简介:Objective:Tostudythemechanismofelectroacupuncture(EA)ofscalp-pointsforregulatingabnormaldischargesofneuronsindifferentregionsaroundthecerebralhemorrhagefocusbyusingneuro-electrophysiologicalmethods.Methods:80Wistarrats(anesthetizedwith20%urethane1g/kg,I.p.)wererandomlydividedintonormal,saline,modelandEAgroups,with20casesineachgroup.Cerebralhemorrhagemodelwasestablishedbyintracerebralinjectionoftherat'sownarterialbloodsample(40uL).Inratsofsalinegroup,thesamevolumeofsalinewasgivenforintracerebralinjection.ExtracellularelectricalactivityofneuronsofthecaudatenucleusandparafascicularnucleusandTailfiliformneedlesandstimulatedelectricallywithstimulatingparametersofstrengthof1V,frequencyof15Hzanddurationof15min.Results:Comparedwithnormalgroup,TFLvaluesofmodelgroupandEAgroupincreasedsignificantly(P<0.01);andcomparedwithmodelgroup,thoseofEAgroupdecreasedsignificantly(P<0.01),suggestingthatthepainthresholdincreasedsignificantlyincerebralhemorrhageratswhileafteracupuncturestimulation,itloweredstrikingly.Comparedwithnormalandsalinegroups,thelatencyvaluesofthepainexcitementandinhibitoryresponsesofthecellulardischargesofthecaudateandparafascicularnucleiinmodelandEAgroupsincreasedsignificantly(P<0.05~0.01),whileafterEA,itrecoveredapparently(P<0.01),showinganapparentregulativeeffectofEAontheabnormalchangesofdischargesofneuronsaroundthecerebralhemorrhagefocus.Conclusion:Scalp-acupuncturepossessesanapparentregulatoryeffectontheabnormalelectricalactivityofneuronsaroundthecerebralhemorrhagefocuswhichmayfavortheearlyrecoveryoffunctionalactivityofneuronsnearthefocustissues.