简介：Electrophoresis,chromatography,immunoassay,sequencingandothertimeconsumingap-proacheshavebeendevelopedtodetermineDNAbasemismatching,oxidativelesionorstrandbreaks.Sometimes,however,onlyqualitativeinformationisenoughtodecidewhethermutationhashappenedtoDNAanditsextent.Convolutionspectrometry(CS),anewtechniquetodiscoverultrafmedifferenceonultraviolet(UV)absorptionofdifferentsubstances,isoriginallyemployedtofindoutanysubtlemutationofDNAinducedbyUVradiation.Muta-tiveDNAiscomparedwithegocriteriabasedonthespectraoftheformerDNA,anydifferenceisquantitativelyex-pressedbydispersion(5).Visiblechangescannotbeobservedonsecond-derivativespectrauntilthemutationgets5upto11.48%.DimethylsulfoxideisanintensifierofUV254nminducedDNAmutationandprotectorat365nm,whichissimplyconfirmedbyincreasinganddecreasing5.Everyconvolutionproceduretakeslessthan1min.Convolutionspectrometryprovidesafast,simple,sensitiveandinexpensivealternativetodetermineDNAmutation,andtoscreenanti-mutationalmedicines.

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简介：Aims：TotaltriterpenoidfromPrunellavulgarisL.（TTP）,knownasmedicinehad,hadapreventiveeffectagainsthepaticsteatosisinourpreviouswastoevaluatewhetherTTPcouldimproveliverfibrosisnismofactionofTTPonhepaticstellategrowthfactor（PDGF）.atraditionalChinesestudy.Ourobjectiveinratsandtoinvestigatethemecha-cell（HSC）proliferationinducedbyplatelet-derivedgrowthfactor（PDGF）.

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简介：Aim:TostudytheeffectofEcdysterone(ECR)ontheexpressionofTaufromthecerebralcorticeandhippocampusandbehaviorsinpassiveavoidancereactionandspatialdiscriminationofthemiceinducedbyoverloadaluminumsalt.MethodsFourty-fiveNIHmicewererandomlydividedintofivegroups,thecontrolgroup,themodelgroup,thetreated

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简介：AIM:ToexploretheeffectsofCompoundYi-Zhi(YZC)onlearningandmemorycapacityandfreeradicalmetabolisminD-galactoseinducedmicedementiamodel.METHODS:ThemicedementiamodelwasinducedbyadailyD-galactose0.15g/kgscfor45daysandafter5days'D-galactoseinjection,themiceweretreatedwiththreedosesofYZC

简介：Objective:ToexplorethemechanismofEcdysterone(ECR)inpreventionoflearningandmemorydysfunctionoftheratsinducedbyβ-amyloidpeptide(Aβ25-35).Methods:NinetyWistarmaleratswererandomlydividedintofivegroups,thecontrolgroup,themodelgroup,thetreatedgroups(ECR4mg·kg^-1andECR8mg·kg-1andNimodipine

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简介：AIMToinvestigatetheeffectsofCapsuleYi-Zhi(CYZ)onlearningandmemorydisorderandbeta-amyloidproteininducedneurotoxieityinrats.MethodsVariousdosesofCYZwereadministeredtoSprague-Dawley(SD)ratsfor8days,twiceaday.Thenscopolaminehydrobromide(Sco)intraperitonealinjectionwasperformedoneachratandthe

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