简介:AbstractPhenuiviridae, a member of the Bunyavirales order, can lead to significant human morbidity and mortality. Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon (IFN). Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs, and viral nonstructural proteins (NSs) had been further identified as an IFN antagonist. This study found that the NSs proteins of Dabie bandavirus (DBV), Sandfly fever Sicilian virus (SFSV), and Uukuniemi virus (UUKV) can inhibit Sendai virus-induced activation of IFN-β promoter and phosphorylation of IFN regulatory factor 3 (IRF3). Moreover, detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I (RIG-I) and degrade it via a proteasome-dependent pathway. In short, this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity, which may help understand these pathogens and suggest novel therapeutic approaches.
简介:摘要:近年来,物探采集技术向“单点、高密度、大道数”方向发展,对地震数据质量的要求也愈来愈高。伴随着地震采集设备的技术进步,新一代节点仪器系统正日新月异更新换代,替代有缆仪器在大多数石油地震勘探项目中广泛使用。随之而来的质量控制需要技术人员严格管理,才能达到生产要求。本文将探讨I-Nodal节点仪器在生产工作中质量控制的流程和方法,供同行参考。
简介:摘要:本文阐述机场行李输送设备智能目的地编码小车系统中现场底层网络AS-I总线的应用。通过AS-I网络安全回路的设计来实现系统封闭式运行,提高设备使用上的安全性。
简介:摘要:烟气在线监测系统(简称CEMS系统)是火电厂排污控制的基础工作与数据来源,是电厂进行废气污染物控制的运行与管理依据。准确可靠的环保监测数据是环境监督执法与总量减排核算体系的组成部分,在环境保护工作中有着举足轻重的地位和作用。受限于CEMS系统与DCS系统之间相对独立,环保数据的小时均值长久以来只能在CEMS系统上位机的报表软件中查看,DCS系统只能实时监控瞬时数据,而环保标准针对的是氮氧化物、二氧化硫、烟尘浓度的小时均值,这就给运行监盘人员带来了不可控性。目前我厂CEMS系统PLC通讯端口已用于同上位机的通讯,无法通过通讯的方式同DCS系统建立数据链接。
简介:摘要:本文对2022年的高考数学试卷进行分析,从试题背景素材,立意开放创新,对学生引导等方面论述了试题的变化,并依此提出了自己的看法和意见
简介:摘要:《普通高等学校本科外国语言文学类专业教学指南》指出商务英语专业学生应具备在商务背景下进行跨文化交流能力。《综合商务英语I》作为专业基础课程,需要有限的课时内统筹兼顾夯实学生语言基本功和培养跨文化交流能力。在我校“ETC”人才培养模式的方针指导下,本研究旨在探索如何在本门课程教学改革中实现培养学生跨文化交流能力的教学目标。
简介:AbstractSchatzkter type-I tibial plateau fracture is a split fracture of the lateral tibial plateau in sagittal plane, consequent to valgus impaction caused by low velocity of trauma. However, a deep understanding of the different columns of the tibial plateau and patho-mechanisms of the injury led to the unmasking of atypical fractures around the tibial plateau. We have encountered 2 cases with unusual fracture pattern of the lateral tibial condyle caused by road traffic accidents. The fracture pattern and severity of injury deviate from the original description of Schatzker type 1; in view of dual plane split, there is rotation of the posterolateral column fragment along its sagittal plane plus grade-III medial collateral ligament injury. The patients were initially treated with knee spanning external fixator and after a latency of 5 days, definitive fracture specific fixation was done, combined with repair of grade-III medial collateral ligament injury. At the 6 months follow-up both the patients achieved satisfactory knee functions (knee society score case 1:100 and case 2: 92) and returned to their jobs. The severity of fracture pattern and displacement as described should prompt for examination of associated ligament injury. Because of timely diagnosis, early and appropriate care promised an excellent function outcome even in such a severe nature of knee injury. To prompt the description of injury pattern we coined the name "dual split and dislocation" of lateral tibial plateau, as a complex injury variant of split fracture of lateral tibial plateau fracture.
简介:摘要分化型甲状腺癌(DTC)患者在规范的手术、选择性131I治疗、TSH抑制治疗下多数预后良好。131I治疗目标分为清甲治疗、辅助治疗及清灶治疗,其可完善疾病分期、便于随诊、降低疾病复发及死亡风险,但临床实践中仍在存诸多待明确的问题,如术后131I治疗前评估中,亚临床病灶判断困难,且无用以指导治疗的Tg临界值,增加了辅助治疗的决策难度;治疗后随诊中,尚无评价结构性病灶131I治疗疗效的标准;TgAb的存在会影响病情判断;131I累积剂量相关并发症亦需监测管理。本期重点号刊登了数篇DTC患者131I治疗相关的文章,多方位讨论了当下131I治疗中的难点和我国学者的探索。