Stability and Determination of Metamizole Sodium by Capillary Electrophoresis Analysis Combined with Infra-red Spectroscopy

(整期优先)网络出版时间:2007-06-16
/ 1
Metamizolesodiumwaschosenasarepresentativeofunstableanalytesforinvestigationbydiscussingtheeffectsofoxygenandsolventonitsdegradationreactionusingthecapillaryelectrophoresistechnique.Apossibledegradationmechanismwasdeducedfromtheobservedbehaviorandwasconfirmedbyinfra-redspectroscopicstudy.Thedegradationreactioncouldbeinhibitedobviouslybymethanolinsteadofwaterasthesolventofanalyte.Undertheoptimizedconditions:separationvoltageof20kV,and5mmol/Ldisodiumhydrogenphosphateand5mmol/Lboraxwith10%methanol(pH9.12)astherunningbuffer,thestandardcurveofmetamizolesodiumwaslinearinarangeof3.77—74.07mg/L.Asatisfactoryresultwasachievedwhenthetechniquewasusedtodetectmetamizolesodiumintablet.