简介：AIM:Todeterminethenormativevaluesofwhite-towhitecornealdiameterwithOrbscanIITopographySystemandtocomparerightandlefteyesdatainthenormalyoungpopulation.METHODS:Atotalof1001healthyparticipantsaged18-45yparticipatedinthisobservationalcross-sectionalstudy.Thestudypopulationconsistedof616femaleand385malesubjects.ThecornealdiameterwasmeasuredwiththeOrbscanII.Thedifferencesbetweengenders,betweenrightandlefteyesandage-relatedchangeswereevaluated.StatisticalanalyseswereperformedusingStudent’st-test.RESULTS:Theaveragewhite-to-whitedistanceinourstudypopulationwasrecordedas11.65±0.36mm(median:11.60mm,mode:11.70mm,minimum:10.50mmandmaximum:13.60mm).Thewhite-to-whitedistancewas11.60±0.35mminmalesand11.71±0.36mminfemaleswhichwasstatisticallydifferentbetweengenders(P<0.01).However,white-to-whitedistancewasnotstatisticallydifferentbetweenrightandlefteyes.Inaddition,thisparameterdecreasedwithincreasingage.Considering95%confidenceinterval,cornealdiameterlessthan10.93mmandgreaterthan12.34mmwouldbeconsideredasmicrocorneaandmegalocornea,respectivelybasedonthisstudypopulation,usingtheOrbscanIItopography.CONCLUSION:DetaileddescriptionandanalysisofcornealdiameterwithOrbscandemonstratethattheobtainedaveragevalueofhorizontalwhite-to-whiteishigherinmalethanfemaleanddecreasesslightlywithincreasingage.Ourdataalsosuggeststhecutoffvaluesfordefinitionofmicrocorneaandmegalocornea,whichcanbeemployedwiththispopulation.

简介：HEMINGWAY’sstory,“HillsLikeWhiteElephants”,isaboutlovingrelationshipsbetweenanAmericanmanandagirl.Aslovers,theyarein-timate,withthegirlinthestateofpregnancy.Thestoryistoldfromtheobjectivepointofview.Ittakesplaceduringa40-minutewaitbetweentrains.Whatliesbehindthemisindicatedbythelabelsontheirbags.Whatliesaheadofthemimpliesentireforceanddir-ectionofthestory.Itisatthestationthatadecisionwillbemadethat

简介：Laboratoryexperimentsandfieldobservationsshowthattheequilibriumrangeofwindwavespectrapresentsa–4powerlawwhenitisscaledproperly.Thisfeaturehasbeenattributedtoenergybalanceinspectralspacebymanyresearchers.Inthispaperwepointoutthatwhitenoiseonanoscillationsystemcanalsoleadtoasimilarinversepowerlawinthecorrespondingdisplacementspectrum,implyingthatthe–4powerlawfortheequilibriumrangeofwindwavespectramayprobablyonlyreflecttherandomicityofthewindwavesratherthananyotherdynamicalprocessesinphysicalspace.Thisexplanationmayshedlightonthemechanismofotherphysicalprocesseswithspectraalsoshowinganinversepowerlaw,suchasisotropicturbulence,internalwaves,etc.

简介：Akindofsulphide,CaS:Eu2+,activatedbyeuropiumionforwhiteLEDlightingwassynthesizedviasolid-statereactionrouteinreducingatmospheres.Thephosphorswerethenencapsulatedwithsiliconeresin.Moreover,chemicalstructureofthephosphorswascharacterizedbyXRD.MicrostructureofthepowderswasobservedbySEM.Spectraofexcitationandemissionforthephosphorswerealsoobtainedbyaspectrophotometer.Effectofprocessingparametersontheluminescentpropertiesofthepowderswassystematicallystudiedtoresultinthephosphorswithgoodchemicalstabilityandmaximalrelativeluminescentintensity.

简介：MicroRNAs(miRNAs)是在优核质在许多新陈代谢的活动起关键规章的作用的小、非编码的内长的RNA的一个新奇的班。在Sogatellafurcifera(支持白人的planthopper)的miRNAs的鉴定的报告，那作为唯一扮演的昆虫证实了南部的米饭的向量黑条纹的矮子病毒(SRBSDV)，被限制。在这研究，382miRNAs的一个总数在S被识别。furcifera，包括106保存了并且276新奇miRNAs，用从viruliferous和non-viruliferousS的基于二个小RNA图书馆的高产量的定序。furcifera，和这些miRNAs属于52个保存miRNA家庭和58S。furcifera特定的家庭分别地。多于保存miRNA家庭的一半高度在Hexapoda被保存，有从在miRBase的26昆虫种类和五另外的种的miRNAs的比较显示出那，当另外的miRNAs仅仅在non-dipterans被保存时。而且，为382预言的4117目标基因鉴别miRNAs能被分成基因本体论注解的45个功能的组。与non-viruliferous房间相比，八起来调整的miRNAs和四下面调整的miRNAs在与SRBSDV，miR-14和miR-n98a可以在之中涉及对SRBSDV感染的有免疫力的反应接种的房间被识别。识别miRNAs的分析将在涉及新陈代谢，发展和S的病毒的感染的基因的规定和表示提供卓见进这些miRNAs的角色。furcifera。

简介：AbstractBackground:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by complex and various clinical manifestations. The study aimed to analyze clinical features and cerebral magnetic resonance imaging (MRI) changes of hyperintense white matter (WM) lesions in SLE patients.Methods:This was a retrospective study based on a consecutive cohort of 1191 SLE patients; 273 patients for whom cerebral MRI data were available were enrolled to assess hyperintense WM lesions associated with SLE. Patients were assigned to two groups, ie, with or without hyperintense WM lesions. The MRI assessment showed that the hyperintense WM lesions could be classified into three categories: type A, periventricular hyperintense WM lesions; type B, subcortical hyperintense WM lesions; and type C, multiple discrete hyperintense WM lesions. The clinical and MRI characteristics were analyzed. Factors related to hyperintense WM lesions were identified by multivariate logistic regression analysis.Results:Among the 273 SLE patients with available cerebral MRI scans, 35.9% (98/273) had hyperintense WM lesions associated with SLE. The proportions of types A, B, and C were 54.1% (53/98), 11.2% (11/98), and 92.9% (91/98), respectively. Fifty-one percents of the patients showed an overlap of two or three types. Type C was the most common subgroup to be combined with other types. Compared with those without hyperintense WM lesions, the patients with hyperintense WM lesions were associated with neuropsychiatric SLE (NPSLE), lupus nephritis (LN), hypertension, and hyperuricemia (P = 0.002, P = 0.018, P = 0.045, and P = 0.036, respectively). Significantly higher rates of polyserous effusions and cardiac involvement were found in the patients with hyperintense WM lesions (P = 0.029 and P = 0.027, respectively), and these patients were more likely to present with disease damage (P < 0.001). In addition, the patients with hyperintense WM lesions exhibited a higher frequency of proteinuria (P = 0.009) and higher levels of CD8+ T cells (P = 0.005). In the multivariate logistic analysis, hyperuricemia and higher CD8+ T cells percentages were significantly correlated with hyperintense WM lesions in SLE patients (P= 0.019; OR 2.129, 95% confidence interval [CI] 1.313-4.006 and P < 0.001; OR 1.056, 95% CI 1.023-1.098, respectively).Conclusions:Hyperintense WM lesions are common in SLE patients and significantly associated with systemic involvement, including NPSLE, LN, polyserous effusions, cardiac involvement, and disease damage. Hyperuricemia and a higher number of CD8+ T cells were independent factors associated with hyperintense WM lesions in SLE.

简介：ComparativeanalysisofChina’shumanrightswhitepapersprovidesavaluableperspectiveonchangesintheofficialhumanrightsdiscourse.Intermsoftheirstructures,thewhitepaperscanbedividedintothreetypes:themixedmodel,thefive-in-onemodelandtherights-listmodel.Therights-listmodelhasaconsistentstyle,standardterminology,andanarrangementofrightsinlinewithChina’sreality.Intermsofcontents,therighttosubsistencehasbeengraduallyreducedandtherighttodevelopmentisincreasing.Inthe2013whitepaper,therewasawholechapteronsocialsecurityrights,whichhighlightsChina’ssocialdevelopmentandthepriorityplacedonthepeople’swellbeing.TherighttodevelopmentandsocialsecuritywillbecomeanewfocusofhumanrightsdiscourseinChina.

简介：AbstractBackground:Total and differential white blood cell counts are important for the diagnostic evaluation of suspected diseases. To facilitate the interpretation of total and differential white blood cell counts in pediatric patients, the present study investigated age-dependent changes in total and differential white blood cell counts in healthy reference children.Methods:Data were obtained from the Pediatric Reference Intervals in China study (PRINCE), which aims to establish and verify pediatric reference intervals for Chinese children based on a nationwide multicenter cross-sectional study from January 2017 to December 2018. Quantile curves were calculated using the generalized additive models for location, shape, and scale method. The 2.5th, 50th, and 97.5th quantile curves were calculated for both total and differential white blood counts. Percents of stacked area charts were used to demonstrate the proportions of differential white blood cells. All statistical analyses were performed using R software.Results:Both 50th and 97.5th quantiles of total white blood cell count and monocyte count were highest at birth, then rapidly decreased in the first 6 months of life; relatively slow reduction continued until 2 years of age. The lymphocyte count was low during infancy and increased to its highest level at 6 months of age; it then exhibited moderate and continuous reduction until approximately 9 years of age. The pattern of neutrophil count changed with age in a manner opposite to that of lymphocyte count. Besides, there were two inter-sections of lymphocyte count and neutrophil count during infancy and at approximately 5 years of age, based on locally weighted regression (LOESS) analysis. There were no apparent age-related changes in eosinophil or basophil counts.Conclusion:These data regarding age-related changes in total and differential white blood cell counts can be used to assess the health of pediatric patients and guide clinical decisions.

简介：Inthispaper,theanalysismethodofstochasticresponseofpiledoffshoreplatformexcitedbystationaryfilteredwhitenoiseispresented.Withthismethod,thestronggroundmotionisconsideredasthreedirectionstationaryfilteredwhitenoiseprocess,thetheoreticsolutionsofthreespecialintegrationequationsarederivedwiththeresiduetheorem,andtheexpressionofresponsenodaldisplacementsandmemberforcesofoffshoreplatformexcitedbythestationaryfilteredwhitenoiseisputforward.Thestochasticresponseofapiledoffshoreplatformexcitedbythestationaryfilteredwhitenoise,whichislo-cated114.3minwaterdepth,iscomputed.Theresultsarecomparedwiththoseobtainedwiththere-sponsespectrumanalysismethodandthestationarywhitenoisemodelanalysismethod,andthecorre-spondingconclusionisdrawn.

简介：重建的向量pCANTAB5EE被插入包含了一个EcoRV识别序列进pCANTAB的34搁浅bpdouble的oligonucleotide获得5E。Whitespot症候群病毒(WSSV)染色体DNA被sonication碎裂主要在0的范围孤立碎片。8～2.0kb，当时，碎片与T4DNA聚合酶是钝结束的并且克隆5EE进pCANTAB的EcoRV地点。图书馆的主要recombinant克隆是随机的选择re-combinants的5.ColonyPCR显示出的3.0x10~inserts的尺寸是0.12～整个图书馆recombinant噬菌体感染了的1.77kb.AfterEscherichi--关口iHB2151房间，细胞外并且periplasmic摘录在PVDF膜上被扔执行点污点，usingpoly同种细胞的老鼠anti-VP24浆液，anti-WSV026浆液，anti-WSV063浆液，anti-WSV069浆液，anti-WSV112浆液，anti-WSV238浆液，anti-WSV303浆液和anti-VP26浆液结果证明显示图书馆能表示病毒的蛋白质。

简介：Weobservedthecharacteristicsofwhitematterfibersandgraymatterinmultiplesclerosispatients,toidentifychangesindiffusiontensorimagingfractionalanisotropyvaluesfollowingwhitematterfiberinjury.Weanalyzedthecorrelationbetweenfractionalanisotropyvaluesandchangesinwhole-braingraymattervolume.Theparticipantsincluded20patientswithrelapsing-remittingmultiplesclerosisand20healthyvolunteersascontrols.Allsubjectsunderwentheadmagneticresonanceimaginganddiffusiontensorimaging.Ourresultsrevealedthatfractionalanisotropyvaluesdecreasedandgraymattervolumeswerereducedinthegenuandspleniumofcorpuscallosum,leftanteriorthalamicradiation,hippocampus,uncinatefasciculus,rightcorticospinaltract,bilateralcingulategyri,andinferiorlongitudinalfasciculusinmultiplesclerosispatients.Graymattervolumesweresignificantlydifferentbetweenthetwogroupsintherightfrontallobe(superiorfrontal,middlefrontal,precentral,andorbitalgyri),rightparietallobe(postcentralandinferiorparietalgyri),righttemporallobe(caudatenucleus),rightoccipitallobe(middleoccipitalgyrus),rightinsula,rightparahippocampalgyrus,andleftcingulategyrus.Thevoxelsizesofatrophicgraymatterpositivelycorrelatedwithfractionalanisotropyvaluesinwhitematterassociationfibersinthepatientgroup.Thesefindingssuggestthatwhitematterfiberbundlesareextensivelyinjuredinmultiplesclerosispatients.Themainareasofgraymatteratrophyinmultiplesclerosisarethefrontallobe,parietallobe,caudatenucleus,parahippocampalgyrus,andcingulategyrus.Graymatteratrophyisstronglyassociatedwithwhitematterinjuryinmultiplesclerosispatients,particularlywithinjurytoassociationfibers.

简介：ObjectiveToobservetheeffectofaccessorypathway(AP)conductiononPJintervalinpatientswithWolff-Parkinson-Whitesyndrome.Methods129patientswithasinglemanifestationofAPwhounderwentsuccessfulradiofrequencyablation(RFCA)wereincluded.Patientsweredividedinto10groupsaccordingtoAPlocation.ThePRintervals,QRSdurationsandthePJintervalsweremeasuredusingsimultaneous12-leadECGbeforeandafterablation.ThePJintervalsbeforeablationwerecomparedwiththatafterablation.Theatrioventricular(AV)conductiontimeviaatrioventricularnode-HisconductionsystembeforeablationwerecomparedwiththePRintervalsafterablation.Theventriculardepolarizationtimeviaatrioventricularnode-HisconductionsystembeforeablationwerecomparedwiththeQRSdurationsafterablation.Deltawaveswerecomparedbetweeneachtwogroups.Results(1)ThePJintervalsofrightposterior(RP)groupandrightposteroseptal(RPS)groupbeforeablationwereshorterthanthatafterablation(RPgroup226±18msvs236±19ms,P<0.01,RPSgroup221±18msvs238±31ms,P<0.05,respectively).(2)Therewerenosignificantdifferencesbetweentheatrioventricular(AV)conductiontimeviaatrioventricularnode-HisconductionsystembeforeablationandthePRintervalsafterablation.(3)Theventriculardepolarizationtimeviaatrioventricularnode-HisconductionsystemofRPgroupandRPSgroupbeforeablationwereshorterthanthePRintervalsafterablation(RPgroup79±12msvs87±9ms,P=0.01;RPSgroup70±13msvs86±9ms,P<0.05,respectively).(4)ThedeltawavesofRPgroupandRPSgroupwerelongerthanthatofleftposteriorgroupandleftposteroseptalgroup(P<0.05).ConclusionPJintervalisshortenedbyAPconductionwhichpre-excitesthegenerallastexcitedpartofleftventricle.ItisdeterminedbyAPlocationandtheextentofpreexcitation.

简介：

简介：由介绍直角的频率部门multiplexing(OFDM)技术，用5的一个可见轻通讯(VLC)系统

简介：吉本斯们在进化期间经历了广泛的karyotype重新整理并且为学习进化chromosomal重新整理的内在的分子的机制代表一个理想的模型。克隆和进化chromosomal断点的顺序描述将提供重要卓见进驾驶了如此的激进的karyotype的分子的力量，这被期望在长臂猿改组。我们构造了并且描绘非包含192,000的白脸颊的长臂猿(Nomascusleucogenys)的一个高质量的fosmid图书馆--有38kb和2.5褶层染色体范围的一种平均insert尺寸的冗余的克隆。到100随机选择的fosmid克隆定序的结束，我们为图书馆产生了196个顺序标签。这些定序结束的fosmid克隆然后被荧光在situ杂交印射到白脸颊的长臂猿的染色体上，并且没有假妄想的克隆被检测。对人的染色体的强风搜索显示出在点击克隆的数字和染色体的数字之间的好关联，fosmid图书馆的不偏的chromosomal分发的一个指示。印射的克隆的chromosomal分发与对人、白脸颊的长臂猿染色体的BLAST搜索结果也一致。fosmid图书馆和印射的克隆愿望在更小的无尾猿为进一步学习长臂猿的chromosomal重新整理和内在的分子的机制以及为比较genomic学习用作一个珍贵资源。

简介：语义韵是人类语言能力的一部分。不同的语言在概念同一客体的语言符号中往往蕴涵着不同的意义，在语义韵上的表现也往往不尽相同。以现代汉语“白”和现代英语“white”为例，通过语料库数据，比较二者语义韵异同的表象，并运用认知语言学的相关理论深入探究造成其异同的根源，发现认知主体的主体性是造成语义韵异同的深层原因。

简介：Fortilinisamultifunctionalproteinimplicatedinmanyimportantcellularprocesses.SinceinjectionofPm-fortilinreducesshrimpmortalitycausedbywhitespotsyndromevirus(WSSV),thereispotentialapplicationoffortilininshrimpculture.Inthepresentstudy,inordertoimprovetrans-membranetransportationefficiency,theproteintransductiondomainofthetransactivatoroftranscription(TAT)peptidewasfusedtofortilin.ThePichiapastorisyeastexpressionsystem,whichiswidelyacceptedinanimalfeeds,wasusedforproductionofrecombinantfusionprotein.Greenfluorescenceprotein(GFP)wasselectedasareporterbecauseofitsintrinsicvisiblefluorescence.Thefortilin,TATandGFPfusionproteinwereconstructed.Theirtrans-membranetransportationefficiencyandeffectsonimmuneresponseofshrimpwereanalyzedinvitro.ResultsshowedthatTATpeptideimprovedinvitrouptakeoffortilinintothehemocytesandmidgutofLitopenaeusvannamei.Thephenoloxidase(PO)activityofhemocytesincubatedwithGFP-FortilinorGFP-Fortilin-TATwassignificantlyincreasedcomparedwiththatinthecontrolwithoutexpressedfortilin.ThePOactivityofhemocytesincubatedwith200μgmL-1GFP-Fortilin-TATwassignificantlyhigherthanthatinthegroupwiththesameconcentrationofGFP-Fortilin.HemocytesincubatedwithGFP-Fortilin-TATatallconcentrationsshowedsignificantlyhighernitricoxidesynthase(NOS)activitythanthoseinthecontrolorintheGFP-Fortilintreatment.ThepresentinvitrostudyindicatedthatTATfusionproteinimprovedtheimmuneeffectoffortilin.

简介：Thepresentstudywasconductedtoevaluatethefeasibilityofreplacingfishmeal(FM)withbioactivepeptides(BPs)indietofwhiteshrimp(Litopenaeusvannamei).Thechangesingrowthperformance,bodycomposition,non-specificimmunity,andwaterqualitywereexaminedaftertheshrimpwerefedfourdiets,inwhich0%(control),33.3%,66.7%and100%ofFMwasreplacedbyBPs,respectively.ThegroupsweredesignatedasCon,1/3BPs,2/3BPs,and3/3BPs.Atotalof720shrimpwithaninitialbodyweightof1.46±0.78gwerefedtheexperimentaldietsfor56days.Theresultsrevealedthat:1)theweightgainrate(WGR)in1/3BPs,2/3BPs,and3/3BPswassignificantlyhigherthanthatinCon(P<0.05),whilenosignificantdifferencewasfoundonsurvivalrateandfeedconversionratio(FCR);2)thewhole-bodycrudeprotein(CP)andcrudelipids(CL)weresignificantlydifferentamonggroups,whiletherewasnosignificantdifferencebetweencrudeashandphosphoruscontents;3)thelevelsofacidphosphatase(ACP),lysozyme(LZM),superoxidedismutase(SOD),phenoloxidase(PO)andbactericidalactivityincreasedsignificantlywiththeinclusionofBPs;4)intermsofwaterquality,nosignificantdifferencewasfoundinpHanddissolvedoxygenamongdietsduringthewholeexperimentalperiod.Moreover,eventhoughnitriteandammoniumlevelstendedtoincreasewithtime,therewasnosignificantdifferenceamonggroups.TheresultsindicatedthatBPsisanapplicablealternativeofproteinsource,whichcansubstituteFMinthedietsofL.vannamei;itisabletoeffectivelypromotegrowthperformanceandimproveimmunity.Moreover,BPsinthedietshadnonegativeimpactonwaterquality.

简介：Whitespotsyndromevirus(WSSV)-resistantmolecularmarkerswerescreenedfromtheselectivelybrednewvariety‘HuanghaiNo.2’ofFenneropenaeuschinensisusingunlabeled-probehigh-resolutionmelting(HRM)technique.AftertheartificialinfectionwithWSSV,thefirst96deadshrimpsandthelast96survivingshrimpswerecollected,representingWSSV-susceptibleand-resistantpopulations,respectively.Thegenotypesatwell-developed39singlenucleotidepolymorphisms(SNPs)lociwereobtained.AsrevealedintheChi-squaretest,3SNPs,genotypeA/AofcontigC364-89AT,genotypeA/AofC2635-527CAandgenotypeC/TofcontigC12355-592CT,werepositivelycorrelatedwithdisease-resistancetraits.Other2SNPs,genotypeG/GofcontigC283-145AGandgenotypeC/CofcontigC12355-592CT,werenegativelycorrelated.Moreover,analysiswithBlastXprogramfordisease-resistantSNPsindicatedthat3contigs,Contig283,Contig364andContig12355,matchedtothefunctionalgenesofeffectorcaspaseofPenaeusmonodon,peptidetransporterfamily1-likeprotein,and40SribosomalproteinS2ofPercaflavescenswithhighsequencesimilarity.Theresultswillbehelpfultoprovidetheoreticalandtechnicalsupportsformolecularmarker-assistedselectivebreedingofF.chinensis.

简介：Whitespotsyndromevirus(WSSV)isoneofthemajorshrimppathogenscausinglargeeconomiclossestoshrimpfarming.Inanattempttoidentifytheenvelopeproteinsinvolvedinthevirusinfection,purifiedWSSVvirionsweremixedwiththreeantiseraagainstWSSVenvelopeproteins(VP39,VP124andVP187),individually.Andthentheywereinjectedintramuscularlyintocrayfish(Procambarusclarkii)toconductinvivoneutralizationassays.TheresultsshowedthatforgroupsinjectedwithvirionsonlyandgroupsinjectedwiththemixtureofvirionsandantiserumagainstVP124,thecrayfishmortalitieswere100%and60%onthe8thdaypostinfection,individually.ThevirusinfectioncouldbedelayedorneutralizedbyantibodyagainsttheenvelopeproteinVP124.QuantitativePCRwasusedtofurtherinvestigatetheinfluenceofthreeantiseradescribedaboveonthevirusinfection.TheresultsshowedthattheantiserumagainstVP124couldrestrainthepropagationofWSSVincrayfish.AlloftheresultssuggestedthattheviralenvelopeproteinVP124playedaroleinWSSVinfection.