简介:它的图表类型很多,科学图表和极坐标图表需要給PEP_faXDATA、PEP_faYDATA和PEP_faZDATA赋值,有以下的几个DLL函数可以为图表赋值
简介:AdditivelymanufacturedTi-6Al-4Vlatticestructureshavefoundimportantnicheapplications.However,theyoftenshowinsufficientcompressiveductilityorinsufficientstructuralintegrity.Inthisstudy,abatchof45octahedralTi-6Al-4Vlatticestructureswasmanufacturedinthreedifferentstrutdiameters(0.5,1.0,1.5mm)byselectiveelectronbeammelting(SEBM).Theinfluenceofpost-SEBMannealingonthecompressivedeformationcharacteristicsofthelatticestructurewasinvestigated.Theas-builtTi-6AI-4Vlatticesfragmentedwhenthecompressivestrainreached13%-23%dependingonstrutdiameter.Annealingat950℃(Ptransustemperature:995℃)onlyslightlyimprovedthecompressiveductilityofthelatticestructures.However,annealingat1050℃(p-annealing)fundamentallychangedthecompressivedeformationmodeofthelatticestructures.Theresultantcompressivestress-straincurvewasfeaturedbyalongsmoothplateauandnofactureoccurredevenaftersignificantdensificationofthelatticestructurehadtakenplace(>50%ofcompressivestrain).
简介:Anovel,Ti-6A1-4V(Ti64)/Hydroxyapatite(HAat5%byweightconcentration)metal/ceramiccompositehasbeenfabricatedusingelectronbeampowderbedfusion(EPBF)additivemanufacturing(AM):specifically,thecommercialelectronbeammelting(EBMR)process.InadditiontosolidTi64andTi64/5%HAsamples,fourdifferentunitcell(model)open-cellularmeshstructuresfortheTi64/5%HAcompositewerefabricatedhavingdensitiesrangingfrom0.68to1.12g/cm^3,andcorrespondingYoung'smodulirangingfrom2.9to8.0GPa,andcompressivestrengthsrangingfrom-3to11MPa.ThesolidTi64/5%HAcompositeexhibitedanoptimaltensilestrengthof123MPa,andelongationof5.5%incontrasttoamaximumcompressivestrengthof875MPa.Boththesolidcompositeandmeshsamplesdeformedprimarilybybrittledeformation,withthemeshsamplesexhibitingerratic,brittlecrushing.Solid,EPBF-fabricatedTi64sampleshadaVickersmicroindentationhardnessof4.1GPawhiletheTi64/5%HAsolidcompositeexhibitedaVickersmicroindentationhardnessof6.8GPa.ThelowestdensityTi64/5%HAcompositemeshstrutsectionshadaVickersmicroindentationhardnessof7.1GPa.Opticalmetallography(OM)andseanningelectronmicroscopy(SEM)analysisshowedtheHAdispersoidstobehighlysegregatedalongdomainorgrainboundaries,buthomogeneouslydistributedalongalpha(hcp)plateletboundarieswithinthesedomainsintheTi64matrixforboththesolidandmeshcomposites.Thealphaplateletwidthvariedfrom-5μmintheEPBF-fabricatedTi64to-1.1μmfortheTi64/5%HAmeshstrut.TheprecursorHApowderdiameteraveraged5μm,incontrasttothedispersedHAparticlediametersintheTi64/5%HAcompositewhichaveraged0.5μm.ThisworkhighlightstheuseofEPBFAMasanovelprocessforfabricationofatruecompositestructure,consistingofaTi64matrixandinterspersedandexposedHAdomains,whichtotheauthorsknowledgehasnotbeenreportedbefore.Theresultsalsoillustratetheprospectsnotonlyforfabrica
简介:Three-dimensional-printed(3D-P)titaniumimplantsdisplaymanyadvantages,suchasdesignflexibility,higherefficiency,thecapabilitytoeasilyconstructcomplexorcustomizedstructures,etc.,andisbelievedtopotentiallyreplacetraditionalimplants.However,thebiologicalperformanceofthe3D-Ptitaniumsurfacehasnotbeeninvestigatedsystematically.Herein,weanalyzedthesurfacecharacteristicsof3D-PTi6AI4Vimplantsandevaluatedthebiologicalresponsesofbonemarrowderivedmesenchymalstromalcells(BMSCs)tothe3D-Psurfaceinvitro.Moreover,afterimplantationintotheratfemoralcondylefor3and6weeks,theosseointegrationperformaneewasevaluated.Theresultsshowedthe3D-PTi6Al4Vimplantpresenteddistinctfluctuantmacroscaleroughsurfaceandrelativelybetterhydrophilicitywhichenhancedtheadhesion,proliferation,osteogenicdifferentiationandangiogeneticfactorexpressionofBMSCs.Moreover,theinvivoosseointegrationperformancewasalsobetterthanthatofthecontrolgroupattheearlystage.Thepresentstudysuggestedthe3D-Ptitaniumalloyisapromisingcandidatetobeusedasimplantmaterial.
简介:本研究通过检测大肠癌患者外周血CD4+、CD25+、CD127lo/-Treg的水平,Ⅳ期大肠癌患者外周血CD4+、CD25+、CD127lo/-Treg高于Ⅱ期大肠癌患者(P<,方法流式细胞术检测36例大肠癌患者及30例健康人外周血中CD4+、CD25+、CD127lo/-Treg的变化
简介:Recently,thehumancochleahasbeenshowntocontainnumerousresidentmacrophagesundersteady-state.Themacrophagesaccumulateinthestriavascularis,amongtheauditorynerves,andarealsospottedinthehumanorganofCorti.ThesemacrophagesmayprocessantigensreachingthecochleabyinvasionofpathogensandinsertionofCIelectrode.Thus,macrophagesexecuteaninnate,andpossiblyanadaptiveimmunity.Here,wedescribethemolecularmarkersCD4andCD8ofTcells,macrophagemarkersMHCⅡandCD11b,aswellasthemicroglialmarkersTEME119andP2Y12,inthehumancochlea.Immunohistochemistryandtheadvantageoussuper-resolutionstructuredilluminationmicroscopy(SR-SIM)wereusedinthestudy.CD4~+andCD8~+cellswerefoundinthehumancochleae.Theywereseeninthemodiolusinasubstantialnumberadjacenttothevessels,intheperipheralregionoftheRosenthal’scanal,andoccasionallyinthespiralligament.Whilethereareasurprisinglylargenumberofmacrophagesinthestriavascularisaswellasbetweentheauditoryneurons,CD4~+andCD8~+cellsarehardlyseenintheseareas,andneitherareseenintheorganofCorti.Inthemodiolus,macrophages,CD4~+andCD8~+cellsappearedofteninclusters.InteractionbetweenthesedifferentcellswaseasilyobservedwithSR-SIM,showingcloselyplacedcellbodies,andtheprocessesfrommacrophagesreachingoutandtouchingthelymphocytes.OtherwisetheCD4~+andCD8~+cellsinhumancochleartissuearediscretelyscattered.Thepossiblerolesoftheseimmunecellsarespeculated.
简介:Objective:Secretorybreastcarcinoma(SBC)isararetypeofbreastmalignancy,accountingforlessthan0.02%ofallinfiltratingbreastmalignancies.ThepureSBC,atypeofSBCwithoutanothertypeofbreastmalignantneoplasm,isparticularlyrare.ThisstudyaimedtoinvestigatetheclinicopathologicandmolecularfeaturesofpureSBC.Methods:Themainpathologicalparameterssuchasestrogenreceptor(ER),progesteronereceptor(PR),andhumanepithelialgrowthfactorreceptor2(C-erbB-2)weredetectedbyimmunohistochemistry(IHC),andtheclinicopathologicandprognosticdifferencewerecomparedwithinvasiveductalcarcinoma(IDC).Fluorescentinsituhybridization(FISH)andreversetranscriptionpolymerasechainreaction(RT-PCR)wasperformedtoidentifytheETV6-NTRK3rearrangementofSBC.Results:WefoundthatthepositivityratesofER,PR,C-erbB-2,p53,andS-100were47.7%(21/44),52.3%(23/44),36.4%(16/44),27.3%(12/44),and95.5%(42/44),respectively,whichwerehigherthanthosereportedinpreviousstudies.Specialperiodicacid-Schiffanalysiswasperformedin36patients,andthevalueoftheKi-67indexrangedfrom1%to50%(meanvalue:10%).Interestingly,mostpatientswithpureSBCharboredanETV6-NTRK3rearrangementwithan88.6%(39/44)expressionrate.ComparedwithIDC,thetumorsizeofmostpatientswithSBCwaslargerthan2cm(P=0.024).Ultrasoundshowedbenignlesions,andthetotalmisdiagnosisratewashigher(P=0.020).Althoughthepathologicalclassificationwasmostlytriple-negativebreastcancers(P=0.036),therewaslessmetastasis(P=0.029),andtheoverallprognosiswasbetterthanthatoftheIDCgroup.Conclusions:Althoughaxillarylymphnodemetastasis,localrecurrence,ordistantmetastasismayoccur,SBCisalsoconsideredanindolentneoplasmwithagoodprognosis.Oncediagnosed,surgicaltreatmentshouldbeperformedassoonaspossible,followedbyappropriateadjuvantchemotherapy,irradiation,andendocrinetherapies.