简介:Mobileplatformdevelopsrapidlyinrecentyears,withitsperformanceandcapacityincreasing.Alargenumberofvirtualrealityapplicationssuchas3Dsimulationandvisualizationhaveappearedonmobileplatform.However,duetorestrictions,suchasthelackofcomputingresourcesandthelimitednetworkbandwidth,thevirtualrealitysystemsonmobileplatformcouldnothavecomparableperformanceastheirpeersondesktopplatform.Takingresourcerestrictionsintoconsideration,trade-offshavebeenmaderegardingthedisplayofvirtualrealitysystems.Weproposeaunifiednetworkschedulingstrategybasedonasynchronousmulti-thread,databasecache,prioritizationandeliminationofoverduerequests.ThisstrategyhasbeentestedontheprototypesystemofvirtualrealitysystemonAndroid.Theresultsdemonstratehighernetworkresourceutilizationandbetteruserexperience.
简介:Multiplesclerosisisachronicinflammatorydiseasethatisaccompaniedbydemyelinationandaxonaldamageresultinginneurologicaldeficits.Remyelinationisthenaturalendogenousrepairmechanismofdemyelinatedaxonsanditissupposedtoprotectaxons/neuronsfromdegenerationandthusthepatientfromprogressivedisability(FranklinandFfrench-Constant,2008).Currenttherapeuticsforpatientswithmultiplesclerosis
简介:<正>Theinitiationofthe"SilkRoadEconomicBeltandthe21st-CenturyMaritimeSilkRoad"strategy("BeltandRoad"strategy)inthefallof2013haspromotedboththeoffshoreandmaritimedevelopmentbetweenChinaanditsneighbors.Inthebeginningof201S,theChineseGovernmentofficiallyannouncedtheimplementationofthe"BeltandRoad"strategy.Asaninternational-
简介:Brainischemicstrokeistheleadingcauseoflong-lastinginjury,disability,anddeathinadults.Althoughthebrainrepresentsonlyabout2%ofthetotalbodymass,itconsumesalmost20%ofthebody’soxygen.Asaresult,braincellsareextremelysensitivetohypoxia.Oncecerebralischemiaoccurs,thecoreofthe
简介:Weinthispaperexaminewarrantystrategyinatwo-stagesupplychainconsistingofamanufacturerandtwocompetingretailers.Themanufacturerproducestwosubstituteproductsandmarketsthemthroughthetworetailerstoagroupofconsumers,respectively.Foreachtypeofproducts,themanufacturer’sbasewarrantyandaretailer’sextendedwarrantyarebundledwiththeproduct.Weusegametheoreticmodelstoexploretheinteractionsbetweenthetwotypesofwarrantiesandthecompetitionbetweentheretailers.Forthispurpose,twoscenariosareconsidered:noretailerandboththetworetailersprovidingtheextendedwarranties,respectively.Ineachscenario,themanufacturer’sbasewarrantiesareassumedtobeoffered.Ourresultsshowthatwhentheretailersoffertheirextendedwarranties,themanufacturerhasnoincentivetoofferthebasewarranties;otherwise,themanufacturerhastoprovidethebasewarranties.Thecompetitionbetweenretailersintermsoftheproductsubstitutabilityhasnoimpactonwarrantydecisions,butaffectsallplayers’profitsinthesupplychain.Themanufacturercanprovidealongerwarrantylengthandhighercustomerwelfaretoacustomerthantheretailersdo,ifitismoreefficientthantheretailersinwarrantycost-efficiency,andviceversa.
简介:BackgroundComparedtoclopidogrel,Ticagrelorsignificantlyreducestheriskofcardiovasculareventsinpatientswithacutemyocardialinfarction(AMI)howeverincreasestheincidenceofbleedingandtheriskoffatalintracranialhemorrhage.Inthisstudy,wescreenedtheAMIpatientswithclopidogrelresistence,anddeterminedwhetherticagrelorsequentialtherapycouldreducetheriskofcardiovasculareventsandbleedingrisk.MethodsAtotalof319AMIpatientswereenrolledinthisprospectiveclinicalstudy.Theplateletinhibitionratesinadenosine5'-diphosphate(ADP)pathwaysweremeasuredbyathrombelastography(TEG)system.ThepatientswithclopidogrelresistanceweredividedintoTicagrelorsequentialtherapygroup(ticagrelorfor3monthsandclopidogrelfor9months,n=143)andClopidogrelgroup(clopidogrelfor12months,n=176).Theriskofmajoradversecardiacevents(MACE)andthesafetyendpointsat1-yearfollow-upwereanalyzed.ResultsTheratesofstentthrombosis(ST)(2.1%vs.8.0%,P=0.017)orMI(2.8%vs.10.2%,P=0.009)werelowerintheticagrelorsequentialtherapygroupthanintheclopidogrelgroup.Dyspneawasmoreoftenintheticagrelorsequentialtherapygroupthanintheclopidogrelgroup(17.5%vs.4.5%,P<0.001).Nosignificantdifferenceintherateofmajorbleedingwasfoundbetweenthegroups(3.4%vs.3.9%,P=0.528).ConclusionsInAMIpatientswithhyporesponsivenesstoclobidogrelticagrelorsequentialtherapygroupsignificantlydecreasedtheratesofSTandMIwithoutincreasedriskofmajorbleedingascomparedwithclopidolgrel.