简介:AbstractHidradenitis suppurativa (HS) is a chronic, inflammatory skin condition that poses a significant diagnostic and therapeutic challenge for clinicians, as the underlying etiology and pathogenesis remains unclear. The host of genetic mutations and immune dysfunction has been identified to be involved in the pathogenesis of HS during recent years. These genetic defects, including monogenetic mutations altering subunits of γ-secretase, a protease that functions through Notch signaling to maintain skin appendages, promote epithelial stability, suppress/terminate innate immune responses (ie, Toll-receptors), further have the propensity to induce aberrant cytokine responses that create to a proinflammatory environment, consequently induce hyperkeratosis and promote expression of pro-inflammatory, locally destructive matrix metalloproteinases. Cytokine-driven inflammation propagates the disease state of HS and contributes to the formation of painful subcutaneous nodules, abscesses, and eventually, fistulas and draining sinus tracts. A closer look at genetic mutations linked to the disease may explain the immune perturbations seen in HS. An understanding of the immune cells and inflammatory markers expressed in affected individuals provides insight into disease pathogenesis and can help identify therapeutic targets.
简介:Thispaperisdevotedtothestudyofsecondordernonlineardifferenceequations.ANonlocalPerturbationofaDirichletBoundaryValueProblemisconsidered.AnexhaustivestudyoftherelatedGreen'sfunctiontothelinearpartisdone.Theexactexpressionofthefunctionisgiven,moreovertherangeofparameterforwhichithasconstantsignisobtained.Usingthis,someexistenceresultsforthenonlinearproblemarededucedfrommonotoneiterativetechniques,theclassicalKrasnoselskifixedpointtheoremorbyapplicationofrecentfixedpointtheoremsthatcombineboththeories.
简介:这篇论文证明一个引起注意的人是的一条公理的Hausdorff尺寸在随机的不安下面稳定。
简介:这份报纸给有限维的无法缩减的操作员的概念((FDI)操作员)并且无限的维的无法缩减的操作员((IDI)操作员)。讨论关系(FDI)操作员,(IDI)操作员和强烈无法缩减的操作员((SI)操作员)并且说明操作员的三个班的一些性质。为有上面的三角形的操作员矩阵的形式的操作员的有限维的irreducibility的一些足够的条件被给。这份报纸证明有一个单条系列的每个操作符是小紧缩的不安一(FDI)在每围住的线性操作符T能被操作符接近在的可分离的Banach空格和表演(FDI)的操作员关于强壮操作员的拓扑学和每个紧缩的操作符K罐头的(X)由操作符接近了在(FDI)关于有一个Schauder基础的Banach空格X上的标准拓扑学的(X),在此(FDI)(X):={TB(X):T=i=1kTi,Ti(FDI),k}。
简介:Anewmethodforstructuraldamageidentificationispresentedbasedonperturbationsofcurvaturemodeshapeandfrequency.Firstly,thestructure'smassandstiffnessmatricesareexpressedasfunctionsofitselements'physicalparameters,whichreflecttheirdamagestates.Accordingtodifferencesinthecurvaturemodeshapeofthestructureinundamagedanddamagedstates,possibledamageequationsanddetermineddamageequationsareestablishedandusedtosolvefortheelements'damageparameters.Then,toensuretheaccuracyoftherecognitionresult,areasonablesolutionissubstitutedintoadamage-checkingequationbasedonthechangeoffrequencyofthedamagedstructure.Numericalexamplesareusedtoshowthat,toidentifythedamage,onlyoneordermodeneedstobetested.Whenthedegreeofdamageislow,first-orderperturbationequationscanbeusedtorecognizethedamagewithsufficientaccuracy.Iftheextentofthedamageishigh,second-orderperturbationequationscanbeusedtoprovidemoreaccurateidentificationresults.
简介:Weinvestigatetheorbitlossofalphaparticlesunderhelicalmagneticperturbationinatokamak.Theresultsshowthatlow-frequencyandlow-modenumbermagneticperturbationcancausestochasticlossofalphaparticles.Thiseffectissignificantforthoseparticlesclosetotheboundarybetweenthetransitzoneandthetrappedzone.Theparticlelossissensitivetothephaseofthemagneticperturbation,indicatingthemodulationoftheparticlelosswithrespecttomagneticperturbation.Itisalsofoundthattheprecessionoftheparticlebananaorbitcanevenfurtherenhancetheparticleloss.
简介:Thestabilityofsupplychainsystemiskeytoimplementefficientlyinventorypoliciesandimprovequalityofserviceinthesupplychain.Ifthesupplychainsystemwereunstable,thelead-timewouldbeuncertain.Asaresult,directlyaffectstheprocessofmanufacture,andtheservicelevel.Inthispaper,weanalyzethestabilityofthesupplychainsystemunderperturbationsofdynamicparametersbasedontheCobb-Douglasproductionfunctionandstudyinfluencesonsupplychainperformance.Weprovethatthesupplychainsystem,withtheincreasesofthere-productioninputfunding,becomesunstable.Further,whentheoptimalcombinationofinputparameterelements,thesupplychainsystembecomesunstable.
简介:Whethertheinitialconditionscontainpronouncedmesoscalesignalsisimportanttothesimulationofthesouthwestvortex.Aneastward-movingsouthwestvortexissimulatedusingthePSU/NCARMM5.Amodestdegreeofsuccessisachieved,butthemostseriousfailureisthattheformationanddisplacementofthesimulatedvortexinitsearlyphaseareaboutfourteenhourslaterthantheobservedvortex.Consideringtherelativelysparsedataonthemesoscalevortexandinanattempttounderstandthecauseoftheforecastfailure,anadjointmodelisusedtoexaminethesensitivityofthesouthwestvortextoperturbationsofinitialconditions.Theadjointsensitivityindicateshowsmallperturbationsofmodelvariablesattheinitialtimeinthemodeldomaincaninfluencethevortex.Alargesensitivityforzonalwindislocatedunder400hPa,alargesensitivityformeridionalwindislocatedunder500hPa,alargesensitivityfortemperatureislocatedbetween500and900hPa,andalmostallofthelargesensitivityareasarelocatedinthesouthwesternarea.Basedontheadjointsensitivityresults,perturbationsareaddedtoinitialconditionstoimprovethesimulationofthesouthwestvortex.Theresultsshowthattheinitialconditionswithperturbationscansuccessfullysimulatetheformationanddisplacementofthevortex;thewindperturbationsaddedtotheinitialconditionsappeartobeacyclonecirculationunderthemiddleleveloftheatmosphereinthesouthwesternareawithananticyclonecirculationtoitssouthwest;awatervaporperturbationaddedtoinitialconditionscanstrengthenthevortexandthespeedofitsdisplacement.
简介:Theflowstructuresinaseparatedshearlayeractuatedbyasyntheticjetactuatorwerestudiedusingexperimentalmethods.Whenforcedatafrequencymuchlowerthanthenaturalsheddingfrequency(fH/U=0.042orfX_r/U=0.24),theverticalflappingmotionoftheshearlayerdownstreamoftheseparationpointbecameprominent.Thesizeofthepeakinthepressurespectraattheforcingfrequency(St_A=f_AH/U)measuredneartheseparationpoint(x/H=1)increasedlinearlywiththeforcingamplitude(u′/U)suggestingalinearresponseofthepressurefluctuationstotheforcingbythesyntheticjet.ThelinearresponsedidnotholdforthepressurefluctuationsawayfromthejetexitasthemagnitudeofthepeakforSt_Ameasuredatx/H=3soonsaturatedwhentheforcingamplitudebecamelargerthan0.3.
简介:Ingraphene,conductanceelectronsbehaveasmasslessrelativisticparticlesandobeyananalogueoftheDiracequationintwodimensionswithachiralnature.Forthisreason,theboundingofelectronsingrapheneintheformofgeometriesofquantumdotsisimpossible.Ingaplessgraphene,duetoitsuniqueelectronicbandstructure,thereisaminimalconductivityatDiracpoints,thatis,inthelimitofzerodoping.Thiscreatesaproblemforusingsuchahighlymotivatednewmaterialinelectronicdevices.Oneofthewaystoovercomethisproblemisthecreationofabandgapinthegraphenebandstructure,whichismadebyinversionsymmetrybreaking(symmetryofsublattices).WeinvestigatetheconfinedstatesofthemasslessDiracfermionsinanimpuredgraphenebytheshort-rangeperturbationsfor"localchemicalpotential"and"localgap".Thecalculatedenergyspectrumexhibitsquitedifferentfeatureswithandwithouttheperturbations.Acharacteristicequationforboundstates(BSs)hasbeenobtained.Itissurprisinglyfoundthattherelationbetweentheradialfunctionsofsublatticeswavefunctions,i.e.,f_m~+(r),g_m~+(r),andf_m~-(r),g_m~-(r),canbeestablishedbySO(2)group.
简介:Asetofparameterscalledrelativeorbitalelementsweredefinedtodescribetherelativemotionofthesatellitesintheformationflying.Withthehelpoftheseparameters,theeffectoftheperturbationsontherelativeorbittrajectoryandgeometricpropertiesofsatelliteformationcanbeeasilyanalyzed.First,therelativeorbitalelementsarederived,andpointedout:iftheeccentricityoftheleadingsatelliteisasmallvalue,therelativeorbittrajectoryisdeterminedbytheintersectionbetweenanellipticcylinderandaplaneintheleadingsatelliteorbitframereference;andtheparametersthatdescribetheellipticcylinderandtheplanecanbeusedtoobtaintherelativeorbittrajectoryandtherelativeorbitalelements.Second,byanalyzingtheeffectsofgravitationalperturbationsontherelativeorbitusingtherelativeorbitalelements,itisfoundthatthepropagationofarelativeorbitconsistsoftwoparts:oneisthedriftoftheellipticcylinder;andtheotheristherotationoftheplaneresultedfromtherotationofthenormaloftheplane.Meanwhile,theanalyticformulaeforthedriftandrotationratesofarelativetrajectoryundergravitationalperturbationsarepresented.Finally,therelativeorbittrajectoryandthecorrespondingchangeswereanalyzedwithrespecttotheJ2perturbation.
简介:Pelletinjectionexperimentshavebeenwidelycarriedoutwithvarioustoroidalplasmas,peakeddensityprofileandimprovedconfinementarefrequentlyobserved,andsomeinterestingphenomenahavealsobeenfound.Oneofthemisthelong-livedm=1/n=1oscillationobservedonsoftX-rayemissionandotherdiagnostics(notablythemicrowaveinterferometersandtheECEsystems)afterpelletinjectioninJET,JT-60,
简介:作者作为为整体由使用barotropic预报提供起始的不安的一个工具使用有条件的非线性的最佳的不安(CNOP)的技术伪因地球自转而引起(QG)在一种完美模型的情形当模特儿。为中等范围(14天)的整体预报由起始的状态制造由CNOP和单个向量(SV)使不安。当分析错误是一种快成长错误时,13个不同盒子被选择了。我们的实验证明CNOP的介绍比SV方法提供更好的预报技巧。而且,传播技巧关系表明第一SV被CNOP在代替的整体样品比SV从到白天14的白天6获得的那些显得优异。等级图被采用把新方法与SV途径作比较。结果说明CNOP的介绍为中等范围的整体预报有更高的可靠性。
简介:Therehavebeenreportsformanyyearsthattheionosphereisverysensitivetoseismiceffects,andthedetectionofionosphericperturbationsassociatedwithearthquakes(EQs)attractsalotofattentionasaverypromisingcandidateforshort-termEQprediction.InthisreviewwepresentapossibleuseofVLF/LF(verylowfrequency(3-30kHz)/lowfrequency(30-300kHz))radiosoundingofseismo-ionosphericperturbations.Inordertoavoidtheoverlappingwithmyownpreviousreviews,wefirstshowsomepioneeringresultsfortheKobeEQandwetrytopresentthelatestresultsincludingthestatisticalevidenceonthecorrelationbetweentheVLF/LFpropagationanomalies(ionosphericperturbations)andEQs(especiallywithlargemagnitudeandwithshallowdepth),medium-distance(6-8Mm)propagationanomalies,thefluctuationspectraofsubionosphericVLF/LFdata(theeffectofatmosphericgravitywaves,theeffectofEarth’stides,etc.),andthemechanismoflithosphere-atmosphere-ionospherecoupling.Finally,weindicatethepresentsituationofthiskindofVLF/LFactivitiesgoingonindifferentpartsoftheglobeandwesuggesttheimportanceofinternationalcollaborationinthisseismo-electromagneticstudy.
简介:ByemployingthereductiveperturbationtechniquewederivedaKadomtsev-Petviashviliequationforunmagnetizeddustyplasmas.Itsuggeststhatthenonlineardustacousticsolitarywaveswithadiabaticvariationofdustchargearestableeventherearesomehigherordertransverseperturbatoins.Thereareonlyrarefactivesolitarywavesforthissystemwhichhasbeenverifiedanalyticallyinthispaper.