简介:Objective:Toanalyzeretrospectivelytheclinicalsymptoms,signs,radiologicalfindingsandresultsoftreatmentofposttraumaticsyringomyelia.Methods:Thedataof7patientswithposttranmaticsyringomyeliaconfirmedbycomputerizedtomography(CT)andmagneticresonanceimaging(MRI)inourhospitalbetween1999and2004werereviewedretrospectively.Thepatientsunderwentdecompressivelaminectomyorsyringo-subarachnoid(S-S)shuntingwithmicrosurgery.Long-termfollow-upwasavailable(range:13-65months).Results:Themajorclinicalmanifestationsofposttraumaticsyringomyefiausuallyincludedtheonsetofincreasingsignsandthedevelopmentofnewsymptomsafteranapparentlystableperiod.Theclinicalsymptomsincludedpain,sensorydisturbance,weakness,andproblemsinautonomicnerves.Syrinxexistedmerelyatthecervicallevelin4casesandextendeddownwardtothethoraciclevelsintheother3cases.Onecaseunderwentdecompressivelaminectomy,6casesweretreatedbyS-Sshunting.Duringtheearlypostoperativeperiod,allthepatientsshowedanimprovementofsymptomsofsyrinxwithoutmajorcomplicationordeath.ThedecreasedsizeorcollapseofthesyrinxwasdemonstratedbypostoperativeMRI.Conclusions:Posttraumaticsyringomyeliaisadisablingsequelaofspinalcordinjury,developingmonthstoyearsafterspinalinjury.MRIisthestandarddiagnostictechniqueforsyringomyelia.Thepatientswithposttraumaticsyringomyeliacombinedwithprogressiveneurologicaldeteriorationshouldbetreatedwithoperations.S-Sshuntingprocedureiseffectiveinsomepatientswithposttraumaticsyringomyelia.Decompressiveproceduremaybeanalternativeprimarysurgicaltreatmentforpatientswithkyphosisandcordcompression.
简介:Objective: Tostudytheclinicalfeaturesofcraniocerebralinjury(CI)intheaged. Methods: Thedataof149oldpatientswithCIhospitalizedinthedepartmentfromJuly1991toMay2000werestudiedretrospectivelyinthisstudy.Thecausesofinjury,traumaticpathology,clinicalmanifestationandcausesofdeathwereanalyzed,too. Results: Automobileswerethemainvictim-makers,andfallswerethesecond.Andtherewasnosignificantdifferencebetweenthefirsttwokindsofvictim-makers.Thepatientssufferedmainlyfromcerebralcontusion,intracerebralhematomasandsubduralhematomas,andrelativelyfewerfromepiduralhematomas.ThescoresofGlasgowComaScale(GCS)wererelatedcloselytotheprognosiswhenhospitalizedorbeforesurgicaltreatment.Thetotalmortalityratewas37.5%inthisstudy.Themaincauseofdeathwasbraininjury. Conclusions: TheoldpatientswithCIhaveahighmortalityrate.Andthecausesofinjury,traumaticpathologyandclinicalmanifestationarepeculiarintheaged.
简介:Objective:Implantableportthrombosis(IPT)incancerpatientsisarelativelyrarebutseverecomplication.Severalfactorsarereportedlyassociatedwiththeoccurrenceofthrombosis.WeaimedtodescribetheprevalenceandtheanatomoclinicalfeaturesofIPTobservedincancerpatientswhoweretreatedinamedicaloncologydepartmentinTunisia.Methods:Atotalof600cancerpatientswhohadportimplantationfromJanuary2013toDecember2015wereretrospectivelyidentified.Caseswithsymptomatic/incidentalIPT(radiologicallyconfirmed)werefurtheridentified.Epidemiologicalandanatomoclinicalfeatureswerecollectedfrompatientrecordsandthedepartmentdatabase.Results:Weobservedthat33ofthe600patientshadIPT;thus,theprevalencewas5.5%.Themedianagewas57years,andthegenderratiowas0.43.Overweightorobesitywasobservedin73%ofthepatients.IPToccurredmainlyinpatientswithbreast(36.4%)andcolorectal(33.3%)cancers,whichweremostlynonmetastatic(79%).Atleastoneidentifiedclassicalthromboembolicriskfactorwasfoundin13patients(smokingin9,tamoxifenin2).IPTwassymptomaticin93%ofthecases,occurringwithinanaveragetimeof56days.Implantableportswereremovedbecauseofinfectionin2casesandnonfunctionalityin3cases.IPTtreatmentwasbasedonlow-molecular-weightheparins(94%)andantivitaminK(6%)foranaverageof130days.Fourpatientshadpost-therapycomplications:onethrombosisrecurrenceandthreeinfections.Conclusions:IPTcasesinthe600patientswereobservedtooccurinobesenonmetastaticcancerpatientswithinthefirst3monthsafterIPimplantation.
简介:Objective:Tostudytheemergencymanagementprinciplesofseveretraumainhospital(injuryseverityscore≥16).Methods:Weused'ATPprinciple'tomanageseveretraumaticpatients.TheATPprincipleiscomposedof:1)attendingsurgeonsofferinginitialmanagement(A);2)teamworkcommencementimmediatelyafterpatientsadmittedtohospital(T);3)parallelprinciple,ie,emergencyresuscitation,evaluationandlaboratorytestperformedsimultaneously(P).ClinicaleffectsbeforeandafterapplyingATPprinciplewereretrospectivelyanalyzedandcompared.Results:DuringJanuary1,2002toDecember31,2003,338patientsweretreatedwithoutapplyingATPprinciple,inwhichISSwas25.9±6.4,152casesdiedwiththemortalitybeing39.2%,andthetimestayedinemergencydepartmentandthetimetooperationroomafteradmissionwere(102.8±16.7)min,(140.3±20.6)min,respectively.DuringJanuary1,2004toDecember31,2005,438patientsweretreatedbasedonATPprinciple,inwhichISSwas28.6±7.8,87casesdiedwiththemortalitybeing19.9%,andthetimeinemergencydepartmentandthetimetooperationroomafteradmissionwere(69.5±11.5)min,(89.6±9.3)min,respectively.ISSshowednosignificantdifferencebetweenthetwogroups(P>0.05),butthemortality,thetimestayedinemergencydepartmentandthetimetooperationroomafteradmissionweregreatlyreducedandshowedsignificantdifferencebetweenthetwogroups(P<0.05).Conclusions:ApplyingATPprincipletotreatseveretraumaticpatientscanshortenemergencytreatmenttimeinhospitalanddecreasemortality.
简介:Objective:TostudytheimmunologicalmechanismsofCondylomaacuminata(CA)throughinvestigatingTlymphocytesubsetlevelsandcytokineprofileintheperipheralbloodofpatientswithCondylomaAcuminata.Methods:Tricolorandbicolorimmunofluorescentstainingantibodyofcellsurfaceantigenandintracel-lularIL-2,IL-4,IL-12,IFN-γinCD4^+andCD8^+T-lymphocytesfrom20patientswithCAwereperformedandfollowedbyflowcytometry.Results:ThenumberofCD3^+T,CD4^+T-lymphocytescellsandCD4^+/CD8^+Tcellsratioweresignificantlydecreased(P<0.01)inpatientswithCAComparedtocontrols,andIL-2,IL-12,IFN-γproductioninCD4^+Tcellswasdecreased(P<0.01),IL-4andIFN-γproduc-tioninCD4^+Tcellswasnotsignificantlydifferent(P>0.05),whileIL-2andIL-12productioninCD8^+Tccellswasdecreased(P<0.01),whereasIFN-γandIL-4pro-ducinginCD4^+Tcellswereofnosignificantlydifference(P>0.05).Conclusions:TherewasanimbalanceofTlympho-cytesubsets,Th1/Th2cytokinesandTc1/Tc2intheperipheralbloodofCApatients,whichmayplayanimportantroleinthepathogenesisandprogressionofCA.
简介:Purpose:Toinvestigateatreatmentforfemaleurethralsyndrome.Method:Electroacupuncturewasusedtotreat36casesoffemaleurethralsyndrome,withmedicationfor42casesasacontrol.Results:Thetotaleffectiveratewas88.9%fromelectroacupunctureand52.4%frommedication.Therewasasignificantdifferenceincurativeeffectbetweenthetwogroups(p<0.05).Conclusion:Electroacupunctureisaneffectivemethodfortreatmentoffemaleurethralsyndrome.
简介:瞄准:为了评估磁性的回声cholangiopancreatography(MRCP),与磁性的回声(先生)一起的调查结果在自体免疫的胰腺炎(AIP)想象病人。方法:有AIP的九个病人经历了MRI,MRCP,内视镜后退cholangiopancreatography(ERCP),计算断层摄影术,和ultrasonography。在类固醇治疗前后拿的MRCP和先生图象被考察并且与另外的成像形式相比。AIP盒子的MRCP调查结果与有胰的头的癌的10个盒子的那些相比。结果:在MRCP上,在ERCP上注意的主要的胰腺的管的缩小的部分没被设想,当主要的胰腺的管的非包含的片断被设想时。近似的主要的胰腺的管的在上游的膨胀的度比在胰腺的癌的情况下看温和。更低的胆汁管的狭窄或阻塞在8个病人被检测。先生图象在T1加权的先生图象上与减少的信号紧张显示出胰的增大,T2加权的先生图象上的增加的信号紧张,并且,在3个病人,低亚硫酸钠强烈像囊的边界。在类固醇治疗以后,以前没设想主要的胰腺的管的部分被看见,与胆汁管狭窄的改进一起。胰腺的增大减少了,并且T1加权、T2加权的先生图象上的反常信号紧张成为了isointense。结论:MRCP不能区分从与胰腺的癌看见的主要的胰腺的管的狭窄与AIP看见的主要的胰腺的管的不规则的变窄。然而,与在T1加权、T2加权的先生图象上显示出反常信号紧张的胰腺的增大的先生成像一起的MRCP调查结果在支持AIP的诊断是有用的。
简介:Objective:TostudycentralfunctionalnetworkconnectionsandtheiralterationsintinnituspatientsusingfMRI.Methods:Regionalhomogeneity(ReHo)valuesonfMRIwereobtainedfrom18tinnituspatientsand20ageandgender-matchedcontrolsubjects.ReHovalueswerecomparedbetweentinnituspatientsandcontrolsubjectstoevaluatefunctionalnetworkconnectiondifferences.Results:TinnituspatientsshowedincreasedReHovaluesingyrusfrontalisinferioranddecreasedReHovaluesintheanteriorlobeofcerebellumincomparisonwiththecontrols.Analysisoffunctionalnetworkconnectionfromthegyrusfrontalisinteriorshowsstrongerconnectionstothemiddlebrain(FWE,P<0.001)andrightventralstriatum(FEW,P<0.05,smallvolumecorrection).Conclusions:ThefMRIresultsindicatethatbothauditoryandnon-auditorycentersplayimportantrolesintinnitus.Functionalconnectionsamongtheauditorycortex,thalamus,medialtemporalgyrus,parahippocampalgyrusandinsulamaybeanunderlyingcauseforthedevelopmentoftinnitus.
简介:Objective:ThisstudyexaminedHerpesSimplexVirus(HSV)subclinicalsheddinginthegenitaltractofpatientswithgenitalherpes(GH)ornon-gonoccalurethritis(NGU).Method:SwabswerecollectedafterexposuretorashandgenitaltractduringGHrelapseorremissiononaweeklybasisforfourtosixweeks.NGUpatientswithnegativechlamydiaandmycoplasmatestswerealsoswabbedforasimilarduration.AllswabsunderwentHSVDNAdetectionwithquantitativePCR.Result:TherewasasignificantdifferenceintherateofasymptomaticHSVsheddinginurinarytractscomparingGHandthecontrolgroupandcomparingNGUandthecontrolgroup(P<0.05).TherateofHSVsheddingwas22%,9.8%and3.3%forGH,NGUandcontrolgroupsrespectively.TherateofHSVsheddingwas21.7%(20/92)forpatientswithactiveGHand23%forthoseinremission.TheHSVpositiveratewassignificantlyhigherinthegroupwithpatientswhohadmorethansixrelapseswithinoneyearcomparedtothegroupofpatientswithlessthansixGHrelapses.Conclusion:ThereisHSVsubclinicalsheddingintheirgenitaltractduringactiveGHandremission.SubclinicalHSVsheddingismorecommoninpatientswithmorethansixGHrelapsesperyearcomparedtoGHpatientswithfewerrelapses.Approximately9.9%ofNGUpatientswithnegativechlamydia,mycoplasmatestingwasfoundtohavesubclinicalHSVinfection.
简介:AbstractBackground:Moyamoya disease (MMD) is a relatively important and common disease, especially in East Asian children. There are few reports about EEG in children with MMD in China till now. This study is aimed to analyze the electroencephalographic features of MMD in pediatric patients in China preliminarily.Methods:Pediatric patients with MMD who were hospitalized in Peking University International Hospital and Beijing Tiantan Hospital from January 2016 to December 2018 were collected. Clinical and electroencephalography (EEG) findings were analyzed retrospectively.Results:A total of 110 pediatric patients with MMD were involved, and 17 (15.5%) cases had a history of seizure or epilepsy. Ischemic stroke was associated with a 1.62-fold relative risk of seizure. A subset of 15 patients with complete EEG data was identified. Indications for EEG in patients with MMD included limb shaking, unilateral weakness, or generalized convulsion. Abnormal EEG was seen in 14 (93.3%) cases, with the most common findings being focal slowing 12 (80.0%), followed by epileptiform discharge 10 (66.7%), and diffuse slowing 9 (60.0%). "Rebuild up" phenomenon on EEG was observed in one patient.Conclusions:Seizure and abnormal background activity or epileptiform discharge on EEG were common in pediatric patients with MMD. EEG may play a role in differential diagnosis among the transient neurological events in MMD such as transient ischemic attack and seizure.
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