简介：MitralstenosisduetorheumaticheartdiseaseisnotcommonintheUnitedStatesbutiscommoninthedevelopingworldbecauserheumaticfeverisstilloccurringfrequently.Symptomsusuallygraduallyoccurintheyoungadult(mostcommonlyfemale).Atrialfibrillationisacommonaccompanyingrhythminpatientswithprovenmitralstenosis.Themainphysiologiceventisapressuregradientbetweentheleftatriumandtheleftventricle.DiagnosisisrelativelystraightforwardusingphysicalexamandsimplelaboratorystudiessuchasChestX-Ray(elevatedLeftmainstembronchus,DoubleDensityindicatingenlargedleftatrium)andECG(P-Mitrale).Cardiacultrasoundconfirmstheclinicaldiagnosis(Domingofmitralvalveindiastole,Hockeystickdeformityoftheanteriormitralvalveleaflet,largeleftatrium,Dopplerestimationofvalvegradient).Mitralcommisurotomy(surgicalorBalloon)iswarrantedifthevalveispliableandnotheavilycalcified.

简介：BackgroundCongenitaltrachealstenosis(CTS)isachallengingairwayproblem.CTSininfantsandchildrencanbelife-threatening.Duringlastthirtyyears,alargenumberofstudiescoveringthediagnosis,clinicalpresentation,managements,especiallysurgicaltreatmentsofCTShavebeenreported.ThisreviewaimedtoconcluderecognizedknowledgeofCTSandprovidecluesformanaginginfantsandchildrenwithCTS.

简介：Theheartistheprincipalorganthatcirculatesblood.Innormalconditionsitproducesfoursoundsforeachcardiaccycle.However,mostoftenonlytwosoundsappearessential:S1andS2.Twoothersounds:S3andS4,withloweramplitudethanS1orS2,appearoccasionallyinthecardiaccyclebytheeffectofdiseaseorage.Thepresenceofabnormalsoundsinonecardiaccycleprovidevaluableinformationonvariousdiseases.Theaorticstenosis(AS),asbeingavalvularpathology,ischaracterizedbyasystolicmurmurduetoanarrowingoftheaorticvalve.Themitralstenosis(MS)ischaracterizedbyadiastolicmurmurduetoareductioninthemitralvalve.Earlyscreeningofthesediseasesisnecessary;it'sdonebyasimpletechniqueknownas:phonocardiography.Analysisofphonocardiogramssignalsusingsignalprocessingtechniquescanprovideforcliniciansusefulinformationconsideredasaplatformforsignificantdecisionsintheirmedicaldiagnosis.Inthisworktwotypesofdiseaseswerestudied:aorticstenosis(AS)andmitralstenosis(MS).Eachonepresentssixdifferentcases.Theapplicationofthediscretewavelettransform(DWT)toanalysepathologicalseverityofthe(ASandMSwaspresented.Then,thecalculationofvariousparameterswasperformedforeachpatient.ThisstudyexaminesthepossibilityofusingtheDWTintheanalysisofpathologicalseverityofASandMS.

简介：损害模仿条纹异种，指定了为lms1(损害模仿条纹1)，从60CoY放射的M2子孙被获得对待的装饰用的梨树米饭变化Jiahua1。lms1异种越过整个生长和发展阶段显示了繁殖类型损害。当在高温度下面成长时，生理学和组织化学分析证明异种展出了白条纹的显型(30潭敤吗？

简介：ossicular链的损害是损害听觉的感觉的普通耳朵疾病。人的耳朵的一个全面数字模型能提供健全传播的更好的理解。在这研究，我们建议合并运河，鼓膜的膜，ossicular骨头，中耳悬带系带/肌肉，中耳洞和内耳液体的人的耳朵的一个三维的有限元素模型。数字分析被进行并且采用了预言中耳洞，锤骨柄缺点，砧骨的长过程的发育不全，和镫骨的脚的效果在健全传播上背叛。现在的有限元素模型被显示在预言人的耳朵的ossicular力学讲理。

简介：A70-year-oldmanisseenforevaluationofaheartmurmurheardbyhisprimarycareprovider.Thepatientplaysdoublestennistwiceperweekandclaimstobeasymptomatic.–Medication:amlodipineforhypertension.–Physicalexamination(PE):pulse82bpm;bloodpressure140/90mmHg.–Neck:neckveinsflat.Carotidsdelayed.–Chest:clear.–Cardiovascular:grade2/6latepeakingsystolicejectionmurmur.–Extremities:normalpulses.–Echocardiogram:heavilycalcifiedaorticvalve.Peakjetvelocity4.6m/s.Aorticvalvearea0.7cm2.Rightventricularsystolicpressurenotobtainable.

简介：Westudytarget-searchingprocessesonapercolation,onwhichahuntertracksatargetbysmellingodorsitemits.Theodorintensityissupposedtobeinverselyproportionaltothedistanceitpropagates.TheMonteCarlosimulationisperformedona2-dimensionalbond-percolationabovethethreshold.Havingnoideaofthelocationofthetarget,thehunterdeterminesitsmovesonlybyrandomattemptsineachdirection.Forlagerpercolationconnectivityp(＞～)0.90,itrevealsascalinglawforthesearchingtimeversusthedistancetothepositionofthetarget.Thescalingexponentisdependentonthesensitivityofthehunter.Forsmallerp,thescalinglawisbrokenandtheprobabilityoffindingoutthetargetsignificantlyreduces.Thehunterseemstrappedintheclusterofthepercolationandcanhardlyreachthegoal.

简介：ＡｉｒｂｏｒｎｅＴａｒｇｅｔＳｔａｔｅＥｓｔｉｍａｔｏｒ￥ＨａｏＪｉａｎｋａｎｇ；ＺｈａｎｇＭｉｎｇｌｉａｎ＆ＷｅｎＣｈｕａｎｙｕａｎ（Ｆａｃｕｌｔｙ３０５ｏｆＢｅｉｊｉｎｇＵｎｉｖｅｒｓｉｔｙｏｆＡｅｒｏｎａｕｔｉｃｓ＆ＡｓｔｒｏｎａｕｔｉｃｓＢｅ...

简介：现在的学习是为检测HIFU调查微分成像方法(高紧张集中了超声)导致的损害和为有木头的损害评估的变细的变化的评价光谱差别算法。在vitro的牛的肌肉和肝的实验结果被获得。为损害察觉的几个算法-绝对差别(广告)，加绝对差别(悲伤)并且加摆平的差别(SSD)-与几种窗户尺寸和阀值价值被分析。当时，三个变细参数与相比评估织物的度损坏。它被发现吝啬的变细的那个变化()是一个有效参数评估损害。

简介：Thebraincontrolsvirtuallyallbodyfunctions,bothinternallyandininteractionwiththeexternalenvironment.Asthebasicbodyanatomyofallvertebrateshasabilateralsymmetry,structuresandfunctionsofvertebratebrainsarealsoorganizedaccordingtothisfundamentalanatomicalprincipletomeetallsensory,motor,andinternalrequirementsofbodycontrol.Consequently,particularpartsorfunctionsofthebodyarecontrolledbyparticularbrainstructures.Formammalswhosebrainsonlyhaveaverylimitedcapacityto

简介：Spindlecellcarcinomaofthebreastisararetumor.Thistumorcanproliferaterapidlyandcausecysticchangesbecauseofinternaltissuenecrosis.Weevaluateda54-year-oldwomanwithrightbreastlump.Mammographyshowedacategoryfourmasswithadiameterof2.5cm.Ultrasonography(US)revealedacomplexcysticlesion,andfine-needleaspiration(FNA)cytologydemonstratedbloodyfluidandmalignantcells.Partialbreastresectionandsentinellymphnodebiopsywereperformed.Immunohistologyrevealedspindlecellswithpositiveresultsforcytokeratin(AE1/AE3)andvimentin,partiallypositiveresultsfors-100,andnegativeresultsfordesminandα-actin.ThepathologicalstagewasIIA,andbiochemicalcharacterizationshowedthatthetumorwastriplenegative.SixcoursesofFEC-100chemotherapy(5-fluorouracil500mg/m2,epirubicin100mg/m2,andcyclophosphamide500mg/m2)wereadministered.Radiotherapywasperformed.Thiscaseisdiscussedwithreferencetotheliterature.

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简介：ObjectivesPercutaneousballoonmitralvalvuloplasty(PBMV)isonewaytoimprovetherheumaticmitralstenosis.Howdoestheprocedureworkingravidaandfetusisnotveryclear.WeanalyzedtheeffectsandsafetyofPBMVoperationonpregnantpatientswithsevererheumaticmitralstenosis.MethodsEightpregnantpatientssufferingfromseveremitralstenosisunderwentfacilitatedPBMVoperationwithInoueballoon,andwerefollowedupfor(2.0±1.1)years.Contentsincludedoutcomeofpregnancy,infantgrowth,hemodynamics,echocardiography,cardiacfunction,mitralvalvesreplacementorrepeatvalvuloplasty.ResultsMitralvalvearea(MVA)before,oneweekandoneyearafterfacilitatedPBMVwere(0.84±0.21)cm2,(1.69±0.23)cm2and(1.51±0.24)cm2respectively.Thetransmitralpressuregradientdroppedfrom(22.1±4.7)mmHgto(9.9±3.1)mmHg(P<0.001)(1mmHg=0.133kPa).AfterfacilitatedPBMV,allpatientsshowedremarkableimmediatesymptomaticandhemodynamicimprovementwithoutseveremitralregurgitation.AllofthesepatientscouldmaintainNewYorkheartassociation(NYHA)ⅠorⅡfor(2.0±1.1)yearsaftertheoperation.TwopatientsdemandedinducedabortionconcerningabouttheteratogeniceffectofX-rayonfetus.Alltheothersixpatientscontinuedtheirgestationandhadfull-termcesareansectionwithoutcomplications.Theirnewbornsdevelopedhealthyandnormallytillnow.ConclusionsFacilitatedPBMVisafeasible,safeandeffectivedeviceforselectedpregnantpatientswithmitralstenosis.Theoperationiswelltoleratedbythefetus.

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简介：AbstractPancreatic neuroendocrine tumors are in low incidence compared with other pancreatic tumors, and they present as various pathological forms, including solid, cystic and solid-cystic lesions. Herein, we report a rare case that presents cystic lesions in liver originating from solid pancreatic neuroendocrine tumors. It can be easily misdiagnosed pancreatic ductal adenocarcinoma or primary hepatic cancer according to imaging by surgeons without extensive professional experience. Therefore, it reminders surgeons the privotal role of pathological biopsy to diagnose the disease correctly. The ethical approval and written consent were waived by the institutional review board of our hospital owing to the retrospective nature of the study and routine treatments performed on this patient in clinical practice.

简介：Transcatheteraorticvalvereplacement(TAVR)isincreasinglyusedforthetreatmentofhighorveryhighsurgicalriskpatientswithsevereaorticstenosis(AS)orfailingsurgicalbioprosthesis(valve-in-valve,VIV-TAVR).InTAVR,thecollapsedtranscatheterheartvalve(THV)isintroducedusingthedeliverysysteminsertedfromthefemoralartery(preferred)orotheralternativeaccesses(transapical,transaortic,transcarotid,subclavian/transinnominateortranscaval).Thedeliverysystemisthenadvanceduntilcoaxiallyalignedwiththeaorticannulus,wheretheTHVisdeployed.Thisprocedurecanbeassociatedwithcomplicationssuchasaccesssiteinjury(vascularcomplication),paravalvarleak,cerebrovasculareventsandconductiondisturbances.However,therapidacceptanceandsuccessesobservedwithTAVRhavebeenmadepossiblethroughcarefulpatientselection,preproceduralplanning(i.e.MDCTannularsizing),THVtechnology(i.e.newgenerationvalves),andproceduraltechniques(i.e.minimalistTF-TAVRandalternativepercutaneousaccessoptions),aswellasadecreaseincomplicationsasTAVRexperiencegrows.ThoughtheresultsorongoingclinicaltrialsevaluatingTAVRinintermediatesurgicalriskpatientsarepending,itislikelythatTAVRwillsoonbeapprovedforlowerriskpatientsaswell.

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简介：AbstractThe incidence and prevalence of asthma have increased remarkably in recent years. There are lots of factors contributing to the occurrence and development of asthma. With the improvement of sequencing technology, it has been found that the microbiome plays an important role in the formation of asthma in early life. The roles of the microbial environment and human microbiome in the occurrence and development of asthma have attracted more and more attention. The environmental microbiome influences the occurrence of asthma by shaping the human microbiome. The specific mechanism may be related to the immune regulation of Toll-like receptors and T cells (special Tregs). Intestinal microbiome is formed and changed by regulating diet and lifestyle in early life, which may affect the development and maturation of the pulmonary immune system through the intestinal-pulmonary axis. It is well-recognized that both environmental microbiomes and human microbiomes can influence the onset of asthma. This review aims to summarize the recent advances in the research of microbiome, its relationship with asthma, and the possible mechanism of the microbiome in the occurrence and development of asthma. The research of the microbial environment and human microbiome may provide a new target for the prevention of asthma in children who have high-risk factors to allergy. However, further study of "when and how" to regulate microbiome is still needed.

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