简介：AIM:Toreviewpublishedclinicalstudiesexaminingtheeffectofnatamycininthetreatmentoffungalkeratitis.METHODS:WeselectedthepublicationsinCENTRAL,MEDLINE,EMBASE,CNKI,andCBM.Thisstudysystematicallyreviewedpublishedrandomizedcontrolledtrials(RCTs)thatcomparednatamycintootherantifungalagents,andconductedfeasibleMeta-analysisofefficacyresultsusingRevman5.2software.RESULTS:WeincludedseventrialswhichweremainlycarriedoutindevelopingcountriesofAsia,withfivetrialsconductedinIndia,oneeachinChinaandBangladesh.Atotalof804participantswererandomizedtofollowingcomparisons:2%econazoleversus5%natamycinshowedlittledifferenceintheeffectsoftreatmentoffungalkeratitis[RR=0.99,95%confidenceinterval(CI),0.8to1.21];chlorhexidinegluconateversus5%natamycinindicatedthattheresultsonhealingoftheulcerat21dwaslessconclusive(RR=0.77,95%CI,0.55to1.08;I2=0%);1%voriconazoleversus5%natamycinsuggestedthatnatamycintreatmentappearedtobesignificantlybetteroutcomesthanvoriconazole(regressioncoefficient=-0.18logMAR;95%CI,-0.30to-0.05;P=0.006),especiallyinFusariumcases(regressioncoefficient=-0.41logMAR;95%CI,-0.61to-0.20;P<0.001);natamycinversusfluconazoleshowedasignificantdifferenceincurerate(χ2=5.048,P<0.05)andnatamycingroupwasmoreeffectivethanfluconazoleinaverageperiodoftherapy(t=7.94,P<0.01).CONCLUSION:Natamycinwasapreferablechoiceinthetreatmentoffungalkeratitis,especiallyintheearlyperiodofFusariumcases.

简介：AIM:Toestimateoverallprevalenceofretinopathyofprematurity(ROP)inIranusingasystematicreviewandMeta-analysis.METHODS:AsystematicreviewandMeta-analysiswasperformedofallpublishedstudiespertainingtoprevalenceofROPusinginternationalandnationalelectronicdatabases(ISIWebofSciences,PubMed,Scopus,GoogleScholar,SID,MagIran,andIranMedex)fromtheirinceptionuntilMay2016withstandardkeywords.BeggandEggertestswereusedtoexaminethepublicationbiasandCochrantestandI~2statisticswereusedtoevaluatethestatisticalheterogeneity.PooledestimateoftheprevalenceofROPwerecalculatedusingrandomeffectsMetaanalysis.RESULTS:ThepublicationbiasassumptionwasrejectedbyEggertestswithP-valueequalto0.024.TheresultsofCochrantestandI~2statisticsrevealedsubstantialheterogeneity(Q=1099.02,df=25,I~2=97.7%,P=0.001).TheoverallprevalenceofROPusingtherandomeffectmodelinIranwas26.1%(95%CI:20.3%-31.8%).CONCLUSION:TheprevalenceofROPisrelativelyhighinIran.Lowbirthweightandgestationalagearesignificantriskfactorsforthedisease.Improvedcare,includingoxygendeliveryandmonitoring,forpretermbabiesinallfacilitysettingswouldreducethenumberofbabiesaffectedwithROP.

简介：AIM:Tosystematicallyreviewwhethertheincreasedfluctuationofintraocularpressure(IOP)isariskfactorforopenangleglaucoma(OAG)progression.METHODS:ScientificstudiesrelevanttoIOPfluctuationandglaucomaprogressionwereretrievedfromMEDLINE,EMBASEandCENTRALdatabases,andwerelistedasreferencesinthispaper.Thehazardratio(HR)wascalculatedbyusingfixedorrandom-effectsmodelsaccordingtotheheterogeneityofincludedstudies.RESULTS:Individualdatafor2211eyesof2637OAGpatientsinfourteenprospectivestudieswereincludedinthisMeta-analysis.Allstudieswerelongitudinalclinicalstudieswithfollow-upperiodrangingfrom3to8.5y.ThecombinedHRwas1.23(95%CI1.04-1.46,P=0.02)fortheassociationbetweenIOPfluctuationandglaucomaonsetorprogressionwiththeevidenceofheterogeneity(P<0.1).SubgroupanalyseswithdifferenttypesofIOPfluctuationwerealsoevaluated.ResultsindicatedthatthesummaryHRwas0.98(95%CI0.78-1.24)inshort-termIOPfluctuationgroup,whichshowednostatisticalsignificancewithheterogeneity,whereas,thecombinedHRwas1.43(95%CI1.13-1.82,P=0.003)inlong-termIOPfluctuationgroupwithouthomogeneity.SensitivityanalysisfurthershowedthatthepooledHRwas1.10(95%CI1.03-1.18,P=0.004)forlong-termIOPfluctuationandvisualfunctionprogressionwithhomogeneityamongstudies(P=0.3).CONCLUSION:Long-termIOPfluctuationcanbeariskfactorforglaucomaprogressionbasedonthepresentedevidence.Thus,controllingtheswingofIOPiscrucialforglaucomaorglaucomasuspectingpatients.

简介：目的：评价非穿透性小梁手术和小梁切除对降低开角型青光眼患者眼压的疗效。方法：计算机检索Cocharane图书馆、PubMed（1966～2013）、Embase（1980～2013）、中国生物医学文献数据库（1979～2013）中关于非穿透性小梁手术和小梁切除术对降低开角型青光眼患者眼压的疗效的随机对照试验、同时筛检纳入文献的参考文献。对文献质量进行评价，对符合质量标准的随机对照试验（RandomizedControlledTrial，RCT）用RevMan4．2软件进行Meta分析。结果：共纳入10个RCT，7篇研究均显示，非穿透性小梁切除术与小梁切除术比较，小梁切除术能提高患者术后眼压降低的水平和手术的成功率，但是8篇研究均显示非穿透性小梁切除术较传统小梁切除术能更有效的降低术后并发症发生率。结论：与非穿透性小梁切除术相比，传统小梁切除术能够提高眼压的降低水平和手术成功率；而非穿透性小梁切除术能较好降低术后并发症的发生率。

简介：目的：系统评价白内障超声乳化吸除术前加用非甾体抗炎药（nonsteroidalanti-inflammatorydrugs,NSAIDs）对术后黄斑囊样水肿（cystoidmacularedema,CME）的影响。方法：计算机检索CochraneLibrary、PubMed、BMC、中国期刊全文数据库（CNKI）、维普中文期刊数据库（VIP）。收集NSAIDs的不同给药时机（试验组予以NSAIDs术前及术后局部点眼治疗,对照组予以NSAIDs术后治疗）对白内障超声乳化吸除术后CME及黄斑中心凹厚度影响的临床随机对照试验文献。采用RevMan5.2软件及Stata12.0软件进行Meta分析。结果：共纳入6项研究。术前是否加用NSAIDs对白内障超声乳化吸除术后CME的发生在术后1wk差异无统计学意义（OR=1.58,95%CI：0.48~5.18,P〉0.05）、术后1mo差异无统计学意义（OR=0.78,95%CI：0.30~2.00,P〉0.05）,术后3mo差异有统计学意义（OR=0.22,95%CI：0.11~0.43,P〈0.01）;黄斑中心凹厚度在术后1wk差异无统计学意义（WMD=-7.20,95%CI：-15.17~0.77,P〉0.05）、术后1mo差异无统计学意义（WMD=-3.98,95%CI：-14.05~6.08,P〉0.05）,术后3mo差异有统计学意义（WMD=-18.25,95%CI：-33.80~-2.70,P〈0.05）。结论：术前及术后联合应用NSAIDs治疗可以显著降低白内障超声乳化吸除术后CME的发生,降低术后黄斑中心凹的厚度,提示NSAIDs的术前术后联合应用较单独术后应用更具有优越性。

简介：在在IOP上调查了triamcinoloneintravitrealtriamcinoloneacetonide的注射的效果的研究的triamcinoloneacetonide.METHODSSystematic文学评论的intravitreal注射以后的intraocular压力(IOP)上的AIMTo报告根据Cochrane合作方法论被进行，报导效果被分析了，Meta-analysis.RESULTSWe发现了IOP跟随inverted-U随着时间的过去以14.81±的平均价值开始的形状模式；1.22而且，学习的土地，变老，绿内障和性作文物质为的以前的历史跨学习在报导IOPchanges.CONCLUSIONOur调查结果是不同的可能在象象反脉管的endothelial生长因素代理人那样的更最近的治疗把它与那些作比较一样决定intravitrealtriamcinoloneacetonide治疗的压力举起风险有用。

简介：AIM:ToperformaMeta-analysistoexplorethecorrelationbetweenmetabolicsyndromeandintraocularpressure(IOP).METHODS:WesearchedPubMedandEmbaseinNovember2017forstudiesdiscussingtherelationshipbetweenmetabolicsyndromecomponentsandIOPinpatients.Pearsoncorrelationcoefficients,oddsratiosandstandardizedbetaswereextractedfrominclusivestudies.Heterogeneityandpublicationbiaswerechecked.RESULTS:Of295articles,10metinclusioncriteriaandprovidedsufficientdataforMeta-analysis.ResultsshowedasignificantpositiverelationbetweenmetabolicsyndromeandIOP(Z=0.47,95%CI:0.15-0.79,P=0.005).Thefivecomponents[waistcircumference,hypertriglyceridemia,highbloodpressure,highfastingglucoseandlowhighdensitylipoprotein(HDL)-cholesterol]ofmetabolicsyndromeallshowedpositivecorrelationwithIOPexceptthelowHDL-cholesterolwhichhadnostatisticalsignificance.ThepooledZwas0.08(95%CI:0.04-0.12),0.16(95%CI:0.11-0.21),0.16(95%CI:0.10-0.22),0.30(95%CI:0.20-0.40)and0.12(95%CI:0.08-0.16),respectively.Begg’stestandEgger’stestshowednoevidenceofsignificantpublicationbiasofthisMeta-analysis.CONCLUSION:OurfindingssuggestthatmetabolicsyndromeanditscomponentsaresignificantlyassociatedwithIOP,besidestheHDL-cholesterol.ThisassociationmaybeusedtocontrolIOPbyinterveningtheoccurrenceofmetabolicsyndrome.

简介：AIM:Tocomparetheeffectivenessandsafetybetweenbevacizumabandranibizumabinthetreatmentofagerelatedmaculardegeneration(AMD)throughasystematicreviewandmeta-analysis.METHODS:Weperformedacomprehensivesearchofrandomizedcontrolledtrials(RCTs),non-RCTs,casecontrolandcohortstudiesthatcomparedbevacizumabandranibizumabusingPubMedandtheCochraneLibrary.Aftertherelateddatawereextractedbytwoinvestigatorsindependently,pooledweightedmeandifferences(WMDs)andriskratios(RRs)with95%confidenceintervals(CIs)wereestimatedusingarandom-effectsorafixed-effectsmodel.RESULTS:AtotaloffourRCTsinvolving1927patientsandelevenretrospectivecaseseriesinvolving2296patientswereincluded.Fortheprimaryoutcomes,nosignificantdifferenceswerefoundbetweenranibizumabgroupandbevacizumabgroupinvisualacuity(WMD:-0.04;95%CI:-0.08to0.00;P=0.06),bestcorrectedvisualacuity(WMD:-0.05;95%CI:-0.10to0.00;P=0.05),retinathickness(WMD:-4.69;95%CI:-13.15to3.76;P=0.86)andfovealthickness(WMD:10.91;95%CI:-14.73to36.56;P=0.40).Thepooledanalysesintheevaluationofsafetyshowedthatcomparedtobevacizumab,ranibizumabwasassociatedwithdecreasedrisksofocularinflammation(RR:0.45;95%CI:0.23to0.89;P=0.02)andvenousthromboticevents(RR:0.27;95%CI:0.08to0.89;P=0.03).However,therewerenosignificantdifferencesobservedindeaths(P=0.69)andarterialthromboembolicevents(P=0.71)betweenthetwogroups.CONCLUSION:Withequalclinicalefficacy,ranibizumabwasfoundtobeassociatedwithlessadverseeventscomparedtobevacizumab,indicatingthatranibizumabmightbeasafermanagement.

简介：AIM:ToconductaMeta-analysisforinvestigatingthevariationsinintraocularpressure(IOP)andcentralcornealthickness(CCT)duringnormalpregnancy.METHODS:WesearchedforclinicaltrialspublisheduptoNovember2015withoutlanguageorregionrestrictionsinPubMed,EMBASE,WebofScience,theCochraneCentralRegisterofControlledTrials,Ovid,EBSCO,Elsevier,theChineseBiomedicineDatabase,WanFang,CNKI,CQVIPandGoogleScholar.Studiesoftheocularchangesobservedinpregnantwomenwereselected.ThemainoutcomeswereassessedbychangesinIOPandCCT.RESULTS:Fifteenstudieswereincluded.Insubgroupanalyses,IOPwassignificantlydecreasedduringthesecondMD=-1.53,95%CI(-2.19,-0.87);P<0.00001,andthirdMD=-2.91,95%CI(-3.74,-2.08);P<0.00001trimestersofpregnancy.CCTwasincreasedduringthesecondMD=10.12,95%CI(2.01,18.22);P=0.01,trimesterofpregnancy;moreover,duringthethirdtrimesterofpregnancy,theCCTdisplayedanincreasingtrend,butthedifferencewasnotsignificantMD=5.98,95%CI(-1.11,13.07);P=0.1.CONCLUSION:AdecreaseinIOPisaccompaniedbyanincreaseinCCTinthesecondandthirdtrimestersofanormalpregnancyinwomen.

简介：AIM:TocomprehensivelyevaluatethepotentialassociationofCOL1A1polymorphismswithhighmyopiabyasystematicreviewandMeta-analysis.METHODS:AllassociationstudiesonCOL1A1andhighmyopiareporteduptoJune10,2014inPubMed,Embase,WebofScience,andtheChineseBiomedicalDatabasewereretrieved.Oddsratios(ORs)and95%confidenceintervals(95%CIs)wereanalyzedforsinglenucleotidepolymorphisms(SNPs)usingfixed-andrandom-effectsmodelsaccordingtobetween-studyheterogeneity.PublicationbiasanalyseswereconductedbyEgger’stest.RESULTS:Atotaloffourstudiesfromreportedpaperswereincludedinthisanalysis.TheMeta-analysesforCOL1A1rs2075555,composedof2304highmyopiapatientsand2272controls,failedtodetectanysignificantassociationwithhighmyopia.Atotalof971casesand649controlsweretestedforCOL1A1rs2269336.TheassociationofCOL1A1rs2269336withhighmyopiawasobservedinrecessivemodel(CCvsCG+GG,P=0.03)andinheterozygousmodel(CGvsGG,P=0.04),butnotinothermodels.CONCLUSION:ThisMeta-analysisshowsthatCOL1A1rs2269336(CCvsCG+GG)affectsindividualsusceptibilitytohighmyopia,whereasthereisnoassociationdetectedbetweenSNPsrs2075555andhighmyopia.Giventhelimitedsamplesize,furtherinvestigationsincludingmoreethnicgroupsarerequiredtovalidatetheassociation.

简介：AIMTo系统地基于快速的培植和trabeculectomy(Trab)的功效和费用考察当前的证据因为不受管束的glaucoma.METHODSClinical审判被电子数据库(PubMed，EMBASE，科学的ISI网和Cochrane图书馆)识别，并且数据例如intraocular压力(IOP)，完全、合格的成功率，手术后的复杂并发症和费用，是从这些相关研究的exacted。加权的吝啬的差别(WMD)，机会比率(或)并且95%信心间隔(CI)用相关出版物和二篇摘要遇见了的随机效果的model.RESULTSEleven被计算并且被分享包括标准。快车的功效在1点类似于在IOP减小(IOPR%)的百分比的Trab的，2y(WMD：-2.01；95%CI：-7.92-3.90；P=0.50和WMD：2.89；95%CI：-8.05-13.83；P=0.60，分别地)。快车拥有了重要更高完全、合格的成功率(或：1.59；95%CI：1.07-2.35；P=0.02并且或：1.74；95%CI：1.06-2.86；P=0.03，分别地)。而且，快车比Trab施加了hypotony和hyphema的显著地更低的频率(或：0.39；95%CI：0.21-0.72；P=0.003并且或：0.27；95%CI：0.10-0.69；P=0.003，分别地)。然而，根据以前的三studies.CONCLUSIONBothTrab和快车在二个组之间的费用上没有一致结果在阴沉的IOP有相等的功效，还快速比Trab有hypotony和hyphema的更低的风险。不过，快车的费用是否是不到Trab的应该进一步被调查长远来说保证基于证据的结论。

简介：AIM:Toevaluatetheefficacyandsafetyofanti-vascularendothelialgrowthfactor(VEGF)combinedwithphotodynamictherapy(PDT)versusanti-VEGFmonotherapyforpolypoidalchoroidalvasculopathy(PCV).METHODS:WeconductedaMeta-analysisof9studiestocomparetheefficacyandsafetybetweencombinedtherapyandanti-VEGFmonotherapyforPCV.TheprogramsofRevMan5.3andStata12.0wereusedtoanalyzedata.RESULTS:Thebestcorrectedvisualacuity(BCVA)incombinedtherapygroupweresignificantlybetterthanthoseofanti-VEGFmonotherapygroupat6,24and36mo,withpooledweightedmeansdifferences(WMDs)of0.12(0.06,0.18),0.25(0.12,0.38)and0.28(0.13,0.43),respectively.Thecentralretinalthickness(CRT)reductionsincombinedtherapygroupwerehigherthanthatinantiVEGFmonotherapygroupat1,3,6and9mo,withpooledWMDsof63.90(20.41,107.38),33.47(4.69,62.24),30.57(0.12,60.01)and28.00(2.51,53.49),respectively.Theregressionrateofpolypsincombinedtherapygroupwasmuchhigherthanthatinanti-VEGFmonotherapygroup[RD:0.47(0.26,0.68);P<0.0001].Theadverseeventretinalhemorrhagedidnotdiffersignificantlybetweenthetwogroups.CONCLUSION:OurfindingsclearlydocumentthatantiVEGFcombinedwithPDTisamoreeffectivetherapyforPCVcomparedwithanti-VEGFmonotherapy.Furthermore,combinedtherapydoesnotincreasetheincidenceofretinalhemorrhage.

简介：AIM:Tostudytheassociationsbetweenlysyloxidaselike1(LOXL1)polymorphismsandprimaryopenangleglaucoma(POAG)remaininconsistent.Inthisstudy,wehaveperformedameta-analysistoinvestigatetheassociationofLOXL1polymorphismswithPOAGrisk.METHODS:PublishedliteraturefromPubMedandotherdatabaseswereretrieved.AllstudiesevaluatingtheassociationbetweenLOXL1polymorphisms(rs2165241,rs1048661,rs3825942)andPOAGriskwereincluded.Pooledoddsratio(OR)and95%confidenceinterval(CI)werecalculatedusingrandom-orfixed-effectsmodel.RESULTS:Twelvestudieswereidentifiedaseligiblearticles,withthirteen(2098casesand16473controls),thirteen(1795casesand2916controls)andsixteenpopulationcohorts(2456casesand2846controls)fortheassociationofrs2165241,rs1048661andrs3825942withPOAGriskrespectively.OverallanalysesshowednoassociationbetweeneachLOXL1polymorphismandPOAGrisk,andthenegativeassociationswereremainedwhenthesubjectswerestratifiedasCaucasianandAsian.Theheterozygoteofrs2165241wasassociatedwithreducedPOAGriskinhospital-basedpopulations(TCvsCC:OR,0.79,95%CI:0.63-0.99),andrs1048661wasassociatedwithincreasedPOAGriskinhospitalbasedpopulationsinadominantmodel(TTvsCC+CT:OR,1.23,95%CI:1.01-1.50);however,theseassociationswerenotfoundinpopulation-basedsubjects.CONCLUSION:Thismeta-analysissuggeststhatLOXL1polymorphismsarenotassociatedwithPOAGrisk.Giventhelimitedsamplesize,theassociationsofLOXL1polymorphismswithPOAGriskinhospital-basedpopulationsawaitfurtherinvestigation.

简介：AIM:Tocomparetheeffectsofintravitrealinjectionofbevacizumab(IVB)withintravitrealtriamcinoloneacetonide(IVTA)onthetreatmentofcystoidmacularedema(CME)secondarytoretinalveinocclusion(RVO).·METHODS:AliteraturesearchwasconductedusingPubMed,theCochraneCentralRegisterofControlledTrials,WebofScienceandtheChineseBiomedicalDatabase.Thecomparisonwasdividedintotwogroups,group1conductedcomparisoninbranchRVO(BRVO)orcentralRVO(CRVO),group2conductedcomparisoninischemic-RVOornonischemic-RVO.Pooledmeandifferences(MDs)forchangesinvisualacuity(VA),centralmacularthickness(CMT)andintraocularpressure(IOP)werecalculatedingroupsat4,12and24wkaftertreatmentrespectively.·RESULTS:EightstudiescomparingtheefficacyofIVBwithIVTAwereincludedintheMeta-analysis.Ingroup1,inBRVO,significantdifferencewasshownonthecomparisonofCMTat24wk(MD,-45.66;95%CI,-76.03to-15.28;P=0.003),IVBwaseffectiveonBRVOforatleast24wk;nosignificantdifferenceswerefoundinthecomparisonofVAateachtimepoints(P>0.05respectively).InCRVO,nosignificantdifferenceswerefoundinthecomparisonofVAorCMTbetweenIVBandIVTAateachtimepoints(P>0.05,respectively).Ingroup2,inischemic-RVO,significantdifferenceswereshowninthecomparisonofVA(MD,-0.28;95%CI,-0.42to-0.14;P<0.0001)andCMT(MD,-86.50;95%CI,-151.18to-22.43;P=0.008)at24wk;Innonischemic-RVO,nosignificantdifferencesweredemonstratedinthecomparisonofVAorCMTbetweenIVBandIVTAateachtimepoints(P>0.05,respectively).TheoccurrenceofhighIOPwasmuchlowerinIVBgroup.·CONCLUSION:ThisMeta-analysissuggestedthatIVBwaseffectiveindecreasingCMTinBRVOforatleast24wk,IVBismoreeffectiveonimprovingVAandreducingCMTinischemic-RVO.IVBismorepromisingonRVOthanIVTA.

简介：AIMTo在小切口lenticule抽取(微笑)和在situkeratomileusis(FS-LASIK)帮助激光的femtosecond以后估计角膜的敏感和干燥眼睛的发生.METHODSThe元分析用RevMan5.3被执行。我们从开始在PubMed上寻找了到2016年3月。概括加权的吝啬的差别(WMD)和95%信心间隔(CI)被用来分析资料。随机效果或改正效果模型被选择直到在学习之间异质。主要结果由眼睛的表面疾病索引(OSDI)分数，眼泪电影分散时间(TBUT)，Schirmer测试和角膜的sensitivity.RESULTSEight组成包括772只眼睛的合格研究(386在微笑组织，386在FS-LASIK组织)被识别。参数没外科手术前地有在微笑和FS-LASIK组之间的significiant差别异质。手术后地手术后地在在一个和三个月点的OSDI分数的二个组之间有重要差别，在在一个和三个月点的TBUT，在在一个星期，大约一个月和三个月的角膜的敏感手术后地。然而，没有重要差别，在后续periods.CONCLUSIONCompare在Schirmer测试观察到FS-LASIK，干燥眼睛和角膜的敏感在SMILE组更好恢复，在在外科以后的开始的三个月内。

简介：目的：系统评价拉坦前列素（Latanoprost）滴眼液与噻吗心安（Timolol）滴眼液降眼压的有效性和安全性。方法：计算机检索PubMed，Medline，CNKI及中国生物医学文献数据库收录的，并辅以手工检索、因特网搜索的有关拉坦前列素与噻吗心安治疗原发性开角型青光眼和高眼压症的随机对照试验（RCT）。按照纳入和排除标准限定研究对象，通过Jadad评分量表进行文献质量评估后，针对眼压下降比例、药物不良反应2项内容，使用Cochrane协作网提供的RevMan5．0软件进行Meta分析。结果：共纳入9项RCT，合计555例患者。Meta分析结果显示：（1）拉坦前列素滴眼液与噻吗心安滴眼液降眼压效果，在2，6，12wk时差异均有统计学意义（P＜0．01），加权平均差（WMD）分别为：在2wk[WMD＝-0．76，95％CI（-1．32，-0．20）]，在6wk[WMD＝-1．15，95％CI（-1．68，0．63）]和12wk[WMD＝-1．01，95％CI（-1．42，-0．61）]。（2）随访结束时，结膜充血、异物感为拉坦前列素的两种较为常见的不良反应，但其发生率拉坦前列素组与噻吗心安组比较，结膜充血的发生率[OR＝2．25，95％CI（0．99，5．08）]，异物感的发生率[OR＝2．48，95％CI（1．02，6．03）]，显示二者差异均无统计学意义。结论：治疗原发性开角型青光眼和高眼压症，拉坦前列素降眼压效果在用药12wk内较噻吗心安好；两者在12wk内引起结膜充血、异物感、虹膜色素加深、视野损害等的不良反应方面，差异不明显。由于纳入研究的样本量偏小，且方法学质量中等，致使本系统评价结果论证强度不高，因此还需要开展更多的高质量的临床随机对照研究，以便更客观、准确、全面地评价其疗效和安全性。

简介：AIMTo调查锰superoxidedismutase(MnSOD)的协会有糖尿病的retinopathy(医生)的Val16Ala多型性.METHODSPubMed，Embase，中国知识基础结构，和Wanfang数据库被寻找。分享的机会比率(ORs)和95%信心间隔(CI)被计算评估协会的力量。亚群，敏感，和累积分析被执行。出版偏爱也是analyzed.RESULTSEight研究在分享的分析被包括。MnSODVal16Ala多型性在主导的模型下面与医生的风险被联系(OR=0.66，95%CI=0.48-0.91，P<0.0001)，这结果被表明在累积分析相对稳定。没有重要出版偏爱被发现。这多型性也在主导的模型下面在白种人与医生的风险被联系(OR=0.64，95%CI=0.42-0.97，P=0.04，)并且在在后退的模型下面的亚洲人(OR=0.31，95%CI=0.11-0.88，P=0.03).CONCLUSIONThese调查结果建议MnSODVal16Ala多型性是为医生的一个风险因素，并且更多的注意竟然对这些危险性基因的搬运人被给予。

简介：AIM:Tocomparetheefficacyandsafetyofcombinationofranibizumabwithphotodynamictherapy(PDT)vsranibizumabmonotherapyinthetreatmentofage-relatedmaculardegeneration(AMD).METHODS:TheCochraneCentralRegisterofControlledTrials(CENTRAL)intheCochraneLibrary,Pubmed,andEmbaseweresearched.Therewerenolanguageordatarestrictionsinthesearchfortrials.Onlyrandomizedcontrolledtrials(RCTs)wereincluded.MethodologicalqualityoftheliteratureswasevaluatedaccordingtotheJadadScore.RevMan5.2.6softwarewasusedtodothemeta-analysis.RESULTS:Sevenstudieswereincludedinoursystematicreview,amongwhichfourofthemwereincludedinquantitativeanalysis.Theresultshowsthattheranibizumabmonotherapygrouphadabettermeanbestcorrectedvisualacuity(BCVA)changevsbaselineatmonth12comparedwiththatofthecombinationtreatmentgroup,andthestatisticaldifferencewassignificant(WMD,-2.61;95%CI,-5.08to-0.13;P=0.04).However,aftertheremovalofonestudy,thedifferencebetweenthetwogroupsshowednosignificantdifference(WMD,-2.29;95%CI,-4.81to0.23;P=0.07).Meanwhile,nosignificantcentralretinalthickness(CRT)reductionwasfoundinthecombinationtreatmentgroupandtheranibizumabmonotherapygroupat12monthsfollow-up.Nevertheless,thecombinationgrouptendedtohaveagreaterreductioninCRT(WMD,-4.13μm;95%CI,-25.88to17.63,P=0.71).Theproportionofpatientsgainingmorethan3linesatmonth12intheranibizumabgroupwashigherthaninthecombinationgroupandtherewasasignificantdifference(RR,0.72;95%CI,0.54to0.95;P=0.02).Whereastherewasnosignificantdifferencefortheproportionofpatientsgainingmorethan0lineatmonth12betweenthetwogroups(RR,0.93;95%CI,0.76to1.15;P=0.52).Thegeneraltendencyshowsareductioninranibizumabretreatmentnumberinthecombinationtreatmentgroupcomparedwiththeranibizumabmonotherapygroup.Asmajoradverseevents,thedifferencesinthenumberofeyepain,endophthalmitis,hypertensionandarterialt

简介：目的探讨两种不同手术方式治疗翼状胬肉对泪液功能的影响及影响因素。方法选取翼状胬肉患者40例（40只眼）随机分成两组：A组20个病人（20只眼）翼状胬肉切除联合冻干羊膜移植术；B组20＋病人（20只眼）翼状胬肉切除联合带自体角膜缘干细胞结膜瓣移植术。术前，术后1mo，术后3mo行泪膜破裂时间（BUT）、泪液分泌试验（SchirmerI）、角膜荧光素染色（CSF），评价翼状胬肉及翼状胬肉切除术后泪膜功能变化对患者生活质量的影响。结果两组病人术后lmoBUT缩短，角膜荧光素染色增多，差异有统计学意义（P〈0．05），而术后SchirmerI与术前相比无统计学意义，两组术后3moBUT，SchirmerI，CFS与术前相比无统计学意义，翼状胬肉切除联合带自体角膜缘干细胞结膜瓣移植术组术后早期泪膜稳定性优于翼状胬肉切除联合冻干羊膜移植术，差异具有统计学意义∞〈0．05）。结论翼状胬肉切除术早期对泪膜功能有影响。翼状胬肉切除联合带自体角膜缘干细胞结膜瓣移植术早期对泪膜的影响小于翼状胬肉切除联合冻干羊膜移植术。

简介：目的比较翼状胬肉切除联合生物羊膜移植与翼状胬肉切除联合自体角膜缘干细胞移植对原发性翼状胬肉的治疗效果.方法翼状胬肉患者186例190眼.分为A、B二组,A组60眼翼状胬肉切除联合生物羊膜移植术；B组130眼翼状胬肉切除联合自体角膜缘干细胞移植术.术后随访6-24个月,观察翼状胬肉复发率.结果A组60眼中9眼复发,复发率15.0％;B组130眼中7眼复发,复发率5.38％,x2=4.922,P=0.03,差异有统计学意义.结论在防止胬肉复发方面,角膜缘干细胞移植组优于生物羊膜移植组.