谱增加操作员M的性质：FF。当F与n有codimensionn性质时，我们描绘标准，光谱，必要标准和如此的操作员的必要光谱{1，2，，+}。

简介：Filledfunctionmethodisanapproachtofindtheglobalminimumofnonlinearfunctions.ManyProblems,suchascomputing,communicationcontrol,andmanagement,inrealapplicationsnaturallyresultinglobaloptimizationformulationsinaformofnonlinearglobalintegerprogramming.Thispapergivesamodifiedfilledfunctionmethodtosolvethenonlinearglobalintegerprogrammingproblem.Thepropertiesoftheproposedmodifiedfilledfunctionarealsodiscussedinthispaper.Theresultsofpreliminarynumericalexperimentsarealsoreported.

简介：q-p阶段空间分发函数是一个流行工具学习半古典作品物理并且描述一个系统的量方面。在由使用Husimi操作员Δh(q,p；κ)=|p，q〉κ；κ〈p，q|我们推出激动的挤压的真空状态的Husimi功能。然后，我们图形地学习Husimi分发的行为。

简介：T房间激活是在仅仅通过这个过程后来开始适应有免疫力的反应的一个批评过程特定的T房间区分进调停的武装受动器T房间的na(i)ve抗原实际有免疫力的response.DuringT房间激活，na(i)veT房间经历同种细胞的扩大并且获得能力杀死感染病原体的目标房间或生产为调整有免疫力的反应必要的cytokines。T房间的不恰当的激活或inactivation导致autoimmunity或严重免疫不全。PKC-有选择地在T房间被表示并且为调停要求了T房间激活过程。在PKC-缺乏的老鼠在T房间激活，幸存和activation-inducedcell死亡展出缺点。PKC-有选择地translocates到免疫学的触处并且调停为为T房间activation.Furthermore是必要的NF-B，AP1和NFAT的激活要求的信号，PKC--/-鼠标在vivo在T调停房间的有免疫力的回答的开发显示了多重缺点。PKC-因此是在vivo在T调停房间的有免疫力的回答在多重阶段调整T房间功能的一个批评分子。细胞与分子的免疫学。2006；3(4):263-270。

简介：WedevelopedanRfunctionnamed'microarrayoutlierfilter'(MOF)toassistintheidentificationoffailedarrays.Insortingagroupofsimilararraysbythelike-lihoodoffailure,twostatisticalindiceswereemployed:thecorrelationcoefficientandthepercentageofoutlierspots.MOFcanbeusedtomonitorthequalityofmi-croarraydataforbothtroubleshooting,andtoeliminatebaddatasetsfromdown-streamanalysis.Thefunctionisfreelyavaliableathttp://www.wriwindber.org/applications/mof/.

简介：在这份报纸，我们建立几不平等为概括线性失真功能(一，K)由使用某些联合的monotonicity和凸状(一，K)

简介：Background:Childrenareaffectedbydisordersthathaveanimpactontherespiratorymuscles.Inspiratorymusclefunctioncanbeassessedbymeansofthenoninvasivetension–timeindexoftheinspiratorymuscles(TTImus).OurobjectivesweretoidentifythedeterminantsofTTImusinhealthychildrenandtoreportnormalvaluesofTTImusinthispopulation.Methods:Wemeasuredweight,height,upperarmmusclearea(UAMA),andTTImusin96childrenaged6–18years.Thelevelandfrequencyofaerobicactivitywasassessedbyquestionnaire.Results:TTImuswassignificantlylowerinmalesubjects(0.095±0.038,mean±SD)comparedwithfemalesubjects(0.126±0.056)(p=0.002).TTImuswassignificantlylowerinregularlyexercising(0.093±0.040)comparedwithnonexercisingsubjects(0.130±0.053)(p<0.001).TTImuswassignificantlynegativelyrelatedtoage(r=-0.239,p=0.019),weight(r=-0.214,p=0.037),height(r=-0.355,p<0.001),andUAMA(r=-0.222,p=0.030).MultivariatelogisticregressionanalysisrevealedthatheightandaerobicexerciseweresignificantlyrelatedtoTTImusindependentlyofage,weight,andUAMA.ThepredictiveregressionequationforTTImusinmalesubjectswasTTImus=0.228-0.001×height(cm),andinfemalesubjectsitwasTTImus=0.320-0.001×height(cm).Conclusion:Gender,age,anthropometry,skeletalmuscularity,andaerobicexercisearesignificantlyassociatedwithindicesofinspiratorymusclefunctioninchildren.NormalvaluesofTTImusinhealthychildrenarereported.

简介：AbstractPericyte, a kind of pluripotent cell, may regulate the irrigation flow and permeability of microcirculation. Pericytes are similar to the smooth muscle cells, which express several kinds of contractile proteins and have contractility. The dysfunction of pericytes is related to many microvascular diseases, including hypoxia, hypertension, diabetic retinopathy, fibrosis, inflammation, Alzheimer's disease, multiple sclerosis, and tumor formation. For a long time, their existence and function have been neglected. The distribution, structure, biomarker, related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review.

简介：Risler&Trotmanin1997provedthatthemultiplicityofananalyticfunctiongermisleft-rightlipschitzinvariant,whichprovidedapartialanswertoZariskiconjecture.Inthisnote,basedontherecentworkofComte,Milman&Trotman,wegeneralizetheworkofthemtoprovethatthemultiplicityofaC~∞-differentiablefunctiongermisalsoleft-rightlipschitzinvariant.

简介：在处理的地球物理和图的一些数学模型需要在范围上与散布数据计算积分。因此，求容积法公式在计算这些球形的积分起一个重要作用。这份报纸被奉献给为球形的基础函数网络建立一个准确积极求容积法公式。作者为球形的基础函数网络给准确积极求容积法公式的一个存在证明，并且证明在求容积法公式需要的求容积法点不比散布数据的数字大。

简介：Thebilevelprogrammingisappliedtosolvehierarchicalintelligencecontrolproblemsinsuchfieldsasindustry,agriculture,transportation,military,andsoon.Thispaperpresentsaquadraticobjectivepenaltyfunctionwithtwopenaltyparametersforinequalityconstrainedbilevelprogramming.Undersomeconditions,theoptimalsolutiontothebilevelprogrammingdefinedbythequadraticobjectivepenaltyfunctionisprovedtobeanoptimalsolutiontotheoriginalbilevelprogramming.Moreover,basedonthequadraticobjectivepenaltyfunction,analgorithmisdevelopedtofindanoptimalsolutiontotheoriginalbilevelprogramming,anditsconvergenceprovedundersomeconditions.Furthermore,undertheassumptionofconvexityatlowerlevelproblems,aquadraticobjectivepenaltyfunctionwithoutlowerlevelproblemsisdefinedandisprovedequaltotheoriginalbilevelprogramming.

简介：代数学的独立被证明，在此胃1，。..，胃s与代数学的元素是代数学的数字，或某些先验的继续的部分的某些差距系列或力量系列。关键词代数学的独立-指数的功能-差距系列-力量系列-继续的部分-代数学的数字先生(2000)题目分类11J85-11J91由中国(号码10571180)的NNSF支持了

简介：Inthispaper,wegivesomecreativecharacterizationsofCampanatospacesviatheboundednessofcommutatorsassociatedwiththeCalder′on-Zygmundsingularintegraloperator,fractionalintegralsandHardytypeoperators.Furthermore,weputforwardafewproblemsonthecharacterizationsofCampanatotypespacesviatheboundednessofcommutators.

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简介：自由民建议的光线的基础功能(RBF)插值途径被用来解决遇到在的反的问题记载得好并且另外的petrophysical问题。途径是根据物理岩石数据集在实验室预言petrophysical性质，它包括形成因素，粘性，渗透，和分子的作文。然而，这条途径不在插值结果上考虑刻度数据的空间分发的效果。这研究基于自由民RBF插值途径，联合起来的基础功能一致地被在空间领域占据建议一条新RBF插值途径。二条途径的反的结果被使用我们的数据集比较地分析。我们决定尽管二条途径的插值效果是相等的，新途径为当数据库大时，减少基础函数的数字更灵活、有益，导致插值函数表达式的简化。然而，当数据簇是差距很大的时，中央数据的预言的结果足够地没满足。

简介：TheConwaypotentialfunction(CPF)forcoloredlinksisaconvenientversionofthemultivariableAlexander–Conwaypolynomial.WegiveaskeincharacterizationofCPF,muchsimplerthantheonebyMurakami.Inparticular,Conway’s"smoothingofcrossings"isnotintheaxioms.Theproofusesareductionschemeinatwistedgroup-algebraP_nB_n,whereB_nisabraidgroupandP_nisadomainofmulti-variablerationalfractions.Theproofdoesnotusecomputeralgebratools.Aninterestingby-productisacharacterizationoftheAlexander–Conwaypolynomialofknots.

简介：Inthisnote,theauthorprovesthattheinverseproblemofsubmodularfunctionondigraphswithl∞objectivefunctioncanbesolvedbystronglypolynomialalgorithm.Theresultshowsthatmostinversenetworkoptimizationproblemswithl∞objectivefunctioncanbesolvedinthepolynomialtime.

简介：充满的功能方法是为连续全球优化的有效算法的一个班。在这份报纸，一个新充满的函数方法被介绍并且过去常解决整数编程。第一，分离优化的一些基本定义被给。然后，一个算法和几个测试问题上的这个算法的实现被显示出。计算结果证明算法是有效的。[从作者抽象]

简介：ThesufficientconditionsofHoldercontinuityoftwokindsoffractalinterpolationfunctionsdefinedbyIFS(IteratedFunctionSystem)wereobtained.Thesufficientandnecessaryconditionforitsdifferentiabilitywasproved.ItsderivativewasafractalinterpolationfunctiongeneratedbytheassociatedIFS,ifitisdifferentiable.