简介:Therehasbeenaparadigmshiftinmedicineawayfromtradition,anecdoteandtheoreticalreasoningfromthebasicsciencestowardsevidence-basedmedicine(EBM).Inpalliativecarehowever,statisticallysignificantbenefitsmaybemarginalandmaynotberelatedtoclinicalmeaningfulness.Thetypicaltreatmentvs.placebocomparisonnecessitatedby‘goldstandard'randomisedcontrolledtrials(RCTs)isnotnecessarilyapplicable.Thecomplexmultimorbidityofendoflifecareinvolvesconsiderationsofthepatient'sphysical,psychological,socialandspiritualneeds.Inaddition,thefieldofpalliativecarecoversaheterogeneousgroupofchronicandincurablediseasesnolongerlimitedtocancer.Adequatesamplesizescanbedifficulttoachieve,reducingthepowerofstudiesandhighattritionratescanresultininadequatefollowupperiods.Thisreviewusesexamplesofthemanagementofcancer-relatedfatigueanddeathrattle(noisybreathing)todemonstratethecurrentstateofEBMinpalliativecare.ThefutureofEBMinpalliativecareneedstobeasdiverseasthepatientswhoultimatelyderivebenefit.Non-RCTmethodologiesofequivalentquality,validityandsizeconductedbycollaborativeresearchnetworksusinga‘mixedmethodsapproach'arelikelytoposethecorrectclinicalquestionsandderiveevidencebasedyetclinicallyrelevantoutcomes.
简介:Inthispaper,firstlywedemonstratetheuseofnodaladmittancematrixtoconvertalow-passband-passfilterbasedonoperationalamplifier(op-amp)toacircuitbasedonasecond-generationcurrentconveyor(CCII).Thistechniqueallowsustogeteightpresumptionsoffiltercircuits.Secondly,wepresentanovelarchitecturecircuitofCCII,whichcanoperateatlowsupplyvoltageof±0.75V.AllsimulationsareperformedbyTSPICEmodels.ThesimulationresultsshowthatthiscircuithasalowimpedanceatterminalX(RX=1.01Ω),averyhighinputimpedanceatterminalY,andwidebandwidthcurrentandvoltage.Thecenterfrequencyoftheproposedfilterisvariableontheinterval[157kHz,196MHz].
简介:Thispaperextendstheresourcedragstudiesbyempiricallyinvestigatinghowspatialfactorsaffecttheregionaleconomicgrowth.Usingspatialpaneleconometricmodels,thispaperestimatesthedraggingeffectofenergyresourcesoftheYangtzeRiverDeltametropolitanareas.WefindthatthegrowthdragofenergyintheYangtzeRiverDeltaisabout6%onaverage,whichmeansthatenergyconstraintsdecreasetheeconomicgrowthby6%annually,higherthanthenationallevelthathasbeenpreviouslymeasuredintheliterature.Thisresulthastakenintoaccounttheimpactofneighboringcities’economicdevelopment,soastoobtainamoreaccurateestimate.Basedonthesemeasurementresults,weproposesomepolicyrecommendations.
简介:TheunsteadycavitationevolutionaroundtheClark-Yhydrofoilisinvestigatedinthispaper,byusinganimprovedfilter-basemodel(FBM)withthedensitycorrectionmethod(DCM).Toimprovethepredictionaccuracy,thefilterscaleisadjustedbasedonthegridsize.Thenumericalresultsshowthatasmallfilterscaleiscrucialfortheunsteadysimulationsofthecavitysheddingflow.ThehybridmethodthatcombinestheFBMandtheDCMcouldhelptolimittheoverpredictionoftheturbulentviscosityinthecavitationregiononthewallofthehydrofoilandinthewake.Thelargevalueofthemaximumdensityratio?l/?v,clippromotesthemasstransferratebetweentheliquidphaseandthevaporphase,whichresultsinalargesheetcavitylengthandthevaporfractionriseinsidethecavity.Thecavitypatternspredictedbytheimprovedmethodareverifiedbytheexperimentalvisualizations.Thetime-averagelift,thedragcoefficientandtheprimaryoscillatingfrequencyStforthecavitationnumber?=0.8,theangleofattack,?=8o,ataReynoldsnumberRe=7?105are0.735,0.115and0.183,respectively,andthepredictederrorsare3.29%,3.36%and8.93%.Thetypicalthreestagesinonerevolutionarewell-captured,includingtheinitiationofthesheet/attachedcavity,thegrowthtowardthetrailingedge(TE)withthedevelopmentofthere-entrantjetflow,andthelargescalecloudcavityshedding.ItisobservedthatthecloudcavitysheddingflowinducesthevortexpairsoftheTEvorticesinthewakeandthesheddingvortices.Thepositivevorticityvortexofthere-entrantjetandtheTEvorticesinteractsandmergeswiththenegativevorticityvortexoftheleadingedge(LE)cavitytoproducethesheddingflow.
简介:Thereisgrowinginterestinthecorrelationbetweenworkingtimeandenvironmentalpressures,butpriorempiricalstudiesmostlyfocusedonstaticmethodologies.Thisarticleuseddynamicpanelregressionapproachestoexamineandcomparetherelationshipamongwestern,southern,andnorthernEuropeancountriesovertheperiod1970-2010,andprovedtheexistenceofstronglysignificantrelationshipsinallmodels.Furthermore,thisarticledetectedtherelationshipbetweenworkinghoursandenvironmentalindicators(carbonemissionandenergyuse)atdifferentphases.Wecontributetoafurtherunderstandingoftheenvironmentaleffectsoftheworkingtimereductionpolicybycomparingthedifferencesamongvariousperiodsandcountrygroupsinasystemgeneralizedmethodofmoments(GMM)dynamicframework.
简介:Ghostimagingcouldbeusedtomakeaquickidentificationoforthogonalobjectsbymeansofphotocurrentcorrelationmeasurements.Inthispaper,weextendthemethodtoidentifynonorthogonalobjects.Inthemethod,anobjectisilluminatedbyonephotonfromanentangledpair,andtheotheroneisdiffractedintoaparticulardirectionbyapre-establishedmultiple-exposurehologramintheidlerarm.Bythecorrelationmeasurements,thenonorthogonalobjectinthesignalarmcouldbediscriminatedwithinaveryshorttime.Theconstraintsfortheidentificationofnonorthogonalobjectsarepresented,whichshowthatthenonorthogonalobjectscanbediscriminatedwhentheoverlappingportionbetweenanytwoobjectsislessthanhalfofalltheobjectsintheset.Thenumericalsimulationsfurtherverifytheresult.
简介:Theinstabilityofboreholewallisalwaysadifficultquestionindrillingboreholeprogress.Itincreasesthecostofproductionandprolongsproductioncycle.Soithasasignificantresearchvalue.Consideringtheeffectofmudpressureandporepressureonthestabilityofboreholewall,thispaperestablishesamathmodelbyapplyingthetwo-dimensionalbondtheoryofBiot.Itappliesthemethodofthenumericalsimulationtoanalyzetheeffectofmudpressureandporepressureonthestabilityofboreholewall.Thesimulationresultsshowthatthemudpressureimposesgreatinfluenceonstressfieldandonthedeformationofboreholesoil,whichprovidesatheoreticalbasisduringthedrillingprocesstoavoidtheinstabilityoftheboreholeandtostudyhowtoselectreasonablemudandmudpressure.
简介:Duringrecentyears,somenotionsabouttaskshavebeenconsideredasthemajorpartofanalysisindifferentteachingapproachesandteachersarebeingmoreinterestedintheuseoftaskbasedapproachbothinforeignandinsecondlanguageteaching.Themaingoalofthisarticleistointroduceanddiscusssomemajorprinciplesoftask-basedlanguageteachingandindicateshowteacherscanapplythemintheircurriculum.
简介:Traumaticinjuriestospinalcordelicitdiversesignalingpathwaysleadingtounselectiveandcomplexpathologicaloutcomes:deathofmultipleclassesofneuralcells,formationofcysticcavitiesandglialscars,disruptionofaxonalconnections,anddemyelinationofsparedaxons,allofwhichcancontributemoreorlesstodebilitatingfunctionalimpairmentsfoundinpatientswithspinal
简介:LanthanidedopedNaYF4microcrystalsweresynthesizedviaafacilehydrothermalmethod.MulticolorupconversionluminescencewasobservedinNaYF4microcrystalsdopedwithYb3+/Er3+,Yb3+/Tm3+,andYb3+/Er3+/Tm3+undertheexcitationof980nminfraredlight.Importantly,theexcitationpowerdensitydependenceofupconversionemissionintensityindicatedclearlytheenergytransferfromTm3+toEr3+ionsundertheexcitationoflowpowerdensity(5×102–9×102W/cm2).Meanwhile,theinverseenergytransferfromEr3+toTm3+ionsundertheexcitationofrelativelyhigherpowerdensity(4.1×104–4.9×104W/cm2)wasalsorevealed.ThiswasadirectevidenceforreversibleenergytransferbetweenEr3+andTm3+ions.Undertheexcitationofhighpowerdensity(4.1×104–4.9×104W/cm2),darksensitizerswerealsomotivatedsothatthebottleneckeffectofhighconcentrationYb3+iondopingwasbroken.ThiswasthemainreasonforrealizinghighupconversionefficiencyofthesampleswithheavydopingofYb3+ion.
简介:第四代(4G)无线通讯系统被部署了或不久在许多国家被部署。与无线移动设备和服务的爆炸,然而,仍然有一些挑战,不能甚至被4G提供,例如光谱危机和内部房间的干扰。电信操作符转弯了承诺自己分享可得到的资源,包括硬件和软件资源。因此与相互的基础结构,‘integration’应该被加亮,特别在第五代(5G)被期望到的无线系统超过2020被部署。在文章的作者建议了潜在的细胞的体系结构,并且讨论了内部操作员的收音机接口为5G的基于的同步(肋骨)无线通讯系统。内部操作员的肋骨和典型情形的一个计划,与相应干扰的分析一起被给。分享的参数,内部操作员的肋骨的发信号的协作和为肋骨的信号(RS)设计也是的听的引用的分析执行了。