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170 个结果
  • 简介:Itisstandardpractice,wheneveraresearcherfindsanewgene,tosearchdatabasesforgenesthathaveasimilarsequence.Itisnotstandardpractice,wheneveraresearcherfindsanewgene,tosearchforgenesthathavesimilarexpression(coexpression).Failuretoperformco-expressionsearcheshasleadtoincorrectconclusionsaboutthelikelyfunctionofnewgenes,andhasleadtowastedlaboratoryattemptstoconfirmfunctionsincorrectlypredicted.WepresentheretheexampleofGliaMaturationFactorgamma(GMF-gamma).Despiteitsname,ithasnotbeenshowntoparticipateingliamaturation.ItisageneofunknownfunctionthatissimilarinsequencetoGMF-beta.ThesequencehomologyandchromosomallocationledtoanunsuccessfulsearchforGMF-gammamutationsinglioma.WeexaminedGMF-gammaexpressionin1432humancDNAlibraries.Highestexpressionoccursinphagocytic,antigen-presentingandotherhematopoieticcells.WefoundGMF-gammamRNAinalmosteverytissueexamined,withexpressioninnervoustissuenohigherthaninanyothertissue.OurevidenceindicatesthatGMF-gammaparticipatesinphagocytosisinantigenpresentingcells.Searchesforgeneswithsimilarsequencesshouldbesupplementedwithsearchesforgeneswithsimilarexpressiontoavoidincorrectpredictions.

  • 标签: GMF-gamma 基因表达 序列分析 同源性 基因功能 神经胶质
  • 简介:Asingle-particlemicrobeamfacilityhasbeenconstructedattheLaboratoryofIonBeamBioengineering(LIBB),ChineseAcademyofSciences.Thesystemisdesignedtodeliverthedefinednumberofhydrogenions,coveringarangeofenergyfrom1.0to3.5MeV,intoanareasmallerthanthenucleiofindividuallivingcells.AccuracyoftheparticledetectionsystemandthecelltargetingsysteminthefacilityhasbeenassessedusingCR39(nucleartrackdetector)for2.3MeVprotons.Theresultsdemonstratethattheparticledetectionefficiencyisabove98%,andtheoveralltargetingaccuracyofthemicrobeamislimitedwithin3μmformorethan90%hits.

  • 标签: 单粒子微光束设备 精确性测量 生物工程离子束实验室 单细胞照射 原子核轨迹探测
  • 简介:FrequencyresponseoftiltmetersandtidalfactorJUNYANG(杨军)SeismologicalBureauofJiangsuProvince,Nanjing210014.ChinaAbstractTherela...

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  • 简介:Objective:Tostudytheexpressionofactivatedepi-dermalgrowthfactorreceptor(EGFR)andtranscrip-tionfactorE2F(E2F)inCondylomaAccuminata(CA)patients.Methods:ImmunofluorescenttechniqueswereusedtoinvestigatetheexpressionofactivatedEGFRandE2FinCApatients.Results:TheexpressionofactivatedEGFRonthemembraneofepithelialcellsinCAlesionswassig-nificantlygreatercomparedtoexpressionleversinthecontrolgroup(P<0.01).Moreover,theco-expres-sionofactivatedEGFRandE2Fwassignificantlyin-creasedcomparedtothecontrolgroup(P<0.01).Conclusion:Ourobservationssuggestthatthein-creaseinactivatedEGFRexpressionmaystimulatehyperplasiainCApatientsthroughtheactivationoftranscriptionfactorE2F.

  • 标签: 尖锐湿疣 活化型表皮生长因子受体 转录调节因子E2F 免疫荧光法
  • 简介:Objective:Tostudytheexpressionlevelsofplatelet-derivedgrowthfactor(PDGF)andgranulocytecolony-stimulatingfactor(G-CSF)inperipheralbloodandtheirroleinthepathogenesisofCondylomaacuminatum(CA).Methods:Seraweretakenfrom70patientswithCondylomaacuminatumandcomparedwith35healthycontrols.PDGFandG-CSFinserumwerequantitatedusingadualantibodysandwichenzyme-linkedimmunoabsorbentassay(ELISA).Results:SerumconcentrationsofPDGFandG-CSFweresignificantlyincreasedinpatientswithCondylomaacuminatum(CA)comparedtocontrols(P<0.001andP<0.005respectively).SerumlevelsofPDGFandG-CSFcorrelatedwithclinicalseverityofCA,butnosignificantdifferencewasobservedbetweendifferentdurationofdiseasegroups.AsignificantpositivecorrelationwasnoticedbetweenneutrophilcountandG-CSFlevels(γ=0.38,P<0.001),andtheneutrophilcountshowednosignificantcorrelationwithPDGF.Conclusion:TheresultsindicatedthatincreasedexpressionofPDGFandG-CSFinperipheralbloodmightbeinvolvedinpathogenesisofCA.

  • 标签: 尖锐湿疣 CA 血小板源性生长因子 PDGF 粒细胞集落刺激因子 G-CSF
  • 简介:客观:为了与M-CSFR验证MAF-J6-1受体的抗原协会并且进一步学习M-CSF和它的受体的角色,调停了在支持白血病的房间增长的juxtacrine。方法:MAF-J6-1RRE2的Monoclonal抗体(McAb)和rhM-CSFR的polyclonal抗体(PolyAb)被准备。到M-CSFR的McAbRE2的特性被ELISA被间接ELISA,有J6-1房间殖民地形成的跨neutralizing试金和中立化测试证实。结果:到M-CSFR的净化的RE2的反应活动是超过1:16000。M-CSFR和MAF-J6-1R的禁止的活动能被RE2和anti-M-CSFR抗体堵住。到M-CSFR的RE2的反应能被M-CSFR减少。结论:到M-CSFR的RE2的特性被证实,有M-CSFR的MAF-J6-1R的抗原协会被证明。它建议M-CSF和它的受体调停了auto-juxtacrine刺激能是在白血病或nonhematological恶意的起作用的机制。

  • 标签: MACROPHAGE COLONY stimulating factor RECEPTOR MONOCLONAL
  • 简介:Variousworkhardeningmechanisms,onthebasisoftheircharacteris-tics,areclassifiedintotwocategories:thepile-uphardeningandthetanglehardening.Togetherwithadiscussionabouttheexperimentalinvestigationsofworkhardening,thedescriptionsforthosetwobasichardeningmechanismsaresuggested,respectively.Combiningthesedescriptions,anewsinglecrystalhardeninglawisproposed,whichcanbeusedtodescribeworkhardening,particularlythecyclichardeningofacrystalgraininapolycrystallinematerial.Furthermore,somerelevantdiscussiononthenewsinglecrystalhardeninglawisalsomadeinthispaper.

  • 标签: CRYSTAL PLASTICITY single CRYSTAL HARDENING CYCLIC
  • 简介:ABSTRACT:Westudytheevolutionofsingleellipticvortexringforinitialaspectratio(AR)=2,4,6.TheincompressibleNavier-Stokesequationsaresolvedbyadealiasedpseudo-spectralmethodwith64~3gridpointsinaperiodiccube.WefindthattherearethreekindsofvortexmotionasARincreasesandvortexbifurcationoccursatacertainAR.Theprocessesofadvection,interaction,anddecayofvortexringareanalyzed.Numericalresultscoincidewithexperimentsandothernumericalsimulations.

  • 标签: ELLIPTIC VORTEX RING DNS pseudo-spectral method
  • 简介:Anewsimilarsingle-differencemathematicalmodel(SS-DM)anditscorrespondingalgorithmareadvancedtosolvethedeformationofmonitoringpointdirectlyinsingleepoch.ThemethodforbuildingtheSSDMisintroducedindetail,andthemainerrorsourcesaffectingtheaccu-racyofdeformationmeasurementareanalyzedbriefly,andthebasicalgo-rithmandstepsofsolvingthedeform-ationarediscussed.Inordertovalidatethecorrectnessandtheaccuracyofthesimilarsingle-differencemodel,thetestwithfivedualfrequencyreceiversiscarriedoutonaslidewaywhichmovedinplaneinFeb.2001.Inthetest,fivesessionsareobserved.Thenumericalresultsoftestdatashowthattheadvancedmod-eliscorrect.

  • 标签: 运算法则 GPS 变形监测 数学模型
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  • 简介:Inthispaper,asingle-columnstructureusedaswell-headplatformisstudied.Theloadsofwaveandcurrentexertedonthesingle-columnwillbegreatlyreduced,thereforethecostofthestructurewillbedecreased.Theadvantagesofthesingle-columnstructurecomparedwithordinaryjacketstructureareexplained.Adynamicanalysisofthistypeofstructureismadeandsomeproblemsrelatedtodynamicanalysisaresolved.Inordertocheckthereliabilityofcomputationtheoryandprogramme,modeltestshavebeencarriedout.However,asspaceislimited,theconclusionoftestswillbeintroducedinanotherpaper.Therefore,thistypeofstructureisapplicableforprocticalengineering.

  • 标签: single-column structure DYNAMIC ANALYSIS diffraction wave
  • 简介:Inthispaperamodeloftransvcrsalfilterispresentedtostudytheadaptivematchofthetimevariantchannel.Theleastmeansquareerrorfil-teringmethodisusedtoobtaintheweightingcoeffcientsofthefilter.Withthepurposeofspeedinguptheconvergenceoftheiterationequationofadaptivefiltering,anadaptivefactoroftheiterationstepsizeμ_aisderivedinthispaper.Theresultofcomputersimulationshowsthatinthecaseofusingadaptiveμ_a,theconvergencespeedoftheiterationequationisincreased2timesapproximatelyincomparisonwithconstantμ_f.Thestudysuggeststhattheadaptivefilterwithadaptiveμ_a.havetheperformancetofollowthechangeoftime-variantcharacteristicsofthechannel.

  • 标签: ITERATION MATCH FILTERING weighting CORRECTION instead
  • 简介:与高档护肤品牌SK-Ⅱ同出一门的大师级彩妆品牌蜜丝佛陀MaxFactor创立于20世纪初,以充满创意的彩妆产品、推陈出新的革新精神引领彩妆行业百年潮流。MaxFactor不仅是彩妆专指名词“make-up”的提出者,也是第一套供大众使用的彩妆用品的发明者,更是假睫毛、粉饼、唇彩、睫毛膏等划时代产品的发明者,是现代彩妆行业之父。MaxFactor的产品为诸多彩妆大师挚爱,为一代又一代的明星打造出传世妆容。2005年,进入中国后,MaxFactor将带着众多兼具想象力和实用性的明星彩妆品,为中国女性打造出与众不同的巨星风采。

  • 标签: 彩妆 化妆品 护肤品 化妆技巧
  • 简介:客观:在在人的创伤的奔流和正常透镜的上皮的房间之间的原子factor-KB(NF-κB)的表示学习差别。方法:全部的RNAof前面的囊标本从受不了创伤的奔流做半量的RT-PCR并且在在他们之间的NF-κB的表示进行差别的分析的正常cadaveric眼睛施主和那些在显微镜下面被拿。结果:作为与在正常控制组的0.8337的平均数相比,NF-κB的表示等价物为在创伤的奔流患者的透镜的上皮的房间是0.9074,并且差别具有显著意义(t=2.447,P<0.05)因此。结论:NF-κB是可能的对必要的一种抄写因素维持正常透镜的上皮的房间的新陈代谢。在创伤的奔流患者可得到的更高的NF-κB“透镜的上皮的房间工具NF-κB具有到创伤的奔流的出现和开发的可能的关联的s。

  • 标签: 核因子-ΚB 创伤 白内障 基因表达