简介：GaNmicrocrystallinegrainsweregrownbyhot-wallchemicalvapordepositiononSi(111)substrate.Thesegrainswithdiametersof2-4μmweredetectedbyscanningelectronmicroscopy.X-raydiffraction,Fouriertransformationinfraredtransmissionspectroscopyandphotoluminescencewereusedtoanalyzethestructure,compositionandtheopticalpropertiesofthesamples.TheresultsshowthatthemicrocrystallinegrainsarehexagonalwurtziteGaN,andthepropertyofthegrainswasgreatlyaffectedbythegrowthtime.

简介：Consideringthetimedelayindifferenthohlraumwallpositionscausedbyobliqueincidence,thespatio-temporalopticalfielddistributioncharacteristicsofahohlraumwall,especiallyduringtherisingedgeofaflat-toppedpulse,issimulatedbyafastFouriertransformmethodtogetherwithchromatography.Resultsdemonstratethatbeampropagationalongthehohlraumwallisapush-broomprocesswithcomplexdynamicspatial–temporalevolution.Inthefirstfewpicoseconds,theopticalintensityofthefrontpositionincreasesrapidly,whilethatoftherearpositionisrelativelyweak.TheratioRoftheopticalintensityduringtherisingedgeissmallerthanthatofthesteadystate.Rgraduallyincreasesandfinallytendstothevalueofthesteadystatewithtime.Calculationalsoshowsthat,withshortertotalwidthoftherisingedge,Roftheopticalfielddecreasesandthedifferencecomparedtothesteadystatebecomeslarger.Theevolutionismoreseverewithsmallerangleofinclination.

简介：Animpedanceanalyticalmethod(IAM)isdevelopedtostudytheinteractionofplanewaterwavewithaslotted-wallcaissonbreakwater.Thenon-linearboundaryconditionattheslotted-wallisexpressedintermsofflowresistance.Asetofalgebraicexpressionsareobtainedforfreesurfaceelevationinsideandoutsidechamber,andreflectioncoefficient.Thepredictionofthereflectioncoefficientsshowsthattherelativewidthsofthechamberinducingtheminimumreflectioncoefficientforaslotted-wallcaissonbreakwaterareinarangeof0.10～0.20,whicharesmallerthanthat(0.15～0.25)foraperforated-wallcaissonbreakwater.Thereflectioncoefficientsandfreesurfaceelevationobtainedbythepresentmodelarecomparedwiththatoflaboratoryexperimentscarriedoutbypreviousresearchers.

简介：粒子免职行为在飞行员规模水花干衣机的圆锥形的节掠过牛奶，水和maltodextrin在管子中为粒子免职用简单关联被预言。这些材料的预言的粒子免职流动当时与测量免职流动相比。水花干衣机的预言的粒子免职政体被期望在diffusional并且混合(diffusional并且惯性)政体，而是试验性的结果建议粒子免职主要在惯性的政体。因此，使用管子关联在飞行员规模水花干衣机预言免职建议他们足够地不代表实际免职行为。这结果显示粒子流动模式的进一步的研究需要用数字模拟被执行(计算液体动力学，CFD)鉴于水花干衣机的另外的几何复杂性。

简介：在最近的十年，从动物和临床的研究积累证据建议了一个足够地激活的免疫系统可以强烈扩充癌症治疗的各种各样的类型，包括光力学的治疗(太平洋夏季时间)。通过反应的氧种类的产生，太平洋夏季时间根除由触发局部性的肿瘤损坏并且导致反肿瘤免疫的肿瘤。作为反肿瘤免疫的主要部件，在太平洋夏季时间的调停房间的有免疫力的回答的参与很好在过去的十年被调查了，而体液的免疫的角色仍然保持相对未经勘探。在现在的调查，使用photosensitizerBAM-SiPc和CT26忍受肿瘤的BALB/c老鼠模型，调停房间、体液的适应有免疫力的部件能涉及太平洋夏季时间，这被表明。与脉管的太平洋夏季时间(VPDT)政体，BAM-SiPc能根除~的肿瘤70%；忍受肿瘤的老鼠和扳机能持续超过1年的反肿瘤免疫者回答。Th2cytokines的举起是在VPDT以后的检测前vivo，显示体液的回答的潜在的参与。从治好VPDT的老鼠的浆液的分析也揭示了肿瘤特定的抗体的提高的层次。而且，这浆液能有效地妨碍肿瘤生长并且保护老鼠免于进一步以一种T-cell-dependent方式重新质问。一起拿，体液的部件在BAM-SiPc-VPDT以后导致了的这些结果表演能帮助反肿瘤免疫的发展。

简介：AbstractIatrogenic femoral artery pseudoaneurysm is a common complication of the endovascular procedures. Manual compression and thrombin injection are the conventional techniques to occlude the pseudoaneurysms. However, there are still some failed cases that applied these treatment options. The aim of the study is to seek a potential and alternative method with ProGlide system to close the pseudoaneurysm. During April 2018 to February 2019, 2 patients with iatrogenic pseudoaneurysm of the superficial femoral were treated with the suture-base closure device-ProGlide. After punctured the pseudoaneurysm and placed a 6-F sheath, the guide wire was placed in the right femoral artery via the access of the pseudoaneurysm neck. Then the pseudoaneurysm neck was sutured by ProGlide to occlude the blood supply to the pseudoaneurysm. These 2 patients were cured with no complications and complaints, which revealed that percutaneous suture technique with ProGlide at the neck level of pseudoaneurysm provides a novel method for the management of vascular access pseudoaneurysm, especially in those with a wide and short neck.

简介：在反脉管的endothelial生长的一个年以后与有斑点的浮肿的分辨率和foveal消沉的恢复在眼睛报导foveal厚度减小为包含中心的糖尿病的有斑点的浮肿(DME)的因素(anti-VEGF)治疗.METHODSFoveal厚度与光连贯断层摄影术被估计决定中央子字段foveal厚度(CSFT)并且在有DME的42只眼睛的有斑点的体积(CSFT>275湥獴愠?潣灭牡摥琠?敨污桴?潣瑮潲?牧畯？

简介：摘要ObjectivePost-stroke cognitive impairment (PSCI) is resistant to treatment. Recent studies have widely applied repetitive transcranial magnetic stimulation (rTMS) to treat various brain dysfunctions, such as post-stroke syndromes. Nonetheless, a protocol for PSCI has not been established. Therefore, this study is aimed to evaluate the therapeutic effect of our high-frequency rTMS protocol for PSCI during the chronic phase of stroke.MethodsIn this prospective study, ten patients with PSCI were enrolled and received high-frequency rTMS on the ipsilesional dorsola-teral prefrontal cortex (DLPFC) for 10 sessions (5 days per week for 2 weeks). Cognitive and affective abilities were assessed at baseline and 2 and 14 weeks after rTMS initiation. To investigate the therapeutic mechanism of rTMS, the mRNA levels of pro-inflammatory cytokines (interleukin (IL)-6, IL-1β，transforming growth factor beta [TGF-β], and tumor necrosis factor alpha [TNF-α]) in peripheral blood samples were quantified using reverse transcription polymerase chain reaction, and cognitive functional magnetic resonance imaging (fMRI) was conducted at baseline and 14 weeks in two randomly selected patients after rTMS treatment.ResultsThe scores of several cognitive evaluations, i．e., the Intelligence Quotient (IQ) of Wechsler Adult Intelligence Scale, auditory verbal learning test (AVLT), and complex figure copy test (CFT), were increased after completion of the rTMS session. After 3 months, these improvements were sustained, and scores on the Mini-Mental Status Examination and Montreal Cognitive Assessment (MoCA) were also increased (P<0.05). While the Geriatric Depression Scale (GeDS) did not show change among all patients, those with moderate-to-severe depression showed amelioration of the score, with marginal significance. Expression of pro-inflammatory cytokines was decreased immediately after the ten treatment sessions, among which, IL-1β remained at a lower level after 3 months. Furthermore, strong correlations between the decrease in IL-6 and increments in AVLT (r＝0.928) and CFT (r＝0.886) were found immediately after the rTMS treatment (P<0.05). Follow-up fMRI revealed significant activation in several brain regions, such as the medial frontal lobe, hippocampus, and angular area.ConclusionsHigh-frequency rTMS on the ipsilesional DLPFC may exert immediate efficacy on cognition with the anti-inflammatory response and changes in brain network in PSCI, lasting at least 3 months.

简介：在这篇论文，一种合成microtube，由特级的丝绸粉末和聚氨酯制造，由polyster和斯潘德克斯弹性纤维增强了管状的织物，被检验。合成microtubes的剖面图是多微孔的，并且micropores是散布的制服，内部表面是相对光滑的。结果证明合成microtubes的墙厚度增加了，它导致了力量，碎工作和起始的模量incresead；增加的斯潘德克斯弹性纤维内容引起了起始的模量和碎工作，这减少了，但是碎延期和碎负担第一被增加然后减少；并且当SFSP内容增加了，所有机械性质减少了。

简介：Weretrospectivelyanalyzedtheclinicaldataof32patientswithmedicallyintractableidiopathicParkinson'sdiseasewhohadundergonestagedbilateraldeepbrainstimulationofthesubthalamicnucleifromJanuary2007toMay2011.Thevasculartureofthepatientswhoreceivedtwodeepbrainstimulationswasdetectedusingdouble-dosegadolinium-enhancedbrainMRI.Thedimensionsofstraightsinus,superiorsagittalsinus,ipsilateralinternalcerebralveininthethalamicbranchandipsilateralanteriorcaudateveinwerereduced.Thesefindingsdemonstratethatbilateraldeepbrainstimulationofthesubthalamicnucleiaffectscerebralvenousbloodflow.

简介：BackgroundAngiotensinⅡtype1receptor(ATR1)/AngiotensinⅡtype2receptor(ATR2)usuallyinteractwitheachotherintheirexpressionandphysiologicalfunctions,andnitricoxide(NO)isalwaysinvolvedinATR1/ATR2regulationinvivo.Endothelialcellsplayacrucialroleinthemaintenanceofvascularfunctionandinthepreventionofcardiovasculardiseases.ObjectivesToinvestigatetheeffectsofangiotensinⅡ(AngⅡ)andATR1blockervalsartanonATR1,ATR2expressionandtheirrelationwithendothelialnitricoxidesynthase(eNOS)expression,andNOproductioninculturedvascularendothelialcells.MethodsHumanumbilicalveinendothelialcellline(HUVEC)andbovineaorticendothelialcell(BAEC)wereused.BAECwereisolatedfromaortaofnewborncalfbyenzymedigestionandcellsof3-5passageswereused.Cellswereincubatedwithvehicle,AngⅡ,valsartan,orAngⅡplusvalsartanrespectivelyforvariousperiods.ATR1,ATR2,eNOSexpressionandNOproductionweredetected.ResultsIncubationwithAngⅡorvalsartanapparentlydownregulatedATR1mRNAandproteinexpressioninvascularendothelialcells,andthecombinationeffectofthetwodrugsweremoreapparent.AngⅡshowedatransientslightlypromotiveeffectoneNOSandNOgenerationinBAECandanapparentlyinhibitoryeffectwithprolongedincubation,whilevalsartancanapparentlyreversethoseeffects.ConclusionsBothAngⅡandvalsartandownregulatedtheexpressionofATR1invascularendothelialcells.Thesynergisticeffectofthetwodrugswasmoreapparent.ProlongedincubationwithAngⅡcanapparentlyinhibiteNOSexpressionandNOproductioninendothelialcells,whilevalsartancanapparentlyreversethatinhibitoryeffect.

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简介：在导致液化的侧面的传播下面的一面码头墙附近的堆积基础的反应仍然是一个复杂问题。这研究介绍饮料桌子测试的结果在上一2????

简介：这份报纸与可变的墙温度在一个垂直的可渗透的锥上讨论micropolarnanofluid的自然传送对流边界层流动。非类似的答案被获得。在管理流动的边界层近似下面的非线性地联合的微分方程用一个有效、反复的、tri斜的、含蓄的有限差别方法数字地被解决。为两nanofluid的不同试验性的关联有效粘性和nanofluid热电导率被考虑。作为旋涡粘性参数增加，两个都，速度介绍，这被发现并且本地Nusselt数字减少。在在这调查考虑的所有nanoparticles之中，另外，Cu给好传送对流。

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简介：AIM:Toevaluatetheefficacyandsafetyofanti-vascularendothelialgrowthfactor(VEGF)combinedwithphotodynamictherapy(PDT)versusanti-VEGFmonotherapyforpolypoidalchoroidalvasculopathy(PCV).METHODS:WeconductedaMeta-analysisof9studiestocomparetheefficacyandsafetybetweencombinedtherapyandanti-VEGFmonotherapyforPCV.TheprogramsofRevMan5.3andStata12.0wereusedtoanalyzedata.RESULTS:Thebestcorrectedvisualacuity(BCVA)incombinedtherapygroupweresignificantlybetterthanthoseofanti-VEGFmonotherapygroupat6,24and36mo,withpooledweightedmeansdifferences(WMDs)of0.12(0.06,0.18),0.25(0.12,0.38)and0.28(0.13,0.43),respectively.Thecentralretinalthickness(CRT)reductionsincombinedtherapygroupwerehigherthanthatinantiVEGFmonotherapygroupat1,3,6and9mo,withpooledWMDsof63.90(20.41,107.38),33.47(4.69,62.24),30.57(0.12,60.01)and28.00(2.51,53.49),respectively.Theregressionrateofpolypsincombinedtherapygroupwasmuchhigherthanthatinanti-VEGFmonotherapygroup[RD:0.47(0.26,0.68);P<0.0001].Theadverseeventretinalhemorrhagedidnotdiffersignificantlybetweenthetwogroups.CONCLUSION:OurfindingsclearlydocumentthatantiVEGFcombinedwithPDTisamoreeffectivetherapyforPCVcomparedwithanti-VEGFmonotherapy.Furthermore,combinedtherapydoesnotincreasetheincidenceofretinalhemorrhage.

简介：Objective:Tostudytheeffectofnitricoxide-inducedtyrosinephosphorylationoflarge-conductancecalcium-activatedpotassium(BKCa)channelαsubunitonvascularhyporesponsivenessinrats.Methods:Atotalof46Wistarratsofeithersex,weighing250g±20g,wereusedinthisstudy.Modelsofvascularhyporesponsivenessinducedbyhemorrhagicshock(30mmHgfor2hours)invivoandbyL-arginineinvitrowereestablishedrespectively.Thevascularresponsivenessofisolatedsuperiormesentericarteriestonorepinephrinewasobserved.TyrosinephosphorylationofBKCaαsubunitwasevaluatedwithmethodsofimmunoprecipitationandWesternblotting.Results:Inthesmoothmusclecellsofthesuperiormesentericarteries,theexpressionofBKCaαsubunittyrosinephosphorylationincreasedfollowinghemorrhagicshock,andL-argininecouldinduceBKCachannelαsubunittyrosinephosphorylationinatime-anddose-dependentmanner.L-NAME(Nω-nitro-L-arginine-methyl-ester),anitricoxidesynthetaseinhibitor,couldpartlyrestorethedecreasedvasoresponsivenessofthesuperiormesentericarteriesafterhemorrhagicshockinrats.Down-regulatingtheproteintyrosinephosphorylationwithgenistein,awidely-usedspecialproteintyrosinekinaseinhibitor,couldpartlyimprovethedecreasedvasoresponsivenessofthesuperiormesentericarteriesinducedbyL-arginineinvitro,whileup-regulatingtheproteintyrosinephosphorylationwithNa3VO4,aproteintyrosinephosphataseinhibitor,couldfurtherdecreasethenitricoxide-inducedvascularhyporesponsiveness,whichcouldbepartlyamelioratedby0.1mmol/Ltetrabutylammoniumchloride(TEA),aselectiveBKCainhibitoratthisconcentration.Conclusions:NitricoxidecaninducethetyrosinephosphorylationofBKCaαsubunit,whichinfluencesthevascularhyporesponsivenessinhemorrhagicshockratsorinducedbyL-arginineinvitro.

简介：Angiogenesisintheinfarctperipherycanimprovebloodflow.Vascularendothelialgrowthfactor(VEGF)hasbeenconsideredapotentialtherapeutictargetforstroke.BuyangHuanwudecoction(BYHWD)isaclassictraditionalformulaintraditionalChinesemedicineandisusedtotreatstroke;inaddition,thepromotioneffectsonVEGFproteinexpressionhavebeenconfirmed.However,littleisknownabouthowBYHWDregulatesangiogenesis,orabouttheeffectsofBYHWDonVEGFmRNAexpression.Forthisreason,thepresentstudymeasuredmicrovesseldensityinratswithcerebralischemiausingimmunohistochemistry.Inaddition,VEGFexpressionwasmeasuredbyreverse-transcriptionpolymerasechainreactionandenzyme-linkedimmunosorbentassaytode-terminetheeffectsofBYHWDonangiogenesisandVEGFexpressioninratswithcerebralischemia.Resultsdemonstratedthatmicrovesseldensity,aswellasVEGFmRNAandproteinexpression,increasedafter7and14daysofBYHWDtreatment,whichsuggeststhatBYHWDpromotedan-giogenesisfollowingcerebralischemiaandupregulatedVEGFmRNAandproteinexpressioninischemiccerebralregions.

简介：Anultrahighvacuumchemicalvapordeposition(UHV/CVD)systemisintroduced.SiGealloysandSiGe/Simultiplequantumwells(MQWs)havebeengrownbycold-wallUHV/CVDusingdisilane(Si2H6)andgermane(GeH4)asthereactantgasesonSi(100)substrates.ThegrowthrateandGecontentsinSiGealloysarestudiedatdifferenttemperatureanddifferentgasflow.ThegrowthrateofSiGealloyisdecreasedwiththeincreaseofGeH4flowathightemperature.X-raydiffractionmeasurementshowsthatSiGe/SiMQWshavegoodcrystallinity,sharpinterfaceanduniformity.Nodislocationisfoundintheobservationoftransmissionelectronmicroscopy(TEM)ofSiGe/SiMQWs.TheaveragedeviationofthethicknessandthefractionofGeinsingleSiGealloysampleare3.31%and2.01%,respectively.

简介：BaoshanIron&SteelCo.,Ltd.,(referredtoasBaosteel)inChinafirstsucceededindevelopingtheU-ing-O-ing-Expanding(UOE)longitudinalsubmergedarcweldedpipes(SAWLs)offshorelinepipeofamaximumthickness/outsidediameter(T/D)0.042in2011.DescribedinthispaperistheresearchanddevelopmentoftheX70UOESAWLpipesbythecompany.TheresultshowsthatthesaidX70linepipehasbeenincompliancewithrelevantrequirementsasspecifiedinSpecificationsDNV-OS-F101,andhasbeensuccessfullyusedintheSouthChinaSeadeepwatergaspipelineproject.