简介：新闻事件：2016年2月24日。26名在陕西省镇安县医院进行血液透析的患者被确认感染丙肝病毒。据有关部门初步调查，此次感染为医院医务人员违规操作所致。据了解，对26名已确诊的丙肝病毒感染者，医院将制订诊疗方案，对他们实行免费治疗。陕西省卫计委事件调查组已作出决定，对镇安县医院院长给予党内聱告，分管副院长给予行政记过处分，并免去二人职务。目前共有15人受到党纪政纪处分。

简介：Hearinglossisaconditionaffectingmillionsofpeopleworldwide.Conductivehearingloss(CHL)ismainlycausedbymiddleeardiseases.ThelowfrequencyareaisthepivotalpartofspeechfrequenciesandmostfrequentlyimpairedinpatientswithCHL.AmongvarioustreatmentsofCHL,middleearsurgeryisefficienttoimprovehearing.However,variablesuccessratesandpossibleneedsforprolongedrevisionsurgerystillfrustratebothsurgeonsandpatients.Nowadays,increasingnumbersofresearchersexplorevariousmethodstomonitortheefficacyofossicularreconstructionintraoperatively,includingelectrocochleography(ECochG),auditorybrainstemresponse(ABR),auditorysteadystateresponse(ASSR),distortionproductotoacousticemissions(DPOAE),subjectivewhispertest,andopticalcoherencetomography(OCT).Here,weillustrateseveralmethodsusedclinicallybyreviewingtheliterature.

简介：PolyomavirusBK（BKV）infectsupto90%ofthegeneralpopulation.Afterprimaryinfection,occurringearlyduringchildhood,astateofnon-replicativeinfectionisestablishedinthereno-urinarytract,withoutcomplicationsforimmunocompetenthosts.Inimmunocompromisedindividuals,particularlytransplantedpatients,asymptomaticBKVviremiaand/orviruriacanbeobserved.RenalgraftsmayalsobesourcesofinfectionasBKVpreferskidneysratherthanothersolidorgansfortransplantationsuchastheliver.ThemechanismbehindthehigherincidenceofBKVinfectioninkidneytransplantpatients,comparedtoliverorhearttransplantation,isunclearandtheprevalenceofBKVinfectioninnon-renalsolidorgantransplantshasnotbeenyetthoroughlyinvestigated.WeevaluatedtheprevalenceofPolyomavirusBKinfectionamonglivertransplantrecipients.APubMedsearchwasconductedusingthetermsBKVinfectionANDlivertransplantrecipients;BKVANDnon-renalsolidorgantransplant＊;BKVinfectionANDimmunosuppression;thesearchwaslimitedtotitle/abstractandEnglish-languagearticlespublishedfrom2000,toMarch2015.ElevenrelevantstudiessuggestthattheprevalenceofBKVviruriaand/orviremiaamonglivertransplantrecipientsislessthanthatreportedinkidneyorhearttransplantrecipients,exceptwhenchronickidneydisease（CKD）ispresentatthesametime.DataalsosuggestthatviruricandviremicpatientshavehigherlevelsofserumcreatininethanBKVnegativepatients.Moreover,nospecificimmunosuppressivedrugsareassociatedwiththeonsetofBKVnephropathy.ThecomorbidityoftransplantationandCKDcouldplayamajorroleinpromotingBKVreplication.

简介：Inthispaper,asystemofreaction-diffusionequationsarisinginanutrient-phytoplanktonpopulationsisinvestigated.Theequationsmodelasituationinwhichphytoplanktonpopulationisdividedintotwogroups,namelysusceptiblephytoplanktonandinfectedphytoplankton.Anumberofexistenceandnon-existenceresultsaboutthenon-constantsteadystatesofareactiondiffusionsystemaregiven.Ifthediffusioncoefficientoftheinfectedphytoplanktonistreatedasbifurcationparameter,non-constantpositivesteady-statesolutionsmaybifurcatefromtheconstantsteady-statesolutionundersomeconditions.

简介：AIM:ToinvestigateFusobacteriumnucleatum（F.nucleatum）abundanceincolorectalcancer（CRC）tissuesanditsassociationwithCRCinvasivenessinChinesepatients.METHODS:Theresectedcancerandadjacentnormaltissues（10cmbeyondcancermargins）from101consecutivepatientswithCRCwerecollected.Fluorescentquantitativepolymerasechainreaction（FQ-PCR）wasappliedtodetectF.nucleatuminCRCandnormaltissues.ThedifferenceofF.nucleatumabundancebetweencancerandnormaltissuesandtherelationshipofF.nucleatumabundancewithclinicalvariableswereevaluated.Fluorescenceinsituhybridization（FISH）analysiswasperformedon22CRCtissueswiththehighestF.nucleatumabundancebyFQ-PCRtestingtoconfirmFQ-PCRresults.RESULTS:ThemedianabundanceofF.nucleatuminCRCtissues[0.242（0.178-0.276）]wassignificantlyhigherthanthatinnormalcontrols[0.050（0.023-0.067）]（P<0.001）.F.nucleatumwasover-representedin88/101（87.1%）CRCsamples.TheabundanceofF.nucleatumdeterminedby2-ΔCTwassignificantlygreaterintumorsamples[0.242（0.178,0.276）]thaninnormalcontrols[0.050（0.023,0.067）]（P<0.001）.Thefrequencyofpatientswithlymphnodemetastaseswashigherintheover-abundancegroup[52/88（59.1%）]thanintheunder-abundancegroup[0/13（0%）]（P<0.005）.NosignificantassociationofF.nucleatumwithotherclinico-pathologicalvariableswasobserved（P>0.05）.FISHanalysisalsofoundmoreF.nucleatuminCRCthaninnormaltissues(mediannumber6,25th3,75th10vs2,25th1,75th5)（P<0.01）.CONCLUSION:F.nucleatumwasenrichedinCRCtissuesandassociatedwithCRCdevelopmentandmetastasis.

简介：BackgroundDeepsternawoundinfection(DSWI)aftermediansternotomyforcardiacsurgeryisoneofthemostcomplexandpotentiallylife-threateningcomplications.ItsverydifficulttotreatDSWI,andthereislackofagreementregardingthebesttherapystrategy.Thus,weaimedtosummarizeourexperiencesofsurgicaltreatmentforDSWI,inwhichsatisfactoryclinicalresultswereobtained.MethodsWeretrospectivelyanalyzed17caseswhosufferedfromDSWIaftercardiacsurgeryinourdepartmentfromJanuary2010toJune2015.Therewere8maleand9femalepatientswiththeiraverageageof62.7±9.5years(range42~75years).Allpatientsreceivedreservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflaps.ResultsTheaverageintervalbetweencardiacsurgeryanddiagnosedDSWIwas10.9±6.5days(range5~21days).Timeofvacuum-assistedsuctiondrainagewas11.6±4.8days(range5~15days)andwoundhealingtimewas27.3±7.2days(range23~35days).Allpatientshadanuneventfulpostoperativerecoveryandgoodwoundhealing.Follow-uptimewas33.7±13.3months(range8~74months).Norecurrentinfectionwasobserved.ConclusionsReservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflapsisasimpleandeffectivesurgicalstrategyforthetreatmentofDSWIaftercardiacsurgery.

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简介：在印度次洲的中央印度构造地区(CITZ)的更低的外壳的地震出现用magnetotelluric(MT)被调查数据。MT越过CITZ当模特儿，包括越过1938Satpura更低的外壳的地震震中的新抵抗力模型，表演低抵抗(<80Ωm)中间降低外壳并且推断小体积(<1vol%)在更低的外壳的大多数部分存在的水的液体。这与捕虏体和另外的地球物理的数据支持一起，占优势的brittle/semi-brittle降低外壳的流变学。然而，有被印射的2.2%-6.5%的更高的液体内容的本地深外壳的地区暗示高毛孔压力条件。上面的观察和在这个区域的重要种类率在更低的外壳中为易碎的失败提供有利条件(强壮/中等的岩石力量，中等温度，高毛孔压力和高种类率)。在中间降低外壳中的充满液体的衣袋可能由充当本地应力(液体压力)的来源催化地震产生，这能被推断，和地区性的压力，生产批评seismogenic应力调节它。或者，液体减少岩石的shear力量赞成能被转移到seismogenic差错触发地震的构造压力集中。

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简介：-thymosins,高度保存的肽的一个家庭，起一个重要作用在愈合创伤，angiogenesis，抗菌剂过程和抗病毒的免疫。三新奇-thymosin-repeat蛋白质，命名mjthm4，mjthm3和mjthm2，从抑制用表示顺序标签(EST)从Marsupenaeusjaponicus被克隆减少性的杂交。拥有的mjthm4，mjthm3和mjthm2cDNAs打开编码了166，128和90的读的框架氨基酸残余多肽并且包含了四，三和二-thymosin肌动朊绑定模块分别地。强风分析证明mjthm4，mjthm3和mjthm2与已知的无脊椎的多重复-thymosins分享了高相同。这些蛋白质无所不在地检验纸巾在所有被表示，并且transcriptional层次在肠是最高的。进一步的调查表明mjthm4，mjthm3和mjthm2是显著地起来调整的在WSSV感染以后的6h。而且当mjthm4transcriptional层次没显示变化时，mjthm3和mjthm2层次在病毒抵抗的虾减少了。结果显示mjthm4，mjthm3和mjthm2是新奇多重复-thymosin相当或相同事物，与WSSV感染有一种靠近的关系，并且可能贡献在虾的主人防卫或病毒侵略相互作用的更好的理解。

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简介：Background:Plateletrichplasma(PRP)therapyiswidelyusedinenhancingtherecoveryofskeletalmusclefrominjury.However,theimpactofintramusculardeliveryofPRPonhematologicandbiochemicalresponseshasnotbeenfullyelucidatedinexercise-inducedmuscledamage.ThepurposeofthisinvestigationtheeffectsofintramusculardeliveryofPRPonhematologicandbiochemicalresponsesandrecoverystrategymuscledamageinducedbyhighintensitymuscleexercise(exercise-inducedmuscledamage,EIMD).Methods:Moderatelyactivemalevolunteersparticipatedinthisstudyandwereassignedtoacontrolgroup(control,n=6)andPRPadministrationgroup(PRP,n=6).Thesubjectsperformedexercisewithaloadof80%onerepetitionmaximum(1RM)maximalvoluntarycontractionoftheelbowflexorsuntilpointofexhaustionofthenon-dominantarmwasreached.ThearmsweretreatedwithsalineorautologousPRPpost-24hEIMD.Venousbloodsampleswereobtainedinthemorningtoestablishabaselinevalueand1–4dayspost-exerciseandwereanalyzedforserumferritin,iron,ironbindingcapacity(IBC),creatininekinase(CK),lactatedehydrogenase(LDH),aspartateaminotransferase(AST),andalanineaminotransferase(ALT).Results:Thebaselinelevelsofplasmairon,ferritin,IBC,CK,LDH,AST,andALTweresimilarinboththecontrolandPRPgroups.However,24-hfollowingexerciseasignificantincreaseintheseparameterswasobservedinbothgroupsbetween1and4daysduringtherecoveryperiod.Interestingly,PRPadministrationdecreasedplasmaironlevelscomparedtothecontrolontheseconddaypost-exercise.PlasmaIBCincreasedinPRPgroupfromDays2to4post-exercisecomparedtothecontrolgroupwhilstPRPadministrationhadnoeffectonplasmaferritin,CK,AST,ALT,orLDH.Conclusion:Acuteexhaustiveexerciseincreasedmuscledamagemarkers,includingplasmairon,IBC,andferritinlevels,indicatingmuscledamageinducedbyexercise.PRPadministrationimprovesinflammationbyreversingtheincreaseintheironlevelspost-exercisewi

简介：Multiprotein桥因素2(MBF2)基因首先作为涉及Fushitarazu基因的BmFTZ-F1-mediated激活的激活剂被识别。此处，MBF2基因的九相应基因被识别。进化分析显示出那这个基因家庭是昆虫特定的并且家庭成员是仔细与对病原体(REPAT)的反应有关基因。织物分发分析表明这些基因能以一种织物特定的方式被表示。发展侧面分析证明MBF2基因家庭成员高度在不同阶段被表示。九MBF2家庭基因的表示模式的分析证明杆菌bombysepticus处理导致了几MBF2家庭基因的起来规定，包括MBF2-4，-7,-9,-8。而且，我们发现MBF2家庭基因被饥饿和在重新喂之上恢复的这些基因的表示调制，除了MBF2-5，-9。这些调查结果对病原体和滋养的新陈代谢在昆虫防卫为这些蛋白质建议了角色，它为设计害虫控制策略有重要指导意义。

简介：AIM:TodeterminetheassociationbetweenchlamydialconjunctivitisandgenitalinfectionbyChlamydiatrachomatis,MycoplasmagenitaliumandCandidaalbicans,inadditiontothepossiblerelationshipbetweenculturedbacterialpathogensandoculogenitalchlamydialinfection.METHODS:Thisstudywasperformedon100(50symptomaticand50asymptomatic)womenattendingtheGynecologicalandObstetricoutpatientclinicofAlzahrahospital,AlazharUniversity.Simultaneouslyaconjunctivalswabwastakenfromthesepatients.Polymerasechainreaction(PCR)wasdoneonDNAextractedfrombothvaginalandconjunctivalswabsamples.Cultureforbothvaginalandconjunctivalswabswasalsodone.RESULTS:Candidaalbicanswasthepredominantorganismisolatedbyculturein20%and40%ofconjunctivalandvaginalswabsrespectively.BythePCRmethod,ocularChlamydiatrachomatiswaspresentin60%ofsymptomaticwomen,whilegenitalChlamydiatrachomatisinfectionwaspresentin30%ofsymptomaticwomen.Theresultsofthismethodalsoindicatedthat25/50(50%)vaginalswabswerepositivewithPCRforCandidaalbicansversus15/50(30%)werePCRpositiveinconjunctivalswab.Mycoplasmagenitaliumwaspresentinonly10%ofvaginalswabs.ConcomitantoculogenitalPCRpositiveresultsforChlamydiatrachomatisandCandidaalbicanswere30%and28%respectively.CONCLUSION:OcularChlamydiatrachomatiswasassociatedwithgenitalChlamydiatrachomatisinahighpercentageofwomenfollowedbyCandidaalbicans.CulturedbacterialorganismsdonotplayaroleinenhancementofChlamydiatrachomatisinfection.

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简介：蚊子microRNAs(miRNAs)涉及主人病毒相互作用，并且被报导了被登革热改变在豹脚蚊albopictus的病毒(DENV)感染(双翅目：Culicidae)。然而，很少首先对豹脚蚊albopictusmidgut—the的分子的机制被知道在它的抵抗与DENV—involved交往到DENV的机关。这里，我们使用了描绘miRNA和送信人RNA(mRNA)的高产量的定序在响应登革热病毒serotype的豹脚蚊albopictusmidgut的表示模式2。三miRNAs和777mRNAs的一个总数被识别是在DENV感染之上表示的差别。为mRNAs，我们识别了198免疫者相关的基因，他们中的31个是表示的差别。基因和染色体丰富分析的基因本体论和京都百科全书也证明差别表示了免疫者相关的基因涉及有免疫力的反应。然后，六免疫者相关的基因和三miRNAs的微分表示模式被即时反向的抄写聚合酶链反应证实。而且，七已知的miRNA-mRNA相互作用对被排列我们的二数据集识别。miRNA和mRNAtranscriptomes的这些分析为揭开提供珍贵信息DENV反应基因并且在豹脚蚊albopictusmidgut为抵抗机制的未来学习提供一个基础。