简介：BackgroundBasedonpreviousstudies,afragmentedQRS(fQRS)complex,asapredictivebiomarkerofmyocardialscarringcondition,couldbeusedtopredicttheoutcomesofcardiacresynchronizedtherapy(CRT).However,thisconclusionisstilldebatable.MethodsFiftyischemicornon-ischemiccardiomyopathypatientsfailure(aged65±10yrs,34males,16females)withrefractoryheart,diagnosedbythecriteriaofNewYorkHeartAssociationreceivedCRT.TheECGsof18patientswithafQRScomplex(dividedbyDas)werecomparedwiththoseof32patientswithoutafQRScomplex,whowereevaluatedby12-leadECGbeforeCRT.Thepatientswerefollowedupforsixmonths,and12-leadECGandechocardiographywerereviewed.Atleast15%reductionintheleftventricularend-systolicvolume(LVESV)wasdefinedasrespondersaccordingtothedataobtainedforbetween-groupandintra-groupanalysis.ResultsSixpatients(33.3%)inthefQRSgroupand24patients(75%)inthenon-fQRSgrouprespondedwell.Inaddition,comparisonsofindicatorsfromsurfaceECGandechocardiography6monthsafterCRTshowedthatthenon-fQRSgroupbenefitedfromCRTsignificantlymorethanthefQRSgroup.ConclusionsThefQRScomplexhasgoodpredictivevalueforresponsivenesstoCRT.Non-fQRScomplexpatientswithrefractoryheartfailuremaybenefitmorefromCRT,andthesepatientsneedtoreceivethistreatmentasearlyaspossible.

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简介：Theoptimaldurationofdualantiplatelettherapy(DAPT)ofaspirinandaP2Y12receptorblockerafterstentingisstillbeingdebated.ThecurrentrecommendationsforDAPTdurationaresignificantlyfocusedonreducingstentthrombosis;alessfrequenteventwithlaterthanearliergenerationdrugelutingstents(DES).ApersistentoccurrenceoflateandverylatestentthrombosiswithfirstgenerationDESsupportedextendeduseofDAPTbeyondoneyear.However,recentstudieshavedemonstratedthatextendeddurationDAPTisassociatedwithincreasedbleeding;anindependentpredictorforpooroutcomes,includinglong-termmortality.Second-generationDESareassociatedwithlesslateandverylatestentthrombosis.SomerecentstudieshavesupportedashorterdurationofDAPTforsecondgenerationDES.However,thesestudieswereinadequatelypoweredtoassesssignificantdifferencesinstentthrombosis.Furthermore,extendeddurationDAPThasbeenassociatedwithareducedriskofthromboticeventsinnon-culpritvesselsinadditiontostentthrombosisinpatientswithacutecoronarysyndromes(ACS).ThehigherriskofbleedingassociatedwithextendedDAPTtherapyprovidesastrongrationaleforpersonalizedDAPTbasedonpatientriskfactors(e.g.ACSvs.non-ACS),typeofstents,andcost-benefitanalyses.

简介：联系精索静脉曲张的男不孕古典主义地用外科被管理了或帮助了繁殖技术。与在联系精索静脉曲张的不孕作为一个pathophysiological因素增加氧化应力的证据，医药治疗特别抗氧化剂可能与更低的风险成为一种治疗选择。我们在归因于精索静脉曲张的男不孕的管理在各种各样的医药代理人的角色上考察了存在文学。医药治疗典型地与外科对药治疗作为辅助治疗与安慰剂，药对手术的(b)比较，和药的(c)比较处于象二药或一药的(a)比较那样的三种不同状况被评估独自一个。由于数据的异质和进行得好的研究的缺乏，有不够的数据与联系精索静脉曲张的不孕为人推荐医药治疗的平淡的使用，外科仍然是选择的处理。怀孕和实时出生率通常没在精子参数在大多数研究和仅仅的改进被报导或抗氧化剂能力是不够的支持它的平淡的使用。抗氧化剂治疗由于它的理论利益，从现出症状之前的潜的研究的数据，和主要副作用的缺乏是一种潜在的选择。有在精索静脉曲张的外科的修理以后的抗氧化剂的辅助治疗可以改进结果并且是为进一步的研究的一个潜在的区域。

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简介：AbstractPeriodontitis is one of the most prevalent epidemics affecting human health and life recently, and exploration of the pathogenesis and treatment of periodontitis has been valued by scholars. In recent years, sclerostin, a new factor on bone resorption and reconstruction caused by inflammation and mechanical stimulation, has been a research hotspot. This article summarizes the researches on sclerostin in periodontitis development in recent years. Among them, sclerostin has been shown to be a critical negative regulator of bone formation, thereby inhibiting bone remodeling in periodontitis development, and is closely associated with tooth movement. Besides, evidence indicates that the removal of sclerostin seems to reasonably protect the alveolar bone from resorption. Regulation of sclerostin expression is a novel, promising treatment for periodontitis and addresses several complications seen with traditional therapies; accordingly, many drugs with similar mechanisms have emerged. Moreover, the application prospect of sclerostin in periodontal therapy combined with orthodontic treatment is another promising approach. There are also a lot of drugs that regulate sclerostin. Anti-sclerostin antibody (Scl-Ab) is the most direct one that inhibits bone resorption caused by sclerostin. At present, drugs that inhibit the expression of sclerostin have been applied to the treatment of diseases such as multiple myeloma and osteoporosis. Therefore, the application of sclerostin in the oral field is just around the corner, which provides a new therapeutic bone regulation strategy in oral and general health.

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简介：1000patientssufferingfromdysmenorrheahavebeentreatedbyapplyingauricular-plastertherapyinourclinicsince1957.Theyweredifferentiatedinto3typesandthengivenpressingtherapyonselectedauricularpoints.Amongthe1000cases,817caseswerecured,markedeffective159cases,withthetotaleffectiverateof99.6%.Thistherapywaseffectivetoall3typesofdysmen-orrhea.

简介：Temporomandibularjointsyndromeisoneofthecommonlyencountereddiseasesinthedepartmentofstomatologyandismainlycausedbyimproperchewingorbysubluxationofthetemporomandibularjointandismostlyseeninyoungadultsfrom20-40yearsold.Themainsymptomsarepluckingsound,painandabnormalmouth-openingmovementinthetemporomandibularjoint,anditoftenoccursononesideorontwosides.Theauthorhastreated20casesoftemporomandibularjointsyndromebyTuinatherapyplusacupuncture.

简介：ItwasreportedthatProf.YUandhiscolleaguesfromtheFirstAttachedHospitalofHarbinMedicalUniversityhadachievedanewdevelopmentinelectroacupuncture(EA)treatmentofurinarylithiasisinclinic.Bycombiningthemeridian-collateraltheoryoftraditionalChinesemedicine(TCM)andthesegmentaldistributionofthespinalnerveroots

简介：Inthepresentstudy,100patientssufferingfromgastroptosiswererandomlydividedintoauricular-plastergroupandacupuncturegroup.Theeffectiveratesofthetwogroupswerebothabove90%andnostatisticallysignificantdifferenceintherateswasfoundbetweenthesegroups(P>0.05).Itindicatesthatauricular-plasterandacupuncture,thoughtheyaredifferentfromeachotherinmethodology,arebotheffectiveinthetreatmentofgastroptosis.

简介：Insomniaisacommonlyencounteredsleepdisorderinclinicalpractice.Theauthorofthepresentpapertreated40casesofinsomniawithacupunctureandmassagecombinedwithmusictherapyandachievedsatisfiedoutcomes.Followingisthereport.

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简介：目的：分析非手术疗法治疗腰椎间盘突出症的近期、远期疗效。方法：将165例腰椎间盘突出症患者按随机和单盲法分为牵引组、推拿组，推拿加功能锻炼组，治疗2个疗程后，评定近期疗效。然后将取得显效的102例患者按区组随机和单盲法分为功能锻炼组和对照组，随访1年观察两组复发率，并分别于治疗后6和12个月进行腰椎功能评定。结果：推拿组和推拿加功能锻炼组较牵引组近期疗效显效率差异有显著性(x^2=8．359，P<0．01)。功能锻炼组1年内的复发率明显低于对照组(x^=12．631，P<0．01)。结论：推拿加功能锻炼是防治腰椎间盘突出症的有效方法。

简介：捏脊疗法是推拿常用手法之一，这一疗法具有简、便、验、廉的特点。近年来捏脊疗法临床应用的范围不断扩大，用于治疗的疾病已达数十种。遍及内科、妇科、儿科等各科及预防、保健、美容等方面，临床报道很多。本文收集近十年有关捏脊疗法的文献21篇，在分析了这些文献的基础上从捏脊疗法临床运用的角度进行归纳总结。

简介：Acrucialfeatureofnanoparticles,suchasliposomes,magneticnanoparticles,quantumdots,metallicnanoparticles,silicananoparticles,polymersomesanddendrimersetc.,istheirhigheraccumulationinthetumorthaninnormaltissues1-3.Variousnanoparticleshavebeenintensivelyusedasvehiclestodeliverchemotherapeutic

简介：Inthepresentpaper,theauthorsreportafewoftypicalcasesofalergicdiseasesincludingpotlinosis,asthma,redeyesandswellingfaceanddermatitistreatedwithotopointsandsomebackshu-pointsaccordingtothesymptoms.Theresultshowedthatthecurativeeffectwassatisfactory.Itindicatesthatotopointshaveagoodantlanaphylacticeffect.

简介：AbstractThe immune system has the function of immune surveillance to resist the occurrence and development of tumors, and is essential for inhibition of tumor metastasis. Nevertheless, tumor cells can still suppress immune responses through multiple mechanisms to escape recognition and elimination. Photodynamic and sonodynamic therapy involve systemic or local use of sensitizers followed by light or ultrasound treatment of the affected area, leading to tumor cell death by various mechanisms. The capability of the immune system is essentially affected by photodynamic and sonodynamic therapy. To understand the tumor therapeutic mechanisms of photodynamic and sonodynamic therapy and to explore the use of these modalities for improvement of the antitumor immune effect, extensive preclinical and clinical studies have been carried out. Besides direct killing of tumors, photodynamic and sonodynamic therapy also cause inflammatory reactions, achieve antitumor immune responses, and potentially prevent tumor recurrence, thereby treating both primary and metastatic tumors. In this review, we summarize the antitumor immune responses induced by photodynamic and sonodynamic therapy, describe the processes of the antitumor immune responses in detail, and discuss the clinical applications of the resulting antitumor immunity.