简介:Failureofthethyroidglandrequiresthyroidhormonereplacementtherapy,whichisrelativelyeasilyadjustedtoreplicatethenormalphysiologicalstatebymonitoringplasmalevelsofthyroxineand/orthyroid-stimulatinghormone.Incontrast,failureofpancreaticβ-eellsrequiresinsulintherapy,andoptimalreplacementrequiresmonitoring,notoftheabsenthormone(insulin),butofitsmajorsubstmte(glucose).
简介:AbstractIntraamniotic infection (IAI) or chorioamnionitis is a common cause of preterm birth and may cause adverse neonatal outcomes, including neonatal pneumonia, respiratory distress, meningitis, sepsis, and death. Maternal morbidities from intraamniotic infection include dysfunctional labor requiring increased intervention, cesarean birth, postpartum uterine atony with hemorrhage, endometritis, peritonitis, sepsis, adult respiratory distress syndrome and, rarely, death. Chorioamnionitis can result from an ascending infection, iatrogenic causes or transplacental passage from maternal blood-borne infections. The clinical findings of chorioamnionitis include maternal fever (≥38 °C), maternal (>100 beats per minute) and/or fetal tachycardia (>160 beats per minute), maternal leukocytosis on complete blood count (>15 000 cells/mm3), and uterine tenderness and/or purulent and/or foul-smelling amniotic fluid. The management of chorioamnionitis mainly includes antibiotic therapy and delivery. Women with previable preterm premature rupture of membranes should be offered realistic counseling from a multidisciplinary approach. The separation of the mother and the fetus to preserve the life of the mother should prioritize delivery methods that result in a living fetus if possible, with appropriate neonatal resuscitation available.
简介:AsreadersofCancerBiologyandMedicinewellknow,therehasbeenaseismicshiftinhumanmolecularbiologyoverthepastfewyears,asmomentousinitsownwayasthediscoveryofthedouble-helicalstructureofDNAbyWatsonandCrick60yearsago,theelucidationofthegeneticcodeshortlythereafter,theadventofrecombinantDNAandgenecloning
简介:摘要目的通过71例上颌骨骨折患者资料分析,以探讨手术后并发症的发生和治疗方法。方法71例上颌骨骨折患者。60例行微型钛板内固定术;7例颌间牵引复位固定术;3例选择保守治疗;1例未治。结果71例病例随访2~24个月,60例手术患者54例效果满意,成功率为90%。10例出现面神经颞支损伤,术后6个月,患者完全恢复。5例出现错颌、前牙开颌,通过颌间牵引和调颌,恢复正常。1例面部塌陷未进行修复。结论治疗上颌骨骨折的要旨有两。固定方法可分为两类开放复位内固定和颅上颌支架外固定;可根据伤情,择优选用。复位微型钛板内固定术后效果满意,但术后产生并发症的原因及预防措施有待进一步研究,对颌面缺损的修复,视力障碍问题有待解决。
简介:目的探讨妊娠梅毒患者的临床特点和影响妊娠结局的因素。目的:71例经血清学检查确诊为梅毒的孕妇,根据妊娠期是否行全疗程抗梅毒治疗,分为治疗组(39例)及未治疗组(32例)。比较两组孕妇的妊娠结局、围产儿预后及新生儿先天梅毒的发生情况。同时根据母血清快速血浆反应素环状卡片试验(RPR)滴度高低,将71例梅毒孕妇分为≤1:8组与≥1:16组,观察血清滴度与妊娠结局的关系。结果:(1)妊娠结局:治疗组足月分娩率为100%(39/39),未治疗组78%(25/32),两组比较,差异有极显著性(P〈O.01)。治疗组分娩正常新生儿者占72%(28/39),未治疗组仅占25%(8/32),两组比较,差异有极显著性(P〈O.01)。治疗组窒息儿、低体重儿、先天梅毒患儿发生率及新生儿死亡率均明显低于未治疗组,两组比较,差异有极显著性(P〈O.01)。(2)RPR滴度:≤1:8组49例,≥1:16组22例。≤1:8组足月儿占98%(48/49),明显高于≥1:16组的73%(16/22)。≤1:8组早产儿、围产儿死亡率均低于≥1:16组,两组比较,差异有极显著性(P〈O.01),先天梅毒儿发病率两组比较,差异有显著性(P〈O.05)。(3)治疗组孕妇中应用青霉素治疗者发生先天梅毒儿为26.O%(6/23),应用头孢曲松治疗者发生先天梅毒儿为21.4%(3/14),两组比较,差异无显著性(P〉O.05)。另有2例孕妇服用红霉素治疗,所分娩的新生儿均为先天梅毒儿,发生率为100.O%,与其他两组先天梅毒儿发生率比较,差异有极显著性(P〈O.01)。结论:(1)有效的全程抗梅毒治疗是改善妊娠梅毒患者妊娠结局和围产儿预后,以及降低先天梅毒患儿发生率的关键。(2)母血清RPR滴度高低及用药,是影响妊娠梅毒结局的重要因素。
简介:摘要目的探讨妊娠合并子宫肌瘤的并发症和剖宫产时同时行肌瘤剔除术的指征。方法对71例妊娠合并子宫肌瘤进行回顾性分析。结果妊娠合并子宫肌瘤占同期妊娠人数的2.46%,并发症发生率为38.03%。子宫肌瘤使剖宫产率提高。剖官产术中行肌瘤剔除,未明显增加手术出血量。结论妊娠合并子宫肌瘤使妊娠并发症发生率明显提高,行剖宫产时应尽量同时剔除肌瘤,以免患者受二次手术的痛苦。
简介:Aim:Tostudytheadvantageofexcisionofthedistalsymptomaticuretericstumpswiththeretroperitoneallaparoscopicapproach.Methods:Fourpatientswhohadfailedtosettletheirsymptomswiththeinitialconservativemanagementwereincludedinthestudy.Allunderwentexcisionofthedistalsymptomaticuretericstumpswiththeretroperitoneallaparoscopicapproachandthenreceivedprophylacticantibiotics.Results:Wehaveachievedbetterresultsthanthosereportedintheliteratureintermsofoperatingtime(mean1h45min),bloodloss(<10mL),postoperativerecovery(within12h)andhospitalstay(<48h).Conclusion:Retroperitoneallaparoscopicexcisionisasafe,simpleandeffectivemethodinthemanagementofsymptomaticuretericstumps.
简介:Hypertensionisaleadingriskfactorforcardiovasculardisease,theleadingcauseofdeathandmorbidityinoursocietyandonaglobalscale.Majorcomponentsofcardiovasculardiseaseincludestroke,coronaryarterydisease,heartfailure,andchronickidneydisease,inallofwhichhypertensionplaysamajorrole.Theriskofthesecomplicationsincreasesdirectlyandlinearlywithsystolicbloodpressurestartingat115mmHg.Althoughusuallyasymptomatic,hypertensionisreadilydetectableonphysicalexaminationandisamenabletobothlifestylemodificationandpharmacologictreatmentinmostpatients.However,largeproportionsofthehypertensivepopulationremainundetectedandundertreated.Numerousguidelineshavebeenissuedduringthepastfewdecadestopromotedetectionandoptimaltherapy.Despitetheincreaseinriskwithsystolicbloodpressuregreaterthan115mmHg,thegenerallyacceptedthresholdfordiagnosisandtreatmenthasbeensystolicbloodpressuregreaterthan139mmHganddiastolicbloodpressuregreaterthan80mmHgbecauseuntilrecentlytreatmenttolowerlevelshasbeenassociatedwithanunfavorablerelationbetweenclinicalbenefitandharm.Inthepastseveralyears,newguidelines,advisories,commentaries,andclinicaltrialshaveprovidedevidenceforapotentialchangeincurrentrecommendationsforthemanagementofhypertension.Inthisregard,thelong-awaitedeighthreportoftheJointNationalCommitteeonthePrevention,Detection,Evaluation,andTreatmentofHighBloodPressurerecommendedpatientsolderthan60yearsbetreatedtoasystolicbloodpressureoflessthan150mmHg,whichhasgeneratedconsiderablecontroversyandcaution.ThestrikingfindingsoftheSystolicBloodPressureInterventionTrial(SPRINT)havereceivedconsiderableattentionbecauseofthedemonstrationthatintensivetherapytoatargetsystolicbloodpressurebelow120mmHgdecreasescardiovascularmortalityandmorbiditymorethanlessintensivetreatmenttoatargetsystolicbloodpressurebelow140mmHg
简介:Dizzinessaffectsaleutone-thirdofindividualsovertheageof65years,andisoneofthemostconmlonreasonsfortheelderlytoconsulttheirgeneralpractitioner.Syncopeaffectsatleast20%ofthepopulationatmlnetimeandaccountsforabout6%ofgeneralmedicaladmissionsintheUK.Recurrentsymptomsareparticulas-lydisablingbecausetheyaffectanindividual'sabilitytoworkandtodrive,increasesusceptibilitytofallsandassociateinju-rim,andreduceindependenceintheelderly.
简介:Objective:Tosummarizesurgicaltreatmentsandtheircorrespondingcurativeeffectsonsciaticnerveinjuries.Methods:Surgicaltreatmentsonsciaticnerveinjurywereperformedin28patientsfromJanuary1990toJuly2000.Thetreatmentsincludedneurolysis,neurolysispluspartialnerveanastomosis,nerveanastomosisandnervetransplantation.ThecurativeeffectwasevaluatedaccordingtoSunderlandcriteria.Results:Of28cases,22patientswerefollowedupwithafollow-upperiodof13monthsto5years(average30months).Of22nerves,7wereexcellent,5good,7fairand3poor,withanexcellencerateof54.5%.
简介:Thispaperreviewscurrentrecommendationsontheappropriateevaluationandmanagementofcardiacarrhythmiasinthepregnantpatient.Mostarrhythmiasduringpregnancyarebenignandrequirenointervention.Whenrequired,thedecisiontotreatshouldbebasedonsymptomseverityandtheassociatedrisktomotherandfetusposedbypotentiallyrecurringarrhythmiaepisodesthroughoutthepregnancy.Anytreatmentstrategyinthispatientpopulationhasinherentrisktobothmotherandunbornchild.Beforetheinitiationofanyintervention,documentationofaclinicalarrhythmiaandcorrelationwithclinicalsymptomsshouldbeobtained.Thereisnoroleforempirictherapy.