简介：主要睫的运动障碍(PCD)是源于正常睫的功能的损失的正染色体后退的混乱。症状包括新生的呼吸悲痛，长期的窦炎，bronchiectasis，地点inversus，和不孕。然而，仅仅15联系PCD的基因被识别了迄今为止引起男不孕。由于PCD的基因异质，全面分子的基因测试没被认为照顾的标准。这里，我们在与与男不孕联系的PCD有关的基因因素的鉴定上提供进步的更改，总结内在的分子的机制，并且讨论这些调查结果的临床的含意。这块地里的进一步的研究将为男不孕影响诊断策略，使临床医生能向病人提供通知基因建议，并且帮助为开发直接指向的个性化的药采用治疗的最好的功课。

简介：Usingthedatasetof20±2secand(A/T)maxofsurfacewavesrecordedbyType-763andType-SKseismographsfromfivestationsinBeijingandelsewhere,themeansquaredeviationsuandrelativemeandeviationsDofMsvaluesdeterminedbyfivecalibrationfunctions(a,a763,a300aNandfromMsz(NEIS)arecomparedandanalyzed.Resultsshowthataanda763arerathergoodbetween20°and160°;anda763arerathergoodbetween10and30for20sec;a300isrelativelygoodbetween160and179.

简介：Inthisarticle,wepresentanapplicationofAdaptiveGeneticAlgorithmEnergyDemandEstimation(AGAEDE)optimalmodeltoimprovetheefficiencyofenergydemandprediction.Thecoefficientsofthetwoformsofthemodel(bothlinearandquadratic)areoptimizedbyAGAusingfactors,suchasGDP,population,urbanizationrate,andR&Dinputstogetherwithenergyconsumptionstructure,thataffectdemand.Sincethespuriousregressionphenomenonoccursforawiderangeoftimeseriesanalysisineconometrics,wealsodiscussthisproblemforthecurrentartificialintelligencemodel.ThesimulationresultsshowthattheproposedmodelismoreaccurateandreliablecomparedwithotherexistingmethodsandtheChina’senergydemandwillbe5.23billionTCEin2020accordingtotheaverageresultsoftheAGAEDEoptimalmodel.FurtherdiscussionillustratesthattherewillbegreatpressureforChinatofulfilltheplannedgoalofcontrollingenergydemandsetintheNationalEnergyDemandProject(2014—2020).

简介：AbstractIntroduction:There is a known association between primary mediastinal germ cell tumor (PMGCT) and hematologic malignancy that is not linked to treatment. They are exceptionally rare entities with a low morbidity and a poor prognosis.Case presentation:An 11-year-old boy presented with an anterior mediastinal mass diagnosed as a malignant germ cell tumor on the basis of an excisional biopsy. He was found to have acute myeloid leukemia (AML) two years after the chemotherapy for his germ cell tumor. The clinical course was very aggressive with a survival time of only 1 week after diagnosis of AML associated with PMGCT.Conclusion:AML associated with PMGCT needs to be diagnosed correctly. Relevant examinations should be carried out in patients with PMGCTs during and after chemotherapy, and long-term follow-up is still necessary to reduce the risk of morbidity and mortality.

简介：Inrecentyears,withthedevelopmentofsocietyinChina,studentshavebeenaffectedbysomenon-mainstreamculturesduringtheirgrowth,causingtheweaknessofmorality,andthegradualdegradationofhonesty.Thosephenomenaimposeseriousimpactsonthegrowthanddevelopmentofchildren.Thestudyinvestigatedthestatusofelementaryschoolstudentcreditthroughquestionnairesurvey.Basedontheresult,thecausesoftheproblemwereanalyzedfromdifferentperspectives,andthena“three-in-one”educationconceptwasproposed.Thecooperationamongfamily,school,andsocietywasstressedtoachievethecomprehensivepromotionofthemoralityandresponsibilityofprimaryschoolstudents.

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简介：Theinterrelationofvariousfactorsaffectingthemechanicalstrength,thethermalshockresistivityandcreepdeformationofslabinasimplesettingconditionofthefiringoftablewarearediscussed,Theconrolofparametersinfavourofthedesiredperformanceoftheslabispropsed.

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简介：Transcatheteraorticvalvereplacement(TAVR)isincreasinglyusedforthetreatmentofhighorveryhighsurgicalriskpatientswithsevereaorticstenosis(AS)orfailingsurgicalbioprosthesis(valve-in-valve,VIV-TAVR).InTAVR,thecollapsedtranscatheterheartvalve(THV)isintroducedusingthedeliverysysteminsertedfromthefemoralartery(preferred)orotheralternativeaccesses(transapical,transaortic,transcarotid,subclavian/transinnominateortranscaval).Thedeliverysystemisthenadvanceduntilcoaxiallyalignedwiththeaorticannulus,wheretheTHVisdeployed.Thisprocedurecanbeassociatedwithcomplicationssuchasaccesssiteinjury(vascularcomplication),paravalvarleak,cerebrovasculareventsandconductiondisturbances.However,therapidacceptanceandsuccessesobservedwithTAVRhavebeenmadepossiblethroughcarefulpatientselection,preproceduralplanning(i.e.MDCTannularsizing),THVtechnology(i.e.newgenerationvalves),andproceduraltechniques(i.e.minimalistTF-TAVRandalternativepercutaneousaccessoptions),aswellasadecreaseincomplicationsasTAVRexperiencegrows.ThoughtheresultsorongoingclinicaltrialsevaluatingTAVRinintermediatesurgicalriskpatientsarepending,itislikelythatTAVRwillsoonbeapprovedforlowerriskpatientsaswell.

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简介：ObjectiveTodeterminewhethersuccessfulvalvuloplastycausesanincreaseofmitralvalveareareserveinpatientswithmitralstenosis,isoproterenolstressechocardiographywasusedtocomparemitralvalveareaandhemodynamicchangesbetweenpre-andpost-valvuloplastyunderconditionsofincreasedcardiacwork.MethodsThirty-eightpatientswithpurerheumaticmitralstenosiswhohadreceivedsuccessfulpercutaneousballoonvalvuloplastyunderwentisoproterenolstressechocardiographypre-andpost-valvuloplasty.Mitralvalvearea(bydirectplanimetryoftwo-dimensionalechocardiography),meantransmitralpressuregradient(bycontinuous-waveDopplerechocardiography),andcardiacoutput(byM-modeechocardiography)weremeasuredatrestandunderisoproterenolstresstoachieveheartrateofdifferentstages.ResultsMitralvalvearea(0.91±0.28to1.87±0.23cm2,P<0.01),meantransmitralpressuregradient(12.5±6.3to3.9±1.9mmHg,P<0.01)andcardiacoutput(3.93±1.44to4

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简介：Objective:Tointroducetheexperienceoftreatingfractureofbothtibiaandfibulawithmicro-invasivepercutaneousplateinternalfixationthroughfracturesiteapproach.Methods:Thedataof15patients(11malesand4females),including14adults(aged22-73years,mean=40years)and1child(aged10years),withfractureofbothtibiaandfibulawerestudiedretrospectivelyinthisstudy.Asmallincisionwasmadeatthefracturesiteoftibia.Thenrepositionwasmadeunderdirectvision,andinternalfixationwasemployedwithsteelplatesinsertingthroughthesmallincision.Results:Anatomicalreductionwasobtained.Nocomplicationwasfound.Unionoccurredontimein14patients.Onecasehealedafterasecondoperation.Conclusions:Micro-invasivepercutaneousplateinternalfixationisbeneficialtothehealingofboneandsofttissues.WithoutX-rayexamination,itisalsoeasytoreachanatomicalreductionandmaketibialinternalfixationwithbothplateswithmicro-invasivepercutaneousplateinternalfixation.

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简介：Objective:Toevaluatetheeffectofmultidisciplinarycollaborativecare(MCC)inpatientswithbothacutecoronarysyndrome(ACS)anddepressionand/oranxietydisorderscomparedwithusualphysiciancare(UPC).Methods:Depressionand/oranxietywerescreenedbyusingSDSandSAS,ACSpatientswithdepressionand/oranxietydisorderswererandomizedintoMCCandUPCgroups.Thecardiacoutcomesandthelifequalitywereevaluatedat1yearfollow-up.Results:Overall,30.19%(96/318)patientshadpositivescreenresults.At1year,CardiacoutcomemeasuresforpatientsinMCCgroupweresignificantlybetterforcompositeeventsofcardiacdeathandnon-fatalMI(6.12%vs23.40%,p=0.016),cardiacfunction(NYHAfunctionalclassificationIIIorIV,0%vs25%,p=0.05),andanginapectoris(21.28%vs85%,p<0.0005),thanpatientsinUPCgroup;thelifequalitywereimprovedinpatientsinMCCgroup.Conclusion:AfterACS,30.19%ofpatientshaddepressionand/oranxietydisorders,MCChadbettereffectsoncardiacoutcomesandqualityoflifeinACSpatientswithPsychiatricdisorders.

简介：冠的stents是通过导管送到堵住的容器的金属卷或网孔试管，它被汽球扩展再开并且支架目标容器。最近，特殊的药被stents(drug-elutingstents)带进一步在stenting过程以后减少in-stent狭窄率。然而，stents的biomechanical特征上的不断的学习为在stents和织物之间的更好的相互作用是必要的，或提供为drug-elutingstents装载站台的更合适的药。这份报纸的目的是显示出有限元素方法怎么能被用来学习弄弯的冠的stents的房间区域和神气分发变化。一样的弯曲变丑被用于冠的stent由一个僵硬弄弯的容器建模的二个广告。结果证明stent设计在把状况弄弯下面影响了房间区域和神气分发的变化。有连接的stent与山峰山峰在外部弯曲，和stent有更多的房间区域变化()神气设计能有神气接触并且在内部弯曲重叠。在结论，这个有限元素方法能被用来学习并且比较弄弯的stents的房间区域和神气分发变化，并且在新stents的严峻、改进的biomechanical特征为设计者提供一个方便工具。

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简介：Invasivefractionalflowreserve(FFR)measurementiscurrentlythegoldstandardforcoronaryintervention.FFRmeasurementbycoronarycomputedtomographyangiography(FFRCT)isanovelandpromisingimagingtechnologythatpermitsnoninvasiveassessmentofphysiologicallysignificantcoronarylesions.FFRCTiscapableofcombiningtheanatomicinformationprovidedbycoronarycomputedtomographyangiographywithcomputationalfluiddynamicstocomputeFFR.Todate,severalstudieshavereportedthediagnosticperformanceofFFRCTcomparedwithinvasiveFFRmeasurementasthereferencestandard.FurtherstudiesarenowbeingimplementedtodeterminetheclinicalfeasibilityandeconomicimplicationsofFFRCTtechniques.ThisarticleprovidesanoverviewanddiscussestheavailableevidenceaswellaspotentialfuturedirectionsofFFRCT.