简介：迈克尔绝非等闲之辈．他总是那么乐观，总能看到事物积极的一面。在工作中，假如有人问他“你最近好吗？”．他就会说：“太好了．简直没的说。”

简介：HaveyoueverheardofAgathaChristie,anexcellentwriter?AgathaChristieis,withoutadoubt,themostfamousmystery1intheworld.Herbookshavebeentranslatedintomorethan100languages.All77novelsandstorycollectionsshewrotearestillonthemarket25yearsafterher2.AgathaChristiewasbornin1890inasouthwestEnglandseasidetown.She3averycomfortablechildhoodinabighousewithplentyofservants(仆人).Agathawasknown4animaginativechild.Withhersisterandbrotherawayatschool,sheoftenplayedalone.Shepassedthetimeby5upstorieswhichshetoldtoherself.

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简介：针对地下水源能量利用系统建筑负荷的动态变化,基于1D/3D集成分析数值方法的基础上,分析了定流量变温差及定温差变流量两时变模式系统性能参数的变化。结果表明：定温差变流量调控模式由于抽水量小于定流量变温差模式,含水层发生热贯通时间较晚;发生热贯通后,由于抽水温差大于定流量变温差模式,冷水封面向抽水井移动速度较快,抽水温度下降幅度较大,热贯通程度显著。抽灌水流量对热贯通起主导作用,热贯通发生后抽灌水温差对地下水温度影响较大;定温差变流量模式机组的COP值迅速下降,运行过程中耗功较少,系统能效比较大。

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简介：教学目标:基础性目标:I.Knowledgeobjectives:Tolearntousethepresentprogressivetense.II.Abilityobjectives:Tolearntotalkaboutwhatpeoplearedoing.III.Moralobjective:Tolearntogetalongwellwithourfamilymembers,neighborsandfriends.Companyisthelongestconfessionoflove.发展性目标:1.Tohelpthestudentsdevelopthelisteningandspeakingskills.2.Toleadthestudentstoenhancetheresponsibilitiesofhome.

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简介：Cytarabine(1-β-D-arabinofuranosylcytosine,Ara-C),isolatedfromaCaribbeanspongespeciesTethyacrypta,isthefirstantitumordrugfromamarineresource.In1980,theUSFoodandDrugAdministrationapprovedthisdrugforthetreatmentofdifferenttypesofleukemia.Thisdrughasashortplasmahalf-life,lowstability,limitedbioavailability,andseveresideeffects.Toimprovestabilityandbioavailability,wesynthesizedninenovelderivativesbyblockingthecytarabinemetabolicsitesandimprovinglipophilicity.ThecLogPvaluesofthenewlysynthesizedcompoundswerecalculated.Allthesynthesizedcompoundsweremorelipophilicthancytarabine,resultinginmembranepermeabilityandbioavailabilityimprovement.TheantitumoractivitiesagainstleukemiacelllineHL-60wereevaluatedbyusingtheMTTassay.ThebioassayresultsrevealedthattheIC50valuesofcompounds5,8and9were0.080,0.090and0.057μmolL-1,respectively,whichwassimilarwiththatofcytarabine(0.056μmolL-1).Incomparison,compound4withaphosphategroupatO5’wasinactive.Becausephosphoesterbondsareeasilyhydrolyzedbyalkalinephosphataseandarecommonlyusedinproducingprodrugstrategies,compound4mightalsobemetabolizedinvivoandgeneratecompound3orevencytarabinethroughamulti-stepreaction.Thus,compound4mightbeapromisingcompoundtobedevelopedasaprodrug.

简介：摘要目的探讨真菌细胞壁（1-3）-β-D葡聚糖体外检测的影响因素。方法实验组将白色假丝酵母菌分别用正常血浆、无热原蒸馏水、0.9%的生理盐水、0.02%两性霉素B生理盐水和0.75%氟康唑生理盐水稀释为0.05麦氏单位（含白色假丝酵母菌1×107CFU/ml）,对照组将上述各液稀释100倍，采用免疫沉淀试验（G试验）检测其10次（1-3）-β-D葡聚糖含量，并进行体外培养，以此探讨生理盐水、抗真菌药物对（1-3）-β-D葡聚糖体外检测的影响。结果实验组中，正常血浆葡聚糖含量为（92.5±14.2）ug/L，蒸馏水组含量为（94.5±15.2）ug/L，生理盐水组含量为为（93.6±14.8）ug/L，两性霉素B组含量为（95.5±16.2）ug/L,氟康唑组（97.3±16.8）ug/L,经统计检验组内结果间无显著性差异（P＞0.05）。对照组中正常血浆含量为（6.8土2.7）ug/L，蒸馏水组含量为（6.1±2.4）ug/L，生理盐水组含量为为（7.3±2.0）ug/L，两性霉素B含量为（6.8±2.5）ug/L,氟康唑组（6.7±2.8）ug/L,经统计检验组内间结果无显著性差异（P＞0.05）。实验组与对照组比较有显著差异（P＜0.05）。结论体外真菌细胞壁（1-3）-β-D葡聚糖含量变化与液体介质无关，与真菌治疗药物无关，与真菌数量密切相关。

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简介：在这份报纸，完整的分离本地设计稳定了(LPS)方法被建议与相等的顺序元素解决不稳定的海军司烧方程的最佳的控制问题。对流效果和压力被使用LPS方法两个都稳定。一个priori错误关于雷纳兹一致地估计数字被获得，提供真答案是足够的光滑。数字实验被实现说明并且证实我们的理论分析。

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简介：Byemployingaradiofrequency(RF)feedbackchain,theself-interferencecanbecanceledefficientlyinco-timeco-frequencyfullduplex(CCFD).However,theevitablesignalcrosstalkwhichiscausedbytheimperfectRFfeedbackchainisolationusuallydamagestheself-interferencecancelation(SIC)performance.Todealwiththisproblem,firstly,weanalyzetheimpactofRFfeedbackchainisolationonSICperformance.ThenadigitalpreprocessingschemewithRFfeedbackchainisproposedinthemultiple-antennaCCFDarchitecture.Usingbothanalyticalandexperimentalmethods,wefindthattheproposedschemeachievesabetterperformanceonSIC.

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简介：感光度这个指标目前在单反相机上已经划分为常规和拓展两个部分。5DMarkIV（下文简称5D4）的常规感光度是IS0100-12800，拓展后的感光度范围是IS050-102400。

简介：X-rayimagingistheconventionalmethodfordiagnosingtheorthopedicconditionofapatient.ComputerizedTomography(CT)scanningisanotherdiagnosticmethodthatprovidespatient’s3Danatomicalinformation.However,bothmethodshavelimitationswhendiagnosingthewholeleg;X-rayimagingdoesnotprovide3Dinformation,andnormalCTscanningcannotbeperformedwithastandingposture.Obtaining3Ddataregardingthewholeleginastandingpostureisclinicallyimportantbecauseitenables3Danalysisintheweightbearingcondition.Basedontheseclinicalneeds,ahardware-basedbi-planeX-rayimagingsystemhasbeendeveloped;itusestwoorthogonalX-rayimages.However,suchmethodshavenotbeenmadeavailableingeneralclinicsbecauseofthehightcost.Therefore,weproposedawidelyadaptivemethodfor2DX-rayimageand3DCTscandata.Bythismethod,itispossibletothreedimensionallyanalyzethewholeleginstandingposture.TheoptimalpositionthatgeneratesthemostsimilarimageisthecapturedX-rayimage.Thealgorithmverifiesthesimilarityusingtheperformanceoftheproposedmethodbysimulation-basedexperiments.Then,weanalyzedtheinternal-externalrotationangleofthefemurusingrealpatientdata.Approximately10.55degreesofinternalrotationswerefoundrelativetothedefinedanterior-posteriordirection.Inthispaper,wepresentausefulregistrationmethodusingtheconventionalX-rayimageand3DCTscandatatoanalyzethewholelegintheweight-bearingcondition.

简介：摘要本文记录了芜湖城市之光D1地块项目外墙保温脱落及GRC线条维修工程的处理过程，从中分析了该项目之所以产生该工程质量事故的原因，明确了事故处理方向，提出了相关处理方案，简单总结整改结果，作为对该类工程技术方面的一次经验积累，供工程技术人员参考。

简介：目的探讨血浆（1-3）-β-D葡聚糖（即G实验）对院内侵袭性真菌感染的临床价值。方法选择2016.11~2017.4在宁夏医科大学总医院住院患者中院内侵袭性真菌感染的高危患者132例,血浆（1-3）-β-D葡聚糖含量使用MB-80微生物快速检测动态系统及其试剂进行检测,用ROC曲线比较G实验、真菌培养、G实验联合真菌培养的检测结果。结果132例高危院内IFI感染的患者中,共有43例诊断为院内侵袭性真菌感染,真菌培养的敏感度为67%,特异度为96%,阳性预测值（PPV）和阴性预测值（NPV）分别是0.72和0.80,G实验的敏感度为70%,特异度为88%,PPV和NPV分别是0.73和0.86;G实验真菌培养检测的敏感度提高为84%,特异度提高为92%,阳性预测值0.78,阴性预测值0.92;G实验Youden指数0.58,真菌培养Youden指数0.63,联合检测Youden指数提高到0.76;G实验结果、真菌培养结果及联合检测结果进行ROC曲线分析,曲线下面积分别为0.717,0.757及0.798。结论G实验是一种快速、简便、实用的侵袭性真菌感染的早期诊断方法,联合传统真菌培养可提高诊断的敏感度、特异度及诊断价值。