简介：AbstractImportance:Cochlear implantation (CI) is an effective therapy for patients with severe to profound sensorineural hearing loss. It remains controversial whether children younger than 12 months of age should undergo CI.Objective:To evaluate the safety and effectiveness of CI in children younger than 12 months of age.Methods:We performed a retrospective study of clinical data of pediatric patients younger than 12 months of age who underwent CI and were followed up for 1 to 2 years. Patients’ developmental levels were evaluated by the Gesell score before CI. Intraoperative and postoperative complications were recorded to evaluate the safety of CI. Auditory and speech abilities were scored by the LittlEARS® auditory questionnaire (LEAQ), categories of auditory performance (CAP), speech intelligibility rating (SIR), infant-toddler meaningful auditory integration scale (IT-MAIS), and meaningful use of speech scale (MUSS) at 1, 2, 3, 6, 9, and 12 months after CI. The associations between clinical characteristics before CI and postoperative scores at 1 year after CI were analyzed by the linear mixed-effects model.Results:Eighty-nine children (47 boys and 42 girls) were included in this study (mean age at CI, 9.2 ± 1.6 months). Sixteen patients were diagnosed with cochlear malformation and 16 underwent bilateral CI. No severe complications occurred in any patients. The mean developmental quotient of the Gesell score was 78.00 ± 10.03. The median LEAQ scores were 0, 5, 10, 16, 22, 26 and 30 before and at 1, 2, 3, 6, 9, and 12 months after CI, respectively. These findings implied that the LEAQ score greatly improved in the first year after CI. The overall CAP, SIR, IT-MAIS, and MUSS scores also increased with increasing duration after CI. No significant associations were detected between clinical characteristics (age, sex, implant number, pre-CI Gesell score, and inner ear malformation) and LEAQ outcomes at 12 months after CI.Interpretation:With increasing duration after CI, auditory and speech behavior dramatically improve in young children. Our findings indicate that CI is feasible for children younger than 12 months of age.

简介：目的：观察疏肝理气、清心除烦中药结合针刺治疗广泛性焦虑症的疗效。方法：治疗组用针刺结合中药治疗40例，对照组采用口服多虑平治疗38例，治疗前、中、后均作焦虑自评量表（SAS）、副反应量表（TESS）评定。结果：治疗组与对照组总有效率分别为82．5％和84．2％，两组治疗前后SAS组内比较差异有统计学意义（P〈0．01），两组间痊愈显效率、总有效率及SAS评分比较无差异（P〉0．05），但副反应对照组显著高于治疗组（P〈0．01）。结论：针刺结合中药治疗广泛性焦虑症疗效确切，且毒副反应轻微。

简介：

简介：

简介：

简介：ObjectivesToexplorethefeasibility,necessity,andsecurityoftranscatheterclosureofpatentductusarteriosus(PDA)ininfants.MethodsTherewere230infantswithPDA.Theageswere(7.3±3.2)monthsandtheweight(6.6±2.8)Kginaverage.Theywereseparatedintotwogroups.GroupAwasformedbytheinfantsweighinglessthan6Kg,GroupBover6Kg.RightheartcatheterizationwasperformedfirsttocalculatetheratioofQp/Qs.ThendescendingaortographydemonstratedthediameterandshapeofPDA.Properoccluderwasselectedtofinishtheintervention.Echocardiographywasperformedafterintervention24hoursand1,3,6,12and24months.ResultsInGroupAthetechnicalachievementratiowas94.6%withtheaveragediameterofPDA(6.2±3.2)mm.InGroupBthetechnicalachievementratiowas100%withtheaveragediameterofPDA(4.8±2.5)mm.WeusedtheAmplatzerDuctOccluderwiththetypefrom6-8mmto12-14mm,thedeliverysheathfrom6Frenchto8French.24hoursafterintervention,echocardiographydemonstratedthattherewere6residualshuntsinGroupAwhile22inGroupB.After1year,residualshuntexistedinneithergroup.Therewere4patientswhosefemoralarteriespulsedweaklyafterinterventioninGroupA,whileinGroupBtherewere3.Theyallrecovered24hoursaftertheapplicationofurokinase.InGroupAbloodflowvelocityindescendingaortaincreasedin5infants,whileinGroupBtherewere3.Theyallresumedin6-12months.ConclusionsTranscatheterclosureofPDAininfantsissafeandtechnicallyfeasible.However,indicationshouldbestrictlyselectedandtheinterventionshouldbeperformedbyexperiencedphysician.

简介：与ipsilateral联系的Hoffa骨折大腿骨的柄骨折是很稀罕的。损害的这种稀罕类型的三个盒子回顾地被考察。大腿骨的柄破裂和Hoffa破裂的地点被记录。所有大腿骨的柄破裂与内部固定被管理。为Hoffa破裂的错误诊断的率被记录。影响的膝的功能在二年后续为特殊外科(HSS)分数根据修改医院被评估。大腿骨的破裂在所有三个盒子中横向或合成。IpsilateralHoffa破裂在一种情况中在二种情况，和侧面的髁中发生在中间的髁。一仅仅Hoffa破裂外科手术前地被识别。所有大腿骨的柄破裂太平无事地愈合了。在其Hoffa骨折正确地被诊断的病人，修改HSS分数是94。在另一个病人，其Hoffa断裂，被第二个手术对待，修改HSS分数是93。并且在第三个盒子中，为Hoffa破裂拒绝了另外的操作，修改HSS分数仅仅是70。决定性地大腿骨的柄骨折能与ipsilateralHoffa骨折被联系，特别在摩托车事故。这类损害是很稀罕的，错误诊断是普通的。

简介：

简介：Inrecentyears,theclinicalincidenceofthyroidcancerhasbeenincreasingyearbyyear,anditsriskassessmentandclinicalmanagementmethodshavealsobeenaccordinglymodifiedandconstantlyimproved.TherearegreatdifferencesbetweentheclinicaldiagnosticandtherapeuticmodesanddiseasemanagementofthyroidcanceremployedbyvariousmedicalinstitutionsinChina,particularlywithregardtotheclinicalapplicationofserummarkerofthyroidcancer.Tothisend,theChinaAnti-CancerAssociationThyroidCancerSpecializedCommitteeChineseAssociationofThyroidOncologyorganizedthiscompilationofExpertConsensusonClinicalApplicationofSerumMarkerofThyroidCancertohelpandimpelrelevantclinicalinstitutionsandprofessionalstostandardizeclinicaldiagnosis,treatment,andlong-termmanagementofthyroidcancer,andtoproperlyutilizetheserummarkerforscientificauxiliaryclinicaldiagnosisandassessmentofthyroidcancerbeforeandafteroperation.

简介：ＤＥＶＥＬＯＰＥＤＡＮＤＣＬＩＮＩＣＡＬＡＰＰＬＩＣＡＴＩＯＮＯＦＬＯＣＫ－ＲＩＮＧＴＹＰＥＢＩＰＯＬＡＲＨＩＰＰＲＯＳＴＨＥＳＩＳＤＥＶＥＬＯＰＥＤＡＮＤＣＬＩＮＩＣＡＬＡＰＰＬＩＣＡＴＩＯＮＯＦＬＯＣＫ－ＲＩＮＧＴＹＰＥＢＩＰＯＬＡＲＨＩＰＰＲＯ...

简介：AbstractImportance:Within the coronavirus disease 2019 (COVID-19) global pandemic, more attention is warranted for whether this new infectious disease has unique manifestations in children.Objective:To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing, China.Methods:We collected data for 35 children diagnosed with COVID-19 who were admitted to Beijing Ditan Hospital from January 2020 to June 2020, and analyzed their epidemiological characteristics, clinical manifestations, laboratory examinations, chest imaging findings, treatments, and outcomes.Results:The children comprised 18 boys (51.4%) and 17 girls (48.6%) aged 6 months to 15 years. All patients had clear epidemiological history, with family clusters accounting for 28 cases (80.0%) and clear tracing of exposure to high epidemic areas in the remaining 7 cases (20.0%). Four (11.4%) patients were classified as asymptomatic, 17 (48.6%) as acute upper respiratory infection, and 14 (40.0%) as mild pneumonia, with no severe or critical cases. Clinical manifestations were mild, including fever in 18 (51.4%), cough in 14 (40.0%), and nausea and diarrhea in 7 (20.0%) patients. White blood cell count was mostly normal (26 cases, 74.3%) or decreased (7 cases, 20.0%); lymphocyte percentage was increased in 24 (68.7%); neutrophil percentage was decreased in 25 (71.4%); alanine aminotransferase was increased in 3 (8.6%); and serum potassium was decreased in 4 (11.4%). Time to negative viral nucleic acid testing was 2-42 days (mean: 14.0 ± 9.4 days). Chest imaging examination revealed that 20 patients (57.1%) had different forms of lung inflammation. Treatment was mainly isolation and nutritional support. Eleven patients were treated with interferon atomization inhalation. No patients required oxygen therapy. All 35 children were cured and discharged. Length of hospital stay was 9-54 days (mean: 25.4 ± 13.8 days). During regular follow-up after discharge, 5 children showed positivity again in the viral nucleic acid test and were re-hospitalized for observation and treatment. The mean length of re-hospitalization stay was 10.8 days.Interpretation:Children with COVID-19 mainly become infected within their family, and children of all ages are generally susceptible. The disease in children is mostly mild and the prognosis is good. Nucleic acid tests in some patients become positive again after discharge, suggesting that it is of great significance to carry out centralized isolation medical observations and active nucleic acid tests in close contacts for early detection of patients and routine epidemic prevention and control.

简介：AbstractPurpose:This study was designed to compare the clinical efficacy of "8" and "0" wire fixation systems combined with double-head cannulated compression screws or Kirschner wires for the treatment of transverse patellar fractures.Methods:From September 2011 to September 2018, patients with closed transverse patellar fractures treated with a double-head compression screw or Kirschner wire were included and analyzed retrospectively. Patients with patellar fractures combined with distal femoral fractures, tibial plateau fracture or preoperative lower limb dysfunction were excluded. The patients treated with the "8" tension band wire fixation system and Kirschner wire were taken as Group A; those treated with the "0" fixation system and Kirschner wire were taken as Group B; those treated with the "8" fixation system and double-head cannulated compression screw were taken as group C; and those treated with the "0" fixation system and double-head cannulated compression screw were taken as group D. Six weeks and one year after the operation and every month from the third month after the operation until the fractures healed, an X-ray examination was performed to identify fracture healing. The time of fracture healing and postoperative complications of the four groups were compared. One year after the operation, knee function was evaluated by Bostman’s score.Results:During the study period, 168 patients with patellar fractures were treated by operations, and 88 patients were excluded because the fracture type did not meet the requirements or because there were combined fractures of the distal femur or tibial plateau. As a result, 80 patients were included in this study, 20 in each group. All the patients were followed up for an average period of 12.2 months. Compared with Group A, patients in Group D presented less postoperative discomfort in the prepatellar region, quicker fracture healing, less fixation failure and better postoperative knee function scores (all p < 0.05). The incidence of internal fixation failure in Group (B+D) was lower than that in Group (A+C) (p > 0.05).Conclusion:The "0" wire fixation system combined with a double-head cannulated compression screw seems to be more beneficial than the other three fixation systems for the treatment of transverse patellar fractures.

简介：无

简介：Transforminggrowthfactor-β(TGF-β)isakeyfactorincancerdevelopmentandprogression.TGF-βcansuppresstumorigenesisbyinhibitingcellcycleprogressionandstimulatingapoptosisinearlystagesofcancerprogression.However,TGF-βcanmodulatecancer-relatedprocesses,suchascellinvasion,distantmetastasis,andmicroenvironmentmodificationthatmaybeusedbycancercellstotheiradvantageinlatestages.Correspondingmechanismsincludeangiogenesispromotion,anti-tumorimmunitysuppression,andepithelial-to-mesenchymaltransition(EMT)induction.ThecorrelationbetweenTGF-βexpressionandcancerprognosishasalsobeenextensivelyinvestigated.ResultssuggestthatTGF-βpathwaycanbetargetedtotreatcancer;assuch,thefeasibilityofthistreatmentisinvestigatedinclinicaltrials.

简介：无

简介：无

简介：目的：观察推拿在全髋关节置换术后康复治疗中的临床疗效。方法：将60例患者随机分成治疗组和对照组。治疗组30例进行推拿结合康复治疗，对照组30例进行单纯康复治疗。两组均治疗2星期。分别观察两组患者术后7天、术后2星期、术后6星期的改良人工髋关节Harris量表及汉密尔顿焦虑量表（HamiltonAnxietyRatingScale，HAMA）。结果：Harris量表评分总分，两组组内患者不同时间点多重比较差异有统计学意义（P〈0．05）；术后1天、术后7天及术后6星期两组间比较，差畀均无统计学意义（A，0．05）；术后2星期两组间比较差异有统计学意义（P〈0．05）。HAMA量表两组组内患者不同时间点多重比较差异有统计学意义（P〈0．05）；术后1天两纽间评分无显著性差异（P〉0．05）；术后7天、术后2星期、术后6星期两组间评分均有显著性差异（P〈0．05）。结论：单位时间内，推拿结合康复治疗对全髋关节置换术后患者的疼痛、关节活动范围及焦虑等方面的改善作用优于单纯康复治疗。

简介：前列腺癌症(PCa)是在在西方的发达国家的人之中的最普通的癌症之一，它的发生在世界的许多另外的部分更加增加了，包括中国。PCa的病原学大部分是未知的，但是被认为是multifactorial，在继承遗传起一个重要作用的地方。在这篇文章，我们简短首先从家庭聚集和基因危险性的研究考察结果到PCa。我们然后，从连接的稀罕、高外显率的PCa危险性基因的翻新的胎面钥匙调查结果在PCa家庭学习。我们把这篇文章的重要部分奉献给在PCa情况和控制中从基因协会研究总结普通、低外显率的PCa联系风险的单个核苷酸的多型性(SNP)的发现，特别那些从染色体宽的协会研究(GWAS)。这篇文章的一个强壮的焦点是在这些含有的基因标记的潜在的临床的用途上考察文学。大多数这些出版研究用在为前列腺活体检视决定需要从多重联系风险的SNP和它的用途导出的一个基因分数描述了PCa风险评价。最后，我们评论基因分数的最新建议的概念；观点是为基因倾向把它当作一个标记，类似于家庭历史，而非一个诊断标记到从非癌症病人区别PCa病人。到日期的可得到的证据建议那个基因分数比家庭历史是一个目的和PCa的继承风险的更好的测量。这篇文章的另一个唯一的特征是在中国、日本的人口的PCa的基因协会研究的包括。

简介：Objective:Toobservethetherapeuticeffectofscalpacupunctureoncerebralbloodflowinpseudobulbarparalysispatientsforanalyzingmechanismsofscalp-acupunctureinthetreatmentofwindstrokek.Methods:Atotalof38inpatients(26malesand12females)weretreatedwithelectroacupuncture(EA)ofscalp-pointDingzhougxian(MS5),DingnieHouxiexian(MS7),DingpangxianⅡ(MS9)andDingnieQianxiexian(MS6).Beforeandafteracupuncturetreatment,clinicalsymptomsofdysphadiaanddyskphoniaserecompared,andthemeanbloodflowspeed(MBFS)valuesoftheanteriorcerebralartery(ACA),middlecerebralartery(MCA)andposteriorcerebralartery(PCA)detectedbyusingDopplerbloodflowmeter.Results:Followingtwocourses(4weeks)ofscalp-acupuncturetreatment,ofthe38cases,23hadtheirdysphagiaanddyskphoniacured(60.5%),10(25.3%)hadremarkableimprovement,3(7.9%)experiencedimprovementand2(5.3%)hadnoapparentchanges.Simultaneously.MBFSofACA,MCAandPCAincreasedsignificantlyincomparisonwiththatofpre-treatment(P<0.01).Additionally,resultsalsoshowedthatscalpacupuncturecouldstabilizethebloodcirculationbetweenbothhemispheresofthebrain.Conclusion:Scalpacupuncturehasafairlygoodtherapeuticeffectinimprovingstrokecauseddysphagiaanddysphoniaandinfacilitatingcarebralbloodflow.

简介：Objective:ToobtainrecombinantTreponemapallidumsubsp,pallidum(TP17KD)lipoproteininlargequantitiesbyamplificationandtofurtherpurifyantigensforlaboratorydiagnosisofsyphilisanddevelopmentofasyphilisvaccine.Method:TheTppl7lipoproteingenewasamplifiedfromtheTP(strainNichols),andthenitwasrecombinatedintoaplasmidpMAL-2candclonedwithinE.coli12-TB1.ThehostbacteriacontainingrecombinantplasmidswereinducedwithIPTG.TheTpp17KDlipoproteingenewasamplifiedbyus-ingPCRandpositivecloneswerescreenedwithdoubledigestionandPCR.RecombinantplasmidsweretransformedintoE.coliandtheE.colicarryingrecombinantplasmidswereinduced.TheexpressionofTP17KDwasdetectedbysodiumdedecylsulfate-polyacrylamidegelelectrophoresis(SDS-PAGE)andimmunoblot.Results:GelstainingwithCoomassieblueG-250showedthattheinducedE.colicarryingrecombinantplasmidcouldproduce60KDfusionproteinathighlevels.Gelscanningshowedthat17KDproteinexpressioninE.coliaccountedfor10%oftotalcellularprotein.Therecombinantproteinantigenreactedwiththeseraofsyphilispatients.Conclusion:Ourstudylaysacornerstonefordevelopingnewtechniquesoflaboratorydiagnosisforsyphilisandnewvaccines.Preliminaryclinicalapplicationshowedthatthefusionproteincouldbeusedforthediagnosisofsyphilis.