简介:摘要:受高空槽东移加深影响,2023年4月10日,朝阳地区出现大范围大风、沙尘、强对流天气。与历年相比,此次强对流过程出现时间较早,强度较大。本文从环流形势、物理量和加密自动站角度对此次过程进行分析。
简介:摘要:本文以燃气电厂9H.02级燃机的安装为研究对象,深入探讨了该工程的工艺要点。通过系统分析与总结,从土建准备、设备安装、管道连接等多个方面详细论述了9H.02级燃机安装的具体工艺流程。在土建准备阶段,着重介绍了基础设计与施工的关键环节,确保基础结构的牢固稳定;在设备安装阶段,围绕燃机组件的精准安装,突出了设备定位与固定的关键技术;而管道连接阶段则聚焦于燃气输送与排放系统的无缝衔接,确保整体系统运行的高效稳定。本文以务实的角度,通过实际工程经验总结,为类似项目提供了具体可行的操作指南,具有一定的工程实用价值。
简介:摘要:隧道施工是城市网络交通通行保障中的重要的一部分,而盾构机作为一种安全且有时效性的隧道掘进机械,在隧道推进种中得到了大范围的应用。由于上海市城市道路中心受各方面外部条件的制约,在市区的作业环境下基本采用上下层隧道设计,因此盾构机在南、北两个工作井先后下井吊装时存在高差,本文旨在探讨隧道项目中盾构设备下井吊装施工的技术要点,为相关工程提供参考。
简介:AbstractLeucine-rich repeats containing 4 (LRRC4, also named netrin-G ligand 2 [NGL-2]) is a member of the NetrinGs ligands (NGLs) family. As a gene with relatively high and specific expression in brain, it is a member of the leucine-rich repeat superfamily and has been proven to be a suppressor gene for gliomas, thus being involved in gliomagenesis. LRRC4 is the core of microRNA-dependent multi-phase regulatory loops that inhibit the proliferation and invasion of glioblastoma (GB) cells, including LRRC4/NGL2-activator protein 2 (AP2)-microRNA (miR) 182-LRRC4 and LRRC4-miR185-DNA methyltransferase 1 (DNMT1)-LRRC4/specific protein 1 (SP1)-DNMT1-LRRC4. In this review, we demonstrated LRRC4 as a new member of the partitioning-defective protein (PAR) polarity complex that promotes axon differentiation, mediates the formation and plasticity of synapses, and assists information input to the hippocampus and storage of memory. As an important synapse regulator, aberrant expression of LRRC4 has been detected in autism, spinal injury and GBs. LRRC4 is a candidate susceptibility gene for autism and a neuro-protective factor in spinal nerve damage. In GBs, LRRC4 is a novel inhibitor of autophagy, and an inhibitor of protein-protein interactions involving in temozolomide resistance, tumor immune microenvironment, and formation of circular RNA.
简介:摘要:溱页1平台井阜四段深灰色泥岩易造浆,高温下泥岩水化分散尤为严重,钻井液粘切上涨趋势难控制。阜三底含稠油、阜二段轻质油伴生活跃天然气,钻进过程中油气活跃,停泵加立柱单根峰值能达到100%,对常规水基钻井液污染严重,导致其抑制性变差、流变性能波动大不可控、日常维护困难。针对此区块井施工中遇到的井壁失稳、油气活跃、地层流体侵入、水平段摩阻大等问题,结合前期几口井施工过程中的难点进行分析,我们根据室内小型实验摸索出了一种适合溱页1平台井的高性能水基钻井液。通过现场使用情况表明,该钻井液体系抗污染能力强、流变性能稳定易于维护、抑制性强、润滑性好,并且还具有较强的封堵能力,能够满足日常安全钻进的需求。