简介：客观：在食管的恶意的阻塞上学习内视镜的治疗的效果。方法：先进食道的癌症病人的64个盒子有食管的阻塞，7个盒子不能被操作，57个盒子复发了在操作以后的损害和放射治疗。阻塞都与食道的扩张器被扩大，然后用elemene乳剂注射和stent的本地化疗，或本地管理被对待被放在食道的腔。结果：阻塞与膨胀被减轻仅仅大约一个星期，而是阻塞，用用另外的治疗在膨胀以后减轻了超过三个月。在膨胀以后，然而，癌的PR在本地化疗组是大约80%CR是大约8%，PR在elemene的组是大约92%乳剂注射。结论：内视镜的治疗是为先进食道的癌症的一个有效辩解的方法。

简介：AbstractObjective:This study was performed to evaluate the clinical and epidemiological characteristics of inpatients with malignant skin tumors in western Inner Mongolia during the past 10 years.Methods:We collected the clinical data of inpatients with histopathologically diagnosed malignant skin tumors admitted to the Affiliated Hospital of Inner Mongolia Medical University from June 2008 to December 2018. Morbidity was compared using the Chi-square test.Results:In total, 340 inpatients with malignant skin tumors were evaluated, including 163 (47.94%) patients with basal cell carcinoma, 134 (39.41%) with squamous cell carcinoma, 5 (1.47%) with malignant melanoma, 21 (6.18%) with Bowen disease, and 6 (1.76%) with Paget’s disease. Four (1.18%) patients had metastatic skin cancer and seven (2.06%) had other malignant skin tumors. The patients comprised 132 (38.8%) men and 208 (61.1 %) women, and there were no statistically significant sex-related differences among the skin malignancies (x2 = 5.006, P > 0.05). Among the 340 patients, 314 (92.4%) were of Han nationality and 26 (7.6%) were of ethnic minorities. Statistically significant differences were found in the various types of malignant skin tumors between the Han and minority groups (x2 = 19.446, P < 0.05). Among the selected patients, 61.76% were farmers and herdsmen, and the sites mainly affected were the head, face, neck, trunk, limbs, and vulva.Conclusion:The incidence of malignant skin tumors in western Inner Mongolia has substantially increased during the past decade, especially in the past 2 years. Therefore, we should increase the awareness of prevention and treatment of malignant skin tumors to achieve early diagnosis and treatment effects.

简介：AbstractBackground:The association of lipids and cancer has varied greatly among different cancer types, lipid components and study populations. This study is aimed to investigate the association of serum lipids and the risk of malignant lesions in esophageal squamous epithelium.Methods:In the "Endoscopic Screening for Esophageal Cancer in China" (ESECC) trial, serum samples were collected and tested for total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol at the time of subject enrollment. Cases were defined as malignant esophageal lesions identified by baseline endoscopic examination or by follow-up to May 31, 2018. Controls were randomly selected using incidence density sampling in the same cohort. Conditional logistic models were applied to identify the association of serum lipids and the risk of malignant esophageal lesions. Effect modification was evaluated by testing interaction terms of the factor under assessment and these serum lipid indicators.Results:No consistent association between serum lipid levels and esophageal malignant lesions were found in a pooled analysis of 211 cases and 2101 controls. For individuals with a family history of esophageal cancer (EC), high TC, and LDL-C were associated with a significantly increased risk of having malignant lesions (odds ratio [OR]Highvs.Low TC = 2.22, 95% confidence interval [CI]: 1.14-4.35; ORHighvs.Low LDL-C = 1.93, 95% CI: 1.01-3.65). However, a negative association was observed in participants without an EC family history (ORHighvs.Low TC = 0.69, 95% CI: 0.48-0.98, Pinteraction = 0.002; ORHighvs.Low LDL-C = 0.50, 95% CI: 0.34-0.76, Pinteraction < 0.001).Conclusions:In this study, we found that the association of serum lipids and malignant esophageal lesions might be modified by EC family history. The stratified analysis would be crucial for population-based studies investigating the association of serum lipids and cancer. The mechanism by which a family history of EC modifies this association warrants further investigation.

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简介：Objective:Population-basedcancerregistrationdatawereusedtoanalyzetheepidemiologyandtrendofmalignantmesotheliomainChina,andtheresultwouldprovidebasicdataforitspreventionandcontrol.Methods:Malignantmesotheliomadatain2013wereretrievedfromthedatabaseofNationalCancerRegistry.Malignantmesotheliomaincidenceandmortalitywereestimatedusingage-specificratebyurban/ruralandgenderaccordingtothenationalpopulationin2013.Malignantmesotheliomadatafrom22cancerregistrieswereusedfortrendanalysisduring2000–2013.Results:Itisestimatedthattherewere2,041newmalignantmesotheliomacasesand1,659malignantmesotheliomadeathsoccurredin2013.ThecrudeincidencerateinChinawere1.50/106(males1.67/106,females1.32/106),age-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were1.03/106and1.02/106,respectively.ThecrudemortalityrateinChinawas1.22/106(males1.67/106,females1.32/106),age-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were0.83/106and0.81/106,respectively.TherewasanincreasingtrendofincidencerateformalignantmesotheliomainregistrationareasofChinaduring2000–2013withannualpercentagechange(APC)of2.5%[95%confidenceinterval(95%CI):0.6%–4.5%].Afteragestandardization,nosignificantdifferenceswereobserved.Nomatterforcrudemortalityratesorage-standardizedmortalityrates,nosignificantdifferenceswereobservedduring2000–2013.Conclusions:Malignantmesotheliomaisthemajoroccupationalandenvironmentalneoplasmassociatedwithasbestosexposure.Theincreasingincidencetrendsuggeststhatmoreattentionshouldbepaidonthisdisease.

简介：取耳穴肺、风溪、神门、皮质下、肾上腺和大肠，以耳针配合常规方法治疗皮肤瘙痒症患者25例，以常规方法治疗25例为对照。结果两组疗效差别有统计意义，前者好于后者。

简介：AbstractMalignant pleural mesothelioma (MPM) is a rare and aggressive malignant disease. Currently, the platinum doublet of pemetrexed and cisplatin is the standard first-line treatment for unresectable MPM. However, recent promising results of immunotherapy have markedly changed the landscape of MPM treatment. Further, the ongoing innovative therapeutic strategies are expected to expand the range of treatment options; however, several questions remain unanswered. First, establishing predictive biomarkers with high potency is urgently needed to optimize the patient selection process. Second, further exploration of the combination algorithm is expected to unveil more effective and safe regimens. Moreover, other dilemmas, such as the resistance mechanism of immunotherapy and the role of immunotherapy in perioperative settings, still warrant further exploration.

简介：Objective:Tostudythetechniquesofplacementofmemoryalloyplatinggoldbiliarystentandplasticstentforpalliationofmalignantandbenignbiliaryobstruction,andtoassessitsclinicaleffectiveness.Methods:Thepatientsinplasticstentgroupincludedpaplillaofduodenuminflamationalstrictures(n=24),commonbileductinflammationalinferiorsegmentstrictures(n=4),choledocholithiasis(n=5),bileleak(n=11),bileductsurgeryinjurey(n=7)andpancreaticcarcinoma(n=1).Thepatientsinplatinggoldstentgroupincludedcommonbileductcarcinoma(n=5)andpancreaticcarcinoma(n=6).Underfluoroscopicguidancethestentwasinsertedintobiliaryobstructionsitesfromoralcavityinallcases.Complications,liverfunctionandbloodserumamylasewereinvestigatedduringthestudyperiod.Results:Successfulstentplacementwasachievedinallcases.Afteroperationof7days,ingoldbiliarystentgroups,theratesofdecreaseofbloodserumtotalbilirubin,glutamic-pyruvictransaminase,r-glutamyltranspeptidaseandalkalinephosphatasewere67.16%,58.37%,40.63%and41.54%respectively.Inplasticstentgroup,theratesofdecreaseofSTB,ALT,r-GTandAKPwere53.24%,55.03%,37.15%,34.12%respectively.Earlycomplicationincludedpost-ERCPpancreatitisandcholangititis.Occlusionofstentwasthemajorlatecomplication.Conclusion:Memoryalloyplatinggoldbiliarystentandplasticstentweresafeandefficaciousmethodsformalignantandbenignbiliaryobstruction,andcouldimprovepatient'slivingquality.Plasticstentwasanefficientcomplementfortherapyofbileleakandbileductinjury.

简介：生来的杀手(NK)房间对癌症在主人免疫起关键作用。在反应，癌症开发机制逃离NK房间攻击或导致有缺点的NK房间。当前的NK基于房间的癌症免疫疗法试图用几条途径克服NK房间麻痹。一条途径使用扩展allogeneicNK房间，它没被象自体同源的NK房间一样的自我histocompatibility抗原禁止，为采纳细胞的免疫疗法。另一条采纳转移途径使用稳定的allogeneicNK房间线，它为质量控制和大规模生产是更实际的。第三条途径是新鲜NK房间或NK房间线的基因修正高度表示cytokines，Fc受体或妄想的肿瘤抗原受体。治疗学的NK细胞能从各种各样的来源被导出，包括细胞，干细胞或甚至导致的pluripotent干细胞(iPSCs)，和许多激发器能被用于的外设或绳索血在实验室或好生产实践(GMP)的大规模生产设备包括可溶的生长因素，使不能调动的分子或抗体，和另外的细胞的使活跃之物。到在临床的试用的癌症的对待几类型的NK房间治疗的一张表这里被考察。基于NK的免疫疗法的几条不同途径例如织物特定的NK房间，漂亮面向受体的NK房间和化学上对待的NK房间，被讨论。一些新技术或策略到由非侵略的成像的监视器NK房间治疗，预定NK房间治疗由的效率在vivo实验并且在临床的试用评估NK房间治疗途径也被介绍。

简介：Objective:TodetectdifferentialproteinexpressioninmalignantandnormallivercelllinesinvitrousingtheSELDIProteinChipplatform,forinvestigatingthepathogenesisoflivercancer.Methods:Twocelllines,humannormallivercelllineL02andhepatomacelllineSMMC-7721wereculturedroutinely,harvestedingoodconditionandlysed.Afterquantification,thesupernatantofthelysatewastestedbyIMAC3(ImmobilizedMentalAffinityCapture)andWCX2(WeakCationExchange)chipsontheSELDI-TOF-MSProteinChipreader.Results:Proteinexpressiondifferedbetweenthemalignantandnormallivercelllines.Atotalof20differentiallyexpressedproteinswerefound,amongwhich,7werecapturedbytheIMAC3chipand14bytheWCX2chip.Peaksat5,419,7,979and11,265Dawerehigherandat8,103,8,492,10,160and11,304DalowerinSMMC-7721cellsbytheIMAC3chip;peaksat7,517,7,945and7,979Dawerehigherandat5,061,5,551,5,818,7,439,9,401,10,100,10,312,11,621,11,662,11,830and12,772DalowerinSMMC-7721cellsbytheWCX2chip.Interestingly,bothchipscapturedthe7,979Dapeak.Inaddition,the11,081DapeakcorrespondedpreciselywiththemolecularmassofthecalciumbindingproteinS100A10,whichmayparticipateintheformationoflivercancerinassociationwithp36.Conclusion:DetectingdifferentialproteinexpressioninmalignantandnormallivercelllinesusingtheSELDIProteinChipplatformwassimple,sensitiveandrepeatable.Theresultsweobtainedcanserveasabasisforinvestigatingthepathogenesisoflivercancerandaidthediscoveryofnewtherapeutictargets.

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简介：AbstractSkin diseases were characterized by various types and high incidence, which seriously affect people’s health. At present, skin pathogenesis research and the therapeutic drug development for skin diseases are limited by the lack of reasonable research models that recapitulate the development of skin diseases. Organoids are three-dimensionally cultured cell populations derived from skin stem cells, which exhibits the ability of multicell assembly and the similar histological characteristics with the living tissues and organs. This article reviews the establishment of normal skin organoids and skin tumor organoids, and summarizes the application of skin organoids in the evaluation of drug sensitivity, pathological mechanism research, and individualized treatment. In addition, the advantages and limitations of organoids in skin disease research are also discussed, which provides a basis for revealing the pathogenesis of skin diseases and developing preventive and therapeutic drugs for skin diseases.

简介：AbstractIntroduction:Malignant syphilis (MS) is a rare and severe variant of secondary syphilis that is frequently associated with HIV infection. The clinical impact of HIV and syphilis co-infection is bidirectional, and the presence of MS is associated with acute HIV infection. Clinically, MS is characterized by nodular and ulcerative lesions affecting the trunk and extremities, which are covered with thick crusts. The treatment of choice for MS remains benzathine penicillin G. Herein, we report a case in which MS was the initial presentation of HIV infection.Case presentation:A 35-year-old male patient came with the chief complaint of extensive erythematous nodular rash for the past one month, with notable ulceration on some lesions with annular configuration along with fever and malaise. Based on the abovementioned clinical, laboratory, and histopathologic findings, the patient was diagnosed with MS and HIV. The diagnosis was established based on histopathological examination and syphilis serological testing.Discussion:Cutaneous disorders are a frequent presenting feature of HIV infection. The clinical manifestations of syphilis in immunosuppressed patients are often severe and/or atypical. The patient was then treated with weekly intramuscular administration of 2.4 million units of benzathine penicillin G for 3 weeks and achieved rapid and significant clinical improvement, with no Jarisch-Herxheimer reaction.Conclusion:Co-infection with syphilis and HIV alters the course of both diseases, and most HIV-infected patients with syphilis have typical disease manifestations associated with decreased CD4+ T-cell counts.

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简介：Cancerscreeningisasourceofmuchdebate.Attheinterfacebetweenpublichealth,specialistcare,economicsandpolicy,itcreatestensionsbetweenprofessionalgroups,politicians,themediaandthepublic.Ascreeningtestmaybecheap,butapplyingittoapopulation(withrigorousqualitycontrolandeffectiveprocessingofpatientswithabnormalresults)createsahugeworkloadandthereforecost.Screeningcanalsohavepsychologicaleffectsonindividualswithfalse-positiveresultswhorequireinvestigationbutareeventuallyfoundnottohavecancer.

简介：Somaticstemcells(SSCs),beingessentialinmaintaininghomeostasisofnormaltissue,replenishdyingcellsandregeneratedamagedtissuesfororganism.Ontheotherhand,withtheself-renewedability,SSCsareidealcellulartargetstobeacquiredinmultiplemutationstransformingSSCstocancerstemcells(CSCs)whichcausemalignanciesandevenrecurrenceaftercancertreatmentifCSCsfailtobeeradicated(1).OneyearafterDrs.JohnB.GurdonandShinyaYamanakasharedthe2012NobelPrizeinPhysiologyorMedicinefortheirdiscoverythatmaturecellscanbereprogrammedtobecome

简介：THEFIRSTCASEofAIDSintheUSAwasrecognizedtwodecadesago,withtheearlycasesrepresentinghomosexualswithpneumocysticcariniipneumoniaorKaposi’ssarcoma.Sincethenthediseasehasspreadworldwidewithoutsparinganycontinent.HIVhascauseddeathsandseveresocio-economicimpactindevelopedandunderdevelopingcountries.

简介：Objective:Toinvestigatetheculturemethodofskin-derivedprecursors(SKPs)andtoexploreanewcellsourceforcelltransplantationofcentralnervoussystem.Methods:Cellsfromskinsofjuvenileandadultmicewereisolatedandculturedinserum-freemedium.Amechanicalmethodwaschosentopassagethesecellsandtheywereidemifiedbytheimmunocytochemistryassay.Results:SKPscouldbeisolatedfromadultandneonatalskins.Theycouldbemaintainedinvitroforlongperiodswithstableproliferation,andexpandedasundifferentiatedcellsincultureformorethan12passages.About50％ofSKPsexpressednestinandmajorityofthesecellsexpressedfibronectinwhentheywereplatedonpolyornithineandlaminincoatedplates.About5％cellsshowedneuronaldifferentiationandexpressedneurofilament-M(NF-M)andNSEwhenSKPswereplatedinserun-containingmedium,andthesecellscouldalsodifferentiateintoadipocytesandfibroblast-likecells.Conclusions:Thedatasupportthehypothesisthatadultskincontainsstemcellscapableofdifferentiatingintoneurons,adipocytes,andfibroblast-likecells.TheymayrepresentanalternativeautologousstemcellsourceforCNScelltransplantation.

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