简介：AbstractBackground:Leukocyte telomere length shortening is a characteristic of premature senescence, a process that can be accelerated by oxidative stress. In general, patients with end-stage renal disease undergoing regular hemodialysis (HD) are repeatedly exposed to oxidative stress. Patients undergoing HD tend to have cardiovascular diseases associated with oxidative stress and inflammation. Therefore, we assumed that telomere length is associated with HD vintage and the degree of vascular calcification.Methods:A total of 144 patients undergoing regular HD before kidney transplantation and 62 patients on hemodialysis, but not undergoing kidney transplantation, were enrolled. We measured common laboratory values, such as calcium, phosphate, and hemoglobin levels, and assessed the degree of vascular calcification in the patients. The leukocyte telomere length was measured using reverse transcription polymerase chain reaction, and Spearman correlation was used for correlation analysis.Results:The leukocyte telomere length was negatively associated with age (rho = -0.306, P <0.01); it was shorter in middle-aged patients than in young patients (13.48 ± 4.80 vs. 15.86 ± 4.51, P < 0.01). The telomere length was significantly different among patients aged 52-74 years in groups with different HD vintages. Additionally, the telomere length was positively associated with serum hemoglobin (Hb) levels in all patients (rho = 0.290, P < 0.01). There was a significant difference among patients divided into three groups according to the degree of anemia (17.09 ± 5.64 vs. 14.40 ± 4.07 vs. 13.99 ± 3.95, P < 0.01). Further, a significant difference was observed in the telomere length among patients with different degrees of vascular calcification (16.79 ± 4.91 vs. 13.61 ± 2.82 vs. 14.62 ± 3.63 vs. 10.71 ± 3.74, P < 0.01). The telomere length was shorter in the patients on hemodialysis who did not receive a kidney transplant than in the surgical patients (8.12 ± 1.83 vs. 14.33 ± 4.63, P < 0.01).Conclusion:This study demonstrated that the telomere length was significantly correlated with HD vintage in patients of a certain age group. The telomere length was shorter in patients on hemodialysis who matched for age and dialysis vintage with kidney transplant patients. It was also associated with vascular calcification and serum Hb levels in all patients undergoing HD.

简介：识别北半球(NH)温度重建和仪器的数据过去的1000年证明气候在最后千年includeslong术语趋势和各种各样的摆动变化。二个长期的趋势和quasi-70-year摆动在全球温度系列被检测最后140年和NH千年系列。一个重要特征被强调那温度慢慢地减少，但是它基于不同系列的分析很快增加。好处能从理解各种各样的长期的趋势和摆动气候变化被获得。从自然气候系统和非线性的模型系统的时间序列的千年的温度代理在理解自然气候变化并且认识到由使用小浪的方法的潜在的好处转变分析被使用。从主要摆动在数值解释包含了在上的数字当模特儿的表演的结果内部十的时间规模与自然代理的一致。看起来，在气候变化的这些摆动直接没作为外部强迫与太阳辐射被连接。这调查可以断定在interdecadaltimescale的气候可变性强烈在气候系统取决于内部非线性的效果。

简介：ThreekindofapplicationofADCPisreportedforlong-termmonitoringincoastalsea.(1)Therourinemonitoringofwaterqualities.ThewaterqualityandADCPechodata(600kHz)observedinthelong-termareanalgzedatMT(MarineTower)StationofKansaiInternationalAirportintheOsakaBay,Japan.Thecorrelationbetweentheturbidityandechointensityinthesurfacelayerisnotgoodbecauseairbubblesgeneratedbybreakingwavearenotdetectedbytheturbiditymeter,butdetectedwellbyADCP.Whenestimatingtheturbidityconsistsofplanktonpopulationfromechointensity,theeffectofbubbleshavetobeeliminated.(2)Monitoringstirringupofbottomsediment.ThespecialobservationwascardedoutbyusingfollowingtwoADCPintheOsakaBay,OneADCPwasinstalledupwardonthesea.TheotherADCPwashangeddownwardatthegatetypestandabout3mabovefromthebottom.Atthespringtide,highechointensitiesindicatingthestirringupofbottomsedimentwereobserved.(3)Themonitoringfortheboundaryconditionofwatermixingatanestuary.Insummerseason,theADCPwassetatthemouthofTanabeBayinWakayamaPrefecture,Japan.Duringtheobservation,watertemperaturenearthebottomshowedremarkablefallswithintervalofabout5～7d.Whenthebottomtemperaturefell,theinflowcurrentwithlowechointensitywaterappearsatthebottomlayerintheADCPrecord.Itisconcludedthatwhenoccasionalweaknortheastwindmakesweakcoastalupwellingatthemouthofthebay,thecombinationofupwellingwithinternaltidalflowcausesremarkablewaterexchangeanddispelstheredtide.

简介：AgroupofCanadianphysiciansreportssuccessinthelong-termcontroloftreatment-resistantdepressionbyusingdeepbrainstimulation,buttheyacknowledgethatlongerandlargertrialsarestillneeded.

简介：Objective:Toobservethelong-termeffectofhomoharringtonine(HHT)onchronicgranulocyticleukemia(CGL)anditspharmacologicalmechanism.Methods:76patientswithnewlydiagnosedearlychronicphaseCGLreceivedtreatmentofmerely1.5mg/m2dailyHHTforinductionremissionandlong-termmaintenancetreatment.TheapoptosisrateofbonemarrowCD34+cellsinducedbyHHTwasassayedwithflowcytometer.Results:86.8%patientsachievedCHR,13.2%patientsPHRand31.8%patientsgotcytogeneticresponseinHHTtreatmentgroup,whichwaslongerthan31(8-54)monthsinhydroxyurea(HU)group(P<0.05).TheeffectofapoptosisinductionHHTwasstrongeronCGL-CPpatientsbonemarrowCD34+cellsthanonnormalpersonbonemarrowCD34+cells.Conclusion:HHTisaveryeffectivedrugforremissioninductionandlong-termmaintenancetreatmentinearlychronicphaseCGLpatients.

简介：Thisarticleexplorespopulationlong-termbalanceddevelopmentfornationaldefenseaccordingtothestrategicgoalssetatthe18thNationalCongressoftheCommunistPartyofChina.Threemajorissuesarediscussed.Firstly,theconceptandconnotationofthelong-termequilibriumdevelopmentofnationaldefensepopulationaredefined,inwhichpopulationlong-termequilibriumisequaltopopulation'longtermsafety'includingqualitybalance,quantitybalanceandpopulationstructureequilibrium.And'quantityequilibrium'needstobeconsideredinbothabsoluteandrelativeterms.Secondly,the'non-equilibrium'situationofnationaldefensepopulationisexaminedfromtheperspectiveofqualityandquantity.Thirdly,policysuggestionsinpromotingthenationaldefensepopulationequilibriumareproposedwithregardtopopulationregulation,humanresourcedevelopmentandsocialsecurity.

简介：TheNorthChinaPlain(NCP)isthemostimportantfoodgrainproducingareainChinaandhassufferedfromseriouswatershortages.Tocapturevariationwateravailability,itisnecessarytohaveananalysisofchangingtrendsinprecipitation.Thisstudy,basedondailyprecipitationdatafrom47representativestationsinNCPrecordspassedthehomogeneitytest,analyzedthetrendandamplitudeofvariationinmonthly,seasonalandannualprecipitation,annualmaximumcontinuousno-raindays,annualraindays,rainfallintensity,andrainfallextremesfrom1960to2007,usingtheMannKendall(M-K)testandSen’sslopeestimator.Itwasfoundthatmonthlyprecipitationinwinterhadasignificantincreasingtrendinmostparts,whilemonthlyprecipitationinJulytoSeptembershowedadecreasingtrendinsomepartsofNCP.Nosignificantchangingtrendwasfoundfortheannual,dryandwetseasonprecipitationandrainfallextremesinthemajorityofNCP.Asignificantdecreasingtrendwasdetectedforthemaximumno-raindurationandannualraindaysinthemajorpartofNCP.ItwasconcludedthatthechangingtrendofprecipitationinNCPhadanapparentseasonalandregionalpattern,i.e.,precipitationshowedanobviousincreasingtrendinwinter,butadecreasingtrendintherainyseason(JulytoSeptember),andthechangingtrendwasmoreapparentinthenorthernpartthaninthesouthernandmiddleparts.Thisimpliesthatwithglobalwarming,seasonalvariationofprecipitationinNCPtendstodeclinewithanincreasingofprecipitationinwinterseason,andadecreasinginrainyseason,particularlyinthesub-humidnorthernpart.

简介：Objective:Toinvestigatetheprevalenceoflong-termfatigue,anxiety,depressionandsocialsupport,andtherelationshipsamongthesesymptomsinpostoperativepatientswithbreastcancer.Methods:Atotalof180postoperativepatientswithbreastcancermeetingcriterionwererecruitedinthiscross-sectionalstudy.TheBriefFatigueInventory(BFI),HospitalAnxietyandDepressionScale(HADS)andTheSocialSupportSurvey-Chineseversionwereusedtoassessingthefatigue,anxietyanddepression,Socialsupportofparticipants.ThemagnitudeoftherelationshipamongthesymptomsoffatigueandothervariableswasmeasuredbySpearmanRhocorrelation.Results:Theprevalenceoflong-termfatiguewas52.7%,and18.3%occurredmoderate/severefatigue.Two-thirdsofpatientshadabasalsocialsupport,only12.8%ofpatientshadbetter-perceivedsocialsupport.ResultsofHADSshowedthat16.7%and21.1%oftheparticipantshaveanxietyordepressiondisorder.Moderate/severefatiguewasnegativelycorrelatedwithsocialsupport(r=–0.158,P=0.038)andpositivelycorrelatedwithage(r=0.132,P=0.042),chemotherapy(r=0.297,P=0.027),anxiety(r=0.324,P=0.018)anddepression(r=0.211,P=0.034).Conclusions:Long-termfatiguewashighlyprevalentamongoverhalfofpostoperativepatientswithbreastcancer,andmoderate/severefatiguewasassociatedwithsocialandpsychologicalfactorssuchassocialsupport,anxietyanddepression.Ourresultssuggestthatoverallnursingcaremaybeamoreeffectivemannerinimprovingfatigueandqualityoflife.

简介：BackgroundArrhythmogenicrightventricularcardiomyopathy(ARVC)isamajorcauseforsuddencardiacdeathduetoventriculartachycardia.Litterisknownaboutitslong-termoutcomesinChineseARVCpatients.Thepurposeofthisstudywastoevaluatethelong-termclinicaloutcomesinpatientswithARVCandtoclarifytheriskfactorsofcardiacevents.MethodsFortysubjectsfulfillingmodifiedTaskForcecriteriawereincludedinthisstudy.Informationonclinicalpresentation,electrocardiographicandcardiacimagingfindings,andlong-termoutcomeofcaseswereinvestigated.ResultsAveragefollow-upperiodfromonsetwas57.5±42.6months.Themeanageatonsetofsymptoms(32.2±12.7years)andmalepredominance(85.0%)weresimilartothatreportedinotherstudies.Palpitationswerethemostfrequentsymptom(82.5%).T-waveinversionwasthemostcommonpresentingabnormalityonresting12-leadECG(75%).Ventriculartachycardiawithleftbundlebranchblockmorphologywassubsequentlydocumentedinatotalof28(70%)subjectsduringastudyperiod.Thecumulativemortalityratewas7.5%.ConclusionClinicalpresentationinChineseARVCpatientswassimilartothatreportedinotherstudies.ARVCisassociatedwithearlymortalitythatisdifferenttoothercountrypopulation.

简介：Biogenicstabilizationprocessesthatresultintheformationofbiofilmsandinterparticle-networkscansignificantlyalterthetransportcharacteristicsoffinegrainedsedimentlayers.Theincreaseinthethresholdofsedimentmotioncanamounttouptoseveralhundredpercent.Whileplancticorganismsareinvolvedintheformationofdepositingflocsandtheearlystagesofconsolidation,thesecondaryconsolidationiscontrolledbymicrobialbreakdownprocesses,leadingtochangesinthemechanicalpropertiesofcohesivesediments.Whiletheprimarystageofconsolidationiscompletedindays,thesecondaryprocessescanlastfordecades.Apreliminaryseriesoferosiontestsinanannularflumerevealeddemonstratedthebiogenicimpactintheearlystagesofsedimentformation.Surrogatematerialswereusedtosimulatethegoverningpropertiesofnaturalsoftsediments.

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简介：LongtimebehaviorofdegenerateequationswiththenonlinearityofpolynomialgrowthofarbitraryorderonthewholespaceRNisconsidered.Byusing-trajectoriesmethods,weprovedthatweaksolutionsgeneratedbydegenerateequationspossessan(L2U(RN),L2loc(RN))-globalattractor.Moreover,theupperboundsoftheKolmogorovε-entropyforsuchglobalattractorarealsoobtained.

简介：前列腺癌症预防选拔赛(PCPT)是泌尿学的领域里的精液的研究。在它的起始的出版以后的超过10年，从这试用的更新的数据继续塑造我们前列腺癌症的理解。一旦想了在正常范围，在从PCPT的主要调查结果之中是前列腺癌症在有前列腺特定的抗原(PSA)的人是普通的示范，1finasteride阻止良性的prostatic肥大的发展，2它而且增加PSA3和数字直肠的examination.4的敏感PCPT帮助建立在可勃起的机能障碍和心血管的疾病之间的连接，5并且也许，最重要地，finasteride表明了25%相对风险reduc

简介：Plantationresourceisanimportantcomponentofforestresources.OverallplantationqualityisnothighinChina,andtheproblemslikelowgrowth,lowpreservingrateandlowproductivityarecommonlyobserved.Thispaperreviewedthehistoricalbackgroundoftheresearchonplantationproductivity,describedfactorsaffectingplantationproductivityincludingsiteconditions,initialplantingdensity,thinningmeasures,groundclearance,andcontinuousplantedalgebraandfertilization.Finally,itwasproposedtocarryoutkeytechnologysystemresearchonplantationproductivitymaintenanceandstrengthentheresearchonthelong-termness,systematicdevelopmentandmulti-purposeofplantationproductivity.

简介：Ｔｈｅｔｒｅｎｄｏｆｔｈｅｍｏｒｄｅｒｎｃａｔａｒａｃｔｓｕｒｇｅｒｙｉｓ：ｓｍａｌｉｎｃｉｓｉｏｎ，ｐｈａｃｏｍｕｌｓｆｉｃａｔｉｏｎ，ＩＯＬｉｍｐｌａｎｔｅｄｉｎｔｈｅｃａｐｓｕｌｅｂａｇ〔１，２〕．ＢｅｓｉｄｅｓｔｈｅｆｏｌｄａｂｌｅＩＯＬｓ〔...

简介：AIMTo评估Ahmed的长期的结果和复杂并发症在埃及patients.METHODSA的一个队的绿内障阀门(AGV)培植经历了AGV培植并且有5y的最小的后续的有倔强的绿内障的99个病人的124只眼睛的回顾的学习被执行。所有病人经历了完全的眼的检查和intraocular压力(IOP)在外科前并且在1d的测量，为1st月，3，在外科以后并且每年的6mo，和1y后来为5y。IOP被Goldmannapplanationtonometry或Tono钢笔测量。复杂并发症和需要的反绿内障药的数字被记录。成功被定义为不到21公里Hg与或没有反绿内障药并且没有另外的绿内障surgery.RESULTSMean年龄是的IOP23.1viewed.RESULTSSurgical指示包括了rhegmatogenous网膜的分开(n=24)，完整厚度的有斑点的洞(n=12)，糖尿病的retinopathy(n=11)，玻璃的出血(n=6)，Eales疾病(n=4)，病理学的近视相关的玻璃的floater(n=2)，和有斑点的epiretinal膜(n=2)。吝啬的后续是166.4牵敧祲刮卅?協桔???????????????挠灡?潬潴祭?????????????????????????浥瑡硯汹湩攭獯湩?€浩畭潮汦潵敲'諟Ｉ????????吗?????????????？？

简介：AIM:Todeterminethelong-termeffectsofselectivelasertrabeculoplasty(SLT)onintraocularpressure(IOP)andthenumberofmedicationsusedupto5yfollowingtreatmentinglaucomapatientsreceivingmaximallytoleratedmedicaltherapy(MTMT).·METHODS:TheWillsEyeHospitalGlaucomaResearchCenterretrospectivelyreviewedthechartsofglaucomapatientswhounderwentSLTafterreceivingMTMT.Eyesthatdidnotachievetheirtargetpressurewithin3mofollowingSLTwereexcludedfromthestudy.ChangesinmeanIOPandnumberofglaucomamedicationsusedwereanalyzedat1,3,and5yfollowingSLT.·RESULTS:Seventy-fiveeyesof67patientswereincludedinthestudy.FifteeneyesthatreceivedSLTfailedtoachievetheirtargetpressurewithin3moandwereexcludedfromthestudy.Theaveragefollow-uptimewas37.4mo(±14.4).MeanIOPwassignificantlyreduced1yaftertreatment(P=0.005).Itwasalsoreduced3,5yaftertreatmentwithoutreachingstatisticalsignificance(P=0.20andP=0.072,respectively).Therewasasignificantdecreaseinmeannumberofmedicationsused1,3,5yaftertreatment(P<0.001,P<0.001,andP=0.039,respectively).Inthespanof5y,2eyes(2.7%)underwentrepeatSLT,7eyes(9.3%)underwentglaucomasurgeryandanadditional3eyes(4.0%)underwentboth.·CONCLUSION:SLTsignificantlyreducedthenumberofglaucomamedicationsused5yfollowingtreatmentinglaucomapatientsreceivingMTMT.SLTmaydelayoperating-roomsurgery.

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