简介:Liverinjuryisacharacteristicfeatureofhumanimmunodeficiencyvirus(HIV)infection,whichisthesecondmostcommoncauseofmortalityinHIV-infectedpatients.NowitisrecognizedthatliverplaysakeyroleinHIVinfectionpathogenesis.Antiretroviraltherapy(ART),whichsuppressesHIVinfectioninpermissiveimmunecells,islesseffectiveinhepatocytes,therebymakingthesecellsasilentreservoirofHIVinfection.InadditiontodirecthepatotoxiceffectsofHIV,certainARTtreatmentmodalitiesprovidehepatotoxiceffects.TheexactmechanismsofHIV-triggeredchronichepatitisprogressionarenotelucidated,buttheliverisadverselyaffectedbyHIV-infectionandlivercellsareprominentlyinvolvedinHIV-elicitedinjury.Theseeffectsarepotentiatedbysecondhitslikealcohol.Here,wewillfocusontheincidenceofHIV,clinicalevidenceofHIVrelatedliverdamage,interactionsbetweenHIVandlivercellsandtheroleofalcoholandco-infectionwithhepatotropicvirusesinliverinflammationandfibrosisprogression.
简介:June2015,BeijingPrefaceIn2014theCommunistPartyofChina(CPC)andtheChinesegovernmentjointlypushedforwardtheimplementationofthecountry’sfourmajorstrategictasks:(1)buildamoderatelyprosperoussociety;(2)drivethereforminadeeperlevel;(3)advancethe
简介:Since'thestaterespectsandprotectshumanrights'waswrittenintotheConstitutionin2004,theChinesegovernmenthasissuedmanywhitepapersduringashortperiodofafewyearsandhasincluded'respectandprotecthumanrights'inthe11thFiveYearPlanofnationalEconomicandSocialDevelopment.'Respectandprotecthumanrights'hasrisenfrom
简介:ThepathsforapplyingtheinternationalhumanrightsconventionsinChinashouldberecognizedasfollows:OnthepremiseofrespectingtheConstitutionofChina,systematichumanrightswhichcouldcoordinatetherelationshipbetweentheConstitutionofChinaandinternationalhumanrightsconventions.ThesourceofthehumanrightslegislationobligationsofthelegislativeorgansofChinaistheConstitutionofChina,nottheinternationalhumanrightsconventions.ThelegislatureshouldunderstandandgraspthemaincontentsofthehumanrightslegislationobligationsofthelegislatureaccordingtoParagraph3ofArticle33oftheConstitutionwhiletheinterpretationofthisclausemustbebasedontherelevantprovisionsoftheinternationalhumanrightsconventions.Humanrightslegislativeobligationsofthelegislaturecanbeclassifiedintotwotypes:legislativeprotectingobligationsandlegislativereliefobligationsofhumanrights.TheNPCanditsStandingCommitteeshouldbestructurallyresponsibleforthehumanrightslegislationobligation,andtheStateCouncilandotherorgansoftheStatenotforthelegislationprotectionofhumanrights.AspecialhumanrightslawshouldbeenactedbytheNPC.
简介:客观:在在裸体老鼠定位人的chorio癌的异种皮移植学习radioimmuno察觉的效率。方法:Radioimmuno察觉用鸡尾酒抗体被执行标记of131I的老鼠在裸体定位人的choriocarcinoma的异种皮移植的反人的chorionicgonadotropinmonoclonal抗体老鼠。在不同纸巾的放射性被测量,tumor/non-tumor比率是计算的。正常老鼠IgG被用作控制IgG。结果:在异种皮移植区域的放射性的累积能在放射性同位素示踪的抗体的注射以后象24h一样早被认出。72鈥?在注射以后的6h,异种皮移植能清楚地被显示出。最小的显示出的异种皮移植是在直径的0.8厘米。tumor/non-tumor比率与时间增加了并且在控制组显然比那高。结论:Radioimmunodetection能高效地在裸体老鼠定位人的choriocarcinoma异种皮移植。
简介:Inordertocreateanewmimicofglutathioneperoxidase(GPx),bioimprintingwasusedtogenerategluta-thione(GSH)bindingsiteandchemicalmodificationwasusedtoincorporatecatalyticgroupselenocystine(Sec).Humanserumalbumin(HSA)andS-substituteddinitrophenylglutathione(GSH-S-DNP)werechosenastheimprintedmatrixandimprintingtemplate,respectively,togenerateaGSH-imprintedprotein(GSH-HSA)bybioimprinting.SecwasincorporatedintotheGSH-HSAbychemicalmodificationtogiveanewGPxmimic(Se-GSH-HSA).Se-GSH-HSAdisplayedconsiderablyhigherGPxactivitythannon-printedHSA(Se-HSA).TheenzymicpropertiesandkineticsofSe-GSH-HSAwerestudied.Moreover,Se-GSH-HSAwasconfirmedtohavestrongerantioxidantabilitytoprotectmitochondriaagainstoxidativedamagewithferroussulfate/ascorbate-inducedmitochondriadamagemodel,indicatingthatSe-GSH-HSAhaspotentialapplicationinmedicine.
简介:Anationwidedriveofmasseducationinlawhasbeengatheringmomentumsince1986,targetingatallcitizenswhoareabletolearn.Thisis,infact,agovernment-drivencampaigntoimprovecitizens’lawawarenesssothattheywillbelaw-abidingwhilegoodatusinglawstoprotect
简介:Inthecourseofmodernization,insteadoftiptoeingWesterntracks,EastAsiahascreatedamodelallofitsown,amodelwithahumanface,deep-rootedintraditionalorientalvalues.Thispaperaimstomakeacontrastivestudyofthetwo,withnewinterpretationsfororientalvaluesofhumantouch(人情味)or‘guanxi’(关系),i.e.relationshipsandsocialconnections.
简介:
简介:TheChinesegovernmentpaysspecialattentiontopromotingandensuringhumanrightsaccordingtolaw.In2001,theNPCstandingcommitteereviewed30bills,revisedthetrademarklaw,thecopyrightlaw,themarriagelawandthetradeunionlawandadoptedAmendmentⅢtothecriminallawinthelightofterroristactivities.Thejudgelawandtheprocuratoratorlawhavechangedthesystemfortheappointmentofjudgesandprocuratorsandforacquiringthequalificationsoflawyers.Therevisedlawsprovideforaunified