简介：从轻散布光谱学(LSS)察觉上皮的发育异常是一个反的问题，它能被转变成上皮房间的原子核的尺寸分发的倒置。为上皮房间的原子核基于单个极化的LSS的模拟，Chahine算法被采用检索尺寸分发。数字结果证明那个Chahine算法有高倒置精确为达到顶点单人赛并且bimodal当模特儿，它暗示潜力增加LSS的诊断分辨率。科技的南京大学的年轻学者基础部分支持的CLC数字R318.51(资助没有。NJUST200204）

简介：TheDNAcontentandmorphometricfeaturesofhepatocellularcarcinoma(HCC)andlivercelldysplasia(LCD),includingnucleararea,nuclearperimeter,nuclearmaximumdiameterandnuclearcirclediameter,werequantitativelydeterminedbymeansofimageanalysistechnology.Theresultsshowedthatincomparisonwithnormalhepatocytes,LCDhadamarkedlyincreasedDNAcontentandnuclearmorphometricparameters,butthevalueswerelowerthanthoseforHCC.LCDshowedaslightincreaseinnuclearatypiarepresentedbythenuclearirregularindex,whichwasalsolessthanHCC.ThefindingsindicatethatLCDmaybeaprecaneerouslesionofHCC,tothecellsinanabnormalproliferativestate.

简介：客观：借助于高分辨率图象分析(HRIA)预言食道的上皮的发育异常的结果。方法：无征状的成年人从Linxian县的Heshun公社在1983为食管的汽球细胞学被检查。93严重发育异常和食管的122温和发育异常被选择。借助于与电视照相机装备的一台Axiomat显微镜，在染色奶头的有鳞的上皮的中间的层的保存得很好的房间的100个正常原子核随机被检验。结果：93个cytologically诊断的严重发育异常盒子，24,14和7分别地在3，5和9年里进行了到癌。在另外的48个盒子中，发育异常仍然是马厩或regressed到正常。另外的盒子被用作控制。根据染色质特征，盒子的正确诊断被HRIA在75.0%完成(18/24)，85.7%(12/14)并且(6/7)85.7%盒子检验了，分别地(P<0.001)。122cytologically诊断的温和发育异常，16,13和12个盒子分别地在3，5和9年里进行了到癌。另外的81个盒子仍然是马厩或regressed到正常。正确诊断被HRIA在93.8%做(15/16)，76.9%(10/13)并且(10/12)833%盒子检验了，分别地(P<0.001)。结论：HRIA检验的染色质原子特征能预言癌症前期的损害的结果并且从non-progressor区别progressor。它能为chemo预防试用的效率的评估被用作代理人端点biomarkers。

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简介：Objective:Gastriccancer(GC)isoneoftheleadingcausesofdeathinChinaandotherAsiancountries.Recently,gastricendoscopyhasbecomethemainapproachforGCscreening,buttheidentificationofhigh-riskindividualsremainsachallengeinGCscreeningprograms.Methods:Therewere7,302patientswithchronicgastritisinvolvedinthisstudy.Endoscopicexaminationswereperformed,andtheirdemographiccharacteristicsandlifestyledatawerecollected.EachpossibleassociatedfactorofGC/premalignantandprecursorlesionswasevaluatedbyunivariateandmultivariatelogisticregressions.Nomogramswereusedforvisualizationofthosemodels,andreceiveroperatingcharacteristic(ROC)curveanalysiswasusedtopresentthepredictiveaccuracy.Results:Wedetected8(0.11%)gastricadenocarcinomas,17(0.23%)dysplasiacases,14(0.19%)hyperplasiacases,52(0.71%)intestinalmetaplasiacases,217(2.97%)inflammatorylesions,141(1.93%)gastriculcers,10(0.14%)atrophicgastritiscases,1,365(18.69%)erosivegastritiscases,and5,957(81.58%)superficialgastritiscasesin7,302patients.Theage(P<0.001),gender(P=0.086),laborintensity(P=0.018)andleekfoodintake(P=0.143)wereidentifiedasindependentpredictivefactorsofGC/premalignantlesionspossibility.Thecorrespondingnomogramexhibitedanareaunderthecurve(AUC)[95%confidenceinterval(95%CI)]of0.82(0.74–0.89)forthemodelinggroupand0.80(0.75–0.85)forthevalidationgroup.Theage(P=0.002),gender(P=0.024),smoking(P=0.002)andleekfoodintake(P=0.039)wereindependentpredictivefactorsofprecursorlesionspossibility.ThecorrespondingnomogramexhibitedanAUC(95%CI)of0.62(0.60–0.65)forthemodelinggroupand0.61(0.59–0.63)forthevalidationgroup.Conclusions:WeidentifiedseveralpotentialassociatedfactorsandprovidedapreclinicalnomogramwiththepotentialtopredictthepossibilityofGC/premalignantandprecursorlesions.

简介：Objective:Toevaluatetheoutcomeoftotalhiparthroplasty(THA)withcementlesscupsandfemoralheadautograftsforpatientswithhipdysplasiaandosteoarthritis.Methods:Between1995and2002,weimplanted23cementlesscupsandfemoralheadautograftsin20patientswithhipdysplasiaandosteoarthritis.Inthisstudy,aretrospectivestudywasmadeon21hipsin20patients(18femalesand2males,aged50yearsonanaverage)withdevelopmentalhipdysplasiatreatedbyTHAwithacementlesscupandfemoralheadautograft.Theacetabularcupwasplacedatthelevelofthetrueacetabuinmandallthepatientsrequiredautogenousfemoralheadgraftsduetoacetabulardeficiency.Theaveragerateoftheacetabularcupcoveredbythefemoralheadautograftwas31%(rangingfrom10%to45%).Eighthipshadlessthan25%cupcoverageandthirteenbetween25%and50%.Theaveragefollow-upperiodwas4.7years(range,1-8years).ThereplacingoutcomewasevaluatedbymodifiedHarrishipscore.Preoperativeandfollow-upradiographsweremade.Results:Alltheautograftswereunitedtothehostbones.Noautograftwascollapsedornocomponentfromthehipwasloosedinallthepatients.AccordingtothemodifiedHarrishipscore,theaveragehipscoreincreasedfrom46beforeoperationto89atthefinalreview.Beforeoperation,theleg-lengthdiscrepancywasgreaterthan2cminallthepatientsexceptonewithbilateralhipdysplasia.Afteroperation,only2outof20patientshadaleg-lengthdiscrepancygreaterthan1cm.Threehipsshowedminorboneresorptioninthelateralportionofthegraft,whichdidnotsupportthecup.ThreehipsdevelopedGrade1BrookerheterotopicossificationandonedevelopedGrade2.Conclusions:THAwithacementlesscupandafemoralheadautograftforpatientswithosteoarthritisresultedfromhipdysplasiacanresultinfavorableoutcomes.Thismethodcanprovidereliableacetabularfixationandrestoretheacetabularbonestockinpatientswithdevelopmentalhipdysplasiawhenthe

简介：Arrhythmogenicrightventriculardysplasia/cardiomyopathy(ARVD/C)ischaracterizedbyfibro-fattyreplacementoftherightventricle.However,thefeasibilityandsignificanceofmyocardialfibrosisdetec-tedbydelayedenhancement(DE)using3.0Tmagneticresonanceimaging(MRI)in.ARVD/Cisseldomlystudied.MethodsTwenty-sevenconsecutivepatientswereprospectivelyevaluatedforARVD/C.Magneticreso-nanceimagingwasperformedona3.0Tscanner.Tenminutesafterintravenousadministrationof0.2mmol/kgofgadodiamide,DE-MRIwasobtained.DiagnosisofARVD/CwasbasedupontheTaskForcecriteriaandin-cludedMRIfindings.ResultsSeventeen(59%)of27patientsmettheTaskForcecriteriaforARVD/C.Rightven-tricleDEwasfoundinall(100%)ARVD/Cpatientscomparedwithnone(0%)ofthe10patientswithoutARVD/C(P<0.001).AdditionalleftventricularDEwasfoundin8/17ARVD/Cpatientswhilewithoutleftventricularmor-phologicalandfunctionalabnormalitiesdetectedbyechocardiographyorMRI.ConclusionsDEusing3.0TMRIcouldeffectivelydetectmyocardialfibrosisintherightandleftventricularmyocardiuminARVD/Cpatients.DetectionofmyocardialfibrosismayhaveanimportantclinicalsignificanceinARVD/Cdiagnosis.Histologicalleftventriclein-volvementmaybeeasilymissedbyechocardiography.

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简介：AbstractIntroduction:While majority of infants with bronchopulmonary dysplasia (BPD) can be discharged home without low flow oxygen or on supplemental low flow oxygen, some require long term home mechanical ventilation.Case presentation:We present a case of an extremely premature infant with severe bronchopulmonary dysplasia who was successfully managed at home on a new feature of non-invasive ventilation called average volume assured pressure support (AVAPS) without the need for tracheostomy. The AVAPS feature enables the machine to deliver a consistent tidal volume by automatically adjusting the inspiratory pressure within a set range.Conclusion:The use of AVAPS feature in our case improved ventilation as indicated by a more stable gas exchange profile, making home non-invasive ventilation a more practicable method of managing severe BPD in this infant.