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84 个结果
  • 简介:AbstractBackground:Allergic rhinitis (AR) is characterized by mucosal inflammation that leads to a variety of symptoms, such as nasal congestion, rhinorrhea, and sneezing. This rhinitis is triggered by inhalation of allergens, such as pollen, and this condition has a negative impact on the quality of life. AR was shown to be associated with a number of co-morbidities, including hypothyroidism, asthma, and chronic sinusitis.Objective:This study aimed to assess AR-associated comorbidities in patients presenting symptoms and paranasal sinus computed tomography (CT) scan findings in Taif City, Saudi Arabia.Methods:This cross-sectional study evaluated medical and radiological records of AR patients retrospectively from the period of December 2018 to September 2019 in Al-Hada Armed Forces Military Hospital, Taif City, Saudi Arabia.Results:A total of 103 AR patients with a mean age of 39.0 ± 15.6 years with 55.3% males and 44.7% females. The three most common associated comorbidities in allergic rhinitis patients were chronic sinusitis (28.2%), hypothyroidism (21.4%), and asthma (8.7%). Nasal obstruction (30.1%) was the symptom most frequently presented by all patients. Mucosal thickening occurred most frequently in patients with associated chronic sinusitis, while bilateral osteomeatal complex obliteration was observed mostly in asthmatic patients, and bony boundary thinning was more prevalent among patients with associated hypothyroidism.Conclusion:The gender distribution of AR was 10% more common among males; however, the most common three comorbidites in allergic rhinitis patients were chronic sinusitis, hypothyroidism, and asthma, and most of those patients were females. Hypothyroidism can be a hidden predisposing factor for AR, while chronic sinusitis can be caused by AR due to secretion stasis or immune system activation.

  • 标签: Allergic Rhinitis Asthma Chronic Sinusitis CT scan Hypothyroidism Nasal obstruction Paranasal sinuses
  • 简介:AbstractPurpose:Iatrogenic coracoid and clavicle fracture is a known complication of drilling bone tunnels during anatomic coracoclavicular ligament reconstruction (ACCR). This study aims to measure the dimensions of coracoid process and clavicle in an Asian population to evaluate the suitability of drilling coracoid and clavicle tunnels for ACCR in Asians.Methods:Width measurements of 196 coracoids and 189 clavicles were obtained after reviewing all computed tomography (CT) scans of the shoulder performed over a 6 years period. Coracoid measurements were made on the CT slice which showed the maximum cross sectional width of the coracoid base. Medial to lateral measurements of the coracoid width were taken on an axial view, 4 mm above the identified junction of the coracoid base and glenoid base. Antero-posterior clavicle width was measured through a point directly above the midpoint of the coracoid and perpendicular to the long axis of the clavicle.Results:The overall mean coracoid width was 14.8 mm ± 2.54 mm (range 9.2-23.3 mm) and clavicle width was 17.1 mm ± 2.72 mm (range 11.1-25.3 mm).Conclusion:The Asian coracoid process is smaller than its Western equivalent. More research is required to validate this conclusion as no cadaveric studies with equivalent measurement techniques have been performed on Asians. Given the potentially narrower dimensions of the Asian coracoid process, extra precautions are required to minimize the risk of iatrogenic coracoid and clavicle fractures.

  • 标签: Coracoclavicular ligament reconstruction Coracoid process Clavicle Width
  • 简介:ImprovementofRadiologicalProtectionat600kVCockroft-WaltonGenerator¥ZhengHuazhi;ZhuHongbin;WangGuiling;LiZongqiang;SongWenJie;...

  • 标签:
  • 简介:Spallationtargetrepresentsoneofthemostchallengingcomponentsinacceleratordrivensystems(ADS)sinceitisthecomponentcouplingtheacceleratorandthesub-criticalcore.Itissubjectedtobombardmentofintenseprotonbeamandveryhighthermalloadinastrongradiationfield.TheirradiatedLBEtargetposesseverehandlingproblemsforthemaintenancestaffandotherscientistsduetoitsresidualactivity[1].ToassistthedesignofADS,thegeneralradiologicalsafetyaspectsoflead,lead-bismutheutectic(LBE)andtungstenspallationtargetwerestudiedwithMCNPX2.7code[2].Thespallationtargetwasirradiatedbya250MeV,10mAprotonbeamproducedbyalinearprotonaccelerator.Theneutronyield,neutronspectrum,residualproductionandtimeevolutionfortheirradiatedtargetwereanalyzed.

  • 标签: Designed China ADS
  • 简介:Accordingtothemostrecentepidemiologicaldata,theprevalenceofhypertensionrangedfromabout25%inChineselivingeitherinthemainlandorinTaiwanandKoreans,toapproximately40%inMongolians.Thecontrolrateofhypertensionwasabout35%inKoreansandJapanese,24%inMongolians,andlessthan10%inChinese.Fourplacebo-controlledtrialsinChinaunequivocallyprovedthatantihypertensivetherapymaypreventstrokeandothercardiovascularcomplicationsinhypertensionorpatientswithahistoryofstrokeortransientischemicattack.Fouractively-controlledtrialsinJapandidnotshowsignificantdifferencebetweenvariousclassesorcombinationsofantihypertensivedrugs.TwotrialsthatcomparedintensivewithlessintensivebloodpressurecontrolinelderlyJapanesehypertensivepatientsdidnotshowfurtherbenefitofcontrollingsystolicbloodpressuretoalevelbelow140mmHgincomparisonwithbloodpressurecontroltoalevelof140mmHgorabove.Thesetrialsthatcomparedvariousclassesofantihypertensivedrugsorintensivewithlessintensivebloodpressurecontroloftenhadsmallsamplesizeandhenceinadequatepowertodetectmodestormoderatebenefit.ThereisstillaneedforhighqualityoutcometrialdatainEastAsians.

  • 标签: HYPERTENSION EPIDEMIOLOGY OUTCOME trials EAST ASIAN
  • 简介:AbstractBackground:The importance of identifying osteoporotic vertebral endplate or/and cortex fracture (ECF), which primarily includes endplate fracture (EPF) and vertebral anterior cortex buckling, has been recognized. However, some old traumatic ECFs with healing process in the elderly may be mistaken as osteoporotic. This study analyzes the radiological features of traumatic EPF.Methods:This was a retrospective analysis of 194 spine trauma patients with 263 vertebral fractures (mean age: 42.11 ± 9.82 years, 118 males and 76 females). All patients had traumatic EPF identified by X-ray/CT/MRI.Results:The involved vertebra was mostly L1 (29.7%), followed by T12 and L2. Except EPFs involved both superior and inferior endplates (12.6%), only 1.9% involved inferior endplate alone, with the majority involved superior endplate. If each endplate was divided into five segments of equal lengths (from anterior to posterior: a1, a2, m, p2, p1), the most depressed point of superior EPFs was mostly at segment-a2 (approximately 45%), followed by segment-a1 (approximately 20%) or segment-m (approximately 20%), and very rarely at segment-p1. The upper 1/3 of anterior vertebral wall was more likely to fracture, followed by middle 1/3 of anterior wall. For posterior vertebral wall fracture, 68.5% broke the bony wall surrounding the basivertebral vain. 58.6%, 30.0%, and 11.4% of vertebral fractures had <1/5, 1/5-1/3, and >1/3 vertebral body height loss. As the extent of vertebral height loss increased, the chance of having both superior and inferior EPFs also increased; however, the chance of having inferior EPF alone did not increase.Conclusion:Traumatic EPF features are characterized, which may help the differentiation of traumatic and osteoporotic EPFs.

  • 标签: Spine Vertebral fracture Endplate Traumatic Vertebral cortex
  • 简介:Somestudieshavesuggestedthatearlysurgicaltreatmentcaneffectivelyimprovetheprognosisofcervicalspinalcordinjurywithoutradiologicalabnormality,butnoresearchhasfocusedonthedevelopmentofaprognosticmodelofcervicalspinalcordinjurywithoutradiologicalabnormality.Thisretrospectiveanalysisincluded43patientswithcervicalspinalcordinjurywithoutradiologicalabnormality.Sevenpotentialfactorswereassessed:age,sex,externalforcestrengthcausingdamage,durationofdisease,degreeofcervicalspinalstenosis,JapaneseOrthopaedicAssociationscore,andphysiologicalcervicalcurvature.Amodelwasestablishedusingmultiplebinarylogisticregressionanalysis.Themodelwasevaluatedbyconcordantprofilingandtheareaunderthereceiveroperatingcharacteristiccurve.Bootstrappingwasusedforinternalvalidation.Theprognosticmodelwasasfollows:logit(P)=-25.4545+21.2576VALUE+1.2160SCORE-3.4224TIME,whereVALUEreferstothePavlovratioindicatingtheextentofcervicalspinalstenosis,SCOREreferstotheJapaneseOrthopaedicAssociationscore(0–17)aftertheoperation,andTIMEreferstothediseaseduration(frominjurytooperation).Theareaunderthereceiveroperatingcharacteristiccurveforallpatientswas0.8941(95%confidenceinterval,0.7930–0.9952).Threefactorsassessedinthepredictivemodelwereassociatedwithpatientoutcomes:agreatextentofcervicalstenosis,apoorpreoperativeneurologicalstatus,andalongdiseaseduration.Thesethreefactorscouldworsenpatientoutcomes.Moreover,thediseaseprognosiswasconsideredgoodwhenlogit(P)≥-2.5105.Overall,themodeldisplayedacertainclinicalvalue.ThisstudywasapprovedbytheBiomedicalEthicsCommitteeoftheSecondAffiliatedHospitalofXi’anJiaotongUniversity,China(approvalnumber:2018063)onMay8,2018.

  • 标签: nerve REGENERATION SURGICAL prognostic model CERVICAL
  • 简介:AbstractPurpose:Fingertip injuries are common in industrial production activities as well as in domestic work. Loss of pulp hampers daily life activities. Functional and aesthetic aspects are important in fingertip reconstruction. The bone is usually exposed along with soft tissue loss. Therefore to reconstruct the pulp flap with adequate bulk is required.Methods:We reported a case series of 12 patients with the injury over the volar aspect of distal phalanx of the index or middle finger. In all cases, laterally based thenar flap was chosen. The flap donor site was closed primarily in most of cases, while 4 patients required skin graft. The flap was detached between 2-3 weeks. Functional assessment was done using static and dynamic 2-point discrimination and range of motion at each joint. The aesthetic outcome was assessed through questionnaire. The results were analyzed using the unpaired t-test (SPSS version 21).Results:Partial necrosis occurred in 2 cases while rest of flaps survived successfully. Static 2-point discrimination ranged from 6-10 mm, mean 8.6 mm; and dynamic 2-point discrimination ranged from 8-10 mm, mean 8.9 mm. The mean satisfaction score was (4.0 ± 0.55).Conclusion:Thenar flap is a good choice for reconstruction of the finger pulp as it provides the bulk with good functional and aesthetic outcome.

  • 标签: Finger injuries Finger pulp reconstruction Thenar flap
  • 简介:客观:调查创伤的有三个尖头的不足的外科的治疗的最佳的时间和过程。方法:从1984年5月到2004年9月,八个病人为创伤的有三个尖头的阀门不足经历了操作。所有病人,男性,从7~67年变老[中部:38年,意味着:(38。5±18。1)年]。在损伤和操作之间的间隔从1个月到20年[中部:19个月,意味着:(52.5±80.3)月)]。Inseven病人,有三个尖头的不足被归因在三个病人包括车辆事故弄钝胸损伤,另外的病人是一处stab创伤。诊断是证实的byechocardiography。在病人的外科手术前的心脏的功能作为纽约HeartAssociation(NYHA)班Ⅱ-Ⅳ被分类。在手术期间,有三个尖头的阀门的前面的传单完全或部分在所有病人由于索的破裂被乱摆。氏族的传单的索的破裂在一个病人被发现。前面的传单在二个病人被穿孔。Septalleaflet被缩回并且支持者到在二个病人的室的中隔。阀门修理为所有病人被打算。最后,阀门修理在3个病人成功地被执行,有三个尖头的代替在5个病人被执行。结果:没有早或迟了的死亡发生了。与follow-upthrough为7-129月的临床的表明和回响心动描记法[中部:39个月,平均数:(53.4±42.8)月],所有病人作为NYHA班Ⅰ被分类,没有任何changes.Conclusions:创伤的有三个尖头的不足的令人满意的治疗能被外科的治疗获得。更早的外科可以增加有三个尖头的阀门修理的可行性并且阻止恰好室的功能的恶化。

  • 标签: 手术治疗 三尖瓣不全 创伤 临床表现
  • 简介:lObjectiveTalar身体破裂是稀罕的并且有差的处理结果。学习是报导关上的talardomefractures.MethodsEight的长期的外科的治疗结果的这的目的关上了talar身体破裂,在我们的水平与小碎片cancellous螺丝钉或Herbert螺丝钉由开的减小和内部固定对待我损伤中心回顾地被分析。脚(antero以后、侧面、倾斜的看法)和脚关节的外科手术前、手术后的拍(antero以后,侧面并且榫眼看法)被获得。病人被跟随在上面放射学地并且机能上地(脚功能索引,FFI)在3以后,星期,6个星期,3个月,6个月然后annually.ResultsThere是五压碎破裂并且三砍破裂(二sagittal砍并且一个花冠砍),与5年的平均后续。没有早复杂并发症在这些病人被注意。迟了的复杂并发症在四个病人在talar身体的六个病人和osteonecrosis包括了subtalar/ankle关节的osteoarthrosis。在功能的评价以后,在5年以后的吝啬的FFI是104.63个点,更坏的结果在压碎损害和花冠被注意砍破裂。Sagittal砍破裂有对通过手术对待的talar身体破裂随后的复杂并发症是的好功能、放射学的outcome.ConclusionsLate不可避免尽管准确减小和僵硬固定被完成,因此,病人们应当关于不利结果被建议。尽管压碎和花冠砍,破裂有差的结果,sagittal损害在长期的评估上有好预后。

  • 标签: 手术治疗 骨折 剪切裂缝 股骨头坏死 并发症 治疗效果
  • 简介:ObjectivesPercutaneousballoonmitralvalvuloplasty(PBMV)isonewaytoimprovetherheumaticmitralstenosis.Howdoestheprocedureworkingravidaandfetusisnotveryclear.WeanalyzedtheeffectsandsafetyofPBMVoperationonpregnantpatientswithsevererheumaticmitralstenosis.MethodsEightpregnantpatientssufferingfromseveremitralstenosisunderwentfacilitatedPBMVoperationwithInoueballoon,andwerefollowedupfor(2.0±1.1)years.Contentsincludedoutcomeofpregnancy,infantgrowth,hemodynamics,echocardiography,cardiacfunction,mitralvalvesreplacementorrepeatvalvuloplasty.ResultsMitralvalvearea(MVA)before,oneweekandoneyearafterfacilitatedPBMVwere(0.84±0.21)cm2,(1.69±0.23)cm2and(1.51±0.24)cm2respectively.Thetransmitralpressuregradientdroppedfrom(22.1±4.7)mmHgto(9.9±3.1)mmHg(P<0.001)(1mmHg=0.133kPa).AfterfacilitatedPBMV,allpatientsshowedremarkableimmediatesymptomaticandhemodynamicimprovementwithoutseveremitralregurgitation.AllofthesepatientscouldmaintainNewYorkheartassociation(NYHA)ⅠorⅡfor(2.0±1.1)yearsaftertheoperation.TwopatientsdemandedinducedabortionconcerningabouttheteratogeniceffectofX-rayonfetus.Alltheothersixpatientscontinuedtheirgestationandhadfull-termcesareansectionwithoutcomplications.Theirnewbornsdevelopedhealthyandnormallytillnow.ConclusionsFacilitatedPBMVisafeasible,safeandeffectivedeviceforselectedpregnantpatientswithmitralstenosis.Theoperationiswelltoleratedbythefetus.

  • 标签: pregnancy MITRAL STENOSIS PERCUTANEOUS BALLOON MITRAL
  • 简介:AbstractPurpose:Traumatic brain injury (TBI) generally causes mortality and disability, particularly in children. Machine learning (ML) is a computer algorithm, applied as a clinical prediction tool. The present study aims to assess the predictability of ML for the functional outcomes of pediatric TBI.Methods:A retrospective cohort study was performed targeting children with TBI who were admitted to the trauma center of southern Thailand between January 2009 and July 2020. The patient was excluded if he/she (1) did not undergo a CT scan of the brain, (2) died within the first 24 h, (3) had unavailable complete medical records during admission, or (4) was unable to provide updated outcomes. Clinical and radiologic characteristics were collected such as vital signs, Glasgow coma scale score, and characteristics of intracranial injuries. The functional outcome was assessed using the King's Outcome Scale for Childhood Head Injury, which was thus dichotomized into favourable outcomes and unfavourable outcomes: good recovery and moderate disability were categorized as the former, whereas death, vegetative state, and severe disability were categorized as the latter. The prognostic factors were estimated using traditional binary logistic regression. By data splitting, 70% of data were used for training the ML models and the remaining 30% were used for testing the ML models. The supervised algorithms including support vector machines, neural networks, random forest, logistic regression, naive Bayes and k-nearest neighbor were performed for training of the ML models. Therefore, the ML models were tested for the predictive performances by the testing datasets.Results:There were 828 patients in the cohort. The median age was 72 months (interquartile range 104.7 months, range 2-179 months). Road traffic accident was the most common mechanism of injury, accounting for 68.7%. At hospital discharge, favourable outcomes were achieved in 97.0% of patients, while the mortality rate was 2.2%. Glasgow coma scale score, hypotension, pupillary light reflex, and subarachnoid haemorrhage were associated with TBI outcomes following traditional binary logistic regression; hence, the 4 prognostic factors were used for building ML models and testing performance. The support vector machine model had the best performance for predicting pediatric TBI outcomes: sensitivity 0.95, specificity 0.60, positive predicted value 0.99, negative predictive value 1.0; accuracy 0.94, and area under the receiver operating characteristic curve 0.78.Conclusion:The ML algorithms of the present study have a high sensitivity; therefore they have the potential to be screening tools for predicting functional outcomes and counselling prognosis in general practice of pediatric TBIs.

  • 标签: Pediatrics Traumatic brain injury Machine learning Support vector machine Random forest Logistic regression
  • 简介:男富饶上的精索静脉曲张修理的效果仍然保持争论。它将对有用决定了哪个人将从精索静脉曲张修理有益于大多数,并且在那些个人指向修理努力。为精索静脉曲张修理的预示的因素上的文学的详细评论用PubMedNLM数据库被执行。我们发现postvaricocelectomy精液参数的最好的预言者是外科手术前的精液参数。在精液参数的最大的改进与更大的精索静脉曲张在人被发现。当有争吵,更高的睾丸激素,更年轻的年龄和更大的睾丸尺寸时,在一些,研究在精液参数postvaricocelectomy为改进预言。一张诺模图被开发了基于外科手术前的精液参数,精索静脉曲张等级和这个人(www.fertilitytreatmentresults.com)的年龄预言postvaricocelectomy精液参数。有限数据一致地与更高的基线DNA破碎率在人处于DNA破碎率表明最大的改进。关于繁殖结果,更高的基线精子密度一致地为自然怀孕或帮助繁殖技术(艺术)怀孕率预言。另外,精索静脉曲张修理确实似乎为艺术的更侵略的形式减少需要。在结论,我们现在能开始使用象预言跟随varicocelectomy的修理以后的精液质量和富饶潜力的基线精液质量,精索静脉曲张等级和耐心的年龄那样的特定的参数。

  • 标签: 预言 预后 VARICOCELECTOMY 精索静脉曲张
  • 简介:Objective:Thepaperdiscussesrecentevidenceontheassessmentoflanguageoutcomesinchildrenwithhearinglossacquiringorallanguage.Methods:Researchemphasizesthatlanguagetestsmustbespecificenoughtocapturesubtledeficitsinvocabularyandgrammarlearningatdifferentdevelopmentalages.TheDiagnosticReceptiveandExpressiveAssessmentofMandarin(DREAM)wascarefullydesignedtobeacomprehensivestandardizedMandarinassessmentnormedinMainlandChina.Objective:Thepaperdiscussesrecentevidenceontheassessmentoflanguageoutcomesinchildrenwithhearinglossacquiringorallanguage.Methods:Researchemphasizesthatlanguagetestsmustbespecificenoughtocapturesubtledeficitsinvocabularyandgrammarlearningatdifferentdevelopmentalages.TheDiagnosticReceptiveandExpressiveAssessmentofMandarin(DREAM)wascarefullydesignedtobeacomprehensivestandardizedMandarinassessmentnormedinMainlandChina.Results:Thispapersummarizestheevidence-baseditemdesignprocessandvalidityandreliabilityresultsofDREAM.ApilotstudyreportedhereshowsthatDREAMprovideddetailedinformationabouthearingimpairedchildren’slanguageabilitiesandcanbeusedtoaidinterventionplanningtomaximizeprogress.Conclusion:DREAMrepresentsanexampleoftranslationalscience,transferringmethodsfromempiricalstudiesoflanguageacquisitioninresearchenvironmentsintoapplieddomainssuchasassessmentandintervention.ResearchonoutcomesinChinawilladvancesignificantlywiththeavailabilityofevidence-basedcomprehensivelanguageteststhatmeasureasufficientagerangeofskills,arenormedonMandarinspeakingchildreninmainlandChina,andaredesignedtocapturefeaturescentraltoMandarinlanguageacquisition.

  • 标签: Standardized LANGUAGE test LANGUAGE development OUTCOME
  • 简介:Objective: ToinvestigatethevalueoftranscranialDoppler(TCD)ultrasonographyinevaluatingtheoutcomeofseveretraumaticbraininjuryandtocorrelatetheTCDvalueswithintracranialpressure(ICP)andcerebralperfusionpressure(CPP)monitoring.  Methods: AprospectivestudywasconductedtoevaluatethecontributionofTCDultrasonographytoneurologicaloutcomeinaseriesof96severetraumaticbraininjurypatients.ThequantitativevariablesofTCDultrasonographyincludedthemeanbloodflowvelocityofthemiddlecerebralartery(MCA)andpulsatilityindexwithinthefirst24hoursofadmission.TheICPandCPPvalueswerealsorecorded.Outcomein6monthspostinjurywasevaluatedusingtheGlasgowOutcomeScale(GOS4-5wasconsideredas“good”andGOS1-3as“poor”).  Results: ThemeanbloodflowvelocityoftheMCAwaslargerthan40cm/sin30(51%)patientswithgoodoutcomewhereasitwaslessthan40cm/sin27(73%)patientswithpooroutcome(P<0.025).ThemeanPIincasesofgoodoutcome(34patients,57%)waslowerthan1.5whereasinpooroutcome(30patients,83%)washigherthan1.5(P<0.001).ThecorrelationsofICPandCPPtopulsatilityindexwerestatisticallysignificant(P<0.01).  Conclusions: TCDultrasonographyisvalidinpredictingthepatientsoutcomeof6monthsandcorrelatessignificantlywithICPandCPPvalueswhenitisperformedinthefirst24hoursofseveretraumaticbraininjury.

  • 标签: 重度颅脑损伤 超声波检测 疗效
  • 简介:Extensiveaneurysmsinvolvingtheascendingaorta,aorticarch,andthedescendingaortastandasatherapeuticdilemmainsimultaneousmanagementofmultiplesitesofpathologyoftheaorticarchandthedescendingthoracicaorta.Wesystematicallyreviewedaboutliteraturesofstentedelephanttrunkoperation(SET)identifiedthroughsearchesoftheelectronicdatabasesEMBASEandMedline,andaimedtosummarizestudiesofpatientsundergoingSETforextensiveaneurysms.Since1996,KatoMintroducedahybridtechniquebyusingstentedgraftimplantationtothedescendingaortafortreatmentofthoracicaorticaneurysmordissection.Ithasbeendescribeagoodoptionforextensivethoracicaorticaneurysmsandinafashionsimilartotheelephanttrunktechnique.

  • 标签: 支架技术 动脉瘤 MEDLINE 主动脉弓 躯干 大象
  • 简介:客观:借助于高分辨率图象分析(HRIA)预言食道的上皮的发育异常的结果。方法:无征状的成年人从Linxian县的Heshun公社在1983为食管的汽球细胞学被检查。93严重发育异常和食管的122温和发育异常被选择。借助于与电视照相机装备的一台Axiomat显微镜,在染色奶头的有鳞的上皮的中间的层的保存得很好的房间的100个正常原子核随机被检验。结果:93个cytologically诊断的严重发育异常盒子,24,14和7分别地在3,5和9年里进行了到癌。在另外的48个盒子中,发育异常仍然是马厩或regressed到正常。另外的盒子被用作控制。根据染色质特征,盒子的正确诊断被HRIA在75.0%完成(18/24),85.7%(12/14)并且(6/7)85.7%盒子检验了,分别地(P<0.001)。122cytologically诊断的温和发育异常,16,13和12个盒子分别地在3,5和9年里进行了到癌。另外的81个盒子仍然是马厩或regressed到正常。正确诊断被HRIA在93.8%做(15/16),76.9%(10/13)并且(10/12)833%盒子检验了,分别地(P<0.001)。结论:HRIA检验的染色质原子特征能预言癌症前期的损害的结果并且从non-progressor区别progressor。它能为chemo预防试用的效率的评估被用作代理人端点biomarkers。

  • 标签: ESOPHAGEAL neoplasms PRECANCEROUS LESIONS High resolution
  • 简介:AIM:Topredictthevisualoutcomeinpatientsundergoingmacularholesurgerybytwonovelthree-dimensionalmorphologicalparametersonopticalcoherencetomography(OCT):arearatiofactor(ARF)andvolumeratiofactor(VRF).METHODS:Aclinicalcaseserieswasconducted,including54eyesof54patientswithanidiopathicmacularhole(IMH).EachpatienthadanOCTexaminationbeforeandaftersurgery.Morphologicalparametersofthemacularhole,suchasminimumdiameter,basediameter,andheightweremeasured.Then,themacularholeindex(MHI),tractionalholeindex(THI),andholeformfactor(HFF)werecalculated.Meanwhile,novelpostoperativemacularhole(MH)factors,ARFandVRFwerecalculatedbythree-dimensionalmorphology.Bivariatecorrelationswereperformedtoacquireasymptoticsignificancevaluesbetweenthesteadybestcorrectedvisualacuity(BCVA)aftersurgeryand2D/3DargumentsofMHbythePearsonmethodwithtwo-tailedtest.Allsignificantfactorswereanalyzedbythereceiveroperatingcharacteristic(ROC)curveanalysisofSPSSsoftwarewhichwereresponsibleforvisionrecovery.ROCcurvesanalyseswereperformedtofurtherdiscussthedifferentparametersonthepredictionofvisualoutcome.RESULTS:Themeanandstandarddeviationvaluesofpatients'age,symptomsduration,andfollow-uptimewere64.8±8.9y(range:28-81),18.6±11.5d(range:2-60),and11.4±0.4mo(range:6-24),respectively.Steady-postBCVAanalyzedwithbivariatecorrelationswasfoundtobesignificantlycorrelatedwithbasediameter(r=0.521,P<0.001),minimumdiameter(r=0.514,P<0.001),MHI(r=-0.531,P<0.001),THI(r=-0.386,P=0.004),HFF(r=-0.508,P<0.001),andARF(r=-0.532,P<0.001).Othercharacteristicparameterssuchasage,durationofsurgery,height,diameterholeindex,andVRFwerenotstatisticallysignificantwithsteady-post-BCVA.Accordingtoareaunderthecurve(AUC)values,valuesofARF,MHI,HFF,minimumdiameter,THI,andbasediameterare0.806,0.772,0.750,0.705,0.690,and0.686,respectively.However,Steady-post-BCVAanalysiswithbivar

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