简介：Electrophoresis,chromatography,immunoassay,sequencingandothertimeconsumingap-proacheshavebeendevelopedtodetermineDNAbasemismatching,oxidativelesionorstrandbreaks.Sometimes,however,onlyqualitativeinformationisenoughtodecidewhethermutationhashappenedtoDNAanditsextent.Convolutionspectrometry(CS),anewtechniquetodiscoverultrafmedifferenceonultraviolet(UV)absorptionofdifferentsubstances,isoriginallyemployedtofindoutanysubtlemutationofDNAinducedbyUVradiation.Muta-tiveDNAiscomparedwithegocriteriabasedonthespectraoftheformerDNA,anydifferenceisquantitativelyex-pressedbydispersion(5).Visiblechangescannotbeobservedonsecond-derivativespectrauntilthemutationgets5upto11.48%.DimethylsulfoxideisanintensifierofUV254nminducedDNAmutationandprotectorat365nm,whichissimplyconfirmedbyincreasinganddecreasing5.Everyconvolutionproceduretakeslessthan1min.Convolutionspectrometryprovidesafast,simple,sensitiveandinexpensivealternativetodetermineDNAmutation,andtoscreenanti-mutationalmedicines.

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简介：Anuranmetamorphosisinvolvessystematictransformationsofindividualorgansinathyroidhormone(TH)-dependentmanner.Morphologicalandcellularstudieshaveshownthattheremovaloflarvalorgans/tissuessuchthetailandthetadpoleintestinalepitheliumisthroughprogrammedcelldeathorapop-tosis.RecentmolecularinvestigationssuggestthatTHregulatesmetamorphosisbyregulatingtargetgeneexpressionthroughthyroidhormonereceptors(TRs),whichareDNA-bindingtranscriptionfactors.Cloning

简介：Introduction:Theabsenceofvertigoduringthecalorictest,despitearobustresponse,hasbeensuggestedtorepresentacentralvestibularsystemphenomenon.Thepurposeofthisinvestigationwastodeterminetheprevalenceofabsentcaloric-inducedvertigoperceptioninanunselectedgroupofpatientsandtoassesspossiblepredictingvariables.Methods:Prospectiveinvestigationof92unselectedpatientswhounderwentcalorictesting.Inclusioncriteriawerethateachpatientgenerateamaximumslowphasevelocity(maxSPV)
15deg/secandacaloricasymmetryof10%.Followingthecaloric,patientswereasked,“Didyouhaveanysensationofmotion?”Results:Resultsshowed75%ofpatientsreportedmotionwithameanageof56.51yearscomparedtoameanageof66.55inthe25%ofpatientsreportinganabsenceofmotion.Alogisticregressionwasperformedandtheoverallmodelwasstatisticallysignificantaccountingfor29%ofthevarianceincaloricperception.ThesignificantpredictorvariableswerepatientageandmaxSPVofthecaloricresponse.Theeffectsizeforbothvariableswassmallwithanoddsratioof.9formaxSPVand1.06forage.Conclusions:ThecurrentinvestigationshowedthatbothageandmaxSPVofthecaloricresponseweresignificantpredictorsofvertigoperceptionduringthecaloricexam.However,theassociationbetweenageandcaloricperceptionisnotconclusive.Althoughthereisevidencetosuggestthatthesefindingsrepresentage-relatedchangesinthecentralprocessingofvestibularsystemstimulation,thereareadditionalunmeasuredfactorsthatinfluencetheperceptionofcaloric-inducedvertigo.

简介：Basedonthesphericalcavityexpansiontheoryintheelastichalfspace,thegroundsurfacemovementcharacteristicsofshallowlyburiedexplosionsareanalyzed.TheresultsshowthattheinducedseismicwaveisalongitudinalwaveinthenearzoneandaRayleighwaveinthefarzone.Themaximumdisplacement(velocity)ofthelongitudinalwaveandtheRayleighwaveareinverselyproportionaltothescaleddistance,andcanbedescribedbyexponentialfunctionwithexponentsequalto1.4and0.5,respectively.Thevibrationfrequenciesofthewaveshavealmostnochange.Thevibrationfrequencyofthelongitudinalwaveapproximatesthenaturalvibrationfrequencyofthecavityinthebrokenarea,andthevibrationfrequencyoftheRayleighwaveisabouthalfthatofthelongitudinalwave.Onthesamereducedburieddepthandreduceddistance,theparticledisplacementisdirectlyproportionaltotheproductoftheboundaryloadingandcavityradius,andisinverselyproportionaltothetransversalwavevelocity.Meanwhile,theparticlevelocityisdirectlyproportionaltotheboundaryloadingandinverselyproportionaltothewavevelocityratio.Inthefarzone,theburieddepthoftheexplosiveonlyhasaslighteffectonthelongitudinalwave,buthasalargereffectontheRayleighwave.

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简介：在不到10年里自从它的开始，RNA干扰(RNAi)在生物医学的科学上有非凡的影响。RNAi被表明了到影响众多生物并且疾病小径。RNAi技术的开发和采纳是丰富的从基本loss-of-function工具，到药品的目标确认的染色体宽的屏蔽图书馆和治疗学的开发。然而，RNAiis的分子的机制理解远非完全。这简短评论的目的是在阐明加亮关键成就导致RNA的silencing建筑群并且到的生化学机制为这块地构画出主要挑战。

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简介：Anti-androgentherapyistheleadingtreatmentforadvancedprostatecancerandiscommonlyusedforneoadjuvantoradjuvanttreatment.Bicalutamideisanon-steroidalanti-androgen,usedduringtheinitiationofandrogendeprivationtherapyalongwithaluteinizinghormone-releasinghormoneagonisttoreducethesymptomsoftumor-relatedflaresinpatientswithadvancedprostatecancer.Assideeffects,bicalutamidecancausefatigue,gynecomastia,anddecreasedlibidothroughcompetitiveandrogenreceptorblockade.Additionally,althoughnotascommon,drug-inducedliverinjuryhasalsobeenreported.Herein,wereportacaseofhepatotoxicitysecondarytobicalutamideuse.Typically,bicalutamideinducedhepatotoxicitydevelopsafterafewdays;however,inthiscase,hepaticinjuryoccurred5moaftertreatmentinitiation.Basedonthisrarecaseofdelayedliverinjury,werecommendcarefulmonitoringofliverfunctionthroughoutbicalutamidetreatmentforprostatecancer.

简介：Aminoglycosides(AmAn)arewidelyusedfortheirgreatefficiencyagainstgram-negativebacterialinfections.However,theycanalsoinduceototoxichearingloss,whichhasaffectedmillionsofpeoplearoundtheworld.Aspreviouslyreported,individualsbearingmitochondrialDNAmutationsinthe12SrRNAgene,suchasm.1555A>Gandm.1494C>T,aremorepronetoAmAn-inducedototoxicity.Thesemutationscausehumanmitochondrialribosomestomorecloselyresemblebacterialribosomesandenableastrongeraminoglycosideinteraction.Consequently,exposuretoAmAncaninduceorworsenhearinglossintheseindividuals.Furthermore,awiderangeofseverityandpenetranceofhearinglosswasobservedamongfamiliescarryingthesemutations.StudieshaverevealedthatthesemitochondriamutationsaretheprimarymolecularmechanismofgeneticsusceptibilitytoAmAnototoxicity,thoughnuclearmodifiergenesandmitochondrialhaplotypesareknowntomodulatethephenotypicmanifestation.

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简介：Acupunctureinducedpneumothoraxisararelyseenclinicalaccident.Inthepresentpaper,theauthorsanalyzeitscausesofonset,clinicalmanifestationsandmeasuresforpreventionandmanagement.

简介：Thispaperpresentsreal-timemonitoringdataandanalysisresultsofthenon-stationaryvibrationsofanoperationalwindturbine.Theadvancedtime-frequencyspectrumanalysisrevealsvariednon-stationaryvibrationswithtimevaryingfrequencies,whicharecorrelatedwithcertainsystemnaturalmodescharacterizedbyfiniteelementanalysis.Undertheeffectsofstrongwindload,thewindturbinesystemexhibitscertainresonancesduetobladepassingexcitations.Thesystemalsoexhibitscertaininstabilitiesduetothecouplingofthetowerbendingmodesandbladeflapwisemodewithbladepassingexcitationsunderthevariationofwindspeed.Ananalyticalmodelisusedtoelaboratethenon-stationaryandinstabilityphenomenaobservedinexperimentalresults.ThepropertiesofthenonlinearinstabilitiesareevaluatedbyusingLyapunovexponentestimation.

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