简介:Over20yearsofresearchhasledtothenowwidelyacceptedroleofcardiacresynchronizationtherapy(CRT)inmedicallyrefractory,mildtoseveresystolicheartfailure(HF)withincreasedQRSduration.Inadditiontoconferringamortalitybenefit,CRThasbeenshowntoreduceHFhospitalizationratesandimprovefunctionalstatusinthispopulation.However,notallpatientsconsistentlydemonstrateapositiveresponsetoCRT.EffortstoimproveresponsetoCRThavefocusedonimprovingpatientselectionandoptimizingdeviceimplantationandfollow-up,therebycorrectingelectricalandmechanicaldyssynchrony.Inthisarticlewereviewthepathobiologyofcardiacdyssynchrony,therationalefortheuseofCRT,thehistoryandthestateoftheartofCRT,andguidelinesandrecommendationsforCRT,whilealsofocusingontheareasofcontroversyandpotentialfutureapplications.
简介:Inthefirsthalfof2015,rareearthmarketdeclinedafteraperiodofpricerising.Rareearthpricesfacedseverdownwardpressurecurrently.Itwasthoughtthefallingtrendcouldlastforsometime.InearlyJanuary,mainstreampriceofdidymiumoxidewas280,000-285,000yuan/ton.Itstartedtoriseslowlyandincreasedby10,000-12,000yuanpertoninearlyFebruary.Thepriceofdidymiumoxidehad