简介：AbstractPancreatic ductal adenocarcinoma (PDAC) is an extremely malignant disease, which has an extremely low survival rate of <9% in the United States. As a new hallmark of cancer, metabolism reprogramming exerts crucial impacts on PDAC development and progression. Notably, arginine metabolism is altered in PDAC cells and participates in vital signaling pathways. In addition, arginine and its metabolites including polyamine, creatine, agmatine, and nitric oxide regulate the proliferation, growth, autophagy, apoptosis, and metastasis of cancer cells. Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy. However, drug resistance develops during arginine depletion treatment, along with the re-expression of ASS1, metabolic dysfunction, and the appearance of anti-drug antibody. Additionally, arginase 1 exerts crucial roles in myeloid-derived suppressor cells, indicating its potential targeting by cancer immunotherapy. In this review, we introduce arginine metabolism and its impacts on PDAC cells. Also, we discuss the role of arginine metabolism in arginine deprivation therapy and immunotherapy for cancer.

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简介：ThisarticledescribesthefabricationofasuiteoflasertargetsbytheTargetFabricationgroupintheCentralLaserFacility(CLF),STFCRutherfordAppletonLaboratoryforthefirstacademic-accessexperimentontheOrionlaserfacility(Hoppsetal.,Appl.Opt.52,3597–3601(2013))atAtomicWeaponsEstablishment(AWE).Thisexperiment,partofthePOLARproject(Falizeetal.,Astrophys.SpaceSci.336,81–85(2011);Busschaertetal.,NewJ.Phys.15,035020(2013)),studiedconditionsrelevanttotheradiation-hydrodynamicprocessesoccurringinaremarkableclassofastrophysicalstarsystemsknownasmagneticcataclysmicvariables.Alargenumberofcomplexfabricationtechnologiesandresearchanddevelopmentactivitieswererequiredtofieldatotalof80high-specificationtargets.Targetdesignandfabricationproceduresaredescribedandinitialalignmentandcharacterizationdataarediscussed.

简介：Paralysisfollowingspinalcordinjury(SCI)isduetofailureofaxonalregeneration.Itisbelievedthatthecapacitiesofneuronstoregrowtheiraxonsareduepartlytotheirintrinsiccharacteristics,whichinturnaregreatlyinfluencedbyseveraltypesofinhibitorymoleculesthatarepresent,orevenincreasedintheextracellularenvironmentoftheinjuredspinalcord.Manyoftheseinhibitorymoleculeshavebeenstudiedextensivelyinrecentyears.IthasbeensuggestedthatthesmallGTPaseRhoAisanintracellularconvergencepointforsignalingbytheseextracellularinhibitorymolecules,butduetothecomplexityofthecentralnervoussystem(CNS)inmammals,andthelimitationofpharmacologicaltools,thespecificrolesofRhoAareunclear.ByexploitingtheanatomicalandtechnicaladvantagesofthelampreyCNS,werecentlydemonstratedthatRhoAknockdownpromotestrueaxonregenerationthroughthelesionsiteafterSCI.Inaddition,wefoundthatRhoAknockdownprotectsthelarge,identifiedreticulospinalneuronsfromapoptosisaftertheiraxonswereaxotomizedinspinalcord.Therefore,manipulationoftheRhoAsignalingpathwaymaybeanimportantapproachinthedevelopmentoftreatmentsthatarebothneuroprotectiveandaxonregeneration-promoting,toenhancefunctionalrecoveryafterSCI.

简介：Adopting'simultaneoustransmitting,simultaneousreceiving'operationalscheme,instantaneouspolarizationradar(IPR)canmeasuretargetpolarizationscatteringmatrix(PSM)usingonlyoncetargetechoesintwoorthogonalpolarizationchannels.Firstly,signalmodelandsignalprocessareadvancedundernarrowbandcondition.Secondly,measurementperformancesoftwotypicalIPRwaveformsareanalyzedindetail.Atlast,fieldexperimentsarecarriedoutusingX-bandIPRsystemdesignedbyNationalUniversityofDefenseTechnology(NUDT),China.Comparedwithresultsobtainedbyalternativepolarizationmeasurementscheme,followingresultscanbeobtained:thedifferenceofrelativeamplitudemeasurementresultsissmallerthan2dBandthatofrelativephasemeasurementresultsissmallerthan10?,verifyingthevalidityofinstantaneouspolarizationmeasurementscheme.

简介：Thedesignsofinertialconfinementfusion(ICF)targets,whichfieldonShenGuangIII,arebecomingmorecomplexandmorestringentintermsofassemblyprecision.Akeyspecificationofthesetargetsisthespatialanglealignmentaccuracy.Tomeettheseneeds,wepresentanewspatialangleassemblymethod,usingtargetpart's3Dmodel-baseddualorthogonalcameravision,whichisbettersuitedfortheflexibleautomationoftargetassemblyprocesses.Thetwo-handsstructuremicromanipulatesystemanddualorthogonalstructurevisualfeedbacksystemwereinvestigatedbyconsideringthekinematics,spatialanglemeasuring,andmotioncontrolinanintegratedway.Inthispaper,wediscussthemeasurementaccuracyofspatialangleassemblymethod,whichcomparedthereal-timeimageacquisitionwiththeredrawing2Dprojection.Theresultshowsthattheassemblymethodproposedisveryeffectiveandmeetstherequirementsofangleassemblyaccuracy,whichislessthan1°.Also,thisworkisexpectedtocontributegreatlytotheadvancementofothertargetmicroassemblyequipments.

简介：Anovelopticaltestingtarget(OTT)withthreedegreesoffreedom(DOFs)isproposedformeasuringthetrackingperformanceofaphotoelectrictheodolite.Themaincomponents,suchastheazimuthaxissystem,thepitchingaxissystem,thelinearmotionsystem,andthesimulatedtargetgenerator,aredesigned.Furthermore,thelinearmodulewiththeformofalarge-spanandlow-stiffnesscantileverbeamisstrengthenedusinganintegratedoptimizationmethod.Afterthestructureisstrengthened,the1st-ordernaturalfrequencyincreasesfrom14Hzto32Hz.Finally,afunctionaltestisperformedandtheresultsshowthatcomparedwithatraditionalopticaltesttarget,thesimulatedtargetgeneratedbythenoveltargetisadvantageousinpractice.

简介：Weproposeimprovedmultilevelfilters(IMLFs)involvingtheabsolutevalueoperationintothealgorithmicframeworkoftraditionalmultilevelfilters(MLFs)toimprovetherobustnessofinfraredsmalltargetenhancementtechniquesunderacomplexinfraredclutteredbackground.Comparedwiththewidelyusedsmalltargetenhancementmethodswhichonlydealwithbrighttargets,theproposedtechniquecanen-hancetheinfraredsmalltarget,whetheritisbrightordark.Experimentalresultsverifythattheproposedtechniqueisefficientandpractical.

简介：Anovelefficienttrackinitiationmethodisproposedfortheharshunderwatertargettrackingenvironment(heavyclutterandlargemeasurementerrors):tracksplitting,evaluating,pruningandmergingmethod(TSEPM).Trackinitiationdemandsthatthemethodshoulddeterminetheexistenceandinitialstateofatargetquicklyandcorrectly.Heavyclutterandlargemeasurementerrorscertainlyposeadditionaldifficultiesandchallenges,whichdeteriorateandcomplicatethetrackinitiationintheharshunderwatertargettrackingenvironment.Therearethreeprimaryshortcomingsforthecurrenttrackinitiationmethodstoinitializeatarget:(a)theycannoteliminatetheturbulencesofcluttereffectively;(b)theremaybeahighfalsealarmprobabilityandlowdetectionprobabilityofatrack;(c)theycannotestimatetheinitialstateforanewconfirmedtrackcorrectly.Basedonthemultiplehypothesestrackingprincipleandmodifiedlogic-basedtrackinitiationmethod,inordertoincreasethedetectionprobabilityofatrack,tracksplittingcreatesalargenumberoftrackswhichincludethetruetrackoriginatedfromthetarget.Andinordertodecreasethefalsealarmprobability,basedontheevaluationmechanism,trackpruningandtrackmergingareproposedtoreducethefalsetracks.TSEPMmethodcandealwiththetrackinitiationproblemsderivedfromheavyclutterandlargemeasurementerrors,determinethetarget’sexistenceandestimateitsinitialstatewiththeleastsquaresmethod.What'smore,ourmethodisfullyautomaticanddoesnotrequireanykindmanualinputforinitializingandtuninganyparameter.Simulationresultsindicatethatournewmethodimprovessignificantlytheperformanceofthetrackinitiationintheharshunderwatertargettrackingenvironment.

简介：AbstractBackground:Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population.Methods:A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥ 60 years) and acute ischemic stroke.Results:Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants (P < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278–2.275, P < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group (P < 0.001), but not in the mid-life group (P = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P < 0.001; non-stroke group, P = 0.027).Conclusions:An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population.

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简介：Abasicassumptionofmostrecentlyproposedwaveformdesignalgorithmsisthatthetargetimpulseresponseisaknowndeterministicfunctionorastochasticprocesswithaknownpowerspectraldensity(PSD).However,itiswell-knownthatatargetimpulseresponseisneithereasilynoraccuratelyobtained;besidesitchangessharplywithattitudeangles.Bothoftheaforementionedcasescomplicatethewaveformdesignprocess.Inthispaper,anadaptiverobustwaveformselectionmethodforunknowntargetdetectioninclutterisproposed.Thetargetimpulseresponseisconsideredtobeunknownbutbelongstoaknownuncertaintyset.Anadaptivewaveformlibraryisdevisedbyusingasignal-to-clutter-plus-noiseratio(SCNR)-basedoptimalwaveformdesignmethod.Byapplyingtheminimaxrobustwaveformselectionmethod,theoptimalrobustwaveformisselectedtoensurethelowestperformanceboundoftheunknowntargetdetectioninclutter.Resultsshowthattheadaptivewaveformlibraryoutperformsthepredefinedlinearfrequencymodulation(LFM)waveformlibraryontheSCNRbound.

简介：在里面在水下目标察觉，底部回响有一些象目标回响的一样的性质，它在表演上有大影响。学习目标回响和回响之间的差别是必要的。在这份报纸，基于目标区别上的人的听能力的唯一的优点，Gammatone过滤器作为听觉的模型被拿。另外，时间频率感觉展示并且听觉光谱特征为活跃声纳目标回响和底部回响分离被提取。试验性的数据的特征在一样的类上有好集中特征并且有不同的类之间的大量差别，它证明这个方法罐头有效地在目标回响和回响之间区分。

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简介：AveryDennisonRFID日前宣布与Target公司签订-项全球射频识别合作协议.AveryDennison将向Target的1600家门店提供RFID技术支持,以最大限度提升库存可用性及客户体验.该项目的规模是全球同类项目中最大的.Target将利用AveryDennison广泛的UHFRFID产品组合,以满足其各类需求.

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简介：熔化力量输出不仅与参予反应的燃料粒子数字密度而且到熔化反应率系数成正比(或反应)，它依赖于反应物速度分发功能。他们通常被假定是有为热核聚变情形的一样的温度的双Maxwellian分发功能。不管多么高驱动中立横梁注射和少数离子种类ICRF血浆加热，或多拧的血浆横梁迎头向前的碰撞，在收敛，区域在未来被要求并且调查大规模熔化反应堆，当时，源于电离或费用交换的注射精力充沛的快离子尾巴的部分将足够大，他们对non-Maxwellian分发功能的贡献不是可以忽略的，因此评估fu的系数或计算到熔化反应在如此的情况，横梁目标，和横梁横梁反应改进中，效果贡献应该起很重要的作用。在这份报纸，为不同横梁和目标联合情形计算熔化反应率系数的几个有用公式详细被导出。