简介:Objective:Forthepurposeofunderstandingthechangingprocessofsyphilishistomorphologyanditsinjurymechanism,theultrastructureofdermatictissuesofsecondarysyphiliswasstudied.Methods:Differentskininjurytissuesofsecondarysyphilispatients,whoseserumRPRandTPHAtestsinthelabbothappearedpositivereaction,wereobservedthroughtransmissionelectronmicroscope(TEM).Results:Inflammationsappearedonepidermidesandcoria,agreatdealofneutrocytes,lymphocytesandasmallamountofplasmainfiltratedthem.Karyopyknosis,karyorrhexis,epicytelysisandmitochondrionvaculardegenerationoccurred.Spirochetapallidawasdistributedonintercellularsubstances,epicytesandcollagenousfibers.Theepicyteswerepressedtofoveation.ConclusionThepathologicalchangeofcharacteristictissueultrastructurereportedhereisahistomorphologicalfoundationtostudytheorganisminjurymechanismcausedbvsvnhilis.
简介:AbstractImportance:Extensive population-based studies have explored the prevalence of primary hypertension (HTN) in children and adolescents. However, there is little published data on the characteristics of different types of pediatric HTN and the causes of secondary HTN.Objective:To investigate the characteristics of different types of pediatric HTN and the causes of secondary HTN in a hospital setting.Methods:The study cohort comprised pediatric inpatients (<18 years of age) discharged with a diagnosis of HTN from Beijing Children’s Hospital during 2015-2020. Pediatric patients with HTN were allocated to secondary and primary HTN groups on the basis of comprehensive analyses of their diagnoses, family history of HTN, and findings on physical examination, as documented in their medical records. The Mann-Whitney U test, χ2 and Fisher’s exact test were used to assess differences in characteristics of patients with different HTN types and causes of secondary HTN.Results:Data of 1470 inpatients with HTN from 18 clinical departments were included in the analysis. Among them, 458 (31.2%) had primary HTN, and 1012 (68.8%) had secondary HTN. Compared with patients had primary HTN, children with secondary HTN were younger and had lower body mass indexes and longer lengths of stay. Moreover, children with primary HTN had mostly been managed by the Endocrinology and Cardiology Departments, 75.8% of them having obesity-related comorbidities. In contrast, most patients with secondary HTN had been managed by the Nephrology Department, renal diseases being the leading cause of their HTN (46.3%).Interpretation:Secondary HTN is more common than primary HTN in pediatric clinical settings, renal diseases being the leading cause of secondary HTN.
简介:A28YEAR-OLDmalepatientpresentedatthedepartmentofgenitourinarymedicineonAugust14,2000withgenitalpapules,generalizederythematousmacules,andscalesofmorethan2months'duration.Twomonthsearlier,thepatienthadpresentedatthelocalhospitalwiththreesitesoferythematousmacularpapulesontheglanspenis,ofnoclearcause.Atthattime,guttateerythematousmaculeswithscalesalsoappearedonthewholebodywithseverepruritus.Hewasdiagnosedwithpsoriasisvulgaris,wasadministeredcapsulesofretinoicacid,andtreatedfortwomonths.However,whenthelesionsandprurituswerenotrelieved,hepresentedatourclinic.
简介:AbstractAcute respiratory distress syndrome (ARDS) is one of the most common severe diseases seen in the clinical setting. With the continuous exploration of ARDS in recent decades, the understanding of ARDS has improved. ARDS is not a simple lung disease but a clinical syndrome with various etiologies and pathophysiological changes. However, in the intensive care unit, ARDS often occurs a few days after primary lung injury or after a few days of treatment for other severe extrapulmonary diseases. Under such conditions, ARDS often progresses rapidly to severe ARDS and is difficult to treat. The occurrence and development of ARDS in these circumstances are thus not related to primary lung injury; the real cause of ARDS may be the "second hit" caused by inappropriate treatment. In view of the limited effective treatments for ARDS, the strategic focus has shifted to identifying potential or high-risk ARDS patients during the early stages of the disease and implementing treatment strategies aimed at reducing ARDS and related organ failure. Future research should focus on the prevention of ARDS.
简介:Toinvestigatethemechanismofsecondarycirculationsinripcurrentsystems,andtoexploretherelationshipbetweenwaveconditionsandsecondarycirculationintensity,aseriesofnumericalexperimentsisperformedusingcouplednearshorewavemodelandcirculationmodel.Intheseexperiments,theripcurrentsandsecondarycirculationsgeneratedabovebarredbeacheswithripchannelsaresimulated.Acomparisonexperimentisconductedtoinvestigatetheformationandhydrodynamicsofthesecondarycirculations.Modelresultsindicatethatthesecondarycirculationsconsistofalongshoreflowsdrivenbywaveset-upneartheshoreline,partofthefeedercurrentsdrivenbythewaveset-upoverthebars,andonshoreflowsattheendoftheripchanneldrivenbywavebreakingandconvection.Theexistenceofthesecondarycirculationbarelyaffectstheripcurrent,butnarrowsandintensifiesthefeedercurrents.Threegroupsofexperimentsofvaryingincidentwaveconditionsareperformedtoinvestigatetherelationshipbetweenwaveconditionsandsecondarycirculationintensity.Thevelocityofthealongshoreflowofthesecondarycirculationissensitivetothevariationoftheincidentwaveheightandwaterdepth.Itisalsofoundthatthealongshoreflowintensityisindirectproportiontothealongshorevariationofthewaveheightgradientbetweenthebarsandtheshoreline.
简介:Theeffectoftheimprovementofcommercialactivatedcarbon(AC)onitsspecificcapacitanceandhighratecapabilityofdoublelayer(dl)charging/dischargingprocesshasbeenstudied.TheimprovementofACwascarriedoutviaasecondaryactivationundersteaminthepresenceofcatalystNiCl2,andthesuitableconditionwasfoundtobeaheattreatmentatabout875℃for1h.Underthoseconditions,thedischargespecificcapacitanceoftheimprovedACincreasesupto53.67F/g,showinganincreaseofabout25%ascomparedwiththatofas-receivedAC.Thegoodrectangular-shapedvoltammogramsandA.C.impedancespectraprovethatthehighratecapabilityofthecapacitormadeoftheimprovedACisenhancedsignificantly.Thecapacitanceresistance(RC)timeconstantofthecapacitorcontainingtheimprovedACis1.74s,whichismuchlowerthanthatoftheonecontainingas-receivedAC(anRCvalueof4.73s).ItisnotedthatbothkindsofACsamplesshowasimilarspecificsurfaceareaandporesizedistribution,butsomechangeshavetakenplaceinthecarbonsurfacegroups,especiallyadecreaseintheconcentrationofsurfacecarbonylgroupsaftertheimprovement,whichhavebeenverifiedbymeansofX-photoelectronspectroscopy.Accordingly,itissuggestedthatthedecreaseintheconcentrationofsurfacecarbonylgroupsfortheimprovedACisbeneficialtotheorganicelectrolyteionpenetratingintothepores,thusleadingtotheincreaseinboththespecificcapacitanceandhighratecapabilityofthesupercapacitor.
简介:IntheapplicationofRNAitechnology,itisanessentialsteptodesignsiRNAapplicabletotargetgene.Atpresent,therearemanyresearchesandconclusionsonsiRNAdesign.ThispaperaimstotheinfluencesofmRNAsecondarystructureorsiRNAantisense-strandsecondarystructureonsiRNAsilenceefficiency.Thepaperalsodiscussestheproblemsandsetsoutfurtherinsightsintheresearch.
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简介:为睾丸激素代替治疗(TRT)的许多方法存在,并且TRT的主要潜在的风险有建立的井。开发对外长的睾丸激素(T)第二等的红血球增多症的风险被报导了从0.4%~40%。自从1972,可植入的T小团被使用了,并且第二等的红血球增多症被报导了与这种管理形式象0.4%一样低。然而,我们的经验建议了更高的率。我们进行了同意板的、单个机构的、回顾的图表评论(2009-2013)与皮下地植入的睾丸激素小团对待在228个人决定第二等的红血球增多症的率的机构的评论。Kaplan-Meyer失败曲线被用来估计时间直到红血球增多症的发展(分血器>50%)。管理的小团的吝啬的数字是12(范围:6-16)。吝啬的后续是566天。50%病人开发了红血球增多症的红血球增多症的开发的中部的时间是50个月。在6个月的红血球增多症的估计的率是10.4%,12个月17.3%,和24月是30.2%。我们断定第二等的红血球增多症的发生当在T上小团治疗可能比以前建立高时。