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500 个结果
  • 简介:Liverinjuryisacharacteristicfeatureofhumanimmunodeficiencyvirus(HIV)infection,whichisthesecondmostcommoncauseofmortalityinHIV-infectedpatients.NowitisrecognizedthatliverplaysakeyroleinHIVinfectionpathogenesis.Antiretroviraltherapy(ART),whichsuppressesHIVinfectioninpermissiveimmunecells,islesseffectiveinhepatocytes,therebymakingthesecellsasilentreservoirofHIVinfection.InadditiontodirecthepatotoxiceffectsofHIV,certainARTtreatmentmodalitiesprovidehepatotoxiceffects.TheexactmechanismsofHIV-triggeredchronichepatitisprogressionarenotelucidated,buttheliverisadverselyaffectedbyHIV-infectionandlivercellsareprominentlyinvolvedinHIV-elicitedinjury.Theseeffectsarepotentiatedbysecondhitslikealcohol.Here,wewillfocusontheincidenceofHIV,clinicalevidenceofHIVrelatedliverdamage,interactionsbetweenHIVandlivercellsandtheroleofalcoholandco-infectionwithhepatotropicvirusesinliverinflammationandfibrosisprogression.

  • 标签: LIVER cells ANTIRETROVIRAL therapy Apoptosis INFLAMMATION
  • 简介:June2015,BeijingPrefaceIn2014theCommunistPartyofChina(CPC)andtheChinesegovernmentjointlypushedforwardtheimplementationofthecountry’sfourmajorstrategictasks:(1)buildamoderatelyprosperoussociety;(2)drivethereforminadeeperlevel;(3)advancethe

  • 标签: moderately ETHNIC PROSPEROUS jointly INSURANCE JUDICIAL
  • 简介:TheaconitebelongstoplantsofgenusAconituminfamilyofRanunculaceaandhavenotableclinicalfunctionsintreatingrheumaticarthritis,heartfailure,etc.However,accidentsofaconitine(fromaconite)poisoningfrequentlyoccurtomanypeopletakingtheseherbs.

  • 标签: 乌头 乌头碱 代谢物 药物中毒 尿液检验 LC-MS
  • 简介:Since'thestaterespectsandprotectshumanrights'waswrittenintotheConstitutionin2004,theChinesegovernmenthasissuedmanywhitepapersduringashortperiodofafewyearsandhasincluded'respectandprotecthumanrights'inthe11thFiveYearPlanofnationalEconomicandSocialDevelopment.'Respectandprotecthumanrights'hasrisenfrom

  • 标签: 人权 里程 中国政府 社会发展 国民经济 白皮书
  • 简介:OnMarch14,2008,theDalaiLamacliqueplottedandinstigatedthe'March14riots'inLhasawhichresultedinthedeathofseveraldozensofinnocentpeople.TheDalaiLamaclique,however,madeunfoundedslanderouschargesagainsttheCentralGovernment,callingitsresponsetotheriotsas

  • 标签: 中国 西藏 人权 生活状况
  • 简介:ThepathsforapplyingtheinternationalhumanrightsconventionsinChinashouldberecognizedasfollows:OnthepremiseofrespectingtheConstitutionofChina,systematichumanrightswhichcouldcoordinatetherelationshipbetweentheConstitutionofChinaandinternationalhumanrightsconventions.ThesourceofthehumanrightslegislationobligationsofthelegislativeorgansofChinaistheConstitutionofChina,nottheinternationalhumanrightsconventions.ThelegislatureshouldunderstandandgraspthemaincontentsofthehumanrightslegislationobligationsofthelegislatureaccordingtoParagraph3ofArticle33oftheConstitutionwhiletheinterpretationofthisclausemustbebasedontherelevantprovisionsoftheinternationalhumanrightsconventions.Humanrightslegislativeobligationsofthelegislaturecanbeclassifiedintotwotypes:legislativeprotectingobligationsandlegislativereliefobligationsofhumanrights.TheNPCanditsStandingCommitteeshouldbestructurallyresponsibleforthehumanrightslegislationobligation,andtheStateCouncilandotherorgansoftheStatenotforthelegislationprotectionofhumanrights.AspecialhumanrightslawshouldbeenactedbytheNPC.

  • 标签: international HUMAN RIGHTS conventions LEGISLATIVE PROTECTION
  • 简介:客观:在在裸体老鼠定位人的chorio癌的异种皮移植学习radioimmuno察觉的效率。方法:Radioimmuno察觉用鸡尾酒抗体被执行标记of131I的老鼠在裸体定位人的choriocarcinoma的异种皮移植的反人的chorionicgonadotropinmonoclonal抗体老鼠。在不同纸巾的放射性被测量,tumor/non-tumor比率是计算的。正常老鼠IgG被用作控制IgG。结果:在异种皮移植区域的放射性的累积能在放射性同位素示踪的抗体的注射以后象24h一样早被认出。72鈥?在注射以后的6h,异种皮移植能清楚地被显示出。最小的显示出的异种皮移植是在直径的0.8厘米。tumor/non-tumor比率与时间增加了并且在控制组显然比那高。结论:Radioimmunodetection能高效地在裸体老鼠定位人的choriocarcinoma异种皮移植。

  • 标签: CHORIOCARCINOMA NEOPLASM TRANSPLANTATION Disease models animal
  • 简介:Inordertocreateanewmimicofglutathioneperoxidase(GPx),bioimprintingwasusedtogenerategluta-thione(GSH)bindingsiteandchemicalmodificationwasusedtoincorporatecatalyticgroupselenocystine(Sec).Humanserumalbumin(HSA)andS-substituteddinitrophenylglutathione(GSH-S-DNP)werechosenastheimprintedmatrixandimprintingtemplate,respectively,togenerateaGSH-imprintedprotein(GSH-HSA)bybioimprinting.SecwasincorporatedintotheGSH-HSAbychemicalmodificationtogiveanewGPxmimic(Se-GSH-HSA).Se-GSH-HSAdisplayedconsiderablyhigherGPxactivitythannon-printedHSA(Se-HSA).TheenzymicpropertiesandkineticsofSe-GSH-HSAwerestudied.Moreover,Se-GSH-HSAwasconfirmedtohavestrongerantioxidantabilitytoprotectmitochondriaagainstoxidativedamagewithferroussulfate/ascorbate-inducedmitochondriadamagemodel,indicatingthatSe-GSH-HSAhaspotentialapplicationinmedicine.

  • 标签: 人血清白蛋白 抗氧化活性 谷胱甘肽过氧化物酶 印迹 硒代胱氨酸 GSH
  • 简介:Anationwidedriveofmasseducationinlawhasbeengatheringmomentumsince1986,targetingatallcitizenswhoareabletolearn.Thisis,infact,agovernment-drivencampaigntoimprovecitizens’lawawarenesssothattheywillbelaw-abidingwhilegoodatusinglawstoprotect

  • 标签: 山场
  • 简介:Inthecourseofmodernization,insteadoftiptoeingWesterntracks,EastAsiahascreatedamodelallofitsown,amodelwithahumanface,deep-rootedintraditionalorientalvalues.Thispaperaimstomakeacontrastivestudyofthetwo,withnewinterpretationsfororientalvaluesofhumantouch(人情味)or‘guanxi’(关系),i.e.relationshipsandsocialconnections.

  • 标签: 人情味 关系 和为贵 合同
  • 简介:TheChinesegovernmentpaysspecialattentiontopromotingandensuringhumanrightsaccordingtolaw.In2001,theNPCstandingcommitteereviewed30bills,revisedthetrademarklaw,thecopyrightlaw,themarriagelawandthetradeunionlawandadoptedAmendmentⅢtothecriminallawinthelightofterroristactivities.Thejudgelawandtheprocuratoratorlawhavechangedthesystemfortheappointmentofjudgesandprocuratorsandforacquiringthequalificationsoflawyers.Therevisedlawsprovideforaunified

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