简介：Securityofsmarttechnologieslikesmartgridsandcrowdenergysystemscannotrelyonlyontechnicalsolutions,humansplayasignificantroleinfailure,securityculture,informationsecurity,cybersecurity,trustandsharing,andperceptionsandconcern.Thispaperinvestigatessecurityissuesinsmarttechnologiesandtherelatedroleofhumanfailure,whetheritisintentionalorunintentional.Methodsthathelpreducingthisfailurearediscussed.Ahumanorientedframeworkforfailurereductionispresentedinordertoenhancesecurity.IndexTermsCrowdenergy,humanrole,intentionalfailure,security,smartgrids,unintentionalfailure.1.IntroductionManystateofthearttechnologiesaretaggedwiththe'smart'label.Ingeneralunderstandingthismeansinterconnectedness,interactivityand4.0automation,i.e.theapplicationofsensorsandinformationandcommunicationtechnology(SICT)andprocessinganever-changingandexpandingdata/knowledgebase.Fromahigherpointofview'smart'standsbutformorethanjusttheabove-mentionedtechnicalaspects;alsoandinparticularsocial,political,economicandecologicalaspectswillbeaddressed.Thismeansthat'smartmeetschallengestoimprovesustainablewelfare'[1].Inthissense,forexample,thetermsmartgridaddressesnotonlythecommunicativeinterconnectionandcontroloftheentitiesofapowersystem,i.e.technology,butpreciselyalsosustainability,conservationofresources,renewability,andefficiency.Securityhasbeenveryimportantfornewtechnologiesandsystemslikeelectricalgridsandpowerplants.Theseneedtobesecuredcarefullybecauseweaknessesinthesecuritymightleadtopartialdamageandreductionofserviceinseveralways.Inextremecasesdestructioncanhap-

简介：我们常说，读书就是同作者对话；既然这样，能不能通过直接与真人交谈，获得需要的知识呢？这正是HumanLibrary的宗旨。

简介：Humanendogenousretroviruses(HERVs)areretrovirusesthatinfectedhumangenomemillionsofyearsagoandhavepersistedthroughouthumanevolution.About8%ofourgenomeiscomposedofHERVs,mostofwhicharenonfunctionalbecauseofepigeneticcontrolordeactivatingmutations.However,acorrelationbetweenHERVsandhumancancerhasbeendescribedandmanytumors,suchasmelanoma,breastcancer,germcelltumors,renalcancerorovariancancer,expressHERVproteins,mainlyHERV-K(HML6)andHERV-K(HML2).AlthoughthecausativeroleofHERVsincanceriscontroversial,datafromanimalmodelsdemonstratedthatendogenousretrovirusesarepotentiallyoncogenic.HERVproteinexpressioninhumancellsgeneratesanimmuneresponsebyactivatinginnateandadaptiveimmunities.SomeHERV-derivedpeptideshaveantigenicproperties.Forexample,HERV-K(HML-6)encodestheHER-KMELpeptiderecognizedbyCD8+lymphocytes.Inaddition,HERVsaretwoedgedimmunomodulators.HERVsshowimmunosuppressiveactivity.Thepresenceofgenomicretroviralelementsinhost-cellcytosolmayactivateaninterferontypeIresponse.Therefore,targetingHERVsthroughcellularvaccinesorimmunomodulatorydrugscombinedwithcheckpointinhibitorsisattractinginterestbecausetheycouldbeactiveinhumantumors.

简介：新闻事件：重庆出入境检验检疫局发布消息称，春节期间。该局从两名入境幼儿身上检出人博卡病毒。据悉。此为重庆口岸首次检出人博卡病毒感染病例。检验检疫人员在江北国际机场进行出入境人员检疫查验时，经体温监测，分别从香港、澳门飞往重庆的两班次航班旅客中发现2名幼儿出现发热等症状，两名患儿被诊断为人博卡病毒感染病例。

简介：InChina,therearemanyhumanrightsorganizations,becauseoftheirfocusesandprioritiesrelatedtohumanrights.ChinaSocietyforHumanRightsStudies(CSHRS)isthelargestofthem,whichfocusesonhumanrightsresearch,popularizingandinternationalexchanges.ThispapertakesCSHRSasanexampletoshowtheroleofthehumanrightsorganizationsplayinChina.FromthepracticeofCSHRS,wecanseethehumanrightsorganizationsinChinaplayakindofconstructiverolethroughinvolvinginverybroadfieldsandengaginginthevariousactivitiesofhumanrightsprotection.TheirworksincludeparticipatingindraftingtheNationalHumanRightsActionPlans,givingconstructivesuggestions,workinginhumanrightseducation,engagingininternationalexchangesandcooperation,takingpartintheworkofUPR,raisingfundandimplementingprojects,andsoon.TheyaretryinghardtocontributetoimprovehumanrightssituationinChina.

简介：Non-lineardynamics,fractals,periodicoscillations,bifurcations,chaos,andotherterminologieshavebeenusedtodescribehumanbiologicalsystemsintheliteratureforafewdecades.Theeightmanuscriptsincludedinthisspecialissuediscussedthehistoricalbackground,selectedtheoretical

简介：ForewordRespectingandprotectinghumanrightsisaconstitutionalprincipleinChina.ItalsoreflectsthewillandpursuitoftheCommunistPartyofChina(CPC),theChinesegovernmentandtheChinesepeople.Thejudiciaryisthelastlineofdefensetosafeguardsocialfairnessandjustice,andjudicialprotectionofhumanrightsisanimportant

简介：Theergonomicdigitaldesignandevaluationofman-machinesystemisthemainapplicationfieldsofvirtualhumantechnology.Becauseofthecomplexityofphysicalpersonanduncertaintyoffatiguegenerationmechanism,itisdifficulttoexpressandevaluatetheVirtualHuman'sfatiguestate.Thispapersummarizesthecharacteristicsofvirtualhuman'sfatigueevaluation,suchasundeterminable,invisible,theconstraintconditionscanbeenused.Viewedfromthestrengthsandweaknessesofpreexistingmodels,metabolicenergyexpendituremodel,dynamicmusclefatiguemodelandamodeltoassessfatigueatjoint-levelusingthehalf-jointconcept,thispaperputsforwardthefuturedevelopmenttrendthatthecombinationofsubjectiveandobjective,diversificationoftheanalyzablemotion,real-timeandvisualexpression.

简介：'CampusBullying'isessentiallyaformofviolenceagainstchildrenandadolescents,butneglectedforalongtimebecauseitoccurredamongthesegroups.Thispaperproposestore-examinethenatureofcampusbullyingandrelevantpreventionandinterventionactivitiesinahumanrightsframework.Theauthorpointsoutthatbullyingamongchildrenandadolescents,ifwithoutintervention,willbecomeasocializationprocessthroughwhichchildrenlearnviolentandunequalideology.Inconclusion,thepapermakessuggestionsonthepreventionfromandinterventionincampusbullyingfromahumanrightsperspective.

简介：AIM:Totransfectthecatcornealendothelialcells(CECs)withrecombinanthumanβ-nervegrowthfactorgeneadeno-associatedvirus(AAV-β-NGF)andtoobservetheeffectoftheexpressedβ-NGFproteinontheproliferationactivityofcatCECs.METHODS:TheendotheliumofcatcorneawastornunderthemicroscopeandrapidlycultivatedinDulbecco’smodifiedEagle’smedium(DMEM)toformsinglelayerCECsandthepassage2endothelialcellswereusedinthisexperiment.TherecombinanthumanAAV-β-NGFwasconstructed.TherecombinanthumanAAV-β-NGFwastransferredintocatCECsdirectly.Threegroupswereasfollowing:normalCECcontrolgroup,CEC-AAVcontrolgroupandrecombinantCECAAV-β-NGFgroup.Forty-eighthoursaftertransfection,thetotalRNAwasextractedfromtheCECbyTrizol.Theexpressionoftheβ-NGFtargetgenedetectedbyfluorescencequantitativepolymerasechainreaction;proliferationactivityofthetransfectedCECdetectedat48hbyMTTassay;thepercentageofG1cellsamongCECsaftertransfectwasdetectedbyflowcytometrymethod(FCM);cellmorphologywasobservedunderinvertedphasecontrastmicroscope.RESULTS:Thetornendotheliumculturetechniquerapidlycultivatedsinglelayercatcornealendothelialcells.Theself-designedprimersforthetargetgeneandreferencegenewereefficientandspecialconfirmedthroughelectrophoresisanalysisandDNAsequencing.Forty-eighthoursaftertransfect,thehumanβ-NGFgenemRNAdetectedbyfluorescencequantitativepolymerasechainreactionshowedthattherewasnosignificantdifferencebetweennormalCECcontrolgroupandCECAAVcontrolgroup(P>0.05);therewassignificantdifferencebetweentwocontrolgroupsandrecombinantCEC-AAV-β-NGFgroup(P<0.05).MTTassayshowedthattransfectofrecombinantAAV-β-NGFpromotedtheproliferationactivityofcatCEC,whiletherewasnosignificantdifferencebetweennormalCECcontrolgroupandCEC-AAVcontrolgroup(P>0.05).FCMresultshowedthatthepercentageofG1cellsinCECAAV-NGFgroupwas76.8%whi

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简介：Thispaperpresentsahumanactionrecognitionmethod.Itanalyzesthespatio-temporalgridsalongthedensetrajectoriesandgeneratesthehistogramoforientedgradients(HOG)andhistogramofopticalflow(HOF)todescribetheappearanceandmotionofthehumanobject.Then,HOGcombinedwithHOFisconvertedtobag-of-words(BoWs)bythevocabularytree.Finally,itappliesrandomforesttorecognizethetypeofhumanaction.Intheexperiments,KTHdatabaseandURADLdatabasearetestedfortheperformanceevaluation.Comparingwiththeotherapproaches,weshowthatourapproachhasabetterperformancefortheactionvideoswithhighinter-classandlowinter-classvariabilities.IndexTermsBag-of-words(BoWs),densetrajectories,histogramofopticalflow(HOF),histogramoforientedgradient(HOG),randomforest,vocabularytree.

简介：Thecompressedsensing(CS)ofaccelerationdatahasbeendrawingincreasingattentioningaittelemonitoringapplication.Insuchapplication,therestillexistsomechallengingissuesincludinghighenergyconsumptionofbody-worndeviceforaccelerationdataacquisitionandthepoorreconstructionperformanceduetononsparsityofaccelerationdata.Thus,thenovelschemeofcompressivesensingofaccelerationdataisneededurgentlyforsolutionsthatarefoundtotheseissues.

简介：都市化的过程被人的常规运动形成。它在一个城市里产出不同功能的地区，例如居住地区和商业地区。因而，在那里存在在人的活动性模式和城市之间的一个靠近的连接是地区。然而，收集能精确捕获在个人的运动和地区性的功能之间的内在的关系的大规模社会宽的数据不是容易的。因此，我们为理解人的活动性的基本模式的知识仍然是有限的。以便在一个城市里发现不同区域的功能，我们建议一种亲密关系在这份报纸基于方法。亲密关系是为在一个复杂网络测量二个连接节点的关联的一个最近介绍的度量标准。建议模型由经由相对的熵测量用户的到达/离开分发组织不同功能的地区。除了这，我们也由拿核密度评价(KDE)识别每个功能的地区的紧张方法。最后，一些实验被进行与大规模真实数据集评估我们的方法，它从一个月的一个时期由300万个蜂窝电话用户的记录组成。我们在活动性模式和地区性的函数之间的相互作用上的调查结果能高效地捕获城市动力学并且为城市的规划者提供珍贵引用。

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简介：这份报纸基于模型引用论述一个新奇提高的人机器人的相互作用系统适应控制。介绍方法交付保证稳定性和任务性能并且让二控制环。一个机器人特定的内部环，是一个neuroadaptive控制器，在网上学习机器人动力学并且让机器人象一个规定阻抗模型一样反应。这个环不使用任务信息，包括没有规定轨道。一个任务特定的外部环考虑人的操作符动力学并且使规定机器人阻抗模特儿适应以便联合人机器人的系统为任务性能有理想的特征。这个图案基于模型参考适应控制，但是一种非标准的形式。网络结果是有扩充人的操作符提供人机器人的队的改进任务性能的两个适应阻抗特征和assistive输入的一个控制器。模拟在一项重复点对点的运动任务验证建议控制器的表演。一个PR2机器人上的实际试验性的实现进一步支持途径的有效性。

简介：C类型natriuretic肽(CNP)是调停的本地规章的因素的一种最新发现的类型它通过specic的生物效果，膜界限natriuretic肽receptor-B(NPR-B)。最近的研究证实了CNP是仔细与男繁殖功能有关。这研究的目的是通过不同方法在人的呼喊的精子决定CNP/NPR-B的分发，然后在精子功能invitro上评估CNP的影响(例如immunolocalization，实时聚合酶链反应和西方的污点)，例如活动性和acrosome反应。人的精液样品从同意的施主被收集为normozoospermia满足了世界健康组织的标准。我们的结果证明CNP的specic受体NPR-B在头和精子的前端尾巴的膜的acrosomal区域是局部性的，并且没有在人的精子的CNP的信号。与控制相比，CNP能在精子活动性和acrosome反应导致signicant剂量依赖者增加。在摘要，CNP/NPR-B能影响精子活动性和acrosome反应，因此调整男性的繁殖功能。CNP可以是在调整精子功能的一个新关键因素。

简介：AIMTo在真菌的部件zymosan在.METHODSHCFs是的有教养的人的角膜的成纤维细胞(HCF)导致的proinflammatorycytokine和chemokine表示上调查triptolide的效果在zymosan或triptolide的缺席或存在有教养。interleukin(IL)的版本-6,IL-8，和进文化上层清液的单核白血球chemoattractantprotein-1(MCP-1)与连接酶的immunosorbent试金被测量。细胞的许多为这些蛋白质的mRNAs被反向的抄写和即时聚合酶链反应分析决定。激活mitogen的蛋白质kinases(MAPK)和内长的原子factor-κ的phosphorylation；B(NF-κ；B)禁止者Iκ；B-α；被immunoblot分析检验。版本喂奶从HCF的脱氢酶(LDH)活动被测量，比色的assay.RESULTSTriptolide禁止了从在一个集中依赖者和时间依赖者举止的HCF的IL-6，IL-8，和MCP-1的导致zymosan的版本。它也在这些房间禁止了IL-6，IL-8，和MCP-1mRNA丰富的导致zymosan的起来规定。而且，triptolide稀释了MAPK的导致zymosan的phosphorylation细胞外的调整信号的kinase(英皇家空军之阶级最低之兵)，c6月NH2-terminalkinase(JNK)，和象Iκ的phosphorylation和降级一样的p38；B-α；。Triptolide没多半展出cytotoxicity因为HCFs.CONCLUSIONTriptolide由暴露于zymosan的HCF禁止了proinflammatorycytokine和chemokine生产，随这个行动被MAPK和NF-κ的抑制调停；B发信号小径。这混合物可能因此被期望限制煽动性的房间的渗入进与真菌的感染联系的角膜。

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