简介：CLINICALMATERIALSThepatientwas7year-oldboy,bodyweight20kg.HewasadmittedonMay10th,2002becauseoffever,rashes,enlargedlymphnodes,conjunctivaeinjection,strawberrytongue,edemaanderythemaofthehandsandfeet.Laboratorydataasfollow:1.Prominentincreaseinwhitebloodcell(WBC)14.3-22.7×109.2.Anemia,hemoglobin(Hb)121→103g/L.

简介：无

简介：

简介：Radiationtherapyperformsanimportantfunctionincancertreatment.However,resistanceoftumorcellstoradiationtherapystillremainsaseriousconcern,sothestudyofradiosensitizershasemergedasapersistenthotspotinradiationoncology.Alongwiththerapidadvancementofnanotechnologyinrecentyears,thepotentialvalueofnanoparticlesasnovelradiosensitizershasbeendiscovered.Thisreviewsummarizesthelatestexperimentalfindingsbothinvitroandinvivoandattemptstohighlighttheunderlyingmechanismsofresponseinnanoparticleradiosensitization.

简介：

简介：

简介：Objective:TostudytheeffectofantisenseVEGFRNAonratC6gliomasinvivoandfindoutthefeasibilityofantiangiogenesistherapywithantisenseVEGFRNAformalignantgliomas.Methods:ParentalratC6gliomacellsandC6cellstransfectedwithantisenseVEGFcDNAwereimplantedintracerebrallyandsubcutaneouslyintoSDratsascontrolandtransfectedgroup.RatsbearingcerebralandsubcutaneousC6gliomasweretreatedwithantisenseVEGFcDNAastreatedgroupandsenseVEGFcDNAandemptyvectorascontroloftreatedgroup.Thegeneralmanifestation,survivaltime,MRIandhistopathologicalchangesofallratswereobserved.Thevolumeofsubcutaneouslyimplantedtumorswasdeterminedregularly.InsituhybridizationandimmunohistochemicalstainingwereusedfordetectionofVEGFgeneexpressionofgliomaswhilePCNAimmunostainingandTUNELmethodforexaminationofproliferationactivityandapoptosisofgliomas,respectively.Results:Thesurvivaloftheratsintransfectedandtreatedgroupwasprolonged.Thereweretworatssurvivingover90dinthetreatedgroupandtheirtumorsdisappeared.TheVEGFgeneexpression,thenumberofmicrovesselsandtheproliferationactivityweredecreasedandalargeamountofapoptoticcellscouldbefoundincerebralandsubcutaneousgliomasintreatedandtransfectedgroups.Conclusion:VEGFisoneofthecandidategenesforgenetherapyofmalignantgliomas.AntisenseVEGFRNAcombinedwithothertherapiesshouldbestudiedfurtherforenhancingthetherapeuticeffectofmalignantgliomas.

简介：Palliativecareisthereliefofsymptomswithoutdealingwiththeunderlyingcause,e.g.useofanalgesia,torelievepain.Theuseofsuchanagentalleviatesthesymptomswithoutcuringtheunderlyingdisease.Thisisthetypeofcareforpatientswithseriousillnesses.Itfocusesonimprovingqualityoflife,notjustinyourbody,butalsoinyourmindandspirit.Thereisathinlinebetweenpalliativecareandhospicecare.

简介：Melanomaisthedeadliestformofskincancerandhasanincidencethatisrisingfasterthananyothersolidtumor.Metastaticmelanomatreatmenthasconsiderablyprogressedinthepastfiveyearswiththeintroductionoftargetedtherapy(BRAFandMEKinhibitors)andimmunecheckpointblockade(anti-CTLA4,anti-PD-1,andanti-PD-L1).However,eachtreatmentmodalityhaslimitations.Treatmentwithtargetedtherapyhasbeenassociatedwithahighresponserate,butwithshort-termresponses.Conversely,treatmentwithimmunecheckpointblockadehasalowerresponserate,butwithlongtermresponses.Targetedtherapyaffectsantitumorimmunity,andsynergymayexistwhentargetedtherapyiscombinedwithimmunotherapy.Thisarticlepresentsabriefreviewoftherationaleandevidenceforthepotentialsynergybetweentargetedtherapyandimmunecheckpointblockade.Challengesanddirectionsforfuturestudiesarealsoproposed.

简介：观察针灸结合行为医学疗法治疗重复使力损伤(RS1)的疗效。选择重复使力损伤(RS1)患者150例，随机分为针灸结合行为医学疗法治疗组90例，针灸对照组60例，对患者治疗前后疼痛程度、功能状态、疗程、愈后复发率进行统计分析及综合疗效评定。针灸结合行为医学疗法治疗组与单纯针灸治疗组在疗程与愈后复发率的差异均有非常显著性意义(P<0．01)。在针灸的基础上结合行为医学疗法治疗，纠正患者不良的行为习惯，对治疗重复使力损伤有很好的疗效。

简介：

简介：Hormonereplacementtherapy(HRT)isinuseformorethanahalfofcentury,butthequestionofindicationsandidealcandidatesforHRTremainsunclear.Postmenopausalwomenareapopulationwiththeincreasingrisksforcardiovasculardiseaseswhicharethemaincauseofdeathinthisgroup.Declineinoestrogenconcentrations

简介：Platinum-basedanticanceragentsarewidelyusedasfirst-linedrugsincancerchemotherapyforvarioussolidtumors.However,greatsideeffectsandoccurrenceofresistanceremainasthemajordrawbacksforalmostalltheplatinumdrugsdeveloped.Toconquertheseproblems,newstrategiesshouldbeadoptedforplatinumdrugbasedchemotherapy.Modernnanotechnologyhasbeenwidelyemployedinthedeliveryofvarioustherapeuticsanddiagnostic.Itprovidesthepossibilityoftargeteddeliveryofacertainanticancerdrugtothetumorsite,whichcouldminimizetoxicityandoptimizethedrugefficacy.Here,inthisreview,wefocusedontherecentprogressinpolymerbaseddrugdeliverysystemsforplatinum-basedcombinationtherapy.

简介：

简介：Laryngealsquamouscellcarcinoma(LSCC)remainsahighlymorbidandfataldisease.Historically,ithasbeenamodelexamplefororganpreservationandtreatmentstratificationparadigms.Unfortunately,survivalforLSCChasstagnatedoverthepastfewdecades.Astheeraofnext-generationsequencingandpersonalizedtreatmentforcancerapproaches,LSCCmaybeanidealdiseaseforconsiderationoffurthertreatmentstratificationandpersonalization.Here,wewilldiscusstheimportanthistoryofLSCCasamodelsystemfororganpreservation,uniqueandpotentiallytargetablegeneticsignaturesofLSCC,andmethodsforbringingstratified,personalizedtreatmentstrategiestothe21~(st)century.

简介：Usingofactivecardiacmedicaldevicesincreasessteadily.InEurope,therewere183implantsofICDand944implantsofPM,119ofbiventricularICDand41ofbiventricularPM,allpermillionin-habitantsin2014.Healthcareenvironments,includingradiotherapytreatmentrooms,areconsideredchallengingfortheseimplantabledevices.Exposuretoradiationmaycausethedevicetoexperienceprematureelectivereplacementindicator,decreasedpacingamplitudeorpacinginhibition,inappropri-ateshocksorinhibitionoftachyarrhythmiatherapyandlossofdevicefunction.

简介：NatsumeSōseki(1867-1916)sufferedfromcyclicmentaldepressionsthroughhislife,anditwaswhenhewasinthestateofthemostterribleonethathestartedhiscareerasawriterbywritingIAmaCat(1905-1906).TherearesomeevidencebyhiswifeandfriendsthatSōseki’sconditionofdiseasedramaticallyimprovedduringitsserializationonamagazine,andthewriterhimselfadmitedhumorouslyintheprefaceofotherworkthatitwashisdepressionandmaniathatenabledhimtoproduceIAmaCatandotherearlyworks.Thispaperaimsatdescribingtheprocesshowhisactofnarratinghadtherapeuticeffectsonhisstateofmindfocusingontheconstructionofcomplicitousrelationshipbetweenanimpliedauthorandreadersintheworkbytheuniquefunctionsofthefirst-‘person’narrator:ACat.Amongothers,IwillconsidertheinfluenceofLaurenceSterne’sTristramShandy(1759-1767),whichSōsekiintroducedtoJapanforthefirsttime,bydiscussingthefrequentuseofmetalepsisthatthetwoworkshaveincommon.

简介：Weadoptedauricularpressuretherapytotreat32caseswithstrainofrhomboidmuscleandachievedsatisfactoryresults,namely,thecureratewas46.87％,improvedrate40.67％,andthetotaleffectiverate87.54％.

简介：Transcatheteraorticvalvereplacement(TAVR)isincreasinglyusedforthetreatmentofhighorveryhighsurgicalriskpatientswithsevereaorticstenosis(AS)orfailingsurgicalbioprosthesis(valve-in-valve,VIV-TAVR).InTAVR,thecollapsedtranscatheterheartvalve(THV)isintroducedusingthedeliverysysteminsertedfromthefemoralartery(preferred)orotheralternativeaccesses(transapical,transaortic,transcarotid,subclavian/transinnominateortranscaval).Thedeliverysystemisthenadvanceduntilcoaxiallyalignedwiththeaorticannulus,wheretheTHVisdeployed.Thisprocedurecanbeassociatedwithcomplicationssuchasaccesssiteinjury(vascularcomplication),paravalvarleak,cerebrovasculareventsandconductiondisturbances.However,therapidacceptanceandsuccessesobservedwithTAVRhavebeenmadepossiblethroughcarefulpatientselection,preproceduralplanning(i.e.MDCTannularsizing),THVtechnology(i.e.newgenerationvalves),andproceduraltechniques(i.e.minimalistTF-TAVRandalternativepercutaneousaccessoptions),aswellasadecreaseincomplicationsasTAVRexperiencegrows.ThoughtheresultsorongoingclinicaltrialsevaluatingTAVRinintermediatesurgicalriskpatientsarepending,itislikelythatTAVRwillsoonbeapprovedforlowerriskpatientsaswell.

简介：