简介:药的效果的研究,kanamycin,在recombinantEscherichiacoli的生长新陈代谢上,B1被对待的细胞的新陈代谢的活动监视的microcalorimeter执行。种recombinantEscherichiacoli房间暂停的力量时间曲线,与不同kanamycin剂量对待,被记录。效果的程度被变化在microcalorimetric曲线的斜坡评估,药行动的动力学从这些变化在到达了他们的最大的价值并且维持了他们的最大的价值的时间被解释。试验性的剂量效果关系遵循集体行动的法律的中部效果的原则:fa/(1?fa)=(D/D50)m。y=lg的一个阴谋[(fa)1?1]?1对x=lgD给斜坡m,D50和R。试验性的结果表明kanamycin的高集中在lg阶段在recombinantEscherichiacoliB1的生长上有禁止的效果,并且在静止时期有支持的效果。而且,microcalorimetry是为在生物学的调节效果的察觉的一个可靠方法,这被表明。
简介:Asavolunteerorganization,NGOplaysanimportantrolenowadaysforitsuniquesocialfunctions.Inrecentyears,ChineseYoungVolunteersAssociationshavemadegreatprogress,butcomparedwiththeEUcountries,thereisstillasignificantgap.Thispaperincludestheresultofthecomparativeresearchesontwoaspects:Volunteerassociations;Trainingsystems.Fromtheresult,arelativelycomprehensivereferencecanbeprovidedforthedevelopmentoftheChineseYouthVolunteersAssociations.
简介:AbstractBackground:Hypertension is considered an important risk factor for the coronavirus disease 2019 (COVID-19). The commonly anti-hypertensive drugs are the renin-angiotensin-aldosterone system (RAAS) inhibitors, calcium channel blockers (CCBs), and beta-blockers. The association between commonly used anti-hypertensive medications and the clinical outcome of COVID-19 patients with hypertension has not been well studied.Methods:We conducted a retrospective cohort study that included all patients admitted with COVID-19 to Huo Shen Shan Hospital and Guanggu District of the Maternal and Child Health Hospital of Hubei Province, Wuhan, China. Clinical and laboratory characteristics were extracted from electronic medical records. Hypertension and anti-hypertensive treatment were confirmed by medical history and clinical records. The primary clinical endpoint was all-cause mortality. Secondary endpoints included the rates of patients in common wards transferred to the intensive care unit and hospital stay duration. Logistic regression was used to explore the risk factors associated with mortality and prognosis. Propensity score matching was used to balance the confounders between different anti-hypertensive treatments. Kaplan-Meier curves were used to compare the cumulative recovery rate. Log-rank tests were performed to test for differences in Kaplan-Meier curves between different groups.Results:Among 4569 hospitalized patients with COVID-19, 31.7% (1449/4569) had a history of hypertension. There were significant differences in mortality rates between hypertensive patients with CCBs (7/359) and those without (21/359) (1.95% vs. 5.85%, risk ratio [RR]: 0.32, 95% confidence interval [CI]: 0.13-0.76, χ2 = 7.61, P = 0.0058). After matching for confounders, the mortality rates were similar between the RAAS inhibitor (4/236) and non-RAAS inhibitor (9/236) cohorts (1.69% vs. 3.81%, RR: 0.43, 95% CI: 0.13-1.43, χ2 = 1.98, P = 0.1596). Hypertensive patients with beta-blockers (13/340) showed no statistical difference in mortality compared with those without (11/340) (3.82% vs. 3.24%, RR: 1.19, 95% CI: 0.53-2.69, χ2= 0.17, P= 0.6777).Conclusions:In our study, we did not find any positive or negative effects of RAAS inhibitors or beta-blockers in COVID-19 patients with hypertension, while CCBs could improve prognosis.
简介:AIM:ToreviewvisionhealthsituationofIraniancommunity,analyzeitsdeterminants,anddiscusstheadoptedimprovementstrategiesbytheIranMinistryofHealthandMedicalEducation(MOHME).METHODS:Thiswasarapidsituationanalysiswithaqualitativeapproachinthreepartsofrecognition,orientationandimplementation.Thedataweregatheredviareviewofupstreamdocuments,nationalandinternationalexperiences,andexpertsandstakeholders’opinions.RESULTS:Eradicatingtrachoma,increasinghumanresources,increasingeducationalandresearchcentersandpromotionofophthalmictechnologieswereimportantachievementsinthefieldofvisionhealthinIran.Throughtheseachievements,itseemedthatthepatternofcausesofblindnessandlowvisionwassimilartothatofthedevelopedcountries.However,thereviewofIranians’visionhealthindicatorsshowedthataconsiderablepercentoftheblindnessandlowvisionwasavoidablethroughanationalprogramdemanding3typesofinterventionsinsocialdeterminantsofhealth(SDH),communityeducation,andincreasingtheaccesstohealthcareservicesbyintegratingthenecessaryservicesinprimaryhealthcaresystem.CONCLUSION:Managingtheissuerequiresattentionsfromanationalcommitteeforpreventingblindnesswithparticipationofallstakeholders,implementinganationalsurveyonvisionhealth,preparationoftheprimarylevelhealthcentersincludingemploymentandeducationofcommunityhealthworkers(Behvarzes),optometristsandgeneralpractitioners,fairdistributionofspecializedhumanresourcesandestablishingatleastonespecializedcenterineachprovinceforreferringpatientsfromtheprimarylevels.
简介:Inthiswork,weinvestigatethemethodstoimprovetheperformanceofthesweptsourceat1.0μmbasedonapolygonscanner,includingin-cavityparametersandboosterstructuresoutofthecavity.Thethreein-cavityparametersarethecavitylength,therotatingspeedofthepolygonscanner,andthein-cavityenergy.Withthedecreaseofcavitylength,thespectrumbandwidthbecomeswiderandthedutycyclebecomeshigher.Withtheincreaseoftherotatingspeedofthepolygon,thespectrumbandwidthbecomesnarrower,andthedutycyclebecomeslowerbuttherepetitionratebecomeshigher.Withmoreenergyin-cavity,thespectrumbandwidthbecomeswiderandthedutycyclebecomeshigher.Theboosterstructuresincludethebufferedstructure,secondaryamplifier,anddual-semiconductoropticalamplifierconfiguration,whichareusedtoincreasethesweepfrequencyto86kHz,theoutputpowerto18mW,andthetuningbandwidthto131nm,respectively.
简介:一个变压器的停止尽最大努力,产生系统将通常导致一全部系统的shutdown。必然地,大量收入在民用的社区和工业顾客上与实质的否定影响被失去到植物主人。这篇论文分析当前的维护惯例(即,一如此处理模型)一个变压器生产同伴,它提供维护服务给发电植物并且在当前的生意报导主要软弱练习。维护软弱包括孤立的过程并且糊基于的信息通讯。这些低效的过程导致服务延期,费用增加,和对顾客的不恰当的回答特定的请求和抱怨。为了改进全部变压器维护的效率和灵活性,满足系统,一条电子集成途径与三项关键任务被实现。首先,当前的企业过程被重新设计提供一改善(未来)企业模型。然后,我们代替有为有效、划算的信息的一个电子的走系统的基于的文档方法交换的纸。后来,当一张因特网基于系统为设定的维护服务在变压器制造商,最终用户,和服务承包商之中提高相互作用,改进进程模型被实现。案例研究证明实现电子集成途径增加设定的维护服务的效率和有效性。
简介:Thispaperpresentsasimpleapproachforimprovingtheperformanceoftheweightedessentiallynonoscillatory(WENO)finitevolumeschemeonnon-uniformgrids.ThistechniquereliesonthereformulationofthefifthorderWENO-JS(WENOschemepresentedbyJiangandShuinJ.Comput.Phys.126:202–228,1995)schemedesignedonuniformgridsintermsofonecell-averagedvalueanditsleftand/orrightinterfacialvaluesofthedependentvariable.Theeffectofgridnon-uniformityistakenintoconsiderationbyaproperinterpolationoftheinterfacialvalues.Onnonuniformgrids,theproposedschemeismuchmoreaccuratethantheoriginalWENO-JSscheme,whichwasdesignedforuniformgrids.Whenthegridisuniform,theresultingschemereducestotheoriginalWENO-JSscheme.Inthemeantime,theproposedschemeiscomputationallymuchmoreefficientthanthefifth-orderWENOschemedesignedspecificallyforthenon-uniformgrids.Anumberofnumericaltestcasesaresimulatedtoverifytheperformanceofthepresentscheme.
简介:Withthewideapplicationofvirtualizationtechnologyinclouddatacenters,howtoeffectivelyplacevirtualmachine(VM)isbecomingamajorissueforcloudproviders.Theexistingvirtualmachineplacement(VMP)solutionsaremainlytooptimizeserverresources.However,theypaylittleconsiderationonnetworkresourcesoptimization,andtheydonotconcerntheimpactofthenetworktopologyandthecurrentnetworktraffic.Amulti-resourceconstraintsVMPschemeisproposed.Firstly,theauthorsattempttoreducethetotalcommunicationtrafficinthedatacenternetwork,whichisabstractedasaquadraticassignmentproblem;andthenaimatoptimizingnetworkmaximumlinkutilization(MLU).Ontheconditionofslightvariationofthetotaltraffic,minimizingMLUcanbalancenetworktrafficdistributionandreducenetworkcongestionhotspots,aclassiccombinatorialoptimizationproblemaswellasNP-hardproblem.Antcolonyoptimizationand2-optlocalsearcharecombinedtosolvetheproblem.SimulationshowsthatMLUisdecreasedby20%,andthenumberofhotlinksisdecreasedby37%.
简介:Achallengingprobleminrealworldlogisticsapplicationsconsistsinplanningserviceterritoriesforcustomerdeliveries,incontextswherecustomersmustbeclusteredintogroupsthatsatisfyvariousconditionssuchasbalanceandconnectivity.InthispaperweproposenewalgorithmsforproducingsuchclustersbaseduponspecialproceduresforexploitingThiessenpolygons.Ourmethodsareabletohandlemultiplecriteriaforbalancingtheclusters,suchasthenumberofcustomersineachcluster,theservicerevenueineachcluster,orthedelivery/pickupquantityineachcluster.Computationalresultsdemonstratetheefficacyofournewprocedures,whichareabletoassistuserstoplanservicepersonalserviceterritoriesandvehicleroutesmoreefficiently.
简介:BasedonthesurveydataoftypicalvillagesinShaanxiProvince,China,theeffectofsocialcapitalontheincomegapoffarmers’householdswasanalyzedusingtheShapleyvalueofthetotalamountofsocialcapitalandthesocialcapitalstructure.Theresultsshowthefollowing:first,socialcapitalcanexpandthehouseholdincomegap,andtheeffectofthisindexonthehouseholdincomegapis7.54%.Second,theindexesofthesocialcapitaldimensioncanexpandthehouseholdincomegap,andthestructuraleffectsofthehouseholdincomegaponsocialnetworks,socialtrust,andsocialparticipationare3.17%,3.64%,and0.65%,respectively.Third,nodimensionofthepathisthesameastheeffectonthehouseholdincomegap.
简介:Theeffectoftemperatureonthecriticalaggregateconcentration(CAgC)hasbeeninvestigatedforthefirsttime,bymeasurementofthehydrolyticrateconstantsofp-nitrophenyldodecanoate(C12)andhexadecanoate(C16)atdifferenttemperaturesinthe30:70V/V(Φ=0.30)and40:60V/V(Φ=0.40)dioxane(DX)-H2Osystems.TheCAgCvaluesofC12andC16increasewiththeincreaseofthetemperature,i.e.,hightemperaturesdisfavoraggregation.ActivationenergiesforthehydrolysisofC12inthemonomericandaggregatedconcentrationdomainshavealsobeendiscussed.