简介:AbstractAlthough the first-line rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone regimen (R-CHOP) substantially improved outcomes for patients with diffuse large B-cell lymphoma (DLBCL), 40% of the patients suffered from relapsed/refractory disease and had poor survival outcomes. The detailed mechanism underlying R-CHOP resistance has not been well defined. For this review, we conducted a thorough search for literature and clinical trials involving DLBCL resistance. We discussed DLBCL biology, epigenetics, and aberrant signaling of the B-cell receptor (BCR), phosphatidylinositol 3-kinase (PI3K)/Akt, nuclear factor kappa light chain enhancer of activated B-cells (NF-κB), and the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathways as defining mechanisms of DLBCL heterogeneity and R-CHOP resistance. The cell of origin, double- or triple-hit lymphoma and double-protein-expression, clonal evolution, tumor microenvironment, and multi-drug resistance help to contextualize DLBCL resistance in an (epi)genetically and biologically comparative manner. With better understanding of the biological and molecular landscape of DLBCL, a more detailed classification system and tailored treatments will ideally become available to further improve the prognosis of DLBCL patients.
简介:摘要:现如今,制造业竞争空前激烈,生产单位对于设施的无障碍工作时效要求逐渐提升,其重点为部分操控关键性生产程序的自动化生产性,是否能连续工作直接影响整体生产成效,因此单层网络无法顺应控制系统需求。而冗余控制则能长久完成生产需求,进一步提升系统稳定性的方法,其是使用一定或成倍量设施与元器件方法组合成控制系统的操控方法。其中某设施或元器件出现问题时,能够利用硬软件或者人为操控,互相替换当作后备设施或元器件,替换问题设施或配件,确保系统平稳工作,降低设施因突发故障造成停机损耗。
简介:摘 要 福建联合石油化工有限公司2013年10月进行节能改造,异构化催化剂由乙苯转化型更换为脱乙基型催化剂I-350R,本文针对脱乙基型催化剂的投料运行情况进行分析,目前已运行七年多,乙苯的转化率在63%~66%,异构化活性在23%左右。
简介:【摘要】目的:了解阵发性室性心动过速患者最佳的急诊救治护理效果。方法:抽取50例阵发性室性心动过速进行研究,将不同的护理措施应用在患者的护理工作中,比较患者的相关指标。结果:和对照组患者相比,观察组患者的评价指标较为理想,(P<0.05)。结论:将优质的急诊救治护理干预措施应用在阵发性室性心动过速的护理工作中能够获得可观的效果,不但使患者更加依从护理人员的工作,同时还显著改善心理状态,建议临床采纳该急诊救治护理方法。