简介:实在找不出一个词来形容DNA的神奇了,正是这些小得连电子显微镜都无法看清的小家伙,居然隐藏着我们的身高、体重、性格,智商,疾病、寿命等所有信息。另一方面,这种技术也让人担忧。因为假如一个人的性格、智力、会生什么疾病、什么时间死等等,都能通过DNA预先知道得清清楚楚,那多让人丧气!更有甚者,假如将来公司招聘人时通过DNA鉴定,把你的个人身体信息摸得一清二楚,我们岂不就会处于极不利的地位?保险公司为了追求高额利润,也来这一手,把有潜在疾病的人拒之门外,岂不有违保险的初衷……总之,假如你的一切都是由DNA决定的,这样的生活还有什么意思?就像一部惊险复杂的小说,你都知道了结局,还想读它吗?再者,别人又很容易获得你的这种个人隐私,从而决定你的命运,看来生活似乎更没有活头了!科幻电影《变种异煞》讲了类似基因决定命运的故事。
简介:<正>IncelebrationofthediscoveryofthestructureofDNA-thesecretcodedlanguageoflife-intheUK50yearsago,theexhibitionDNA50:Watson,CrickandBeyond,willvisitBeijinginSeptemberandOctober,unlockingsomeofthemysteriesofthismonumentaldiscovery.OrganisedbytheBritishCouncilandtheChineseAcademyofScience,andsponsoredbyGlaxoSmithKline,theexhibitionwilltakeplaceatXinDongAnShopping
简介:摘要目的讨论DNA鉴定结果探究。方法查阅文献资料并结合个人经验进行归纳总结。结论如果办案人员不能正确理解DNA鉴定结论的概率性含义,尤其是不能正确区分三种不同类型的DNA鉴定结论,就可能会对案件事实作出错误的认定。对此,法医学学者指出“关于线粒体DNA鉴定结论,不同的实验室可能会有不同的表述……这些结论的理解对侦查和判案有重要的影响,理解偏颇会将案件向错误方向引导。
简介:DNAisthegeneticmaterialofvariousorganisms.ExtracellularDNAadsorbedorboundonsurface-activeparticlesinsoilshasbeenshowntopersistforlongperiodsagainstnucleasesdegradationandstillretaintheabilitytotransformcompetentcells.ThispaperreviewssomerecentadvancesonthebindingandtransformationofextracellularDNAinsoils,whichisfundamentaltounderstandingthenatureofthesoil,regulatingbiodiversity,andassessingtheriskofreleasinggeneticallyengineeredmicroorganisms(GEMs)aswellasbeinghelpfulfordevelopmentofthegeneticevolutionaltheoryofbacteria.Severalinfluencingfactors,suchassoilpH,ionicstrength,soilsurfaceproperties,andcharacteristicsoftheDNApolymer,arediscussed.Todate,theunderstandingofthetypeofmolecularbindingsitesandtheconformationofadsorbedandboundDNAtosoilparticlesisstillinitsinfancy.
简介:Colorectalcarcinoma(CRC)isacommoncauseofmorbidityandmortalityworldwide.TwopathogenicpathwaysareinvolvedinthedevelopmentofadenomatoCRC.ThefirstpathwayinvolvesAPC/β-catenincharacterizedbychromosomalinstabilityresultingintheaccumulationofmutations.ThesecondpathwayischaracterizedbylesionsinDNAmismatchrepairgenes.AberrantDNAmethylationinselectedgenepromotershasemergedasanewepigeneticpathwayinCRCdevelopment.CRCscreeningisthemostefficientstrategytoreducedeath.SpecificDNAmethylationeventsoccurinmultistepcarcinogenesis.EpigeneticgenesilencingisacausativefactorofCRCdevelopment.DNAmethylationshavebeenextensivelyexaminedinstoolfromCRCandprecursorlesions.ManymethylatedgeneshavebeendescribedinCRCandadenoma,althoughnodefiniteDNAmethylationbiomarkerspanelhasbeenestablished.MultipleDNAmethylationbiomarkers,includingsecretedfrizzled-relatedprotein2,secretedfrizzled-relatedprotein1,tissuefactorpathwayinhibitor2,vimentin,andmethylguanineDNAmethyltransferase,havebeenfurtherinvestigated,andobservationshaverevealedthatDNAmethylationbiomarkersexhibitwithhighsensitivityandspecificity.ThesemarkersmayalsobeusedtodiagnoseCRCandadenomainearlystages.Realtimepolymerasechainreaction(qPCR)issensitive,scalable,specific,reliable,timesaving,andcosteffective.Stoolexfoliatedmarkersprovideadvantages,includingsensitivityandspecificity.AstoolqPCRmethylationtestmayalsobeanenhancedtoolforCRCandadenomascreening.