简介:Itisstandardpractice,wheneveraresearcherfindsanewgene,tosearchdatabasesforgenesthathaveasimilarsequence.Itisnotstandardpractice,wheneveraresearcherfindsanewgene,tosearchforgenesthathavesimilarexpression(coexpression).Failuretoperformco-expressionsearcheshasleadtoincorrectconclusionsaboutthelikelyfunctionofnewgenes,andhasleadtowastedlaboratoryattemptstoconfirmfunctionsincorrectlypredicted.WepresentheretheexampleofGliaMaturationFactorgamma(GMF-gamma).Despiteitsname,ithasnotbeenshowntoparticipateingliamaturation.ItisageneofunknownfunctionthatissimilarinsequencetoGMF-beta.ThesequencehomologyandchromosomallocationledtoanunsuccessfulsearchforGMF-gammamutationsinglioma.WeexaminedGMF-gammaexpressionin1432humancDNAlibraries.Highestexpressionoccursinphagocytic,antigen-presentingandotherhematopoieticcells.WefoundGMF-gammamRNAinalmosteverytissueexamined,withexpressioninnervoustissuenohigherthaninanyothertissue.OurevidenceindicatesthatGMF-gammaparticipatesinphagocytosisinantigenpresentingcells.Searchesforgeneswithsimilarsequencesshouldbesupplementedwithsearchesforgeneswithsimilarexpressiontoavoidincorrectpredictions.
简介:Asingle-particlemicrobeamfacilityhasbeenconstructedattheLaboratoryofIonBeamBioengineering(LIBB),ChineseAcademyofSciences.Thesystemisdesignedtodeliverthedefinednumberofhydrogenions,coveringarangeofenergyfrom1.0to3.5MeV,intoanareasmallerthanthenucleiofindividuallivingcells.AccuracyoftheparticledetectionsystemandthecelltargetingsysteminthefacilityhasbeenassessedusingCR39(nucleartrackdetector)for2.3MeVprotons.Theresultsdemonstratethattheparticledetectionefficiencyisabove98%,andtheoveralltargetingaccuracyofthemicrobeamislimitedwithin3μmformorethan90%hits.
简介:FrequencyresponseoftiltmetersandtidalfactorJUNYANG(杨军)SeismologicalBureauofJiangsuProvince,Nanjing210014.ChinaAbstractTherela...
简介:Objective:Tostudytheexpressionofactivatedepi-dermalgrowthfactorreceptor(EGFR)andtranscrip-tionfactorE2F(E2F)inCondylomaAccuminata(CA)patients.Methods:ImmunofluorescenttechniqueswereusedtoinvestigatetheexpressionofactivatedEGFRandE2FinCApatients.Results:TheexpressionofactivatedEGFRonthemembraneofepithelialcellsinCAlesionswassig-nificantlygreatercomparedtoexpressionleversinthecontrolgroup(P<0.01).Moreover,theco-expres-sionofactivatedEGFRandE2Fwassignificantlyin-creasedcomparedtothecontrolgroup(P<0.01).Conclusion:Ourobservationssuggestthatthein-creaseinactivatedEGFRexpressionmaystimulatehyperplasiainCApatientsthroughtheactivationoftranscriptionfactorE2F.
简介:Objective:Tostudytheexpressionlevelsofplatelet-derivedgrowthfactor(PDGF)andgranulocytecolony-stimulatingfactor(G-CSF)inperipheralbloodandtheirroleinthepathogenesisofCondylomaacuminatum(CA).Methods:Seraweretakenfrom70patientswithCondylomaacuminatumandcomparedwith35healthycontrols.PDGFandG-CSFinserumwerequantitatedusingadualantibodysandwichenzyme-linkedimmunoabsorbentassay(ELISA).Results:SerumconcentrationsofPDGFandG-CSFweresignificantlyincreasedinpatientswithCondylomaacuminatum(CA)comparedtocontrols(P<0.001andP<0.005respectively).SerumlevelsofPDGFandG-CSFcorrelatedwithclinicalseverityofCA,butnosignificantdifferencewasobservedbetweendifferentdurationofdiseasegroups.AsignificantpositivecorrelationwasnoticedbetweenneutrophilcountandG-CSFlevels(γ=0.38,P<0.001),andtheneutrophilcountshowednosignificantcorrelationwithPDGF.Conclusion:TheresultsindicatedthatincreasedexpressionofPDGFandG-CSFinperipheralbloodmightbeinvolvedinpathogenesisofCA.
简介:客观:为了与M-CSFR验证MAF-J6-1受体的抗原协会并且进一步学习M-CSF和它的受体的角色,调停了在支持白血病的房间增长的juxtacrine。方法:MAF-J6-1RRE2的Monoclonal抗体(McAb)和rhM-CSFR的polyclonal抗体(PolyAb)被准备。到M-CSFR的McAbRE2的特性被ELISA被间接ELISA,有J6-1房间殖民地形成的跨neutralizing试金和中立化测试证实。结果:到M-CSFR的净化的RE2的反应活动是超过1:16000。M-CSFR和MAF-J6-1R的禁止的活动能被RE2和anti-M-CSFR抗体堵住。到M-CSFR的RE2的反应能被M-CSFR减少。结论:到M-CSFR的RE2的特性被证实,有M-CSFR的MAF-J6-1R的抗原协会被证明。它建议M-CSF和它的受体调停了auto-juxtacrine刺激能是在白血病或nonhematological恶意的起作用的机制。
简介:Variousworkhardeningmechanisms,onthebasisoftheircharacteris-tics,areclassifiedintotwocategories:thepile-uphardeningandthetanglehardening.Togetherwithadiscussionabouttheexperimentalinvestigationsofworkhardening,thedescriptionsforthosetwobasichardeningmechanismsaresuggested,respectively.Combiningthesedescriptions,anewsinglecrystalhardeninglawisproposed,whichcanbeusedtodescribeworkhardening,particularlythecyclichardeningofacrystalgraininapolycrystallinematerial.Furthermore,somerelevantdiscussiononthenewsinglecrystalhardeninglawisalsomadeinthispaper.
简介:ABSTRACT:Westudytheevolutionofsingleellipticvortexringforinitialaspectratio(AR)=2,4,6.TheincompressibleNavier-Stokesequationsaresolvedbyadealiasedpseudo-spectralmethodwith64~3gridpointsinaperiodiccube.WefindthattherearethreekindsofvortexmotionasARincreasesandvortexbifurcationoccursatacertainAR.Theprocessesofadvection,interaction,anddecayofvortexringareanalyzed.Numericalresultscoincidewithexperimentsandothernumericalsimulations.
简介:Anewsimilarsingle-differencemathematicalmodel(SS-DM)anditscorrespondingalgorithmareadvancedtosolvethedeformationofmonitoringpointdirectlyinsingleepoch.ThemethodforbuildingtheSSDMisintroducedindetail,andthemainerrorsourcesaffectingtheaccu-racyofdeformationmeasurementareanalyzedbriefly,andthebasicalgo-rithmandstepsofsolvingthedeform-ationarediscussed.Inordertovalidatethecorrectnessandtheaccuracyofthesimilarsingle-differencemodel,thetestwithfivedualfrequencyreceiversiscarriedoutonaslidewaywhichmovedinplaneinFeb.2001.Inthetest,fivesessionsareobserved.Thenumericalresultsoftestdatashowthattheadvancedmod-eliscorrect.
简介:Inthispaper,asingle-columnstructureusedaswell-headplatformisstudied.Theloadsofwaveandcurrentexertedonthesingle-columnwillbegreatlyreduced,thereforethecostofthestructurewillbedecreased.Theadvantagesofthesingle-columnstructurecomparedwithordinaryjacketstructureareexplained.Adynamicanalysisofthistypeofstructureismadeandsomeproblemsrelatedtodynamicanalysisaresolved.Inordertocheckthereliabilityofcomputationtheoryandprogramme,modeltestshavebeencarriedout.However,asspaceislimited,theconclusionoftestswillbeintroducedinanotherpaper.Therefore,thistypeofstructureisapplicableforprocticalengineering.
简介:Inthispaperamodeloftransvcrsalfilterispresentedtostudytheadaptivematchofthetimevariantchannel.Theleastmeansquareerrorfil-teringmethodisusedtoobtaintheweightingcoeffcientsofthefilter.Withthepurposeofspeedinguptheconvergenceoftheiterationequationofadaptivefiltering,anadaptivefactoroftheiterationstepsizeμ_aisderivedinthispaper.Theresultofcomputersimulationshowsthatinthecaseofusingadaptiveμ_a,theconvergencespeedoftheiterationequationisincreased2timesapproximatelyincomparisonwithconstantμ_f.Thestudysuggeststhattheadaptivefilterwithadaptiveμ_a.havetheperformancetofollowthechangeoftime-variantcharacteristicsofthechannel.
简介:客观:在在人的创伤的奔流和正常透镜的上皮的房间之间的原子factor-KB(NF-κB)的表示学习差别。方法:全部的RNAof前面的囊标本从受不了创伤的奔流做半量的RT-PCR并且在在他们之间的NF-κB的表示进行差别的分析的正常cadaveric眼睛施主和那些在显微镜下面被拿。结果:作为与在正常控制组的0.8337的平均数相比,NF-κB的表示等价物为在创伤的奔流患者的透镜的上皮的房间是0.9074,并且差别具有显著意义(t=2.447,P<0.05)因此。结论:NF-κB是可能的对必要的一种抄写因素维持正常透镜的上皮的房间的新陈代谢。在创伤的奔流患者可得到的更高的NF-κB“透镜的上皮的房间工具NF-κB具有到创伤的奔流的出现和开发的可能的关联的s。