简介：BackgroundAtrialfibrillation(AF)isthemostcommonsustainedcardiacarrhythmiawithouteffectivetreatment.AFisassociatedwithatrialconductiondisturbancescausedbyelectricaland/orstructuralremodel-ing.Buttheroleofconnexin(Cx)43intheregulationofLtypecalciumchannel(LCC)remainsunclear.WehypothesizedthatCx43mightco-localizeandregulatetheLtypecalciumchannelcurrent(ICa,L).MethodsReal-timePCRandwhole-cellpatchclampwereusedtodetecttheexpressionofLCC1csubunitandthecurrentdensityofICa,L,beforeandafterCx43knockingdownrespectively.Theco-localizationofCx43withLCCwasinvestigatedbyco-immunoprecipitationandconfocalmicroscopy.ResultsKnockingdownofCx43significantlyinhibitedthecurrentdensityofICa,LthroughdecreasingthegeneexpressionofLCCα1cinculturedatrium-derivedmyocytes(HL-1cells).Cx43co-localizedwithLCCα1csubunitinatrialmyocytes.ConclusionsCx43regulatestheICa,LinatrialmyoctyesthroughLCC,representingapotentialpathogenicmechanisminatrialarrhythmias.

简介：纸介绍一个词法模型和它的申请的发展给试验性的模型河。模型考虑隧道移植的关键进程，包括床变丑，河岸失败并且弄湿并且弄干。在拐弯的第二等的流动在侧面的沉积运输起一个重要作用，它进一步影响隧道移植。一个新公式被导出预言近床的第二等的流动速度，速度的大小在被连接到侧面的水水平坡度。因为仅仅非连贯的沉积在当前的学习被考虑，河岸失败基于休息的沉没角度的概念被建模。弄湿并且弄干的过程用一个存在方法被建模。在为各种各样的分泌物的数字模型预言和试验性的观察之间的比较被做了。模型预言隧道平面形状和代表性的形状与实验室观察通常同意很好，这被发现。情形分析也被执行在隧道迁居过程上调查第二等的流动的影响。它证明如果第二等的流动的效果被忽略，在侧面的方向的隧道尺寸将严重被低估。

简介：Calciumsulfatehemihydrate（CSH）whiskersweresynthesizedbyphasetransitioninCaCl2solutionunderatmosphericpressure.Analytical-gradecalciumsulfatedihydrate（ARCSD）wasusedastherawmaterialforthesynthesisofCSHwhiskers,accordingtoorthogonalexperiments.Theeffectsofreactiontemperature,ARCSDcontent,H2SO4content,andreactiontimewereinvestigated,andthecrystallizationconditionswereoptimized.Theas-preparedCSHwhiskersdisplayedaregularmorphologyandahighlyuniformsize,withanaspectratioof105.AsimulationsystemwasalsoestablishedbyblendingvarioussulfateswithARCSD,toevaluatetheeffectsofimpuritiesinfluegasdesulfurization（FGD）gypsum.ThemainaimwastoprepareCSHwhiskersdirectlyfromFGDgypsum,withoutanypurification,usingtheoptimizedconditions.Thisisafacilepotentialalternativeprocessforlarge-scaleproductionofCSHwhiskersusingabundantFGDgypsumassourcematerials.

简介：AIMToinvestigatetheeffectofgingeroloncolonicmotilityandtheactionofL-typecalciumchannelcurrentsinthisprocess.METHODS：ThedistalcolonwascutalongthemesentericborderandcleanedwithCa^2＋-freephysiologicalsalinesolution.MusclestripswereremovedandplacedinCa^2＋-freephysiologicalsalinesolution,whichwasoxygenatedcontinuously.Longitudinalsmoothmusclesampleswerepreparedbycuttingalongthemusclestripsandwerethenplacedinachamber.Mechanicalcontractileactivitiesofisolatedcolonicsegmentsinratswererecordedbya4-channelphysiograph.Colonsmoothmusclecellsweredissociatedbyenzymaticdigestion.L-typecalciumcurrentswererecordedusingtheconventionalwhole-cellpatch-clamptechnique.RESULTS：Gingerolinhibitedthespontaneouscontractionofcoloniclongitudinalsmoothmuscleinadose-dependentmannerwithinhibitionpercentagesof13.3%±4.1%,43.4%±3.9%,78.2%±3.6%and80.5%±4.5%at25μmol/L,50μmol/L,75μmol/Land100μmol/L,respectively（P〈0.01）.Nifedipine,anL-typecalciumchannelblocker,diminishedtheinhibitionofcolonicmotilitybygingerol.GingerolinhibitedL-typecalciumchannelcurrentsincoloniclongitudinalmyocytesofrats.Ata75μmol/Lconcentrationofgingerol,thepercentageofgingerolinducedinhibitionwasdiminishedbynifedipinefrom77.1%±4.2%to42.6%±3.6%（P〈0.01）.GingerolsuppressedIBainadose-dependentmanner,andtheinhibitionrateswere22.7%±2.38%,35.77%±3.14%,49.78%±3.48%and53.78%±4.16%ofcontrolat0mV,respectively,atconcentrationsof25μmol/L,50μmol/L,75μmol/Land100μmol/L（P〈0.01）.Thesteady-stateactivationcurvewasshiftedtotherightbytreatmentwithgingerol.Thevalueofhalfactivationwas-14.23±1.12mVinthecontrolgroupand-10.56±1.04mVinthe75μmol/Lgroup（P〈0.05）withslopefactors,Ks,of7.16±0.84and7.02±0.93（P〈0.05）inthecontroland75μmol/Lgroups,respectively.However,thesteady-st

简介：ECGisanimportanttoolfortheprimarydiagnosisofheartdiseases,whichshowstheelectrophysiologyoftheheart.Inourmethod,asinglematernalabdominalECGsignalistakenasaninputsignalandthematernalP-QRS-Tcomplexesoforiginalsignalisaveragedandrepeatedandtakenasareferencesignal.LMSandRLSadaptivefiltersalgorithmsareapplied.TheresultsshowedthatthefetalECGshavebeensuccessfullydetected.TheaccuracyofDaisydatabasewasupto84%ofLMSand88%ofRLSwhilePhysioNetwasupto98%and96%forLMSandRLSrespectively.

简介：Maenggol隧道和Uldolmok海峡，在朝鲜的西南海岸上定位了，由于潮汐的效果并且到本地地质的因素有尤其是强壮、复杂的水流。在这些区域，电力用强壮的潮汐的水流，其速度在春天潮期间是超过3m/s被产生了。这个区域也为航行提供一条捷径。这些潮汐的条件有时因此是有用的，但是可以也引起可怕的事故或严重经济损坏，当关于海洋条件的精确信息不在时。在2014年4月，旅客渡船MVSewol在Maenggol隧道倾覆了，与杀死的295位旅客一起并且9仍然失踪。当这是时无疑地一人造灾难，强壮的水流是作出贡献的原因之一。给强壮的当前的速度的营救操作，和潮将转弯的时间的精确预言极其因此被需要，对行为配套的水呼吸器潜水也困难。在这研究，我们使用了与许多小岛在如此的区域为强壮的潮汐的水流的分析和模拟预报KOOS(朝鲜运作的海洋学的系统)的系统的高分辨率的沿海的发行量，使用大小并且从这个研究区域当模特儿。为潮汐的水流的精确预言，小格子建模尺寸被需要，并且在这学习我们识别了提供效率以及精确性的一种合适的格子尺寸。

简介：Thispapermakesthethermodynamicanalysisinforcedconvectiveflowofathirdgradefluidthroughaverticalchannel.Duetothereactivenatureofthefluid,theeffectofinternalheatgenerationisconsideredandassumedtobealinearfunctionoftemperature.ThecouplednonlineardimensionlessordinarydifferentialequationsgoverningthefluidflowaresolvedbyusingtheAdomiandecompositionmethod(ADM).Theeffectsofvariousphysicalparameterssuchasthirdgradematerialparameter,buoyancyparameterandheatgenerationparameteronthethermalstructureofflowarepresentedanddiscussed.

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简介：Veryrecently,theBelleandBESIIIexperimentsobservedanewcharmonium-likestateX(3823),whichisagoodcandidatefortheD-wavecharmonium(13D2).BecausetheX(3823)isjustneartheDˉDthreshold,thedecayX(3823)!J=+??canbeagoldenchanneltotestthesignificanceofcoupled-channeleffects.Inthiswork[1],thisdecayisconsideredincludingboththehidden-charmdipionandtheusualquantumchromodynamicsmultipoleexpansion(QCDME)contributions.

简介：深度有限的实验室实验在一张石子床上的开隧道的流动在学习被进行。有相同单个元素尺寸和不同长度(3.81m和7.5m)的二个石子补丁被测试。有亲戚的深度有限制服流动政体浸没Sr(=D/k从2.68～5.94的s)被调整尾板堰生产。速度侧面被使用一个超声速度剖析程序(UVP)和声学的Doppler速度计(副词)测量。过去常决定零飞机的排水量并且估计床的常规方法砍速度然后被考察并且比较。测量双averaged(DA)速度侧面被发现与一个非通用的Karman常数与木头法律和缺点法律适合很好。将近经常的价值遗体并且在为长补丁(LP)的从0.2～0.3的范围，盒子和价值为短补丁(SP)从0.3～0.5在一个更宽的范围以内被散布盒子。当在木头法律的Br值为LP诉讼仍然保持对8.5不变、相等时，Br值被发现随无尺寸的粗糙高度k为SP诉讼的s+。streamwise骚乱紧张分布被发现在补丁长度上独立并且在中间的区域和墙区域与可得到的试验性的数据同意很好。曼宁抵抗系数和DarcyWeisbach磨擦因素被分析。为在小亲戚下面的对数的流动抵抗法律的试穿的到0.22的价值减少浸没。在对数的法律的集成常数Ar的价值在在3.25和6.25之间的正常范围以内掉落。

简介：Aquasi-2Dunsteadyflowandsedimenttransportmodelsuitableforthesimulationoflargelowlandriversystems,includingtheirfloodplains,ispresented.Thewaterflowandsedimentequationsarediscretisedusinganinterconnectedirregularcellsscheme,inwhichdifferentsimplificationsofthe1DdeSaintVenantequationsareusedtodefinethedischargelawsbetweencells.Spatially-distributedtransportanddepositionoffinesedimentsthroughouttheriver-floodplainsystemaresimulated.Themodelisappliedovera208-kmreachoftheParanaRiverbetweenthecitiesofDiamanteandRamallo(Argentina)comprisingariver-floodplainareaof8100km~2.Aftercalibrationandvalidation,themodelisappliedtopredictwaterandsedimentdynamicsduringsyntheticallygeneratedextraordinaryfloodsof100,1000,and10,000yearsreturnperiod.Thepotentialimpactofa56-kmlongroadembankmentconstructedacrosstheentirefloodplainissimulatedandcomparedtomodelresultswithouttheembankment.Theembankmentresultsinincreasesinupstreamwaterlevels,inundationextent,flowduration,andsedimentdeposition.

简介：Semicontinuousequal-channelangularextrusion(SC-ECAE)isanovelsevereplasticdeformationtechniquethathasbeendevelopedtoproduceultrafine-grainsteels.InsteadofexternalforcesbeingexertedonspecimensintheconventionalECAE,drivingforcesareappliedtodiesinSC-EACE.Thedeformationofinterstitial-free(IF)steelwasperformedatroomtemperature,andindividualspecimenswererepeatedlyprocessedatvariouspasses.Anoverallgrainsizeof0.55μmwasachievedafter10passes.DuringSC-ECAE,themaintexturesofIFsteelincluded{111}<110>,{110}<112>,{112}<111>,{110}<111>,and{110}<001>Atanearlystage,increasingdislocationsinducenewtexturesandincreaseintensity.Whenthedeformationcontinues,low-angleboundariesareformedbetweendislocationcellbands,whichcausesomedislocationcellbandstochangetheirorientation,andtherefore,theintensityofthetexturesbeginstodecrease.Aftermorepasses,theintensityoftexturescontinuestodecreasewithhigh-angleboundaries,andthesub-grainsindislocationcellbandscontinuouslyincrease.Thepresentstudyreportstheevolutionoftexturesduringdeformation;thesewereexaminedandcharacterizedusinghigh-resolutionelectronbackscattereddiffraction(EBSD)inafieldemissionscanningelectronmicroscope.Themechanismsoftextureevolutionarediscussed.

简介：TheenigmaticchargedstatesZc(3900),Zc(4020),Zc(4050),Zb(10610),andZb(10650)arestudiedwithinacoupled-channelSchr¨odingermodel[1],whereradiallyexcitedquark-antiquark(qˉq)pairs,withthesameangularmomentaandisospinasthea1(1260)andb1(1235),arestronglycoupledtotheirOkubo-Zweig-Iizuka-allowedde-caychannelsDˉD+ˉDDandDˉD,orBˉB+ˉBBandBˉB,inSandD-wave.Poles,matchingtheexperimentalmassandwidthofalltheabovestates,arefoundbyvaryingonlytwofreeparameters.In

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简介：由有固有的技巧此处，在房间膜上与高度选择的离子隧道和泵在液体从盐内容产生可观的bioelectricity的生物系统启发了一只充分不能生活的、单个杯子圆锥形的nanopores收获精力被表明。圆锥形的nanopores被显示出被取决于离子散开的方向的电解质集中坡度控制的否定地控告的玻璃里的离子当前的校正(ICR)。ICR的度与向前增加被提高集中差别。当集中坡度相对地被使用时，不平常的校正倒置被观察。有单个nanopore的最大的力量产量接近104 pW。这个灵巧、成本效率的收获精力的系统有潜力驱动干净精力的恢复种的微小的生物医学的设备或构造未来。

简介：Weproposeanultra-simpledual-channelconfigurationforsimultaneouslyevaluatingtwobranchesofamultifunctionalintegratedopticchip(MFIOC).Intheconfiguration,theMFIOCisemployedasabeamsplittertoconstructthedemodulationinterferometertogetherwitha2×2fibercoupler.InterferencehappensbetweenpolarizationmodestravelingthroughdifferentchannelsoftheMFIOC.Thecross-couplingsofeachchannelarerespectivelycharacterizedbytheinterferencepeakswhichdistributeonoppositesidesofthecentralinterferencepeak.TemperatureresponsesoftheMFIOCareexperimentallymeasuredfrom-40°Cto80°C.Resultsshowthattheproposedconfigurationcanachievesimultaneousdual-channeltransientmeasurementswithresolutionof-90dBanddynamicrangeof90dB.Inaddition,thetwochannelsoftheconfigurationhaveconsistentmeasuringperformance,andthetwobranchesoftheMFIOChavedifferentresponsestotemperaturevariation.

简介：Inthispaper,asurfacepotentialbasedthresholdvoltagemodeloffully-depleted(FD)recessed-source/drain(Re-S/D)silicon-on-insulator(SOI)metal-oxidesemiconductorfield-effecttransistor(MOSFET)ispresentedwhileconsideringtheeffectsofhigh-kgate-dielectricmaterialinducedfringing-field.Thetwo-dimensional(2D)Poisson’sequationissolvedinachannelregioninordertoobtainthesurfacepotentialundertheassumptionoftheparabolicpotentialprofileinthetransversedirectionofthechannelwithappropriateboundaryconditions.Theaccuracyofthemodelisverifiedbycomparingthemodel’sresultswiththe2DsimulationresultsfromATLASoverawiderangeofchannellengthsandotherparameters,includingthedielectricconstantofgate-dielectricmaterial.